「terms」の検索結果

Performs differential expression on bulk RNA-seq count data with DESeq2's negative-binomial GLM, Wald and LRT testing, apeglm/ashr/normal LFC shrinkage, independent filtering, Cook's outlier handling, VST/rlog transforms, and design formulas including paired, batch, and interaction terms. Use when running bulk DE, choosing DESeq2 over edgeR or limma-voom, building a paired or interaction design, applying LFC shrinkage for ranking or GSEA, choosing Wald vs LRT, troubleshooting padj=NA, picking VST vs rlog, importing salmon/kallisto via tximport, or analyzing prokaryotic RNA-seq.

日本語の概要は準備中です。原文の説明を表示しています。

Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

日本語の概要は準備中です。原文の説明を表示しています。

Cross-company language sweep via Quartr full-text search — date the adoption curve of a term/phrase across the global transcript+filing corpus, identify which companies (and which speaker roles) use it and when they started, and cross-reference against vault theses and graph adjacency to flag terms propagating through supply chains the book owns. Use when user says "sweep", "who is talking about X", "language scan", "adoption curve for X", or "is X inflecting".

日本語の概要は準備中です。原文の説明を表示しています。

Import a single webpage from any URL into canonical EDS block format — structured HTML that authors edit in DA. Scrapes the page, analyzes structure, maps to existing blocks, and generates HTML for immediate local preview. Also triggered by terms like "migrate", "migration", or "migrating". Use this when the goal is canonical EDS authoring; use the snowflake skill instead when the user wants to preserve the original DOM byte-for-byte (static-to-EDS overlay).

日本語の概要は準備中です。原文の説明を表示しています。

Assigns GO terms, Pfam/InterPro domains, KEGG orthologs, EC numbers, and product names to predicted proteins using eggNOG-mapper (orthology), InterProScan (domain signatures), and KofamScan (KEGG), routing specialized functions to dbCAN/antiSMASH/AMRFinderPlus/SignalP. Covers the orthology-vs-domain-vs-homology paradigms, the annotation-error percolation cascade, domain-presence-is-not-function, GO IEA circularity in enrichment, evidence tiering, and bit-score/coverage thresholds. Use when adding functional annotation to predicted genes, choosing between eggNOG-mapper and InterProScan, or judging how much to trust a functional label.

日本語の概要は準備中です。原文の説明を表示しています。

Query UniProt's REST API (post-2022 endpoint at rest.uniprot.org) for protein sequences, annotations, GO terms, cross-references, ID mappings, and proteomes. Use when fetching UniProtKB entries, navigating the JSON schema, choosing between UniProtKB/UniRef/UniParc/Proteomes resources, deciding stream vs search endpoint for batch retrieval, running ID-mapping jobs with the async pattern, handling isoform suffixes, or filtering reviewed Swiss-Prot vs auto-annotated TrEMBL. Encodes the legacy URL migration (2022), the new JSON schema layout, and bulk-pull patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Performs differential expression on bulk RNA-seq count data with DESeq2's negative-binomial GLM, Wald and LRT testing, apeglm/ashr/normal LFC shrinkage, independent filtering, Cook's outlier handling, VST/rlog transforms, and design formulas including paired, batch, and interaction terms. Use when running bulk DE, choosing DESeq2 over edgeR or limma-voom, building a paired or interaction design, applying LFC shrinkage for ranking or GSEA, choosing Wald vs LRT, troubleshooting padj=NA, picking VST vs rlog, importing salmon/kallisto via tximport, or analyzing prokaryotic RNA-seq.

日本語の概要は準備中です。原文の説明を表示しています。

Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks the economic + operational tradeoffs of broker-mediated freight vs direct shipper relationships — margin difference, capital + operational cost, sales effort, payment terms, relationship investment, when to pursue direct, and the hybrid model. Reference industry research on freight broker margins.

日本語の概要は準備中です。原文の説明を表示しています。

Adds comprehensive accessibility testing to CI/CD pipelines using axe-core Playwright integration or pa11y-ci. Automatically generates markdown reports for pull requests showing WCAG violations with severity levels, affected elements, and remediation guidance. This skill should be used when implementing accessibility CI checks, adding a11y tests to pipelines, generating accessibility reports, enforcing WCAG compliance, automating accessibility scans, or setting up PR accessibility gates. Trigger terms include a11y ci, accessibility pipeline, wcag ci, axe-core ci, pa11y ci, accessibility reports, a11y automation, accessibility gate, compliance check.

日本語の概要は準備中です。原文の説明を表示しています。

Codified expertise for customs documentation, tariff classification, duty optimization, restricted party screening, and regulatory compliance across multiple jurisdictions. Informed by trade compliance specialists with 15+ years experience. Includes HS classification logic, Incoterms application, FTA utilization, and penalty mitigation. Use when handling customs clearance, tariff classification, trade compliance, import/export documentation, or duty optimization.

日本語の概要は準備中です。原文の説明を表示しています。

Architecture Decision Records (ADR) — a lightweight method for capturing important architectural decisions with context, trade-offs, and rationale. Based on Michael Nygard's ADR pattern and Google/Meta/ByteDance's design documentation culture. USE WHEN: deciding between technology choices, designing new architecture, changing existing architecture, documenting why a decision was made, onboarding new team members, or preserving design context for future maintainers. Triggered by terms like "tech choice", "architecture decision", "why did we choose", "design rationale", "ADR", or "architectural decision record".

日本語の概要は準備中です。原文の説明を表示しています。

AI legal document generation powered by CellCog. Contracts, NDAs, terms of service, privacy policies, freelance agreements, employment contracts, compliance reviews, legal research. Precision legal drafting from natural language prompts. Not legal advice.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes contracts and agreements for risks, unusual terms, and missing clauses

日本語の概要は準備中です。原文の説明を表示しています。

Draft privacy policies, terms of service, disclaimers, and legal notices. Creates GDPR-compliant texts, cookie policies, and data processing agreements. Use PROACTIVELY for legal documentation, compliance texts, or regulatory requirements.

日本語の概要は準備中です。原文の説明を表示しています。

Import a single webpage from any URL into canonical EDS block format — structured HTML that authors edit in DA. Scrapes the page, analyzes structure, maps to existing blocks, and generates HTML for immediate local preview. Also triggered by terms like "migrate", "migration", or "migrating". Use this when the goal is canonical EDS authoring; use the snowflake skill instead when the user wants to preserve the original DOM byte-for-byte (static-to-EDS overlay).

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes contracts and agreements for risks, unusual terms, and missing clauses

日本語の概要は準備中です。原文の説明を表示しています。

Generate, manage, and track professional invoices with payment terms, recurring billing, overdue automation, and financial reporting. Use when creating invoices, tracking payments, managing clients, or reviewing revenue.

日本語の概要は準備中です。原文の説明を表示しています。

Operationalizing an expungement website — user intake flows, document generation pipelines, court filing integrations, payment processing, state-by-state workflow variations, customer support for sensitive populations, and the handoff between automated systems and human legal review. Activate on 'expungement operations', 'legal tech SaaS', 'court filing integration', 'document automation pipeline', 'expungement business', 'legal service workflow', 'multi-state legal operations'. NOT for expungement law itself (use national-expungement-expert), web design (use legal-tech-web-design), or legal document drafting (use recovery-app-legal-terms).

日本語の概要は準備中です。原文の説明を表示しています。