「dire」の検索結果

Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Review and rank an entire SCF round end-to-end from a CSV export. Supports Open Track, Integration Track, and RFP Track with track-specific scoring dimensions. Reads submission data directly from an Airtable CSV, auto-detects columns, categorizes, runs parallel batch reviews, cross-batch calibration, and final ranking. All output is markdown. Use when you have a CSV export of an SCF Build Award round and need to review, score, and rank every submission.

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Stellar smart contract development (Rust, soroban-sdk). Entry point with project setup, contract anatomy, and build/deploy workflow, routing to three companion files in this directory — development.md (storage/TTL, authorization, cross-contract calls, tokens, events, errors, upgrades, fees, troubleshooting), testing.md (unit, fuzz, property, fork, mutation, integration), and security.md (vulnerability classes, checklists, tooling, audits). Use when writing, testing, reviewing, securing, debugging, or shipping Stellar smart contracts, including anything the user calls "Soroban" — Soroban contracts, soroban-sdk, Soroban auth/storage/TTL errors, SEP-41 tokens, or SAC integration from contract code.

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Guidance for distinctive, intentional visual design when building new UI or reshaping an existing one. Helps with aesthetic direction, typography, and making choices that don't read as templated defaults.

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Guide for implementing smooth, native-feeling animations using React's View Transition API (`<ViewTransition>` component, `addTransitionType`, and CSS view transition pseudo-elements). Use this skill whenever the user wants to add page transitions, animate route changes, create shared element animations, animate enter/exit of components, animate list reorder, implement directional (forward/back) navigation animations, or integrate view transitions in Next.js. Also use when the user mentions view transitions, `startViewTransition`, `ViewTransition`, transition types, or asks about animating between UI states in React without third-party animation libraries.

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Choose and implement local, directed, broadcast, cancellable, and network events.

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Define or review a visual system, DESIGN.md, or redesign direction. Use for typography, layout, color, motion, and interaction design decisions.

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When the user wants to create SEO-driven pages at scale using templates and data. Also use when the user mentions "programmatic SEO," "template pages," "pages at scale," "directory pages," "location pages," "[keyword] + [city] pages," "comparison pages," "integration pages," or "building many pages for SEO." For auditing existing SEO issues, see seo-audit.

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Extract supplier invoice details structured for direct import into ERP systems like SAP, Oracle, or Microsoft Dynamics.

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Extract structured data from multiple invoice PDFs in one call, then pipe the results directly into an XLSX accounts payable tracker.

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Tells you what CARLA on UE 5.5 (branch ue5-dev) cannot do that UE 5.8 (ue58-dev) can, so you do not attempt an unsupported workflow there — no Autoware integration, no ROS 2 middleware choice (FastDDS only), no DLSS or ray-traced-lens camera, no OFPA large-map mount so Town12/13/15 load black, and a few missing World/Actor methods. Also states what is identical, so the ue58 skills can be used directly for everything else. Use when working against a 5.5 checkout, when a ue58 skill's step has no counterpart, or when deciding whether a feature request is possible on 5.5 at all.

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Directly drives a specific vehicle on a running CARLA server — raw VehicleControl (throttle/steer/brake/reverse/hand-brake), Ackermann speed control, vehicle lights, opening/closing doors, and physics-control tuning; ros-info reports the native ROS 2 command topics (vehicle_control_cmd, ackermann_control_cmd) for the hero. Targets the ego by default. Use when the user asks to "drive/steer the car", "accelerate/brake/reverse", "set a target speed", "turn on the headlights/blinkers/brake lights", "open a door", "drive the car from ROS", or "change the vehicle's mass/drag/physics". This is manual control (autopilot off) — for TM-driven traffic use control-traffic.

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Imports a custom RoadRunner map (FBX geometry + XODR OpenDRIVE) into a CARLA source build as a drivable map — reads the map from the directory the user names, runs CARLA's Import.py to cook the level, Traffic Manager graph and (standard maps only) pedestrian navmesh, and verifies it loads on a server. Handles both standard maps and large tiled maps; large maps get no navmesh, matching upstream CARLA. Use when the user asks to "import a map into CARLA", "add a custom/RoadRunner map", "ingest an FBX+XODR map", "make import", bring in a "large/tiled map", or fix missing walkers / a missing pedestrian navmesh.

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Bidirectional conversion between SpecWeave increments and Azure DevOps work items. Use when exporting increments to ADO epics, importing ADO epics as increments, or resolving sync conflicts. Handles Epic/Feature/User Story/Task hierarchy mapping.

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Guide the user to add a data source, connection, or API connector to a Canvas App via Power Apps Studio, then verify and continue. USE WHEN the user asks to add a data source, add a connection, add an API, add a connector, connect to SharePoint / Dataverse / SQL / Excel / OneDrive / Teams / Office 365, or any similar request to make new data available to the app. DO NOT USE WHEN the user is asking to list or describe existing data sources — call list_data_sources or list_apis directly instead.

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Add WhatsApp channel via native Baileys adapter. Direct connection — no Chat SDK bridge. Uses QR code or pairing code for authentication.

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Active Directory ACL 滥用攻击方法论。当 BloodHound 发现 GenericAll/WriteDACL/WriteOwner/GenericWrite/ForceChangePassword 等危险 ACE 时使用。覆盖 ACE 枚举、权限滥用链、Shadow Credentials、RBCD 攻击

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Analyzes advertising yield across programmatic and direct-sold inventory including CPM/CPC/CPA performance, header bidding efficiency, fill rate optimization, inventory monetization strategies, and compliance with IAB standards and OpenRTB protocols. USE THIS SKILL WHEN: - You need to audit ad revenue performance or diagnose yield drops - Someone asks about header bidding configuration or Prebid.js optimization - You are analyzing fill rates, eCPM trends, or ad unit performance - A project involves programmatic advertising, SSP integration, or ad serving - You need to verify ads.txt, sellers.json, or supply chain compliance - Someone mentions CPM floors, bid density, or auction dynamics - You are evaluating ad quality controls, viewability, or ad-related UX impact - A codebase integrates Google Ad Manager, AdMob, Prebid, or any SSP TRIGGER PHRASES: "ad yield", "eCPM", "fill rate", "header bidding", "Prebid", "programmatic ads", "ad monetization", "CPM optimization", "ad revenue", "ads.txt", "ad serving", "SSP", "ad unit performance", "viewability"

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Lay out how a job search will actually run alongside a current job: the hours available each week and what they go to, how weekday daytime slots for interviews will be found, which routes to use (direct applications, job boards, scout sites, agents, referrals, public employment services) and what each one discloses to whom, how to keep the search from reaching the current employer through public profiles or workplace equipment, a single tracker of every application's stage, next action, and deadline, and a date and conditions for reviewing, reducing, or pausing the search. Use when someone has decided to start looking, or to gather information while employed, and asks how to fit it in, which routes to use, whether the applications they are running fit the time they have, or how to keep track of them; do not use to decide whether to change jobs, to pick or rate employers or job postings, to predict outcomes, or to send applications, publish profiles, or contact agents on the user's behalf.

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Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and coverage-biased, so generic Hi-C loop callers (cooltools dots, Juicer HiCCUPS) use the wrong null. Covers FitHiChIP (config-driven coverage+distance-decay spline regression, peak-to-peak vs peak-to-all foreground, loose vs stringent background, coverage vs ICE bias), MAPS (positive Poisson regression on bias factors for PLAC-seq/HiChIP), hichipper (restriction-site-distance bias model + library QC), CHiCAGO (Delaporte two-component Brownian+technical background for asymmetric bait x other-end Capture Hi-C), the with/without separate-ChIP anchor decision, and differential loops via diffloop. Use when calling loops from HiChIP/PLAC-seq/Capture Hi-C, choosing FitHiChIP/MAPS/CHiCAGO, picking peak-to-all vs peak-to-peak, setting the loop FDR, supplying ChIP peaks as anchors, QCing a HiChIP library, or comparing loops between conditions.

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Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.

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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

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Download raw sequencing reads from NCBI SRA using sra-tools (prefetch, fasterq-dump, vdb-validate) or the ENA mirror. Use when pulling FASTQ for SRR/ERR/DRR accessions, deciding between SRA-direct, ENA mirror, or AWS/GCP cloud mirror (STRIDES), handling --include-technical for 10x and other single-cell records, validating with MD5/vdb-validate, navigating SRR/SRX/SRS/SRP/PRJNA hierarchy, or finding accessions via pysradb. Encodes SRA cloud-egress economics, the fasterq-dump uncompressed-scratch trap, and the --max-size default that silently truncates large prefetches.

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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

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