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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Creates sashimi-style plots showing RNA-seq read coverage and splice junction counts using ggsashimi (general-purpose, condition-grouped overlays), rmats2sashimiplot (rMATS-output-aware), MAJIQ-VOILA (LSV posteriors interactive HTML), leafviz (leafcutter clusters Shiny), Jutils (tool-agnostic heatmaps and sashimi for rMATS/leafcutter/MntJULiP/MAJIQ output), or pyGenomeTracks (multi-track publication figures). Tool choice depends on the upstream differential-splicing tool's output format and the publication vs interactive use case. Use when visualizing specific splicing events, validating differential splicing calls, or producing publication-quality figures.

日本語の概要は準備中です。原文の説明を表示しています。

Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

日本語の概要は準備中です。原文の説明を表示しています。

Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.

日本語の概要は準備中です。原文の説明を表示しています。

Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user mentions GRDB performance review, slow GRDB queries, app-group database setup audit, a ValueObservation that stopped updating, or pre-release GRDB scan.

日本語の概要は準備中です。原文の説明を表示しています。

Measure ad effectiveness with privacy-preserving attribution using AdAttributionKit. Use when registering ad impressions, handling attribution postbacks, updating conversion values, implementing re-engagement attribution, configuring publisher or advertiser apps, or replacing SKAdNetwork with AdAttributionKit for ad measurement.

日本語の概要は準備中です。原文の説明を表示しています。

Implement, review, or improve Live Activities and Dynamic Island experiences in iOS apps using ActivityKit. Use when building real-time updating widgets for the Lock Screen and Dynamic Island — delivery tracking, sports scores, ride-sharing status, workout timers, media playback, or any time-sensitive information that updates in real time. Also use when working with ActivityKit, ActivityAttributes, Activity lifecycle (request/update/end), Dynamic Island layouts (compact/minimal/expanded), push-to-update Live Activities, or Lock Screen live widgets.

日本語の概要は準備中です。原文の説明を表示しています。

Verify device legitimacy and app integrity using DeviceCheck (DCDevice per-device bits) and App Attest (DCAppAttestService key generation, attestation, and assertion flows). Use when implementing fraud prevention, detecting compromised devices, validating app authenticity with Apple's servers, protecting sensitive API endpoints with attested requests, or adding device verification to a backend architecture.

日本語の概要は準備中です。原文の説明を表示しています。

Optimize MongoDB client connection configuration (pools, timeouts, patterns) for any supported driver language. Use this skill when working/updating/reviewing on functions that instantiate or configure a MongoDB client (eg, when calling `connect()`), configuring connection pools, troubleshooting connection errors (ECONNREFUSED, timeouts, pool exhaustion), optimizing performance issues related to connections. This includes scenarios like building serverless functions with MongoDB, creating API endpoints that use MongoDB, optimizing high-traffic MongoDB applications, creating long-running tasks and concurrency, or debugging connection-related failures.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill any time a .pptx or .potx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations; reading, parsing, or extracting text from any .pptx or .potx file (even if the extracted content will be used elsewhere, like in an email or summary); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates (.potx), layouts, speaker notes, or comments. Trigger whenever the user mentions "deck," "slides," "presentation," or references a .pptx or .potx filename, regardless of what they plan to do with the content afterward. If a .pptx or .potx file needs to be opened, created, or touched, use this skill.

日本語の概要は準備中です。原文の説明を表示しています。

Reads from, writes to, and manages relational databases using MATLAB Database Toolbox. Use when connecting to databases, reading data with sqlread or fetch, filtering with rowfilter, writing with sqlwrite, updating with sqlupdate, executing SQL statements, managing transactions with commit and rollback, mapping MATLAB classes to tables with ORM (Mappable, ormread, ormwrite, ormupdate), or performing any database operation from MATLAB. Triggers on: database, SQL, sqlread, sqlwrite, sqlupdate, fetch, execute, rowfilter, RowFilter, ORM, Mappable, ormread, ormwrite, ormupdate, orm2sql, transaction, commit, rollback, Database Toolbox, PostgreSQL, MySQL, SQLite, SQL Server, Oracle, database connection, database table, query database, insert data, update rows, delete rows, stored procedure, prepared statement, odbc, databaseConnectionOptions, datasource, data source, DSN, connection string, multithreaded, parallel.

日本語の概要は準備中です。原文の説明を表示しています。

Use when writing MATLAB functions with arguments blocks — repeating arguments (arguments (Repeating)), .?ClassName property import in constructors, name-value forwarding with namedargs2cell, or migrating from inputParser or validateattributes. Also when reviewing signatures for implicit-conversion pitfalls (size reshaping, class coercion, computed defaults), or when restricting, constraining, or validating function inputs — scalar vs vector enforcement, type rejection, size checking. Also when asked to harden inputs, make a function more robust, tighten input checking, or rewrite for safer input acceptance — even without "validation" or "arguments block" wording. Triggers on: arguments block, mustBe validators, name-value arguments, varargin, inputParser, nargin/narginchk, restrict input, type checking, scalar constraint, harden inputs, defensive programming. Not for: App Designer callbacks, Simulink mask parameters, class inheritance, or runtime validation outside function or property declarations.

日本語の概要は準備中です。原文の説明を表示しています。

Read or write data files in MATLAB. Use when the task involves tables, spreadsheets, delimited text, or structured files in CSV, Excel, Parquet, JSON, or XML format — including but not limited to importing, exporting, loading, parsing, converting, validating, configuring import options, reading from URLs, handling locales or encodings, diagnosing file errors, and modernizing legacy file I/O code. MATLAB provides built-in functions for these workflows with no additional products required.

日本語の概要は準備中です。原文の説明を表示しています。

Configure, simulate, debug, and analyze radarDataGenerator within radarScenario. Use for: interactively building radar detection scenarios from datasheets or performance requirements; diagnosing missed detections and configuration errors; interpreting sensor spherical, body, and scenario-frame outputs; deriving ReferenceRange from hardware specs via link budget; scan mode configuration (mechanical, electronic/AESA, hybrid); and validating simulation results against analytical predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Use when writing, solving, or debugging MATLAB optimization code — formulating problems (optimproblem, optimvar, fcn2optimexpr), selecting and configuring solvers (fmincon, linprog, quadprog, intlinprog, lsqnonlin, ga, surrogateopt, optimoptions), or validating results (exitflag, convergence, constraint violations). Covers problem-based and solver-based approaches, solver tuning, and solution verification.

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Perform basic penetration testing and security assessments. Use reconnaissance, vulnerability discovery, and exploitation techniques. Use when validating security controls or assessing system security.

日本語の概要は準備中です。原文の説明を表示しています。

Build automated evaluation suites for AI agents using golden datasets, rubrics, and regression gates. Use when shipping agent features, validating prompt changes, or gating deployments on quality.

日本語の概要は準備中です。原文の説明を表示しています。

Use when syncing or updating previously installed skills to their latest version. Always dry-run updates before applying, and check for breaking changes.

日本語の概要は準備中です。原文の説明を表示しています。

Author or revise a cloud-api-operations recipe (config/source/skills/cloud-api-operations/references/recipes/). Encodes why the long tail of control-plane capabilities is deliberately NOT wrapped as MCP/CLI tools, the API-first admission test for whether a capability deserves a recipe, the negative and positive lists, the fixed recipe structure, the writing rules distilled from writing-for-agents, the user-facing copy red lines, and the product regeneration/verification pipeline. Also routes contributors (and their agents) to the contribution flow and the pre-PR self-test protocol in references/contributing.md. Use when adding a recipe, judging whether a scenario belongs in the recipe set, updating the recipes index, re-checking existing recipes against the admission test, or onboarding someone who wants to submit one.

日本語の概要は準備中です。原文の説明を表示しています。

Sync, validate, and apply App Store metadata and store assets with asc. Use when updating localizations, keywords, App Clip or preview assets, Asset Library media and placements, or migrating legacy fastlane metadata.

日本語の概要は準備中です。原文の説明を表示しています。

Bulk-localize subscription, subscription-group, and in-app purchase display names across App Store locales using asc, including API 4.4.1 version-scoped v2 resources. Use when filling or updating subscription/IAP names and descriptions without App Store Connect UI work.

日本語の概要は準備中です。原文の説明を表示しています。

Run release-readiness checks for this repository. Use when validating docs, scripts, verification coverage, and operational safety before merge or release.

日本語の概要は準備中です。原文の説明を表示しています。