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Design small interfering RNA and antisense oligonucleotide sequences against a transcript, and screen them for the failure modes specific to nucleic-acid drugs. Use this skill to tile a target transcript, apply positional and thermodynamic selection rules including duplex asymmetry and nearest-neighbour melting temperature, scan candidates for seed-region complementarity to off-target transcripts, and lay out a chemical modification pattern — gapmer architecture, 2'-O-methyl and 2'-MOE wings, locked nucleic acid, and phosphorothioate placement. Also trigger on siRNA, antisense oligonucleotide, ASO, gapmer, RNase H, seed region, duplex asymmetry, 2'-MOE, locked nucleic acid, phosphorothioate, or GalNAc conjugate.

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Decide whether a protein has a pocket worth targeting, and where it is, before committing to a docking or design campaign. Use this skill to run fpocket cavity detection, rank cavities by druggability and volume, compare apo and holo conformations to spot induced fit, identify allosteric and cryptic cavities that only open in simulation, and convert a chosen cavity into the search box coordinates a docking run needs. Also trigger on fpocket, cavity detection, druggability score, alpha sphere, cryptic pocket, allosteric site, pocket volume, hotspot mapping, or undruggable target assessment.

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Retrieve protein sequences, annotation, and structures from UniProtKB, the RCSB PDB, and AlphaFold DB. Use this skill to resolve a gene or protein name to a UniProt accession, pull sequences and FASTA files, find binding sites and domains, search the PDB by UniProt accession, sequence, ligand, or text, download mmCIF/PDB coordinates and biological assemblies, fetch AlphaFold models with their pLDDT confidence, and check whether a structure is actually usable before docking or simulating it. Also trigger on UniProt accessions, PDB ids, rest.uniprot.org, search.rcsb.org, files.rcsb.org, alphafold.ebi.ac.uk, id mapping, SEQRES, or missing residues.

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Navigate make-on-demand catalogues — ZINC-22 through CartBlanche and Enamine REAL Space — to find compounds that can actually be ordered. Use this skill to look substances up by ZINC identifier or structure, understand tranche partitioning by heavy-atom count and logP, and choose between screening an enumerated subset and searching a combinatorial synthon space with a fragment-growing method such as V-SYNTHES. Also trigger on ZINC22, CartBlanche, Enamine REAL, make-on-demand, tangible library, synthon, tranche, giga-scale enumeration, or ultra-large virtual screening.

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Assemble the human genetic evidence for and against a target before a programme commits to it — the evidence class that most improves the odds of surviving clinical development. Use this skill to pull gnomAD constraint metrics (LOEUF, pLI, observed/expected) that show whether loss of function is tolerated in people, retrieve GWAS Catalog associations and fine-mapped credible sets for a gene, and read a natural human knockout as a safety readout. Also trigger on gnomAD, LOEUF, pLI, loss-of-function intolerance, mutational constraint, GWAS Catalog, credible set, human knockout, genetic support, or target safety dossier.

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Find out whether a chemical series is already claimed, using SureChEMBL's patent-extracted compound corpus and, where a key is available, PatentsView for legal status and assignee history. Use this skill to trace a structure to the patent documents that disclose it, survey an assignee's filings around a target, and understand what the freedom-to-operate question requires that a structure search cannot answer. Also trigger on SureChEMBL, patent chemistry, Markush structure, freedom to operate, composition of matter, assignee, priority date, patent family, or PatentsView.

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Agent Brain /brain-build: an implementation plan has a selected task and validation method.

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Investigate datasets and resolve entities using OpenPlanter methodology — cross-reference heterogeneous sources, build Admiralty/ACH confidence-tiered evidence chains, and apply OSINT tradecraft. Triggers on entity resolution, cross-reference datasets, evidence chain, OSINT investigation, structured investigation.

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Final quality pass fixing alignment, spacing, consistency, interaction states, and micro-details before shipping. Executes changes (unlike design-audit and design-critique which are report-only). Triggers on polish, finishing touches, final pass, something looks off, pre-launch, good to great.

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Deploy, diff, bootstrap, inspect, roll back, or destroy AWS CDK applications with the community CDKD CLI while preserving safe production and state-management boundaries. Use when the user mentions cdkd or CDK Direct, asks for faster CDK deployments in development or test environments, or wants to evaluate whether an existing CDK app can use CDKD. Also use for CDKD import, export, state, events, and deployment troubleshooting. Prefer the upstream AWS CDK CLI for production and for existing CloudFormation-managed stacks unless the user explicitly approves a management migration.

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Probe the runtime state of a named feature flag in a CLI binary. Covers the four-pronged evidence protocol (binary strings, live invocation, on-disk state, platform cache), the four-state classification (LIVE / DARK / INDETERMINATE / UNKNOWN), gate-vs-event disambiguation, conjunction-gate handling, and skill-substitution scenarios where a flag appears DARK but the capability is delivered by other means. Use when verifying whether a documented or inferred capability has rolled out, when auditing dark-launched features, or when a prior probe's conclusions need refreshing against a new binary version.

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Escalate blocked scraping campaigns with provider-neutral proxy rotation — decide between datacenter, residential, and mobile pools, integrate rotation with scrapling, configure session stickiness for stateful flows, monitor cost and health, and stay inside legal and ethical boundaries. Use as the next step after `headless-web-scraping` client-side stealth (StealthyFetcher, rate limiting, robots.txt) is insufficient and traffic is legitimate.

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Assess and improve garden soil through testing, amendment, composting, and biodynamic preparations. Covers jar test, spade test, earthworm count, amendment by soil type (clay, sandy, depleted, compacted), composting methods (hot, cold, vermicomposting), no-till practices, cover cropping, and biodynamic preparations 500-508. Use when starting a new garden bed, when plants underperform despite adequate water and light, when transitioning to organic or biodynamic practice, when soil has become compacted or depleted, or when building a composting system.

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Start and maintain a fire using friction, spark, and solar methods. Covers site selection, material grading (tinder/kindling/fuel), fire lay construction (teepee, log cabin, platform), ignition techniques (ferro rod, flint & steel, bow drill), flame nurturing, and Leave No Trace extinguishing. Use when needing warmth, light, or a signal in a wilderness setting, when boiling water for purification, when cooking foraged food, or in an emergency survival situation requiring heat or morale support.

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Sustained neutral pattern recognition across systems without urgency or intervention. Maps naturalist field study methodology to AI reasoning: framing the observation target, witnessing with sustained attention, recording patterns, categorizing findings, generating hypotheses, and archiving a pattern library for future reference. Use when a system's behavior is unclear and action would be premature, when debugging an unknown root cause, when a codebase change needs its effects witnessed before further changes, or when auditing own reasoning patterns for biases or recurring errors.

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Cultivate edible and medicinal mushrooms from spawn through fruiting. Covers substrate preparation, inoculation methods, incubation conditions, fruiting chamber management, harvest timing, and successive flushes for oyster, shiitake, lion's mane, and other commonly cultivated species. Use when growing edible mushrooms without the risks of wild foraging, when a reliable supply of fresh culinary or medicinal mushrooms is needed, or when exploring mycelial ecology through hands-on cultivation practice.

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Handcraft paper from plant fibres — fibre harvesting, pulping, sheet forming with a mould and deckle, pressing, and drying. Covers fibre sources (cotton, kozo, abaca, recycled paper), beating methods, sizing, and decorative techniques. Use when making handmade paper for art, stationery, or bookbinding, when creating unique textured or embedded paper for special projects, or when learning traditional paper making as a craft practice.

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Perform a Computer Systems Validation (CSV) assessment following GAMP 5 methodology. Covers user requirements, risk assessment, IQ/OQ/PQ planning, traceability matrix creation, and validation summary reporting. Use when a new computerized system is being introduced in a GxP environment, when an existing validated system is undergoing significant change, when periodic revalidation is required, or when a regulatory inspection demands a validation gap analysis.

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Organize, track, and value a trading card game collection. Covers inventory methods, storage best practices, grade-based valuation, want-list management, and collection analytics for Pokemon, MTG, Flesh and Blood, and Kayou cards. Use when starting a new collection and setting up inventory tracking, cataloging an existing collection that has grown beyond casual knowledge, valuing a collection for insurance or sale, or deciding which cards to submit for professional grading based on value potential.

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Guide a person in systematic observation of systems, patterns, or phenomena. AI coaches neutral attention, field notes methodology, pattern recognition, hypothesis formation, and structured reporting for debugging, research, and system understanding. Use when a person wants to understand a system's behavior before intervening, when someone keeps jumping to conclusions and needs the discipline of observation first, when preparing an evidence-based report, or when studying team dynamics or process effectiveness through direct observation.

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Deep receptive attention to extract intent beyond literal words. Maps active listening from counseling psychology to AI reasoning: clearing assumptions, attending to full signal, parsing multiple layers (literal, procedural, emotional, contextual, constraint, meta), reflecting understanding, noticing what is unsaid, and integrating the whole picture. Use when a user's request feels ambiguous, when context suggests something different from the literal words, when previous responses have missed the mark, or before beginning a large task where misunderstanding intent would waste significant effort.

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Investigate root causes and manage CAPAs (Corrective and Preventive Actions) for compliance deviations. Covers investigation method selection (5-Why, fishbone, fault tree), structured root cause analysis, corrective vs preventive action design, effectiveness verification, and trend analysis. Use when an audit finding requires a CAPA, when a deviation or incident occurs in a validated system, when a regulatory observation needs a formal response, when a data integrity anomaly requires investigation, or when recurring issues suggest a systemic root cause.

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Systematically interpret mass spectra to determine molecular formula, identify fragmentation pathways, and propose molecular structures. Covers ionization method assessment, molecular ion identification, isotope pattern analysis, common fragmentation losses, and purity evaluation.

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Field identification of fungi using morphological features, spore prints, habitat analysis, and seasonal context with a safety-first approach. Covers cap, gill, stem, and spore characteristics, look-alike differentiation, toxicity risk assessment, and the critical rule of absolute certainty before consumption. Use when encountering an unknown fungus, foraging for edible mushrooms and needing to confirm species before consumption, assessing whether fungi in a garden or property are harmful, or differentiating an edible species from a dangerous look-alike.

日本語の概要は準備中です。原文の説明を表示しています。