「esi」の検索結果

Generates complete Mendelian randomization study designs from a user-provided exposure and outcome direction. Always use this skill whenever a user wants to design, plan, or build a Mendelian randomization study — even if phrased as "help me write a paper on X", "design an MR study for Y", or "I want to test whether A causally affects B using GWAS". Covers core two-sample MR design, optional bidirectional follow-up, optional multivariable MR, IV selection logic, ancestry alignment, harmonization, IVW as the default primary estimator, weighted median / MR-Egger / MR-PRESSO / leave-one-out sensitivity analyses, Steiger directionality, heterogeneity / pleiotropy checks, and explicit claim-boundary control. Always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, validation ladder, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references.

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Designs primary aims, secondary aims, and testable hypotheses from broad biomedical research ideas. Use this skill when a user needs to convert a loose study idea into a tighter protocol-framing structure with clear aim hierarchy, hypothesis discipline, and separation between hypothesis-driven and exploratory components. Always keep aims answerable, non-overlapping, and aligned to the intended evidence type and study scope.

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Identifies the real underlying study design used in a medical or biomedical paper, distinguishes primary and secondary design components when papers are hybrid, and converts the paper into an evidence-aware design label suitable for literature appraisal, evidence grading, and downstream review workflows. Always identify the actual design from what the study did, not from how the authors describe it. Never fabricate references, metadata, or study features.

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Use this skill for general PostgreSQL table design. **Trigger when user asks to:** - Design PostgreSQL tables, schemas, or data models when creating new tables and when modifying existing ones. - Choose data types, constraints, or indexes for PostgreSQL - Create user tables, order tables, reference tables, or JSONB schemas - Understand PostgreSQL best practices for normalization, constraints, or indexing - Design update-heavy, upsert-heavy, or OLTP-style tables **Keywords:** PostgreSQL schema, table design, data types, PRIMARY KEY, FOREIGN KEY, indexes, B-tree, GIN, JSONB, constraints, normalization, identity columns, partitioning, row-level security Comprehensive reference covering data types, indexing strategies, constraints, JSONB patterns, partitioning, and PostgreSQL-specific best practices.

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Design or build a page, screen, landing page, website, app or UI from a request - the whole job, end to end. Use this for "design a landing page", "build a settings screen", "make me a website", "design the onboarding", "ออกแบบหน้าเว็บ", "ทำหน้า landing", "ออกแบบ UI", "ทำแอป". It runs the pipeline no single skill covers: the house doctrine, a written Brief Inference so the result is not the statistical mean, a committed visual direction, tokens, build, the objective gates, then an adversarial critic. Hands off to data-dashboard for dense data screens, redesign for existing UI, and image-to-code when a reference image is given.

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AI DevKit · Design phase guidance for reviewing feature design against requirements. Use when the user wants to validate architecture, review design docs, resolve design trade-offs, or run dev-lifecycle phase 3.

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Guides the creation of technical design documents before writing code, producing architecture diagrams, data models, API interface definitions, implementation plans, and multi-option trade-off analyses. Use when the user asks to plan a feature, architect a system, design an API, explore implementation approaches, or requests a technical design or spec before coding — especially for complex features involving multiple components, ambiguous requirements, or significant architectural changes.

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Design and build playable levels — the blockout/whitebox-to-playable workflow, player metrics and grid layout, pacing and flow (tension/rest curve), gating and the critical path, and encounter design. Engine-neutral practice. Use when the user mentions level design, blockout/whitebox/greybox, level layout, level pacing, encounter design, or the critical path through a level.

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Extract design systems from reference UI images and generate implementation-ready UI design prompts. Use when users provide UI screenshots/mockups and want to create consistent designs, generate design systems, or build MVP UIs matching reference aesthetics.

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Work with Canva designs: list designs and folders, create designs, upload assets, and export to PNG/JPG/PDF/MP4. Trigger phrases: canva, canva design, export canva design.

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Cartesia text-to-speech: synthesize speech audio and browse voices. Trigger phrases: cartesia, text to speech, TTS, synthesize voice, voiceover.

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Use for UI/UX design, product flows, frontend or native interface design, design audits, design translation, asset planning, motion direction, design tokens, or distinctive non-generic apps and websites. Covers web and React, Windows and WinUI/Mica, Apple and SwiftUI, Android and Jetpack Compose/Material, cross-platform UI, and token export. Route to the focused skill, then load only the references required for the selected surface and failure mode.

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Use when defending the research design of an American Anthropologist (AA) manuscript — fieldwork and participant observation, interview and archival design for ethnographic/qualitative work, material/contextual analysis for archaeology, and appropriate lab/quantitative design for biological anthropology. AA judges each mode on its own terms with reflexivity. Strengthens the design; it does not write code or run fieldwork.

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Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2/PE3/PE3b/PEmax variants, MOSAIC in situ saturation mutagenesis, the PRIME pooled-screen methodology (Ren 2023; ~3,699 ClinVar variant screens), chromatin context as a major locus-level determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

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Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.

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Designs covalent inhibitors and warheads targeting cysteine, lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.

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Check that the UI you actually rendered uses the design system, by reading computed styles in the running app against the project's design tokens. Catches hardcoded hex colors, off-palette backgrounds, invisible or unusable controls, and animations that never ran. Use after building or restyling a component, when a design review is wanted, when a UI looks slightly off but nobody can say why, or when a design system exists and nothing checks whether the code follows it.

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Browser-based 3D design tool with visual editor, animation, and web export. Use this skill when creating 3D scenes without code, designing interactive web experiences, prototyping 3D UI, exporting to React/web, or building designer-friendly 3D content. Triggers on tasks involving Spline, no-code 3D, visual 3D editor, 3D animation, state-based interactions, React Spline integration, or scene export. Alternative to Three.js for designers who prefer visual tools over code.

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Reviews the design of an existing Power Pages site - a live URL or a local project folder - and recommends what to change, without modifying anything. Captures up to eight key pages at desktop and mobile, scores them against the plugin's design rubric (first impression, hierarchy, narrative, copy, trust, brand, responsive and accessible design, motion, detail), and returns prioritized, concrete recommendations. Use when the user wants a design review, critique, or audit of a site, asks how to make an existing site look better, more polished, or more impressive, or asks why it looks generic or dated.

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Plan and execute user research including research planning, recruiting, interview design, qualitative synthesis, and translating findings into product decisions. Use this skill whenever the user wants to plan user research, design interviews, recruit participants, conduct discovery, run formative research, or synthesize qualitative findings. Triggers on user research, UX research, user interviews, discovery research, generative research, formative research, qualitative research, user insights, research synthesis, recruitment, interview guide, jobs to be done. Also triggers when product decisions are being made without user input and the user wants to fix that.

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Plan and run usability tests on existing or prototype designs including test design, task scripts, moderation, observation, and findings synthesis. Use this skill whenever the user wants to test usability, run a moderated test, run an unmoderated test, validate a design, find usability issues, or improve task completion. Triggers on usability test, usability testing, moderated test, unmoderated test, task script, think aloud, prototype testing, user testing, design validation, task completion. Also triggers when the user has built something and wants to know if real users can use it before shipping.

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Create or refine a creative brief that bridges discovery and execution. Use this skill whenever the user is starting a new project, kicking off a website, beginning a brand build or redesign, briefing a designer or developer or AI agent, or trying to align a team before building. Triggers on creative brief, design brief, brand brief, project kickoff, kicking off, briefing the team, project intake, design direction, brief the designer, brief the dev, where do we start, how do we start, write a brief, project overview, scope this project, align on direction. Also triggers when the user has a vague idea and needs to make it concrete enough to hand off, even if they do not say 'brief' explicitly.

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Apply pre-composed aesthetic archetype defaults to jumpstart brand design work covering color, typography, layout, voice, and imagery direction. Use this skill whenever the user wants a starting point for brand visual and verbal direction, references a brand they want to design near (for example 'something like Stripe' or 'editorial like Linear'), needs to converge faster from many directions to one, or wants known-good defaults for a specific industry vertical. Triggers on archetype, design archetype, brand archetype, near to (brand), in the style of, similar aesthetic, design starting point, brand template, vertical-typical, industry-typical. Also triggers when the user has a brief and wants to map it to a known aesthetic family rather than design from first principles.

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Design or evaluate a brand visual identity system covering logo, color, typography, imagery direction, iconography, and motion principles. Use this skill whenever the user wants to design a logo, build a visual identity, define brand colors, choose brand typography, develop iconography, plan brand imagery, or evaluate an existing identity for cohesion. Triggers on logo design, brand identity, visual identity, brand mark, wordmark, monogram, color palette, brand colors, brand typography, type system, iconography, brand imagery, motion design, brand system, identity system. Also triggers when the user has a brand direction approved and now needs the visual artifacts that express it.

日本語の概要は準備中です。原文の説明を表示しています。