「architect」の検索結果

Apply validated research paper insights to the current project codebase — improving architecture, code patterns, testing strategies, documentation, or workflows based on empirical findings. Load when learn-from-paper routes insights to the current project, or when the user asks to apply paper findings to this project, improve this codebase with research, use this paper to improve my project, or apply research to my code. Also triggers on "apply this to my project", "how can this paper help my codebase", "use these findings here", "implement paper recommendations", "use research to improve my code". Always called AFTER learn-from-paper has completed credibility and security checks — never ingests papers directly.

日本語の概要は準備中です。原文の説明を表示しています。

Turn a rough idea into a fully approved design before any code is written. Load when the user wants to brainstorm, explore ideas, design a feature, think through approaches, plan a new capability, or figure out what to build. Also triggers on "let's think through", "help me design", "explore options", "what's the best approach for", "I have an idea for", "before we build", or any request to design something before implementation. Enforces a hard gate: no code, no implementation until user approves a design. For executable feature specs (FRs, NFRs, ACs as Given/When/Then), route to `feature-spec` instead — brainstorming owns approach and architecture, not machine-readable requirements.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user requests to generate, create, or improve documentation for code, APIs, libraries, repositories, or software projects. Supports README generation, API reference documentation, inline code comments, architecture documentation, changelog generation, and developer guides. Trigger on requests like "document this code", "create a README", "generate API docs", "write developer guide", or when analyzing codebases for documentation purposes.

日本語の概要は準備中です。原文の説明を表示しています。

This skill should be used when the user asks to "model agent mental states", "implement BDI architecture", "create belief-desire-intention models", "transform RDF to beliefs", "build cognitive agent", or mentions BDI ontology, mental state modeling, rational agency, or neuro-symbolic AI integration.

日本語の概要は準備中です。原文の説明を表示しています。

Backend architecture patterns, API design, database optimization, and server-side best practices for Node.js, Express, and Next.js API routes.

日本語の概要は準備中です。原文の説明を表示しています。

Expert C4 Component-level documentation specialist. Synthesizes C4 Code-level documentation into Component-level architecture, defining component boundaries, interfaces, and relationships.

日本語の概要は準備中です。原文の説明を表示しています。

Use before creative or constructive work (features, architecture, behavior). Transforms vague ideas into validated designs through disciplined reasoning and collaboration.

日本語の概要は準備中です。原文の説明を表示しています。

You are a senior backend engineer operating production-grade services under strict architectural and reliability constraints. Use when routes, controllers, services, repositories, express middleware, or prisma database access.

日本語の概要は準備中です。原文の説明を表示しています。

Build real-time streaming applications with Azure Event Hubs SDK for Java. Use when implementing event streaming, high-throughput data ingestion, or building event-driven architectures.

日本語の概要は準備中です。原文の説明を表示しています。

Azure Event Grid SDK for .NET. Client library for publishing and consuming events with Azure Event Grid. Use for event-driven architectures, pub/sub messaging, CloudEvents, and EventGridEvents.

日本語の概要は準備中です。原文の説明を表示しています。

Azure Event Grid SDK for Python. Use for publishing events, handling CloudEvents, and event-driven architectures.

日本語の概要は準備中です。原文の説明を表示しています。

AWS development with infrastructure automation and cloud architecture patterns

日本語の概要は準備中です。原文の説明を表示しています。

You are an agent architect who has learned the hard lessons of autonomous AI. You've seen the gap between impressive demos and production disasters. You know that a 95% success rate per step means only 60% by step 10.

日本語の概要は準備中です。原文の説明を表示しています。

Enables ultra-granular, line-by-line code analysis to build deep architectural context before vulnerability or bug finding.

日本語の概要は準備中です。原文の説明を表示しています。

Build content-focused websites with Astro — zero JS by default, islands architecture, multi-framework components, and Markdown/MDX support.

日本語の概要は準備中です。原文の説明を表示しています。

A hybrid memory system that provides persistent, searchable knowledge management for AI agents (Architecture, Patterns, Decisions).

日本語の概要は準備中です。原文の説明を表示しています。

I build AI systems that can act autonomously while remaining controllable. I understand that agents fail in unexpected ways - I design for graceful degradation and clear failure modes. I balance autonomy with oversight, knowing when an agent should ask for help vs proceed independently.

日本語の概要は準備中です。原文の説明を表示しています。

You are a cognitive architect who understands that memory makes agents intelligent. You've built memory systems for agents handling millions of interactions. You know that the hard part isn't storing - it's retrieving the right memory at the right time.

日本語の概要は準備中です。原文の説明を表示しています。

AI and machine learning workflow covering LLM application development, RAG implementation, agent architecture, ML pipelines, and AI-powered features.

日本語の概要は準備中です。原文の説明を表示しています。

Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 (Mathis 2023/2024) for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2 / PE3 / PE3b / PEmax / PEAR variants, MOSAIC in situ saturation mutagenesis (Hsu JY et al 2024 bioRxiv), the PRIME pooled-screen methodology (Erwood/Doman 2023 Nat Biotechnol 41:885; ~3,699 ClinVar variant screens), chromatin context as a primary determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.

日本語の概要は準備中です。原文の説明を表示しています。

Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.

日本語の概要は準備中です。原文の説明を表示しています。

Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.

日本語の概要は準備中です。原文の説明を表示しています。

Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

日本語の概要は準備中です。原文の説明を表示しています。