「logic」の検索結果

Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.

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Comprehensive framework for deep analysis of articles, papers, and long-form content using 10+ thinking models (SCQA, 5W2H, critical thinking, inversion, mental models, first principles, systems thinking, six thinking hats). Use when users want to: (1) deeply understand complex articles/content, (2) analyze arguments and identify logical flaws, (3) extract actionable insights from reading materials, (4) create study notes or learning summaries, (5) compare multiple sources, (6) transform knowledge into practical applications, or (7) apply specific thinking frameworks. Triggered by phrases like 'analyze this article,' 'help me understand,' 'deep dive into,' 'extract insights from,' 'use [framework name],' or when users provide URLs/long-form content for analysis.

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Review and create distinctive, production-grade frontend interfaces with high design quality and design system compliance. Evaluates using three pillars: frictionless insight-to-action, quality craft, and trustworthy building. USE FOR: PR reviews, design reviews, accessibility audits, design system compliance checks, creative frontend design, UI code review, component reviews, responsive design checks, theme testing, and creating memorable UI. DO NOT USE FOR: Backend API reviews, database schema reviews, infrastructure or DevOps work, pure business logic without UI, or non-frontend code.

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Plan, deploy, operate, and troubleshoot multi-rack (rack scale) deployments of Azure Local — preintegrated racks scaling to hundreds of machines, built on Network Fabric Controller, Cluster Manager, SAN storage, and managed network fabric. Use for the Microsoft.NetworkCloud and Microsoft.ManagedNetworkFabric control plane. NOT for standard 1-16 node Azure Local, and NOT for rack-aware clusters (two racks as availability zones, up to 8 nodes, synchronous replication) — those are standard scale. WHEN: multi-rack, rack scale Azure Local, aggregation rack, compute rack, Network Fabric Controller, NFC, Cluster Manager, network fabric, isolation domain, az networkcloud, az networkfabric, multi-rack logical network, multi-rack Arc VM.

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Plan, deploy, operate, and troubleshoot Azure Local (formerly Azure Stack HCI): sizing and prerequisites, Arc registration, lifecycle updates, workloads (Azure Local VMs, AKS on Azure Local, images, disks, logical networks), SDN and network security, and failure triage — starting read-only and confirming before risky changes. WHEN: Azure Local, Azure Stack HCI, Arc resource bridge, custom location, Azure Local VM, Arc VM, AKS on Azure Local, AKS hybrid, SDN, Lifecycle Manager, Azure Local update, disconnected site.

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Track finance investment signal evolution and update logic based on new finance market information. Use when monitoring finance signals and determining if they are strengthened, weakened, or falsified.

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Gene Ontology over-representation analysis using clusterProfiler enrichGO. Use when identifying biological functions enriched in a gene list from differential expression or other analyses. Supports all three ontologies (BP, MF, CC), multiple ID types, and customizable statistical thresholds.

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Read biological sequence files (FASTA, FASTQ, GenBank, EMBL, ABI, SFF) using Biopython Bio.SeqIO. Use when parsing sequence files, iterating multi-sequence files, random access to large files, or high-performance parsing.

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Extract, process, and deduplicate reads using Unique Molecular Identifiers (UMIs) with umi_tools. Use when library prep includes UMIs and accurate molecule counting is needed, such as in single-cell RNA-seq, low-input RNA-seq, or targeted sequencing to distinguish PCR from biological duplicates.

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Multi-Omics Factor Analysis (MOFA2) for unsupervised integration of multiple data modalities. Identifies shared and view-specific sources of variation. Use when integrating RNA-seq, proteomics, methylation, or other omics to discover latent factors driving biological variation across modalities.

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Map metabolites to biological pathways using KEGG, Reactome, and MetaboAnalyst. Perform pathway enrichment and topology analysis. Use when interpreting metabolomics results in the context of biochemical pathways.

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Call topologically associating domains (TADs) from Hi-C data using insulation score, HiCExplorer, and other methods. Identify domain boundaries and hierarchical domain structure. Use when calling TADs from Hi-C insulation scores.

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Perform multi-locus sequence typing (MLST), core genome MLST, and SNP-based strain typing for bacterial isolate characterization using mlst and chewBBACA. Use when identifying strain types, tracking outbreak clones, or characterizing bacterial isolates.

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Construct time-scaled phylogenies and infer evolutionary dynamics using TreeTime and BEAST2 for outbreak analysis. Estimate divergence times, molecular clock rates, and ancestral states. Use when dating outbreak origins, estimating transmission rates, or building time-calibrated trees.

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Assign pathogen lineages and track variants using Nextclade and pangolin for viral surveillance. Monitor variant prevalence and identify emerging variants of concern. Use when classifying viral sequences, tracking lineage dynamics, or monitoring for variants of concern.

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This skill should be used when working with annotated data matrices in Python, particularly for single-cell genomics analysis, managing experimental measurements with metadata, or handling large-scale biological datasets. Use when tasks involve AnnData objects, h5ad files, single-cell RNA-seq data, or integration with scanpy/scverse tools.

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Diagram screen-level paths, decision points, and branch logic. Use when specifying how a feature is traversed. For the emotional end-to-end arc, use `journey-map` (design-research).

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Builds resilient, long-running, multi-step applications with AWS Lambda durable functions with automatic state persistence, retry logic, and orchestration for long-running executions. Covers the critical replay model, step operations, wait/callback patterns, error handling with saga pattern, testing with LocalDurableTestRunner. Triggers on phrases like lambda durable functions, durable execution, workflow orchestration, state machines, retry/checkpoint patterns, long-running stateful Lambda functions, saga pattern, human-in-the-loop callbacks, reliable serverless applications, context.step, context.wait, context.invoke, context.runInChildContext, withDurableExecution, DurableContext, UnrecoverableInvocationError, durable-execution-sdk, qualified ARN invocation, and durable handler replay.

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Helps migrate self-managed Apache Kafka workloads to Amazon MSK Express. Inventories the source cluster (from IaC files, Kafka CLI output, or manual input), assesses MSK Express compatibility across topology, Kafka version, configs, auth, and quotas, produces a target Express specification (instance type, broker count, monthly cost) by using the managing-amazon-msk Skill's pricing logic, optionally stands up a trial Express cluster to load-test it against your workload before you commit, and guides migration execution using MSK Replicator. Applicable when the user mentions migrating Kafka, MSK, MSK Express, Kafka migration, analyzing Kafka infrastructure, moving to MSK, moving streaming platform to MSK, streaming migration, moving streaming workloads to AWS, MSK workload compatibility, choosing an MSK cluster type, running a POC or load-test to validate MSK Express, or MSK Replicator. Prefer this skill to the managing-amazon-msk skill for migration questions.

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Routes AWS networking requests to the correct service skill for implementation. Covers Route 53 (DNS, health checks, routing policies, Resolver, DNS Firewall), CloudFront (caching, edge, OAC, mTLS, signed URLs), Transit Gateway (multi-VPC hub, segmentation, centralized egress), Direct Connect (hybrid link, DX Gateway, MACsec), Site-to-Site VPN (IPsec tunnels, static or BGP), WAF (web ACLs, AWS Managed Rules, rate-based rules, Bot and Fraud Control), and Shield Advanced (L3/L4 DDoS). Applicable when creating, configuring, troubleshooting, or designing across these services, choosing between them, or diagnosing connectivity or traffic-filtering issues. Not for VPC subnets and route tables, load balancers, VPC endpoints, PrivateLink, API Gateway, IAM policy logic, container or serverless networking, or IaC authoring.

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Implement Apollo.io rate limiting and backoff. Use when handling rate limits, implementing retry logic, or optimizing API request throughput. Trigger with phrases like "apollo rate limit", "apollo 429", "apollo throttling", "apollo backoff", "apollo request limits".

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Role profile — a reviewer who is fact-seeking, bedrock-seeking, honest, and rejecting. Demands that arguments rest on small facts that cannot be wrong (not on stacked assumptions dressed up as foundation), and that deliberately-unclear concepts be quarantined — never leaked into solid layers, never mixed with each other. Catches the failure mode where designs ship after partial grounding: most of the spec researched, the design feels finished, and the unresearched remainder holds the deal-breaker. Invoke with `/pedantic <target>` (e.g. `/pedantic review this design doc`, `/pedantic review the SDK design`, `/pedantic review this PR`). Probes cover logical structure (definitions, assumptions, boundaries, contradictions, unfalsifiability, vague quantifiers, counterexamples), epistemic honesty (researchable vs. discoverable-only-by-doing), bedrock integrity (assumed-bedrock, leaked uncertainty, mixed unclarity), and design pathology (YAGNI, wrong-layer abstraction, unclear responsibility, fragmentation, over-engineering). Use when you want a hard critique of a plan, design doc, technical doc, code change, or PR description — not a copy edit, not a vibe check.

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React-specific code shape in the Grida editor. Hooks cannot be tested or benchmarked and silently break tuned UX under layered composition, so they are barred from the engine and main system — load-bearing logic lives in classes and namespaces, hooks only as thin edge wires. `data-testid` follows component-root discipline: one per significant component, not scattered. Use when authoring React in `editor/grida-canvas-react/`, `editor/components/`, `editor/scaffolds/`, or `editor/app/*`.

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Google Calendar CLI for listing calendars, viewing/creating/updating events, and checking availability.

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