479 件 ・ 関連度順
概要と使いどころ
Expert guide for Ultra-Low Latency Conversational Voice AI (<300ms), WebRTC bidirectional streaming, OpenAI Realtime API, Gemini Multimodal Live Audio, LiveKit Agents, and Semantic VAD / Panduan ahli AI suara percakapan real-time berlatensi ultra-rendah.
日本語の概要は準備中です。原文の説明を表示しています。
Expert guide for chatbot and messaging platform integration (WhatsApp Business, Telegram Bot, Discord.js, Slack Bolt) and conversational AI / Panduan ahli integrasi chatbot dan platform messaging (WhatsApp Business, Telegram Bot, Discord.js, Slack Bolt) dan AI percakapan.
日本語の概要は準備中です。原文の説明を表示しています。
Cheminformatics toolkit for fine-grained molecular control. Parse and write SMILES, SDF, MOL and InChI; compute descriptors (MW, LogP, TPSA, QED, Bertz); build fingerprints (Morgan/ECFP, RDKit, MACCS, atom pair, torsion) and score Tanimoto, Dice or cosine similarity; run SMARTS substructure search and reaction SMARTS; generate 2D depictions and ETKDG 3D conformers; extract Murcko scaffolds and canonical hashes; control sanitization and stereochemistry directly. Also trigger on rdkit, Chem.MolFromSmiles, rdFingerprintGenerator, SDMolSupplier, SMARTS query, ETKDG, or FilterCatalog. For standard workflows with a simpler interface use the datamol skill, which wraps RDKit; use rdkit for advanced control, custom sanitization, and specialized algorithms.
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ES — Critica a fondo una idea, plan, pitch o proyecto entero sin validar ni adular: asume que va a fracasar y lo demuestra por ocho ángulos (premisas, mercado, competencia, viabilidad, números, ejecución, pre-mortem y punto ciego), investiga fracasos reales cuando hay herramientas, y entrega un veredicto franco con la lista priorizada de qué arreglar. Activar con /abogado-del-diablo, "hazme pedazos esto", "critica mi idea sin filtros", "dime por qué va a fallar", "destruye este plan", "segunda opinión brutal", "pre-mortem". EN — Harshly critiques an idea, plan, pitch, or whole project without validating; assumes it will fail and proves it across eight angles, then returns a blunt verdict with a prioritized fix list. Trigger on "devil's advocate", "red team this", "tear this apart", "why will this fail", "brutal second opinion", "pre-mortem".
日本語の概要は準備中です。原文の説明を表示しています。
Build, test, run, lint, format, and manage dependencies for Haskell projects using the hx toolchain CLI. Use whenever working in a Haskell project that has an hx.toml (or when setting one up), or when the user asks to build/test/run/typecheck Haskell code, manage GHC/Cabal versions, or add/remove Hackage dependencies.
日本語の概要は準備中です。原文の説明を表示しています。
Implementation guidance for creating individual agents in the Arcanea system with proper structure, capabilities, and integration.
日本語の概要は準備中です。原文の説明を表示しています。
Reviews AudioUnit v2/v3 plugin implementations for spec compliance, thread safety, and correctness. Use when the user asks to review an AudioUnit plugin, check an AUv3 app extension, audit property or parameter handling, or asks "is my AUComponent thread-safe?" or "why does my AU crash in Logic?". Trigger on phrases like "review my AudioUnit", "check my AUv3", "is my render block safe?", or when you see AURenderCallback, internalRenderBlock, kAudioUnitProperty_*, or AUAudioUnit in the code.
日本語の概要は準備中です。原文の説明を表示しています。
Use when a task needs the judgment of a Coin, Vending, and Amusement Machine Servicer and Repairer — triaging a jam across bill validators, coin mechanisms, refrigerated vending units, and arcade/amusement PCBs on a route, setting restock par levels against route-cycle economics, investigating a cash-collection variance at a stop, or applying food-safety temperature/time discard rules on perishable vending product.
日本語の概要は準備中です。原文の説明を表示しています。
Comprehensive tarot expert covering Major and Minor Arcana, spreads, symbolism, and interpretative frameworks from Rider-Waite to Thoth traditions
日本語の概要は準備中です。原文の説明を表示しています。
Create CodeTour `.tour` files — persona-targeted, step-by-step walkthroughs with real file and line anchors. Use for onboarding tours, architecture walkthroughs, PR tours, RCA tours, and structured "explain how this works" requests.
日本語の概要は準備中です。原文の説明を表示しています。
Ticket/PRD intake: product-area classification, completeness scoring, RCA, technical assessment. Works with Jira, Linear, GitHub, or manual paste. Use to analyze or triage a ticket.
日本語の概要は準備中です。原文の説明を表示しています。
Evaluate Jira ticket complexity and inconsistencies via jira-evaluator agent, read-only. NOT estimation (mk:jira-estimator) or full RCA (mk:jira-analyst).
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Heuristic read-only story-point estimation for one Jira ticket via jira-estimator agent. NOT complexity analysis (mk:jira-evaluator) or full RCA (mk:jira-analyst).
日本語の概要は準備中です。原文の説明を表示しています。
Heuristic story-point estimation for a single Jira ticket via the jira-estimator agent. Read-only. Triggers: 'estimate KEY', 'story points for KEY', 'how complex is KEY'. NOT for complexity-only analysis (mk:jira-evaluator); NOT for full RCA (mk:jira-analyst).
日本語の概要は準備中です。原文の説明を表示しています。
Evaluate Jira ticket complexity + inconsistencies via the jira-evaluator agent. Read-only. Triggers: 'evaluate KEY', 'analyze ticket complexity for KEY', 'check ticket quality for KEY'. NOT for estimation (mk:jira-estimator); NOT for full RCA (mk:jira-analyst).
日本語の概要は準備中です。原文の説明を表示しています。
Ticket/PRD intake: product area classification, completeness scoring, RCA, technical assessment. Works with Jira (via mk:jira-issue / jira-as), Linear (via MCP), GitHub (via gh CLI), or manual paste. Triggers: 'analyze ticket', 'intake PRD', 'triage issue', 'classify ticket', 'check ticket'.
日本語の概要は準備中です。原文の説明を表示しています。
Detects and removes doublets/aggregates from flow, spectral, and mass cytometry before clustering or quantification. Covers FSC-A vs FSC-H singlet discrimination (the Area-Height non-proportionality, not a 1D area gate), FSC-W/SSC width gating, CyTOF Gaussian discrimination parameters (Center/Offset/Width/Residual/Event_length) and DNA intercalator gating, and the residual heterotypic conjugates that survive scatter gating and masquerade as double-positive populations. Use when filtering aggregates before phenotyping, choosing a doublet method for flow vs CyTOF, or diagnosing a suspicious double-positive cluster.
日本語の概要は準備中です。原文の説明を表示しています。
Build interactive HTML/web visualizations with plotly (Python/R), bokeh (Python), and gganimate/plotly frames for animation, with awareness of current Kaleido static-export model (post-orca-EOL), HTML file-size bloat, and the limits of interactive-only output for journal submission. Use when producing zoomable/hoverable plots for notebook EDA, supplementary HTML, dashboards, or animated time-course / iteration visualizations.
日本語の概要は準備中です。原文の説明を表示しています。
Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.
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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.
日本語の概要は準備中です。原文の説明を表示しています。
Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.
日本語の概要は準備中です。原文の説明を表示しています。
Extracts and assigns COSMIC v3.4 mutational signatures (86 SBS / 11 DBS / 18 ID / 21 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.
日本語の概要は準備中です。原文の説明を表示しています。
This skill recommends obtaining an oncology consultation to direct treatment of the underlying malignancy causing hypercalcemia of malignancy. It is triggered when a clinician diagnoses HCM and seeks guidance on coordinating cancer‑directed therapy.
日本語の概要は準備中です。原文の説明を表示しています。