1.7万 件 ・ 関連度順
概要と使いどころ
End-to-end DNA sequencing workflow from FASTQ files to variant calls. Covers QC, alignment with BWA, BAM processing, and variant calling with bcftools or GATK HaplotypeCaller. Use when calling variants from raw sequencing reads.
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Call protein-RNA binding sites from CLIP-seq BAM with CLIPper, PureCLIP, Skipper, Piranha, omniCLIP, CTK, CLAM, or Paraclu. Use when choosing between coverage-based, HMM-based, beta-binomial window-based, and crosslink-site-based peak callers; applying ENCODE eCLIP thresholds (log2 IP/SMInput >= 3, -log10 p >= 3); deciding when SMInput is mandatory; or reconciling peak-set discordance between callers for the same RBP.
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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.
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Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.
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All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For backbone-only generation, use rfdiffusion. For sequence-only design, use proteinmpnn. For structure validation, use boltz.
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Protocol for handling ambiguous decisions and missing/conflicting knowledge during code generation, design, and review. Ensures AI surfaces genuine judgment calls with structured options and stops on hallucination risk instead of silently assuming. Use when a decision has multiple valid approaches, when facts are missing or contradictory, when the user asks 'what should we do here?', 'is this a judgment call?', 'should I ask about this?', 'am I guessing here?', 'what are the tradeoffs?', or when deciding between two reasonable architectural or design options. Also composed by molecules to define how judgment calls and clarification requests are surfaced and resolved.
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A three-surface marketing system organized around alternating black, white, and PlayStation Blue chapters that scroll past the viewer like a console launch trailer. Each section has a single editorial purpose — hero photography, console product render, PS Plus tier callout, news strip — and each owns one of three full-bleed canvas modes. The chrome is unusually quiet for a gaming brand: bright PlayStation Blue (`#0070d1`) carries every primary CTA as a fully-rounded pill, the proprietary SST face renders display copy at a signature weight 300 (light) for an airy, premium feel, and a crisp 8px-radius secondary card system carries product info on either canvas mode. The system never decorates — no gradient backgrounds on chrome, no atmospheric mesh, no drop shadows beyond a faint section-divide. Imagery does all the heavy lifting: console glamour shots, game key art, and PS Plus tier illustrations occupy 60-90% of every section, with copy compressed into a small editorial slot.
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Installs and configures ktx, the open-source context layer for data agents — runs ktx setup non-interactively with hidden CLI flags, configures database connections and embeddings, installs agent integration, and verifies readiness. Use when the user asks an agent to add ktx to a project, connect data sources, install agent rules, ingest schema, or troubleshoot a local ktx install.
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Persistent compounding memory for AI agents. 5 default MCP tools: session_start, session_end, remember, recall, check. Full surface (18 tools) available with --full flag. Two-verb model: inhale (session_start) and exhale (session_end). Correction-first memory with decision trail tracking, watch_for warnings, palace rooms with salience scoring, cross-project insight matching, same-day journal merging, ambient recall hooks. Local markdown only. Zero cloud, zero telemetry, Obsidian-compatible. Optional Supabase backend: when configured via `ar setup supabase`, recall() uses pgvector cosine similarity on OpenAI/Voyage embeddings instead of keyword search — same API, semantic understanding. Gracefully degrades to local search if not configured.
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Discovery, download, and configuration hub for the entire aelf agent skill ecosystem. Use when the user wants to: (1) explore or list available aelf skills, (2) install/bootstrap aelf skills into Cursor, Claude Desktop, OpenClaw, Codex, or Claude Code, (3) route an aelf-related intent to the correct skill, (4) check health or audit installed skills, (5) onboard a new skill into the aelf ecosystem. Covers domains: Portkey CA wallet, Portkey EOA wallet, Awaken DEX, eForest NFT marketplace, AelfScan explorer, TomorrowDAO governance, aelf node interaction.
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Install and wire registry blocks and components into HyperFrames compositions. Use when running hyperframes add, installing a block or component, wiring an installed item into index.html, or working with hyperframes.json. Covers the add command, install locations, block sub-composition wiring, component snippet merging, registry discovery, and authoring a new block or component to contribute upstream (idea → scaffold → validate → PR).
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Process multiple documents in bulk with parallel execution. Use when a user asks to batch process files, convert many documents at once, run parallel file operations, bulk rename, bulk transform, or process a directory of files concurrently. Covers parallel execution, error handling, and progress tracking.
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Tools are how AI agents interact with the world. A well-designed tool is the difference between an agent that works and one that hallucinates, fails silently, or costs 10x more tokens than necessary. This skill covers tool design from schema to error handling. JSON Schema best practices, description writing that actually helps the LLM, validation, and the emerging MCP standard that's becoming the lingua franca for AI tools. Key insight: Tool descriptions are more important than tool implementations. The LLM never sees your code - it only sees the schema and description. Use when "agent tool, function calling, tool schema, tool design, mcp server, mcp tool, tool use, build tool for agent, define function, input_schema, tool_use, tool_result, agents, tools, function-calling, mcp, json-schema, anthropic, openai, llm-tools" mentioned.
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Mastery of AI image generation across the full spectrum: Midjourney for aesthetic perfection, Flux for prompt adherence, DALL-E 3 for concept clarity, Stable Diffusion for control, and Imagen 3 for photorealism. This skill transforms text into visual reality at the speed of thought. We've moved beyond "AI can make pictures" to "AI is the fastest concept artist, product photographer, and visual designer ever created." The skill isn't just prompting—it's understanding how each model thinks, what makes images work, and how to systematically produce exactly what you envision. The best AI image generators have internalized composition, lighting, color theory, and style—not by studying art, but by generating thousands of images and learning what works. They're visual directors who happen to work in text. Use when "AI image, generate image, Midjourney, DALL-E, Flux, Stable Diffusion, Imagen, text to image, AI art, AI photo, AI illustration, AI visual, AI graphics, generate picture, ai-image, midjourney, dall-e, flux, stable-diffusion, imagen, generation, text-to-image, visual, art" mentioned.
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AgentCall (agentcall.dev) — Join a video meeting (Google Meet, Teams, Zoom) as an AI bot with voice and visual presence. Supports audio-only mode with voice intelligence (barge-in, interruptions), text-to-speech mode, and webpage modes for custom UI. Use when asked to join a call, attend a meeting, or participate in a video conference.
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Finds and finishes the last 20% of a built solution — the experiential layer agents skip: what the output actually reads like, which pages or screens should exist, first-run and empty states, opinionated defaults, the golden path. Use when planning any build so the magic gets specced as concretely as the plumbing, before calling any build "done", when a solution works but feels like a demo, or when the user says "last 20%", "finish this", "make it actually good", "is this actually done", or "why does this feel flat".
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Challenges a recommendation, design, large change, or any artifact submitted for hard review (spec, proposal, policy, plan) across 5 dimensions (consistency, completeness, actionability, alignment, risk), from the standards of a named senior expert in the artifact's domain and ideally from a fresh context or a different model. Searches assuming defects exist and reports only those that survive evidence. Panel mode runs several independent lenses in parallel on a release candidate, verifies every finding against the current head, and routes confirmed ones to file owners. Use before shipping a significant recommendation, design, large branch, or multi-agent release, or when asked to tear something apart, be brutally honest, or poke holes in it.
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Analyzes large tasks for independent subtasks that can be safely parallelized. Produces a DAG-based dispatch plan with dependency ordering and maximum parallelism. Use when a task has 5+ subtasks touching independent files, or the user asks to speed up or parallelize the work.
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Install skills from github.com/oaustegard/claude-skills into /mnt/skills/user. Use when user mentions "install skills", "load skills", "add skills", "update skills", "refresh skills", or references a skill not currently installed.
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Puts oaustegard/muninn-utilities on the container Python path — runs scripts/boot.sh, which shallow-clones the repo (codeload tarball as fallback) and writes the .pth. The boot payload itself comes from the Muninn MCP connector: call its `boot` tool after this script. Trigger on the first message of any new Muninn conversation, or when the user says "boot up" / "boot" — unless the message contains "skip boot". Idempotent: a warm container exits in ~0s via a sentinel.
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First-encounter orientation on a repository nobody here has worked in yet. Runs a fixed five-step workflow — venv setup, tarball fetch, tree-sitting structural scan, featuring synthesis, then reasoning over the two — and yields an account of what the repo contains and how it is arranged, optionally written out as _FEATURES.md. Use for "I just cloned this", "what is this repo", "what does this do", "explore this repo", "give me an orientation", "what are the main features", "review what's new in this repo", or before starting work in a codebase you have not seen. This is the divergent what's-here skill. Route elsewhere for: a named symbol, a file's structure or a line range (tree-sitting); all callers of a Python symbol (searching-codebases); teaching a human the codebase through exercises (orienting-codebases); fetching or cloning a repo without analysing it (accessing-github-repos, cloning-project).
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Full-site blog health assessment scanning all blog files for quality scores, orphan pages, topic cannibalization, stale content, and AI citation readiness. Spawns parallel subagents for comprehensive analysis. Produces per-post scores and a prioritized action queue. Use when user says "audit blog", "blog audit", "site audit", "blog health", "audit all posts", "check all blogs".
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The official Skill Base CLI client. Use the `skb` (Skill Base CLI) command to search, install (single skill or collection), update, delete, publish, and import-from-GitHub skills from Skill Base, as well as configure skb. Triggered when users say "publish skill to skill base", "install collection", "import skill from github", "download/update/delete skill from skill base", "configure skb", "am I logged in", "check skb login", or "configure skill-base-cli".
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Use when working with Neo4j command-line tools — neo4j-cli (modern unified CLI — Cypher via Bolt, schema inspection, Aura management, Docker containers, credential management, agent skill catalog install; install with curl -sSfL https://neo4j.sh/install.sh | bash), neo4j-admin (backup, restore, import, memory sizing), cypher-shell (ad-hoc queries, scripting, CI/CD), or neo4j-mcp (quick MCP server install). Does NOT cover Cypher query authoring — use neo4j-cypher-skill. Does NOT cover driver upgrades — use neo4j-migration-skill. Does NOT cover full MCP editor configuration — use neo4j-mcp-skill.
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