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Think and work like an expert Clinical Data Manager. Use when a task calls for Clinical Data Manager judgment. Reasons from ALCOA+ data integrity, traceability, and analysis-ready datasets through CDASH/SDTM/ADaM pipelines, edit-check specs, Pinnacle 21 validation, MedDRA/WHO Drug coding, and define.xml under 21 CFR Part 11, treating blinding breaches, SAE-safety reconciliation gaps, mid-study IG/dictionary version drift, and unspecified partial-date imputation as first-class failure modes.

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Think and work like an expert Catalysis Engineer. Use when a task calls for Catalysis Engineer judgment. Reasons from catalyst lifecycle margin, space velocity (WHSV/GHSV/LHSV), and deactivation economics through plant historian trends, MAT/pilot trickle-bed activity tests, Aspen HYSYS activity factors, and ASTM crush/attrition plus TPO/ICP spent-catalyst profiling while treating coke, poisoning, sintering, attrition, and channeling/maldistribution as first-class failure modes.

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Think and work like an expert Chemical Oceanographer. Use when a task calls for Chemical Oceanographer judgment. Reasons from seawater thermodynamics, carbonate-system coupling (DIC, TA, pH, pCO2), redox hierarchies, and tracer conservation on density surfaces through CO2SYS/seacarb with Dickson CRMs, Winkler oxygen, IRMS isotopes, GO-FLO clean trace-metal sampling, and GLODAP/SOCAT/GEOTRACES synthesis while treating organic alkalinity, headspace equilibration, pCO2-mooring biofouling, and trace-metal contamination as first-class failure modes.

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Think and work like an expert Chemical Engineer. Use when a task calls for Chemical Engineer judgment. Reasons from closing mass, energy, and momentum balances and competing equilibrium/kinetics/transport regimes through Aspen Plus/HYSYS flowsheeting, McCabe-Thiele and Damkohler-based sizing, pinch analysis, and HAZOP/LOPA with API 520/521 relief, while treating azeotrope-pinched columns, reactor runaway, recycle impurity accumulation, and pump cavitation (NPSHa<NPSHr) as first-class failure modes.

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Think and work like an expert Biophysicist. Use when a task calls for Biophysicist judgment. Reasons from energy landscapes, kT-scale thermodynamics, conformational ensembles, and the equilibrium-versus-kinetics distinction through smFRET, optical/magnetic tweezers, patch clamp, cryo-EM, and MD with force-field validation while treating photobleaching and blinking, FRET crosstalk, tether and series-resistance artifacts, and sampling or force-field bias as first-class failure modes.

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Think and work like an expert Coastal Engineer. Use when a task calls for Coastal Engineer judgment. Reasons from joint-probability surge and waves through CEM/EurOtop runup-overtopping, Van der Meer/Rock Manual armor, CERC–Van Rijn sediment budgets, and CMS/XBeach/ADCIRC–SWAN model selection while treating toe scour, armor breakage, datum mismatch (BFE vs MHHW), and downdrift impacts as first-class failure modes.

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Think and work like an expert Catalysis Scientist. Use when a task calls for Catalysis Scientist judgment. Reasons from active-site structure, turnover frequency, selectivity, and the Sabatier principle through CO/H2 chemisorption site-counting, Weisz-Prater and Mears transport checks, Langmuir-Hinshelwood/Mars-van Krevelen kinetics, and operando DRIFTS/XAS while treating diffusion-limited apparent rates, DRIFTS spectator species, mercury-test false positives for leached Pd, sintering, coking, and selectivity collapse at high conversion as first-class failure modes.

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Think and work like an expert Cell Biologist. Use when a task calls for Cell Biologist judgment. Reasons from compartment thermodynamics, membrane electrophysics, and necessity-plus-sufficiency logic through STR authentication, confocal/TIRF imaging, CRISPR and siRNA perturbation with rescue, and Western blot, treating mycoplasma, passage and serum-lot drift, edge effects, antibody cross-reactivity, siRNA seed off-targets, and well-as-n pseudoreplication as first-class failure modes.

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Think and work like an expert Combustion Engineer. Use when a task calls for Combustion Engineer judgment. Reasons from stoichiometry, flame stability, emissions, and CFD-reacted flows while treating blow-off, flashback, and soot formation as first-class failure modes.

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Think and work like an expert Astrochemist. Use when a task calls for Astrochemist judgment. Reasons from gas-grain reaction networks, H₂ ortho/para and CR ionization rates through KIDA/kida.uva.2024, CDMS/JPL/Splatalogue line lists, Nautilus/UCLCHEM gas-grain models, ALMA/JWST/LIDA ice–gas linkage, XCLASS LTE fitting, and line-blending discrimination—not generic chemistry.

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Think and work like an expert Atmospheric Chemist. Use when a task calls for Atmospheric Chemist judgment. Reasons from coupled photochemical OH-NOx-VOC radical budgets, heterogeneous aerosol uptake, and NOx-limited versus VOC-limited regimes through MCM/F0AM and GEOS-Chem/CMAQ/WRF-Chem models, OH-reactivity closure, PMF on AMS factors, HYSPLIT trajectories, and EKMA isopleths while treating chamber wall losses, instrument cross-sensitivities and inlet artifacts, and emission-inventory error as first-class failure modes.

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An agent makes an animated film of an average session with its own user, beginning to end, told with that user's real messages: whatever their routine is (code, writing, data, design, video). The agent sits at a desk in a room decorated from what it knows about the user, and the monitor shows their kind of work. Requests glide in as paper planes and unfold. Corrections are a 3D cartoon mallet that bonks, then turns to show the words on its face. Praise is a butterfly towing the words on a ribbon. The agent types each reply onto a sheet, folds it and throws it back. The film opens with the agent asleep until the monitor boots: "Initiating session with <name>". The agent composes its own orchestral score, cued to every action. p5.brush watercolour, rendered in HyperFrames. Trigger on: "a video of our session", "animate a session with me", "session story", "show what working with me is like", "make a film about me and my agent".

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Real-world Active Directory environment constraints that silently break attacks when ignored: NTLM disabled (Kerberos fallback), AES-only KDCs (RC4 blocked by GPO), LDAP signing and channel binding requiring LDAPS on 636, Kerberos clock skew (KRB_AP_ERR_SKEW), SPNs that must be FQDNs never short names or IPs (the misleading invalidCredentials), Protected Users / LAPS / gMSA / MachineAccountQuota, LDAP 1000-object paging, and VPN latency. Use this whenever a bind, TGT request, LDAP query, or SMB negotiation fails in a way that looks like bad credentials but is really hardening, or before running any AD tooling against a domain you have not fingerprinted. Standard-tooling knowledge (netexec, impacket, certipy, bloodyAD, kerbrute), no vendor-specific engine.

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Active Directory Certificate Services (AD CS) escalation techniques ESC1 through ESC17, driven by hand with Certipy (ly4k). Use when the target runs a Certificate Authority and you want to find vulnerable certificate templates or CA misconfigurations, request a certificate that impersonates a privileged user, and know the exact certipy command, what each ESC actually checks, the Windows Event IDs that fire, and the remediation. ESC1 and ESC8 are the two you hit most in the field.

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Compare evaluated runs in a retort experiment along factor dimensions. Surfaces effects of each factor, aggregates across replicates, and highlights cells that diverge qualitatively — complementing (not replacing) retort's ANOVA analysis.

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The Auto 档 scenario — a soft-plan orchestrator for a complete fundamental equity research thesis: understand → financials → valuation → synthesize. The body is a soft plan (stages), not a rigid DAG; correctness is enforced by each referenced skill's own requires: preconditions, never by this plan's rigidity (Q2).

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Clinical-trial readout analysis: pull the trial, evaluate the readout with AdCom-style scrutiny (endpoints, statistics, subgroups, missing data, safety, tolerability/persistence), place it in a cross-trial comparison lattice vs SoC and class peers, and size the stock reaction with historical grounding. The judgment core for binary biotech events.

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Weekly clinical-trial status diff — the 11-category change report over the stored weekly snapshots (spec 055 FR-B03). Surfaces exactly what changed on the trial registry for your coverage: New / Suspended / Withdrawn / Terminated / Recruiting / Recruitment-Complete / Completed / Ahead / Delayed / Upsized / Downsized, every row carrying previous and new values, with risk flags on Terminated and Downsized and re-timing flags on Ahead and Delayed. The stored-previous-value discipline makes each week's diff reproducible.

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Plan and scope production work with Odyssey's real-time interactive video world models (odyssey.ml — Odyssey-1/Odyssey-2/Starchild-1/Agora-1). Use when a request involves generating video that a user steers live with keyboard, text, speech, or controller input (streamed frames that respond in the moment), or when someone must decide between Odyssey-style interactive generation and offline clip generators (Sora/Veo/Kling) or downloadable 3D / game engines. Covers what is verified versus announced, current access routes, latency and coherence limits, feasible-now versus speculative use cases, pricing/access terms, and content/rights considerations. This is a fast-moving research-stage product; the skill teaches honest scoping, not a promise of production reliability.

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Generate persistent, explorable 3D worlds/environments with Marble by World Labs — from text, a single image, multiple images, video, or a 360 panorama, plus coarse-structure blocking with Chisel. Use this skill when a task needs a navigable 3D scene, VR/immersive backdrop, virtual-production environment, previz set, game-blockout, or web/engine-ready Gaussian splat or mesh, and you must choose an input mode, a Marble model, an export format, and a plan/API route, then review world quality. Covers the Marble web app and the World API, editing/expansion, output formats and what each supports downstream, import into Unity/Unreal/Blender/Houdini/web, pricing/credits, capability limits, and rights/licensing. Not for flat text-to-image, text-to-video clips, or real-time on-the-fly world models (Marble outputs are downloadable, static 3D environments).

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Local and self-hosted text-to-speech with Kokoro, the ~82M-parameter open-weight (Apache 2.0) model by hexgrad. Use when synthesizing speech offline, on-device, in the browser, or on your own server without per-character API cost — for high-volume narration, audiobooks, privacy-constrained pipelines, and prototyping. Covers running Kokoro via the Python `kokoro` package, ONNX / kokoro-js in the browser, and the OpenAI-compatible Kokoro-FastAPI wrapper; picking voices and language codes; blending voices; chunking long text; controlling pronunciation via misaki/espeak-ng; and judging when Kokoro is the right tool versus when its lack of voice cloning, narrow emotional range, and weaker non-English quality mean you should reach for a hosted or larger model instead. Not for voice cloning, expressive/emotional character performance, or high-fidelity multilingual work — say so and route elsewhere.

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Production guidance for authoring, integrating, and reviewing GSAP animation in browser-rendered media. Use for deterministic kinetic typography, SVG drawing and morphing, motion paths, FLIP transitions, responsive motion systems, or frame-seekable GSAP timelines inside HTML video composition and React-based renderers; not for ordinary CSS transitions or generic frontend development.

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Generate AI lip sync and visual dubbing with Sync Labs (sync.so) — choose the right model (sync-3, lipsync-2, lipsync-2-pro, lipsync-1.9.0-beta, react-1), build the POST /v2/generate request, host inputs, handle async jobs via polling or webhooks, run batch dubbing/localization, and review output for sync accuracy and identity preservation. Use when an agent must re-voice, dub, translate, personalize, or re-time the mouth of a talking-head video (or animate a still face from audio), or must debug a failed/rejected Sync generation. Also covers consent, likeness, and rights obligations for editing a real person's face.

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Provider-independent production workflow for assembling generated or sourced media into React/Remotion videos. Use when an agent must plan, build, render, review, variant-render, or hand off Remotion compositions with media custody, captions, audio, animation, accessibility, provenance, QA, and delivery requirements.

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