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概要と使いどころ
Create or update OMA skills in the SSL-lite human-readable format. Use when adding a new `.agents/skills/{skill-name}/SKILL.md`, converting an existing skill to the standardized Scheduling / Structural Flow / Logical Operations / References structure, or validating whether a skill has enough routing, execution, resource, and safety detail.
日本語の概要は準備中です。原文の説明を表示しています。
Best-practice rulebook for a marketing site's pages, organized by page class — campaign landers, product pages, programmatic SEO trees, editorial. Use when writing or updating a landing/marketing page, wiring a campaign lander to an attribution identifier, changing site-wide nav/footer links, touching sitemap/robots/agent-readable surfaces, or auditing a public site's indexing, reachability, and conversion setup.
日本語の概要は準備中です。原文の説明を表示しています。
Use only when writing/updating/fixing C++ tests, configuring GoogleTest/CTest, diagnosing failing or flaky tests, or adding coverage/sanitizers.
日本語の概要は準備中です。原文の説明を表示しています。
Cache expensive file processing results using SHA-256 content hashes — path-independent, auto-invalidating, with service layer separation.
日本語の概要は準備中です。原文の説明を表示しています。
Use for VidSeeds MCP publishing - platform connections, OAuth connect URLs, activate YouTube channel, update connection settings, preflight/confirm/cancel publish, publish status, direct YouTube upload, and updating live YouTube metadata.
日本語の概要は準備中です。原文の説明を表示しています。
Runs the Fabric Git integration lifecycle through fab api or az rest, including connecting a workspace to Azure DevOps or GitHub, committing, updating from Git, reading sync status, resolving conflicts, disconnecting a connected workspace, and automating sync with a service principal. For stage promotion use deployment-pipelines-authoring-cli. Branch switching, fab deploy, fabric-cicd and cross-workspace rebinding are out of scope.
日本語の概要は準備中です。原文の説明を表示しています。
Create, structure, and package agent skills. Use when designing new skills, updating existing skills, or helping users build skills with scripts, references, and assets. Triggers on requests to create skills, write SKILL.md files, or structure skill directories.
日本語の概要は準備中です。原文の説明を表示しています。
Configure a Simulink model for Simulink Real-Time code generation and deployment. Use when setting up a model for Simulink Real-Time, selecting the correct system target file, fixing TLC/STF mismatches, applying fixed-step solver settings, validating target-platform compatibility, or configuring Simulink Real-Time build options before model build.
日本語の概要は準備中です。原文の説明を表示しています。
Generates draft requirements from Simulink models. Use when drafting or updating requirement artifacts from a model. Prefers Requirements Toolbox (.slreqx) when available; falls back to structured YAML.
日本語の概要は準備中です。原文の説明を表示しています。
Specify plant models for closed-loop simulation: system specs, architecture, build plans, validation plans. Use when creating, updating, or reviewing plant model specifications, planning plant model architecture, or planning plant model validation.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill when authoring, reworking, or validating a Classic AUTOSAR software component (SWC) in Simulink, including autosar.api mappings, runnables, timing events, sender-receiver ports, client-server operations, IRVs, BSW service callers, and component ARXML updates.
日本語の概要は準備中です。原文の説明を表示しています。
Use when writing or editing Simscape Language (.ssc) source files — components, domains, or functions. Triggers include: model a physical component in .ssc; write physical equations for a Simscape block; add or modify physics or parameterization options in a Simscape component; build a composite component. Also use for validating .ssc syntax, fixing Simscape Language errors, or converting governing equations into working Simscape component code. Do NOT use for configuring or connecting existing Simscape blocks in a Simulink model — that is model building, not language authoring.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for publishing skills and agents to the dotnet-skills Claude Code marketplace. Covers adding new content, updating plugin.json, validation, and release tagging.
日本語の概要は準備中です。原文の説明を表示しています。
Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.
日本語の概要は準備中です。原文の説明を表示しています。
Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.
日本語の概要は準備中です。原文の説明を表示しています。
Estimates time-scaled phylogenies, molecular-clock rates, effective reproduction number R_e, and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict/relaxed clocks; coalescent, Bayesian-Skyline, Skygrid, Birth-Death-Skyline, and sampled-ancestor priors; structured coalescent via MASCOT). Covers root-to-tip clock QC via TempEst, date-randomisation tests, recombination masking via Gubbins/ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction, multi-chain convergence diagnostics, and reconciling phylodynamic R_e with case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline models, diagnosing temporal-signal failure, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.
日本語の概要は準備中です。原文の説明を表示しています。
Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM), MeTPeak (HMM over sliding windows), MACS3/MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody methods cannot resolve, and orthogonal validation (miCLIP/GLORI/m6A-SAC-seq/m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set, reconciling differing peak sets across tools, validating MeRIP peaks against single-base methods, interpreting 5' peaks where m6Am contamination is possible, or recommending a consensus strategy.
日本語の概要は準備中です。原文の説明を表示しています。
Download raw sequencing reads from NCBI SRA using sra-tools (prefetch, fasterq-dump, vdb-validate) or the ENA mirror. Use when pulling FASTQ for SRR/ERR/DRR accessions, deciding between SRA-direct, ENA mirror, or AWS/GCP cloud mirror (STRIDES), handling --include-technical for 10x and other single-cell records, validating with MD5/vdb-validate, navigating SRR/SRX/SRS/SRP/PRJNA hierarchy, or finding accessions via pysradb. Encodes SRA cloud-egress economics, the fasterq-dump uncompressed-scratch trap, and the --max-size default that silently truncates large prefetches.
日本語の概要は準備中です。原文の説明を表示しています。
Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.
日本語の概要は準備中です。原文の説明を表示しています。
Detect introgression and admixture between species or populations using Dsuite (Malinsky 2021 fast D-statistics), Patterson's D / ABBA-BABA test (Green 2010; Durand 2011), f4-ratio and f-branch statistic (Malinsky 2018), TreeMix (Pickrell & Pritchard 2012), HyDe (Blischak 2018), QuIBL (Edelman 2019), sprime (Browning 2018), Twisst (Martin 2017), PhyloNet (Than 2008) for explicit phylogenetic networks, and qpAdm / qpGraph (Patterson 2012). Distinguish introgression from incomplete lineage sorting (ILS), ancestral structure, ghost-lineage admixture, and rate variation. Use when testing inter-species gene flow, dating admixture events, identifying introgressed segments, building phylogenetic networks for reticulate evolution, or applying the ABBAclustering (Koppetsch-Malinsky-Matschiner 2024) framework for divergent-species gene flow.
日本語の概要は準備中です。原文の説明を表示しています。
Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, applies the Patel et al 2024 *Nat Biotechnol* failure-mode framework, and validates that normalization is applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.
日本語の概要は準備中です。原文の説明を表示しています。
Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
日本語の概要は準備中です。原文の説明を表示しています。
Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.
日本語の概要は準備中です。原文の説明を表示しています。
Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.
日本語の概要は準備中です。原文の説明を表示しています。