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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

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Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).

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Critically review strategy drafts from edge-strategy-designer for edge plausibility, overfitting risk, sample size adequacy, and execution realism. Use when strategy_drafts/*.yaml exists and needs quality gate before pipeline export. Outputs PASS/REVISE/REJECT verdicts with confidence scores.

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Use when the user asks to "triage our comments, DMs, and mentions", "draft replies to this thread", "can we repost this fan post", or "set up inbox SLAs and an escalation path"; produces a ranked triage queue with register detection (sincere / ironic / performative / parasocial, sentiment-inversion table included — "this is so bad" under a comedy register is praise), a commenter taxonomy (troll monitor-only / rager / misguided / unhappy-customer / advocate) with a response-tier ladder and per-channel SLAs, an escalation matrix ending at the crisis path, a moderation ladder plus house rules for owned spaces, and a UGC curation-and-rights mode whose dated permission entries route to the channel registry — every reply is a ranked DRAFT a human posts; nothing is ever auto-sent. Not for launch-window feedback triage — use launch-feedback-synthesizer. 评论私信提及分诊/语域识别/回复草稿/UGC授权

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Use when the user asks to "write SEO content", "draft a blog post / landing page", "update outdated content", or "fix traffic/ranking decay"; two modes — new drafts pages with keywords, headers, snippets, and evidence boundaries; refresh scores decay, prioritizes update work, and produces a republish plan with GEO guidance. Not for AI-citation/GEO readiness scoring — use geo-content-optimizer; not for publish-gate scoring — use content-quality-auditor. SEO文章写作/内容更新/排名恢复

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Reduce defensive disclaimers, stacked hedging, and self-protective narration when drafting, rewriting, or auditing proposals, articles, case studies, captions, and other reader-facing prose. Use when defensive wording is requested for review or appears in a draft, including wording the assistant adds. Preserve meaningful limits; do not perform general style cleanup or ordinary code work.

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Apply meta-principles of software craftsmanship: DRY, orthogonality, tracer bullets, and design by contract. Use when the user mentions "best practices", "pragmatic approach", "broken windows", "tracer bullet", "software craftsmanship", "avoid technical debt", "code ownership", or "how do I become a better developer". Also trigger when evaluating build-vs-buy decisions, designing estimation approaches, or choosing between reversible and irreversible architectural decisions. Covers estimation, domain languages, and reversibility. For code-level quality, see clean-code. For refactoring techniques, see refactoring-patterns.

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Turn an existing blog post into draft text for other channels: X threads, LinkedIn posts, Threads/Bluesky, short-video scripts, YouTube scripts, Reddit posts, newsletter excerpts, podcast scripts. Saves drafts to files; it never posts anywhere. Never invents personal stories or results: first-hand framing appears only when the user supplies it. Use when the user says "repurpose", "turn this post into a thread", "linkedin post from blog", "youtube script from post". Not for writing the blog post itself (blog-write) or scheduling.

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Write a LinkedIn post from a raw idea using 21 proven hook formulas, in the user's own voice, humanized so it does not read as AI. Use whenever the user wants a LinkedIn post, a hook, a draft for the feed, "post about X", "turn this into a LinkedIn post", or asks for hook options. Produces three hook options, one full draft, and a copy-ready block that is never published without an explicit yes.

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Draft professional follow-up emails to contacts made at conferences - not too pushy, but memorable.

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Assist in drafting professional peer review response letters. Trigger.

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Use study limitations drafter for academic writing workflows that need structured execution, explicit assumptions, and clear output boundaries.

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Draft Diversity, Equity, and Inclusion statements for academic applications.

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Draft IACUC protocol applications with focus on the 3Rs principles justification.

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Generates a first draft of a clinical meta-analysis paper. Input the research report (including Methods and Results sections), language, and title to automatically generate a complete paper draft including Abstract, Introduction, Discussion, and other sections, with automatic ...

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Use when drafting patient discharge summaries, creating personalized discharge instructions, simulating post-discharge outcomes, reducing hospital readmissions, or optimizing care transitions. Generates AI-enhanced discharge documentation with digital twin predictions for improved patient safety.

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Writes Specific Aims pages for grant applications. Use when drafting or revising the Specific Aims page (NIH R01/R21/R03), NSF Project Summary, or equivalent for any major funding agency. Also triggers on "write my specific aims", "help me draft specific aims for NIH", "what should a specific aims page include", "NSF project summary", "write my grant aims", or "how do I structure an R01".

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Format, create, and update concise XQUIC pull request bodies and review-state transitions. Use when asked to prepare or edit an alibaba/xquic PR body, create a draft PR from an already-pushed branch, update a PR after code changes pushed a new head, or move a validated draft toward review.

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Verify whether a proposed XQUIC bug issue is real by checking the cited RFC or Internet-Draft mechanism against the repository's actual source behavior, tracing any root cause to current file and line evidence, and returning a fail-closed boolean gate. Use when validating an issue draft, investigating a claimed QUIC, HTTP/3, QPACK, or MoQT protocol violation, or before issue-submit may publish an issue.

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Draft and submit evidence-backed XQUIC GitHub bug issues in the repository's CONTRIBUTING and issue-template format. Use when preparing or opening an alibaba/xquic issue that must identify an exact RFC or draft mechanism, expected-versus-actual behavior, reproduction evidence, and optional verified source root cause; requires issue-check to return true before any GitHub submission.

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Fail closed on published draft XQUIC code pull requests before ready-for-review state. Use when asked to pre-review a code PR or move it out of draft; verify current base-to-head code, protocol conformance, validation coverage, adversarial bad cases, hot-path performance, and memory safety in a five-part local report.

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creates draft task file in .specs/tasks/draft/ with original user intent

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Master Minecraft server plugin development with Bukkit, Spigot, and Paper APIs. Specializes in event-driven architecture, command systems, world manipulation, player management, and performance optimization. Use PROACTIVELY for plugin architecture, gameplay mechanics, server-side features, or cross-version compatibility.

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Scene and sequence craft (场景/段落/细节/道具/悬念/情趣) — merged from Robert McKee's scene design and five-step scene analysis (value turn, beats, text/subtext, turning points, pacing, image systems), McKee's Dialogue scene types (balanced, comic, asymmetric, indirect, reflexive, minimal), Syd Field's sequence and scene elements, Neill Hicks (less is more, enter late leave early, energy), Richard Walter (action over talk, small gestures, avoid phones/cars/restaurants, list twelve alternative locations), Wendy Henson (action paragraphs, transitions, story-doing), Julian Hoxter (scene beats, objectives and tactics), Mei Feng's value test, and Lu Jun's chapters 意趣要足 (suspense, delay, wit), 细节要妙, 道具要精, 场景要当. Use when writing or fixing a single scene, choosing a location, building a sequence, planting a prop or detail, designing suspense and delay, cutting a scene that "nothing happens" in, or turning talk into action.

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