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Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.

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Quantifies alternative splicing as PSI (percent spliced in) from RNA-seq using rMATS-turbo (BAM-based event), SUPPA2 (TPM-based event), MAJIQ V3 (LSV-based Bayesian), leafcutter (annotation-free intron clusters), VAST-TOOLS (cross-species with microexon support), Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage), or IRFinder-S (intron retention coverage-aware). Distinguishes the five canonical event classes (SE, A5SS, A3SS, MXE, RI), special classes (microexons, exitrons, AFE/ALE), intron retention subtypes (canonical RI vs detained introns), and applies effective-length normalization. Use when measuring splice-site usage or isoform inclusion ratios from short-read RNA-seq.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

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Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

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Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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Build iOS augmented reality and 3D experiences with RealityKit and ARKit. Use when adding RealityView content, loading entities or USDZ models, anchoring objects to planes or world positions, distinguishing entity hit tests from ARKit real-world raycasts, handling AR camera availability, world tracking, scene updates, or RealityKit entity gestures and interactions.

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Discover and connect to Bluetooth Low Energy (BLE) peripheral devices from MATLAB. Use this skill when the user wants to scan for BLE devices, connect to a BLE peripheral, read or write BLE characteristics, subscribe to notifications, or any task that requires a BLE connection as a prerequisite (e.g., read sensor data over BLE, monitor heart rate, log accelerometer, stream data from wearable, IoT device communication). Triggers on: BLE, Bluetooth Low Energy, blelist, ble device, BLE characteristic, GATT, service UUID, scan for devices, BLE sensor, subscribe notify, BLE read, BLE write, peripheral device, BLE connect, wireless sensor.

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Discover, configure, and connect to Arduino boards from MATLAB using the Arduino Support Package. Use this skill when the user wants to set up an Arduino board, connect to Arduino hardware, find connected boards, scan serial ports, configure Arduino libraries, or any task that requires an Arduino connection as a prerequisite (e.g., blink LED, read sensor, read digital pin, read analog pin, write pin, plot sensor data, scan I2C, use ultrasonic sensor, control servo, read temperature, read voltage, data logging from hardware). Triggers on: arduino, board setup, COM port, serial port, hardware connection, Arduino Nano, Arduino Uno, Arduino Mega, Arduino Micro, Grove, sensor setup, I2C scan, ultrasonic, servo, readDigitalPin, writeDigitalPin, readVoltage, writePWMVoltage, temperature sensor, air pressure, pin read, pin write, analog input.

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Translate NI-DAQmx C function signatures into correct calldaqlib MATLAB calls. Use when the user mentions calldaqlib, any DAQmx* C function name (DAQmxCfgSampClkTiming, DAQmxExportSignal, DAQmxSetStartTrigRetriggerable, DAQmxGetSampClkRate, etc.), or needs NI-DAQmx functionality not exposed by the daq object. Covers: projection rules (taskHandle implicit, output pointers become return values, buffer-size args, enum-as-string), multi-task semantics, start() clobber, device-level empty-daq workaround, dictionary returns, string getter placeholder, array getter placeholder. Trigger contexts: low-level DAQ, escape hatch, retriggerable acquisition, shared timebase, export signal, connect terminals, external sample clock, trigger configuration, NI driver, C function translation.

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Read BEFORE troubleshooting or enhancing camera image quality. Diagnoses and enhances image quality from cameras connected via Image Acquisition Toolbox or USB Webcams support package. Discovers camera capabilities at runtime, analyzes captured images for quality issues (brightness, contrast, sharpness, noise, color balance, backlighting), suggests hardware setting adjustments tailored to the specific camera, and applies Image Processing Toolbox enhancement functions. Use when a user wants to improve camera image quality, troubleshoot dark/blurry/noisy/grainy/ overexposed/washed out/color cast images, or optimize camera settings.

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Style MATLAB charts and figures. colororder palettes for chart series colors, colormap selection, brand color organization, and the R2025a Theme API for uifigure apps (dark mode with fliplightness, ThemeChangedFcn, uistyle, component colors). Use when customizing chart colors, applying a color palette, organizing brand colors, implementing dark mode, or importing an external color scheme. Triggers: theme, dark mode, brand colors, colororder, colormap, palette, fliplightness, color scheme, styling, chart colors.

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Use when engineering or selecting the best features for single-response classification or regression in MATLAB, whatever the data's modality — for non-tabular data it routes extraction to a domain skill, then selects, assesses, and delivers on the resulting table. Not for multi-response problems, model training, or raw data acquisition.

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Supply Chain Bottleneck Analyzer for Shopify/DTC stores. Diagnose cash flow, inventory, shipping costs, and customer acquisition efficiency. Includes CAC/LTV analysis, 3PL cost optimization, and ad spend benchmarks. No API key required for basic analysis.

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CloudBase auth provider configuration and login-readiness guide. This skill should be used when users need to inspect, enable, disable, or configure auth providers, publishable-key prerequisites, login methods, SMS/email sender setup, or other provider-side readiness before implementing a client or backend auth flow.

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Pre-built animated React component collections combining Magic UI (150+ TypeScript/Tailwind/Motion components) and React Bits (90+ minimal-dependency animated components). Use this skill when building landing pages, marketing sites, dashboards, or interactive UIs requiring pre-made animated components instead of hand-crafting animations. Triggers on tasks involving animated UI components, Magic UI, React Bits, shadcn/ui integration, Tailwind CSS components, or component library selection. Alternative to manually implementing animations with Framer Motion or GSAP.

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Friendly, jargon-free onboarding for people new to coding agents and Power BI agentic development. Invoke for setup, prerequisites, tool installation, terminal guidance, safety questions, or explanations of models, context, prompts, tools, and environments. Use setup mode for concise installation help, explain mode for guided learning, and improve-my-agent-setup for an existing setup audit.

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When the user wants to plan cold start, get first users, or launch a new product with zero traction. Also use when the user mentions "cold start," "cold start problem," "first users," "seed users," "finding users," "finding early users," "Fiverr Upwork," "comment outreach," "Twitter search users," "product launch strategy," "0 to 1 growth," "early-stage acquisition," "launch channels," "get first customers," "Product Hunt launch," "AppSumo," "LTD," "indie hacker," "bootstrapping," or "solo founder." For directory listing copy and submissions, use directory-submission. For Product Hunt day-of execution, use product-hunt-launch. For GTM motion design, use gtm-strategy.

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When the user wants to plan growth using the AARRR framework, diagnose growth bottlenecks, or map actions across the customer lifecycle. Also use when the user mentions "growth funnel," "AARRR," "pirate metrics," "acquisition activation retention," "customer lifecycle metrics," or "growth framework." For retention tactics, use retention-strategy.

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When the user wants to plan paid ads strategy, allocate ad budget, or choose paid channels. Also use when the user mentions "paid ads," "paid media," "PPC," "SEM," "web ads," "app ads," "TV ads," "CTV," "OOH," "banner ads," "ad network," "ad alliance," "Taaft ads," "Shopify App Store ads," "Google Ads," "Meta Ads," "PMF testing," "PMF validation," "test product-market fit with ads," "ad spend," "ad budget," "ROAS," "paid acquisition," "Quality Score," or "ad-to-page alignment." For Google Ads execution, use google-ads. For Meta Ads execution, use meta-ads. For landing page alignment, use landing-page-generator.

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When the user wants to analyze backlinks, audit link profile, or identify link issues. Also use when the user mentions "backlink analysis," "backlink audit," "referring domains," "toxic links," "link profile," or "disavow file." For acquisition, use link-building.

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When the user wants to build backlinks, acquire links, or improve off-page SEO. Also use when the user mentions "link building," "backlinks," "off-page SEO," "link acquisition," "outreach," "guest posting," "broken link building," "link outreach," "acquire backlinks," "how to build backlinks," or "link building strategy." For profile audit, use backlink-analysis.

日本語の概要は準備中です。原文の説明を表示しています。