「r2」の検索結果

複雑な実装・設計変更を Plan → Implement → Review → Test → Retrospect で進める。要件、影響範囲、リスク、レビューや検証の選定を親が管理し、必要な担当だけを委譲する。`--deepplan` は深い計画、`--codex` は既定実装経路の明示、`--claude` はSonnetへ実装委譲する指定。

- Track aircraft and vessels from public ADS-B and AIS broadcasts using ADS-B Exchange, Flightradar24, FlightAware,… Use when following a tail number or flight, looking up an ICAO 24-bit hex code, registration or callsign, tracing a ship by IMO number or MMSI, checking a flag of convenience or port-call history, finding who owns a private jet or vessel

日本語の概要は準備中です。原文の説明を表示しています。

Build a complete but efficient Nature-style Chinese PPTX presentation from a remote-sensing, Earth-observation, geospatial AI, or broader scientific paper, preprint, PDF, article text, abstract, figure legends, or reading notes. Use this skill whenever the user asks to make slides/PPT/PPTX for journal club, group meeting, paper sharing, thesis seminar, lab meeting, department report, or academic presentation from a remote-sensing research paper. It identifies the paper type and argument, selects only the figures needed for the story, writes Chinese slide content and speaker notes, creates the actual .pptx deck, and runs an explicit self-review/corrective revision loop focused on figure quality, text overflow prevention, and non-template visual design before delivery. Also trigger on general academic-presentation requests even without the word "Nature", such as turning a paper into slides, building an academic talk deck, conference/defense presentations, and Chinese phrasings like 论文做PPT、遥感论文汇报、组会PPT、文献汇报、学术汇报、做幻灯片、讲paper、读书报告PPT.

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Use when the user asks to "set up conversion values so tROAS optimizes profit not orders", "map margin onto my purchase value", "build value rules for lead / phone / signup conversions", or "stop bidding to revenue when I care about profit"; defines and QAs the conversion VALUE model — per-conversion values, margin/net-value adjustment, static-vs-dynamic value rules, proxy values for non-revenue actions, and a value-vs-count sanity check — as a value-model spec plus a pre-launch value QA sheet. Not for whether the tag fires or UTMs are clean — use conversion-signal-qa; not for cross-platform double-count de-dup — use attribution-reconciler; not for scoring R1/R2 — that is a scored veto in ad-account-auditor. 付费广告转化价值建模/利润出价/价值规则QA

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user asks to "QA my conversion tracking before launch", "check my UTMs / pixel / event firing", "set up a tracking pre-flight", or "set the dedup rule so Meta and Google stop double-counting"; builds and fixes the measurement plumbing — conversion-event firing, UTM hygiene, cross-platform dedup rules, attribution-window alignment, and offline/iOS-ATT modeled-gap flags — as a pre-flight checklist plus a UTM/event-spec builder. Not for scoring R1/R2 — that is a scored veto in ad-account-auditor; not for account structure — use campaign-architect. 付费广告转化追踪QA/UTM规范/跨平台去重

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Use when platform-reported conversions disagree with GA4/ecommerce, when you suspect Meta and Google are double-counting the same sales, or for a standing (monthly) reconciliation workbook that de-dups stacked credit against an order-ID truth set, normalizes attribution windows and currency, compares attribution models, and reads incrementality from a geo/holdout test. Not for the point-in-time R2 veto or RQS gate — use ad-account-auditor; not for the ROI/ROAS ratio math itself — use roi-calculator; not for organic dark-social share attribution or GA4 direct-traffic decomposition — use dark-social-attributor. 付费广告归因对账/去重/增量

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Provider (v6.x) state management for Flutter using ChangeNotifier and InheritedWidget with MVVM architecture pattern. Use this skill when implementing Provider-based state management, using Consumer/Consumer2 widgets for targeted rebuilds, accessing state with context.read/context.watch/context.select, setting up ChangeNotifierProvider or StateNotifierProvider, configuring MultiProvider for multiple providers, implementing ProxyProvider for dependent state, using Selector for optimized rebuilds, migrating from StatefulWidget to reactive state, maintaining legacy Provider codebases, debugging provider not found errors, preventing memory leaks with proper ChangeNotifier disposal, fixing context access issues in initState, or resolving .value constructor anti-patterns. Essential for apps with shared state across widgets (shopping carts, authentication, global settings, form state, theme management), when teaching state management fundamentals, or when debugging memory leaks and resource cleanup in Provider-based applications.

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Expert in Cloudflare Workers and the Edge Computing ecosystem. Covers Wrangler, KV, D1, Durable Objects, and R2 storage.

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Expert in Cloudflare Workers and the Edge Computing ecosystem. Covers Wrangler, KV, D1, Durable Objects, and R2 storage.

日本語の概要は準備中です。原文の説明を表示しています。

Manual testing + bug filing for Enterprise / SaaS products. Parses a Feishu test doc (scope + repo + bitable URL), observes staging via claude-in-chrome, captures DOM/console/network/screenshot evidence, then dual-tracks each finding — Feishu Bitable record (with attachments) + GitHub issue (<REPO>#<ISSUE_NUMBER> format — English-primary, Chinese collapsed, R2-hosted screenshots, matching type label). Enforces dedup across bitable + GitHub issues + PRs, and mandatory P0/P1/P2 priority prompt when unclear. Trigger whenever the user says "test and report", "test and report side-by-side", "start system testing", "experience staging", "collaborate on bug filing", "collect feedback", a shared Feishu testing doc, a bitable URL + finding, or any UX/bug needing both bitable + GitHub tracking. Do NOT use for writing product code, PR review, CI debugging, or general "how do I use this product" questions — those go to normal dev / PR-review / support flows.

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Decision-grade statistical analysis for metabolomics intensity tables. Covers transformation and scaling (Pareto vs unit-variance as a hidden hypothesis), unsupervised structure (PCA/HCA for QC), permutation-validated PLS-DA/OPLS-DA (R2 vs Q2, double CV, VIP as heuristic), univariate testing (Welch/Mann-Whitney/ANOVA/LMM with covariate adjustment), and dependence-aware multiple testing. Use when testing which metabolites differ, building or validating a discriminant model, choosing a scaling, or correcting many correlated tests. For sample-wise normalization/drift correction see metabolomics/normalization-qc; for ML classifiers and selection-inside-CV leakage see machine-learning/biomarker-discovery and machine-learning/model-validation; for pathway interpretation see metabolomics/pathway-mapping; for design/power/multiplicity regime see experimental-design/multiple-testing.

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Cloudflare-first platform selection. Decision trees for Workers, D1, R2, KV, DO, Queues, Vectorize, Containers, Sandboxes, Flagship, Agent Memory, Workflows v2. Default stack, override conditions, auth, data patterns, reliability.

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MANDATORY deploy after every code change. Typecheck → deploy → purge CDN → E2E on production → visual verify → fix-forward loop. Workers Builds native CI/CD, D1 Time Travel PIT recovery, D1→R2 long-term backups, wrangler rollback, wrangler secrets management, structured observability, cross-browser smoke tests, rollback procedures, and GitHub auto-configuration.

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Predicts protein-coding gene structures (exons, introns, UTRs) in eukaryotic genomes with BRAKER3 (RNA-seq + protein evidence), BRAKER1/BRAKER2, GALBA (protein-only), Funannotate (fungi), GeMoMa (homology projection), or Helixer/Tiberius (deep-learning ab initio). Covers the evidence-first tool decision, mandatory soft-masking, the training-set-quality-dominates principle, OrthoDB clade-partition selection, the one-isoform-per-locus and missing-UTR traps, merge/split errors, and reference bias against orphan genes. Use when annotating a newly assembled eukaryotic genome, choosing a gene-prediction pipeline based on available evidence, or diagnosing a poor annotation.

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Discovers, classifies, and masks repetitive elements and transposable elements with RepeatModeler2 (de novo family library), RepeatMasker (masking against a library), EDTA (plant/structural TEs), or EarlGrey (auto-curating wrapper), and quantifies TE expression from RNA-seq with TEtranscripts/SQuIRE. Covers de-novo-library-as-curation-project, soft-vs-hard masking, the domesticated-gene over-masking massacre, Dfam-vs-RepBase, TE classification (Class I/II, family-vs-copy), Kimura repeat landscapes, LAI, and the RNA-seq multimapping problem. Use when masking repeats before gene prediction, building a TE library for a non-model genome, or analyzing transposable-element content or expression.

日本語の概要は準備中です。原文の説明を表示しています。

Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

日本語の概要は準備中です。原文の説明を表示しています。

Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts protein-coding gene structures (exons, introns, UTRs) in eukaryotic genomes with BRAKER3 (RNA-seq + protein evidence), BRAKER1/BRAKER2, GALBA (protein-only), Funannotate (fungi), GeMoMa (homology projection), or Helixer/Tiberius (deep-learning ab initio). Covers the evidence-first tool decision, mandatory soft-masking, the training-set-quality-dominates principle, OrthoDB clade-partition selection, the one-isoform-per-locus and missing-UTR traps, merge/split errors, and reference bias against orphan genes. Use when annotating a newly assembled eukaryotic genome, choosing a gene-prediction pipeline based on available evidence, or diagnosing a poor annotation.

日本語の概要は準備中です。原文の説明を表示しています。

Discovers, classifies, and masks repetitive elements and transposable elements with RepeatModeler2 (de novo family library), RepeatMasker (masking against a library), EDTA (plant/structural TEs), or EarlGrey (auto-curating wrapper), and quantifies TE expression from RNA-seq with TEtranscripts/SQuIRE. Covers de-novo-library-as-curation-project, soft-vs-hard masking, the domesticated-gene over-masking massacre, Dfam-vs-RepBase, TE classification (Class I/II, family-vs-copy), Kimura repeat landscapes, LAI, and the RNA-seq multimapping problem. Use when masking repeats before gene prediction, building a TE library for a non-model genome, or analyzing transposable-element content or expression.

日本語の概要は準備中です。原文の説明を表示しています。

Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

日本語の概要は準備中です。原文の説明を表示しています。

Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

日本語の概要は準備中です。原文の説明を表示しています。

Generates PSR-20 Clock implementation for PHP 8.5. Creates ClockInterface implementations including SystemClock, FrozenClock, and OffsetClock for time abstraction and testing. Includes unit tests.

日本語の概要は準備中です。原文の説明を表示しています。