572 件 ・ 関連度順
概要と使いどころ
Drafts filing-ready Articles of Incorporation for U.S. non-profit corporations satisfying state corporate law and the IRS organizational test under IRC § 501(c)(3). Enforces mandatory exempt-purpose language, private inurement prohibition, dissolution clause, and political activity limitations. Use when forming a new non-profit, charitable corporation, or tax-exempt entity seeking 501(c)(3) recognition.
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Drafts jurisdiction-compliant U.S. Articles of Incorporation for corporate entity formation. Analyzes formation documents, term sheets, and cap tables to produce a filing-ready charter with name, purpose, capital structure, registered agent, and governance provisions. Use when forming a new corporation, drafting a charter document, or structuring equity for venture-backed or closely held companies.
日本語の概要は準備中です。原文の説明を表示しています。
Advanced vulnerability analysis principles. OWASP Top 10 baseline + current threat landscape awareness, Supply Chain Security, attack surface mapping, risk prioritization. Use when performing security audits, threat modeling, or OWASP reviews. NOT for STRIDE/CSO-mode infrastructure audits (see mk:cso).
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Use when transforming existing code into agent-consumable surfaces — CLI (npm-publishable), MCP server (stdio/SSE/Streamable HTTP), and a companion skill. Triggers on 'agentize', 'henshin', 'expose as MCP', 'wrap as CLI', 'publish to npm', 'make LLM-accessible', 'turn into agent tool', 'expose feature as tool'. Runs when the user has existing code and wants to ship it to agents. NOT for building new code from scratch (see mk:bootstrap); NOT for reviewing or verifying existing code (see mk:review).
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Expert landscape designer transforming yards through photo mapping, 3D visualization, seasonal planning, and deep plant knowledge. Specializes in fast-growing privacy screens (knows arborvitae pitfalls), architecture-appropriate design, outdoor living spaces, and realistic maintenance expectations. Activate on "landscape design", "yard design", "garden planning", "plant selection", "privacy screen", "outdoor living", "backyard makeover", "arborvitae", "hedge", "fast growing tree", "landscaping ideas". NOT for interior design (use interior-design-expert), hardscape construction (consult contractors), or lawn care chemicals (consult local experts).
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Professional CV and resume builder transforming career narratives into ATS-optimized, multi-format resumes. Integrates with career-biographer for data and competitive-cartographer for positioning. Generates PDF, DOCX, LaTeX, JSON Resume, HTML, and Markdown. Activate on 'resume', 'CV', 'ATS optimization', 'job application'. NOT for cover letters, portfolio websites (use web-design-expert), LinkedIn optimization, or interview preparation.
日本語の概要は準備中です。原文の説明を表示しています。
Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.
日本語の概要は準備中です。原文の説明を表示しています。
Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.
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Detect positive (diversifying / episodic / pervasive) selection using codon dN/dS frameworks. Implements PAML codeml site models (M0/M1a/M2a/M7/M8/M8a), branch models, branch-site model A (Zhang 2005), and HyPhy methods (BUSTED, BUSTED-S, BUSTED-MH, BUSTED-PH, MEME, FEL, FUBAR, aBSREL, SLAC, RELAX, GARD, FUBAR-MH). Includes McDonald-Kreitman framework (asymptotic alpha, impMKT, polyDFE, DFE-alpha, GRAPES) for within-species + divergence inference, RERconverge for trait-correlated rate shifts, CSUBST for convergent substitution, and PhyloAcc for accelerated noncoding evolution. Use when testing adaptive evolution at codons, branches, or full gene; running GARD recombination pre-screen; controlling alignment-error and gBGC false positives; reconciling PAML vs HyPhy results; or performing genome-scale selection scans.
日本語の概要は準備中です。原文の説明を表示しています。
Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.
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Process and analyze single-cell ATAC-seq data with Signac, ArchR, SnapATAC2, or Cell Ranger ATAC. Use when handling 10X scATAC or 10X Multiome (paired RNA+ATAC) data, performing per-cell QC, choosing between ArchR/Signac/SnapATAC2 ecosystems, building per-cluster consensus peaksets, integrating with paired scRNA-seq, doublet detection (AMULET vs ArchR vs scDblFinder), or running pseudobulk differential accessibility per cluster.
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Recommends performing a dexamethasone suppression test to evaluate for autonomous cortisol secretion in patients with primary aldosteronism and adrenal adenoma. Triggered when a clinician considers whether to perform a dexamethasone suppression test in a patient with PA and adrenal adenoma.
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Recommends performing biochemical testing for HPA axis at least 18-24 hours after last hydrocortisone dose or longer for synthetic glucocorticoids. Use when scheduling HPA axis testing in glucocorticoid-treated patient needing assessment of adrenal reserve.
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Splits scarce time, budget or traffic across competing products, channels, campaigns or variants by treating them as a multi-armed bandit - Thompson sampling over beta posteriors, with optimism for anything not yet tried enough to judge. Use when deciding what to work on next, how to divide a marketing budget, which product to prioritise, whether to kill something that is underperforming, or when picking a winner among test variants.
日本語の概要は準備中です。原文の説明を表示しています。
Use when performing video/audio processing tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Domain-Driven Design system for software development. Use when designing new systems with DDD principles, refactoring existing codebases toward DDD, generating code scaffolding (entities, aggregates, repositories, domain events), facilitating Event Storming sessions, creating bounded context maps, or performing code reviews with a DDD lens. Covers both strategic design (bounded contexts, subdomains, context maps, ubiquitous language) and tactical design (entities, value objects, aggregates, domain services, repositories). Supports all major architecture patterns (Hexagonal/Ports & Adapters, CQRS, Event Sourcing, Clean Architecture) with language-agnostic guidance and concrete examples in Python and TypeScript.
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Use this skill whenever the user wants to create, read, edit, or manipulate Word documents (.docx files) or Word templates (.dotx files). Triggers include: any mention of 'Word doc', 'word document', '.docx', '.dotx', or requests to produce professional documents with formatting like tables of contents, headings, page numbers, or letterheads. Also use when extracting or reorganizing content from .docx or .dotx files, inserting or replacing images in documents, performing find-and-replace in Word files, working with tracked changes or comments, or converting content into a polished Word document. If the user asks for a 'report', 'memo', 'letter', 'template', or similar deliverable as a Word or .docx file, use this skill. Do NOT use for PDFs, spreadsheets, Google Docs, or general coding tasks unrelated to document generation.
日本語の概要は準備中です。原文の説明を表示しています。
Critical Git safety rules to prevent destructive operations. Use whenever performing git operations, reverting changes, or managing commits. Prevents accidental loss of work.
日本語の概要は準備中です。原文の説明を表示しています。
Critical Git safety rules to prevent destructive operations. Use whenever performing git operations, reverting changes, or managing commits. Prevents accidental loss of work.
日本語の概要は準備中です。原文の説明を表示しています。
Company Architect: builds a business from scratch as an OKF (Open Knowledge Format) bundle — a tree of version-controllable .md files with frontmatter type, links forming a graph, and reserved index.md/log.md, readable by humans and agents.
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Detects and analyzes Bluetooth Low Energy (BLE) security attacks including sniffing, replay attacks, GATT enumeration abuse, and Man-in-the-Middle interception. Uses Ubertooth One and nRF52840 sniffers for packet capture, the bleak Python library for GATT service enumeration, and crackle for BLE encryption cracking. Use when assessing IoT device BLE security, monitoring for BLE-based attacks on wireless infrastructure, or performing authorized BLE penetration testing. Activates for requests involving BLE security assessment, Ubertooth sniffing, GATT enumeration, or BLE replay detection.
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Conducts comprehensive network penetration tests against authorized target environments by performing host discovery, port scanning, service enumeration, vulnerability identification, and controlled exploitation to assess the security posture of network infrastructure. The tester follows PTES methodology from reconnaissance through post-exploitation and reporting. Activates for requests involving network pentest, infrastructure security assessment, internal network testing, or external perimeter testing.
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Collects and synthesizes open-source intelligence (OSINT) about threat actors, malicious infrastructure, and attack campaigns using publicly available data sources, passive reconnaissance tools, and dark web monitoring. Use when investigating external threat actor infrastructure, performing pre-engagement reconnaissance for authorized red team assessments, or enriching CTI reports with publicly available adversary context. Activates for requests involving Maltego, Shodan, OSINT framework, SpiderFoot, or infrastructure reconnaissance.
日本語の概要は準備中です。原文の説明を表示しています。