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概要と使いどころ
Implement and execute approved research Experiment, Tuning, or Design Cards with reproducible logs, metrics, environment, and artifacts. Use for bounded coding, debugging, and runs; not for changing claims, priorities, budgets, or the Research Spine.
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Decide whether a protein has a pocket worth targeting, and where it is, before committing to a docking or design campaign. Use this skill to run fpocket cavity detection, rank cavities by druggability and volume, compare apo and holo conformations to spot induced fit, identify allosteric and cryptic cavities that only open in simulation, and convert a chosen cavity into the search box coordinates a docking run needs. Also trigger on fpocket, cavity detection, druggability score, alpha sphere, cryptic pocket, allosteric site, pocket volume, hotspot mapping, or undruggable target assessment.
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Search the ClinicalTrials.gov registry through its version 2 REST API for interventional and observational studies, their phases, enrolment, endpoints, sponsors, and posted results. Use this skill to survey who is developing what against an indication, date a competitor's programme, read primary and secondary outcome measures, find eligibility criteria, and distinguish a study that completed from one that was terminated or withdrawn. Also trigger on ClinicalTrials.gov, NCT number, trial registry, study phase, enrolment, primary outcome measure, recruiting status, trial sponsor, or competitive landscape.
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Retrieve protein sequences, annotation, and structures from UniProtKB, the RCSB PDB, and AlphaFold DB. Use this skill to resolve a gene or protein name to a UniProt accession, pull sequences and FASTA files, find binding sites and domains, search the PDB by UniProt accession, sequence, ligand, or text, download mmCIF/PDB coordinates and biological assemblies, fetch AlphaFold models with their pLDDT confidence, and check whether a structure is actually usable before docking or simulating it. Also trigger on UniProt accessions, PDB ids, rest.uniprot.org, search.rcsb.org, files.rcsb.org, alphafold.ebi.ac.uk, id mapping, SEQRES, or missing residues.
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Compute relative and absolute binding free energies with the Open Free Energy toolkit — the rigorous alchemical alternative to docking scores when a congeneric series needs reliable potency ranking. Use this skill to plan a perturbation network over a ligand set, choose atom mappings, run hybrid-topology or separated-topology protocols, and analyse the result — per-edge ΔΔG with uncertainty, cycle-closure error, and mean unsigned error against measured affinities. Also trigger on OpenFE, alchemical transformation, thermodynamic cycle, RBFE, ABFE, SepTop, lambda window, MBAR, cycle closure, or perturbation map.
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Queries the NCATS Translator ARAX production API for bounded, typed, provenance-rich one-hop and endpoint-pinned two-hop biomedical knowledge-graph relationships. Use for Biolink-constrained RTX-KG2 lookup, explicit selected-provider ARAX federation, separate entity normalization, qualifier-aware graph traversal, and inspection of TRAPI edge bindings, publications, and knowledge-source provenance. Do not use for inference, ranking, open-ended pathfinding, clinical guidance, or sensitive queries.
日本語の概要は準備中です。原文の説明を表示しています。
Generate and optimise novel small molecules with REINVENT 4 — de novo sampling from a chemical language model, scaffold decoration with LibInvent, fragment linking with LinkInvent, and similarity-constrained analogue generation with Mol2Mol. Use this skill to set up reinforcement-learning or curriculum runs, compose a multi-parameter scoring function from docking scores, predictive models, and physicochemical desirability, and read the resulting sampled sets. Also trigger on REINVENT, LibInvent, LinkInvent, Mol2Mol, scaffold hopping, R-group replacement, linker design, chemical language model, or reinforcement-learning molecule optimisation.
日本語の概要は準備中です。原文の説明を表示しています。
Analyze and engineer protein glycosylation. Scan sequences for canonical N-glycosylation sequons (N-X-S/T with X not proline, including overlapping sites), predict O-GalNAc hotspots, read glycan notation, and reach the curated external tooling (NetNGlyc, NetOGlyc, GlycoShield, GlycoWorkbench, GlyTouCan, GlyConnect). Use this skill for therapeutic antibody glycoengineering and afucosylation for ADCC, Fc glycan control, glycan shielding in vaccine immunogen design, sequon removal or insertion, and half-life engineering through sialylation. Also trigger on N-glycosylation, sequon, NXS/NXT, O-glycosylation, glycoform heterogeneity, afucosylation, high-mannose, GlyTouCan, or WURCS.
日本語の概要は準備中です。原文の説明を表示しています。
Medicinal chemistry filters for compound triage. Apply drug-likeness rules (Lipinski rule of five, Veber, Oprea, CNS, lead-like, rule of three), structural alert catalogs (PAINS a/b/c, NIBR screening-deck severity, Brenk, BMS, Glaxo, Dundee, ChEMBL common alerts), ZINC-15 percentile complexity metrics (Bertz, SAscore, QED, Whitlock, Barone), chemical-group detection, Lilly demerits, and the medchem query language (MATCHRULE, HASALERT, HASPROP, HASGROUP) for filtering a library at scale. Also trigger on medchem, `import medchem as mc`, RuleFilters, NIBRFilters, CommonAlertsFilters, NamedCatalogs, QueryFilter, PAINS filtering, or structural alerts.
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Vets whether to build a feature from scratch, use an existing free/open-source solution, or pay for a third-party API/service. Use this whenever the user asks Claude to implement, add, integrate, or write code for a feature or capability, especially one that sounds like it could already be a solved problem (auth, payments, scraping, animation, comment/DM automation, video/image generation, search, notifications, etc.), even if the user doesn't explicitly ask "should I build or buy this." Make sure to trigger this before writing non-trivial implementation code for any feature-level capability, not just when the user asks about libraries directly.
日本語の概要は準備中です。原文の説明を表示しています。
Use when working with iOS/macOS Keychain Services (SecItem queries, kSecClass, OSStatus errors), biometric authentication (LAContext, Face ID, Touch ID), CryptoKit (AES-GCM, ChaChaPoly, ECDSA, ECDH, HPKE, ML-KEM), Secure Enclave, secure credential storage (OAuth tokens, API keys), certificate pinning (SecTrust, SPKI), keychain sharing across apps/extensions, migrating secrets from UserDefaults or plists, or OWASP MASVS/MASTG mobile compliance on Apple platforms.
日本語の概要は準備中です。原文の説明を表示しています。
Adversarial, security-first review of a pull request from an EXTERNAL or untrusted contributor — a fork PR, a first-time or unknown author, anyone without write access — before a maintainer merges it. Use this whenever you're reviewing, triaging, or deciding whether to merge a PR opened against tbh-meter by someone outside the maintainer team: 'review PR #123', 'someone opened a PR — is it safe to merge?', 'check this contributor's changes', 'can we take this fork PR?', 'is this contribution legit?'. This is supply-chain DEFENSE, not ordinary code review: every merged PR auto-updates onto every user's machine and ships a memory-reading .exe plus an unsandboxed Electron app, so the author and the PR description are UNTRUSTED and the diff is the only evidence. It posts its verdict as a real GitHub review — an inline comment pinned to each problematic line (via the pulls/reviews API), not just one summary comment. NOT for your own or a fellow maintainer's branch (use self-review for that), and prefer this over the generic review flow for anything coming from outside the team.
日本語の概要は準備中です。原文の説明を表示しています。
Vue 3 form patterns: native v-model, vee-validate + zod (most common), VueUse helpers, defineModel for custom inputs, controlled vs uncontrolled, field arrays, multi-step wizards. Use this skill to: - Wire vee-validate with a validation schema (zod / yup). - Build custom form components with defineModel (Vue 3.4+). - Implement multi-step forms. - Handle async validation. - Integrate forms with TanStack Query mutations or Pinia actions. Do NOT use this skill for: - General SFC conventions (see vue-conventions). - State management (see vue-state-management). - Routing (see vue-routing). - Testing forms (see vue-testing).
日本語の概要は準備中です。原文の説明を表示しています。
Vue 3 SFC structure, Composition API + <script setup>, file naming, project layout, props/emits/slots typing, defineModel, composables, lifecycle, watchers, UI library detection. Vue 2 fallback notes. Use this skill to: - Structure a new SFC with `<script setup>`, template, scoped styles. - Type props/emits/slots correctly via macros. - Pick `ref` vs `reactive` (prefer `ref`). - Build composables that compose cleanly. - Apply lifecycle hooks correctly. - Detect UI library (Vuetify/Quasar/PrimeVue/Naive UI/Element Plus/shadcn-vue) and mirror its patterns. Do NOT use this skill for: - State management lib choice (see vue-state-management). - Routing (see vue-routing). - Forms (see vue-forms). - Testing (see vue-testing).
日本語の概要は準備中です。原文の説明を表示しています。
Spring Boot coding conventions: REST controller design, service layer, dependency injection, configuration, DTO patterns, exception handling, and Bean Validation. Apply on any Spring Boot project. Works alongside spring-boot-plugin:spring-data-jpa for persistence and java-foundation:java-conventions for domain objects. Use this skill to: - Structure REST endpoints with @RestController, proper HTTP semantics, and DTO mapping. - Enforce constructor injection and @ConfigurationProperties over @Value on fields. - Write @Service classes with transactional boundaries at the right layer. - Handle errors consistently with @RestControllerAdvice and ProblemDetail (RFC 9457). Do NOT use this skill for: - JPA entity and repository patterns — see spring-boot-plugin:spring-data-jpa. - Spring Security configuration — see the security phase injection in stack.md. - Build tool configuration — see java-foundation:build-tooling.
日本語の概要は準備中です。原文の説明を表示しています。
Doctrine ORM best practices for Symfony: entity mapping as source of truth, repositories, DQL/QueryBuilder with parameters, N+1 prevention with fetch joins, relations (cascade/fetch/orphanRemoval), lifecycle events, batch processing, and generated migrations. Apply when: writing or reviewing Doctrine entities, repositories, and queries. Activated automatically by symfony-plugin/stack.md as a convention skill for the development and database phases. Do NOT use this skill for: - PHP language idioms — see php-foundation:php-conventions. - Controllers/services/forms — see symfony-plugin:symfony-conventions.
日本語の概要は準備中です。原文の説明を表示しています。
JUnit 5, Mockito, AssertJ, and Testcontainers patterns for any JVM project. Covers test structure, parameterised tests, mocking discipline, fluent assertions, and integration testing with real containers. Stack-agnostic — referenced by every Java plugin in the marketplace. Use this skill to: - Write clear, maintainable unit tests with JUnit 5. - Mock dependencies with Mockito without overusing mocks. - Write expressive assertions with AssertJ. - Spin up real infrastructure (DBs, message brokers) with Testcontainers for integration tests. Do NOT use this skill for: - Spring-specific test slices (@SpringBootTest, @WebMvcTest, @DataJpaTest — those are in spring-boot-plugin skills). - Framework-specific mocking utilities (MockMvc, WebTestClient).
日本語の概要は準備中です。原文の説明を表示しています。
Modern Java idioms for any JVM project (Java 17+): records, sealed types, text blocks, pattern matching, Optional discipline, streams, immutability, null safety, package layout, var usage, and code organisation. Apply when the project is a Java 17+ project. Stack-agnostic — referenced by every Java plugin in the marketplace. Use this skill to: - Write self-documenting, immutable-by-default value types with records. - Model closed type hierarchies with sealed classes and interfaces. - Handle optionality explicitly with Optional instead of returning null. - Write expressive pipelines with Stream API without performance footguns. - Lay out packages consistently (feature-first or layer-first) and keep class responsibilities tight. Do NOT use this skill for: - Framework-specific idioms (Spring annotations, JPA mappings — those live in framework plugin skills). - Build tooling (Maven/Gradle) — see java-foundation:build-tooling. - Testing patterns — see java-foundation:jvm-testing.
日本語の概要は準備中です。原文の説明を表示しています。
Angular forms: Reactive Forms (preferred — typed FormGroup/FormControl since Angular 14, FormBuilder, custom + async validators, FormArray, multi-step) and Template-driven (`[(ngModel)]` + FormsModule). Validation strategies, server error mapping, accessibility. Use this skill to: - Build Reactive Forms with typed FormGroup/FormControl. - Use FormBuilder для concise syntax. - Implement custom synchronous and async validators. - Wire FormArray for dynamic field lists. - Map server errors back to form fields. - Pick Reactive vs Template-driven (prefer Reactive). Do NOT use this skill for: - General conventions (see angular-conventions). - State management beyond forms (see angular-state-and-rx). - Routing (see angular-routing). - Testing forms (see angular-testing).
日本語の概要は準備中です。原文の説明を表示しています。
State management for Angular 18-21: signals (signal/computed/effect), services-as-state, NgRx Store + Effects + Selectors, NgRx Component Store, NgRx Signals (newer signal-based store). RxJS essentials — operators, async pipe, takeUntilDestroyed, signal/observable interop. Use this skill to: - Pick the right state tool (signals / services / NgRx variant / vue-query equivalent). - Use signals correctly (signal/computed/effect — when each). - Build a Pinia-style service-as-state singleton. - Set up NgRx Store + Effects + Selectors. - Use RxJS without leaking subscriptions (async pipe, takeUntilDestroyed, Subject patterns). - Bridge signals ↔ observables via toSignal / toObservable. Do NOT use this skill for: - General Angular conventions (see angular-conventions). - Routing state (see angular-routing). - Form state (see angular-forms). - Testing state (see angular-testing).
日本語の概要は準備中です。原文の説明を表示しています。
Etsy SEO optimization for existing and new listings. Auto-detects REWRITE (when user pastes a current title + tags + description) or CREATE (when user gives a short product context). Triggers on "rewrite this listing", "optimize my Etsy listing", "fix my title and tags", "create new listing", "make a new Etsy listing". Uses live Etsy autocomplete + competitor SERP scraping for evidence-driven keyword research. Enforces 2026 Etsy rules — tag ≤20 chars, primary keyword in first 40 chars, indexing spread across title/tags/attributes/description/hero alt, NLP-aware writing, trademark stoplist scan. When the user's problem isn't SEO (CTR, conversion, photos, price, saturated niche), it says so directly and routes to concrete next steps. Silently maintains a markdown listing database at ~/etsy-listings/ for cross-session memory on Claude/Cowork. Catches duplicate primary keywords across the user's own listings.
日本語の概要は準備中です。原文の説明を表示しています。
Use when writing an LLVM pass plugin, registering it for opt -passes, using DominatorTree or LoopInfo, or testing with FileCheck and lit. Not for reading IR: use llvm-ir-and-passes.
日本語の概要は準備中です。原文の説明を表示しています。
Use when reducing header bloat and compilation cascades with Include What You Use, interpreting IWYU reports, mapping files, forward declarations, or CMake integration.
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Use when writing, reviewing, or refactoring Rust code. Routes the task to handbook chapters on idioms, lints, errors, testing, generics, and pointers under the edition 2024 and current-stable pins.
日本語の概要は準備中です。原文の説明を表示しています。