696 件 ・ 関連度順
概要と使いどころ
Detect and remove doublets (multiple cells captured in one droplet) from single-cell RNA-seq data. Uses Scrublet (Python), DoubletFinder (R), and scDblFinder (R). Essential QC step before clustering to avoid artificial cell populations. Use when identifying and removing doublets from scRNA-seq data.
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Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation. For standard design, use proteinmpnn. For ligand-aware design, use ligandmpnn.
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Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, artifacts, posters, or applications (examples include websites, landing pages, dashboards, React components, HTML/CSS layouts, or when styling/beautifying any web UI). Generates creative, polished code and UI design that avoids generic AI aesthetics.
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Overlay doctrine for the embedded-captions workflow — the caption MODEL (drop / rail / embed) and the rule that captions are an OVERLAY composited on top of the film, never a reserved bottom band you shift content up to avoid. Load when adding captions/subtitles to a talking-head or launch video, when deciding whether a phrase should be dropped, ride the verbatim rail, or be promoted to a scarce embedded climax, when laying out a composition that will carry captions (do NOT reserve a keep-out band), or when centering a composition on the true frame center under captions. Quotes the rail+embed model from embedded-captions and constraint
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Implement or refactor Formax tool transcript UI using the Tool UI Blocks (C-lite) pattern (ToolUiBlocks renderer + blocks presenters) to avoid touching many tool presenter files; use when adjusting ⏺/⎿ spacing, indent rules, or migrating additional tools to blocks presenters with targeted Ink/Vitest tests and Codex review before commit.
日本語の概要は準備中です。原文の説明を表示しています。
Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, or applications. Generates creative, polished code that avoids generic AI aesthetics.
日本語の概要は準備中です。原文の説明を表示しています。
Create mathematical animations with Manim Community Edition(manimce), with optional TTS voiceover and synced subtitles. Generates distinctive, production-grade animations that avoid generic "AI slop" aesthetics. Use when user wants to animate concepts, equations, illustrate proofs, visualize algorithms, create math explainers, or produce 3Blue1Brown-style videos.
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direnv loads and unloads environment variables automatically when you enter and leave a directory, using a per-project .envrc file. Use when a user asks to manage env vars per project, auto-switch configs, avoid manually sourcing .env files, set up .envrc, use dotenv with direnv, or pick a Python or Node version per directory.
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Add persistent memory to Claude Code that survives across sessions. Use when: maintaining continuity across Claude Code sessions, building agents with persistent project memory, avoiding repeated context setup. Covers claude-mem (AI-compressed session logs) and Claude Subconscious (Letta-based background agent).
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Paul Graham's founder mode. When to delegate vs. dive deep. Maintaining velocity as you scale. Avoiding "professional CEO" traps. The operating mode that built Apple, Tesla, and every YC unicorn. Founder mode isn't micromanagement - it's having the conviction and context to make decisive moves that employees can't. It's staying in the arena when conventional wisdom says to step back. Use when "founder mode, should i delegate, staying close to work, micromanagement, when to step back, professional ceo, manager vs founder, skip level, how involved should i be, letting go of control, scaling as founder, founder burnout, founder, leadership, delegation, management, scaling, operational" mentioned.
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Strategies for managing LLM context windows including summarization, trimming, routing, and avoiding context rotUse when "context window, token limit, context management, context engineering, long context, context overflow, llm, context, tokens, memory, summarization, optimization" mentioned.
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A/B and multivariate testing methodology. Design experiments, calculate sample sizes, determine statistical significance, avoid common pitfalls, and interpret results. Platform-agnostic framework applicable to landing pages, emails, ads, pricing, and product features. Use when the user asks about A/B testing, split testing, experiment design, statistical significance, or conversion experiments.
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Pre-push hygiene check for GitHub repositories. Scans for PII, secrets, and sensitive data before pushing. Audits commit messages, enforces repo-specific blocklists, and rate-limits pushes to avoid GitHub abuse detection. Use before any git push, especially to public repos.
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Avalonia Layout with Zafiro.Avalonia workflow skill. Use this skill when the user needs Guidelines for modern Avalonia UI layout using Zafiro.Avalonia, emphasizing shared styles, generic components, and avoiding XAML redundancy and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.
日本語の概要は準備中です。原文の説明を表示しています。
Avalonia Layout with Zafiro.Avalonia workflow skill. Use this skill when the user needs Guidelines for modern Avalonia UI layout using Zafiro.Avalonia, emphasizing shared styles, generic components, and avoiding XAML redundancy and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.
日本語の概要は準備中です。原文の説明を表示しています。
影视编剧 (Scriptwriting / Screenwriting) — 为电影 / 电视 / 流媒体剧集写戏剧蓝本的从业者认知操作系统: 决定「讲什么故事、人物是谁为何转变、场景如何被戏剧化、主题为何重要」的学科 —— 区别于导演 (调度 / 视觉实现)、制片 (融资 / 排期)、小说 (无格式 / 场景 / 视觉动作约束)。覆盖 (a) 故事与结构理论 (亚里士多德《诗学》情节 / 人物 / 思想 + 突转 peripeteia / 发现 anagnorisis + 净化 catharsis; Syd Field 范式 / 三幕 / 情节点; Freytag 金字塔; Egri 前提; McKee《故事》掌控性理念 / 鸿沟 / 价值正负转变 / 激励事件 / 渐进式复杂化; Truby《故事剖析》22 步 + 道德论证; Vogler/Campbell 英雄之旅; Blake Snyder《救猫咪》15 拍节拍表; Dan Harmon 故事环; John Yorke 五幕《进入森林》; Frank Daniel 八序列法; 起承转合东亚戏剧结构), (b) 人物 (想要 vs 需要 / 外在目标 vs 内在缺失, 人物弧光 正 / 负 / 平, flaw-wound-ghost 创伤背景, 主动 vs 被动主角的能动性, Egri 三维人物 生理 / 社会 / 心理, 反派是主角的镜子, 群像与关系网, 人物在压力下的选择中显形), (c) 对白 (潜台词 subtext, 对白即动作与冲突而非信息, 避免太直白 on the nose, 人物独特声口, 信息植入 exposition, Mamet/Sorkin 意图-阻碍式对白, 展示而非告知, 中文剧台词工艺), (d) 场景与序列工艺 (场景是有目标 / 冲突 / 转折的微型故事, 场景价值充能与转折点, 晚进早出, 八序列法, set piece, 转场, 场景头 / 动作行 / 括号提示 格式工艺), (e) 主题与前提 (掌控性理念 / 前提, 主题是被戏剧化的论证而非说教, 道德论证 Truby, 主题统一性, 这到底在讲什么), (f) 类型 (类型惯例是对观众的承诺, Snyder 10 类故事, 颠覆 vs 尊重套路, 类型片 vs 文艺片, 中国类型 主旋律 / 古装 / 年代 / 悬疑 / 甜宠 / 都市 / 军旅 / 历史正剧), (g) 格式与工业流程 (好莱坞剧本格式与 Final Draft, logline 一句话故事, treatment 故事大纲, 节拍表, 分场 / 分集大纲, spec 原创剧本 vs 委托, pitch, coverage, 美剧编剧室与 showrunner 制; 中国 大纲→人物小传→分集大纲→剧本, 长剧集 40 集结构, 网络电影 / 网大, 分账剧, 平台定制剧, 微短剧竖屏短剧), (h) 改稿与开发 (写作就是改写, 改稿 / 润色 / 推倒重写, 处理意见 / 改稿意见, 片方与平台 notes, 杀死你的宝贝, 围读, 开发地狱), (i) 改编 (IP改编 小说 / 漫画 / 游戏改编, 忠于精神而非字句, 压缩, 中国网文 IP 热), (j) 中国影视编剧产业现实 (审查 / 广电总局约束, 备案 / 立项, 平台定制剧 爱优腾芒, 分账, 编剧维权 署名权 / 欠薪 / 枪手, 注水剧, 流量 + 大IP 资本逻辑 vs 原创工艺, 导演中心制 vs 编剧话语权), (k) 编剧职业与工艺生涯 (spec vs 委托, 编剧 vs 编审 / 策划, 单兵 vs 编剧室, 在开发链条中的位置, WGA 与署名仲裁规范, 入行, 中国编剧地位与权益)。跨 电影 / 美剧流媒体 / 中国电影与长剧集。不含 导演 / 摄影 / 制片 / 融资 / 表演 / 电影理论批评为终点 / 泛小说写作 / 纪录片 / 新闻 —— 本 skill 是「戏剧化编剧」工艺: 故事 / 人物 / 场景 / 对白 / 主题 / 结构 / 格式 与围绕它们的产业流程。 (Scriptwriting / Screenwriting for film & TV (影视编剧) — the cognitive operating system of practitioners who write the dramatic blueprint of films, television, and streaming series: the discipline of deciding WHAT story is told, WHO the characters are and why they change, HOW the scenes are dramatized, and WHY it matters thematically — distinct from directing (staging/visual realization), producing (financing/scheduling), and prose fiction (which has no format/scene/visual-action constraints). Covers (a) story & structure theory (Aristotle's Poetics — plot/character/thought + reversal peripeteia/recognition anagnorisis + catharsis; Syd Field's paradigm/three-act/plot points; Freytag's pyramid; Lajos Egri's premise; Robert McKee's Story — controlling idea/the gap/value charge/inciting incident/progressive complications; John Truby's 22 steps & moral argument; Christopher Vogler/Joseph Campbell hero's journey; Blake Snyder's Save the Cat 15-beat sheet; Dan Harmon's story circle; John Yorke's 5-act Into the Woods; Frank Daniel's 8-sequence method; 起承转合 East-Asian dramatic structure), (b) character (want vs need/external goal vs internal lack, character arc positive/negative/flat, 人物弧光, flaw-wound-ghost backstory, agency active vs passive protagonist, Egri's 3-dimensional character physiology/sociology/psychology, antagonist as the protagonist's mirror, ensemble & relationship webs, character revealed through choice under pressure), (c) dialogue (subtext 潜台词, dialogue as action & conflict not information, 'on the nose' avoidance, distinct character voice, exposition handling, Mamet/Sorkin intention-obstacle dialogue, show-don't-tell, 台词 craft in Chinese drama), (d) scene & sequence craft (scene as a mini-story with goal/conflict/turn, scene value charge & turning point, enter-late-leave-early, the 8-sequence method, set pieces, transitions, slug line/action line/parenthetical format craft), (e) theme & premise (controlling idea/premise/前提, theme as dramatized argument not message, moral argument Truby, thematic unity, 'what is this really about'), (f) genre (genre conventions as audience promise, Snyder's 10 story types, subverting vs honoring tropes, 类型片 vs 文艺片, Chinese genres 主旋律/古装/年代/悬疑/甜宠/都市/军旅/历史正剧), (g) format & industry process (Holly
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Use when operating peky from the CLI or TUI, especially for AI agents who need reliable, low-error procedures. Covers how to target sessions/panes correctly, use scopes, avoid confirmation prompts, and keep CLI/TUI/daemon in sync.
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Behavioral guidelines to reduce common LLM coding mistakes. Use when writing, reviewing, or refactoring code to avoid overcomplication, make surgical changes, surface assumptions, and define verifiable success criteria.
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Applies the engineering and research philosophies of Jeff Dean, Chief Scientist at Google DeepMind and Google Research. Reach for this skill whenever you are designing large-scale distributed systems, optimizing latency and energy efficiency, or making architectural decisions about machine learning infrastructure. It should trigger automatically for topics involving hardware-ML co-design, model distillation, sparse activation, massively multi-task models, or scaling systems by 5x to 10x. Use this skill to evaluate system bottlenecks, transition from specialized to unified models, and optimize experimental velocity. Apply his mental models to avoid premature 100x scaling and to treat AI models as reasoning engines rather than memorization databases.
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Use this skill whenever you are reasoning about large-scale scientific projects, genomics, bioethics, data infrastructure, or long-term medical translation. Eric S. Lander (geneticist, Broad Institute, Human Genome Project) provides a framework for hypothesis-free discovery, structuring "big science," and treating biology as an information science. Reach for this when the user is discussing open science, collaborative ecosystems, CRISPR/gene editing ethics, managing massive datasets, or setting realistic timelines for technological breakthroughs. Apply his principles to avoid the "lone genius" myth, prevent overpromising, and build foundational infrastructure that serves the broader community.
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Builds distinctive, production-grade UIs that avoid generic AI aesthetics. Use whenever the user wants to build, restyle, or give visual direction to any interface — pages, dashboards, landing pages, components, onboarding flows, mobile screens, or design systems — even without an explicit 'design' request. Also triggers for: picking an aesthetic direction, improving the look of a dull/generic existing page, adding visual personality, or choosing colors/typography. Includes a bundled design intelligence database for concrete guidance across web (React, Next.js, Vue, Tailwind) and mobile (React Native, Flutter, SwiftUI).
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Generate targeted clarifying questions (2-3 max) that challenge vague requirements and extract missing context. Use after request-analyzer identifies clarification needs, before routing to specialist agents. Helps cto-orchestrator avoid delegating unclear requirements.
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Summarize the current Git working tree and create a straightforward non-interactive commit. Use when Codex is asked to quickly commit the current work, commit everything currently changed, prepare a concise commit message from the diff, or avoid extra confirmation and commit splitting unless there is a real safety issue.
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Use when a Java service reads or writes the database - JPA/Hibernate and Panache/Spring Data mapping, transaction boundaries, pagination and avoiding N+1 and entity-over-the-wire leaks
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