1,378 件 ・ 関連度順
概要と使いどころ
Access ClinPGx pharmacogenomics data (successor to PharmGKB). Query gene-drug interactions, CPIC guidelines, allele functions, for precision medicine and genotype-guided dosing decisions.
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Extract decisions, lessons, patterns, and surprises from completed phase artifacts
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Practical guidance for training MoE VLMs in Megatron Bridge. Compares FSDP and 3D-parallel approaches, using rounded lessons from Qwen3-VL, Qwen3-Next, and other multimodal experiments.
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Use this skill when the user is invoking `doca_spcx_cc` (the host-side CLI under /opt/mellanox/doca/tools/) to load, parameterize, start, observe, or stop a Programmable Congestion Control (SPCX) algorithm on a BlueField with a DPA processor against a live RDMA / RoCE fabric, or picking SPCX vs the established `doca-pcc` surface. Trigger even when the user does not say "DOCA SPCX" or "doca_spcx_cc" — typical implicit phrasings include "I want to write a custom RTT-based CC algorithm for my RoCE fabric", "my SPCX session loaded but throughput / latency didn't change", "doca_pcc status shows Active but factory CC seems to still be in charge", "DOCA_PCC_PS_ERROR on start", "is the programmable-CC surface available on my install", or "DPA-side algorithm image won't load". Refuse and route elsewhere for DPA-side algorithm authoring detail, factory PCC firmware configuration, read-only PCC counter inspection, raw DPA cycle profiling, RDMA library programming, or general DOCA install — those belong to other skills.
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Use this skill when building, deploying, evaluating, debugging, or measuring latency for the DeepStream SOP Inference Microservice — a GPU-accelerated FastAPI service that detects whether operators perform assembly-line steps in order via event boundary detection (GEBD) plus VLM classification. Trigger even if the user does not name it: verify operator step sequence, detect missing or out-of-order SOP steps, score factory/work-cell video for procedure compliance, run VLM-based SOP checking on industrial cameras, or call /v1/chat/completions with a file, RTSP, or Basler camera. Also trigger for its internals: SOPVideoProcessor, DeepStream GEBD model (e.g. DDM) via Triton CAPI, nvds_custom_postprocess, Cosmos Reason 1/2 vLLM, SSE streaming, Kafka NvProto/JSON output, Basler/Pylon camera + emulation, Docker compose, chunk-level latency. Do NOT trigger for generic DeepStream pipelines, object detection/tracking, NIM imports, or video summarization.
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Re-derive your knowledge system from first principles when structural drift accumulates. Analyzes dimension incoherence, vocabulary mismatch, boundary dissolution, and template divergence. Preserves all content while restructuring architecture.
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Generates a single standardized submission-style CTF writeup for competition handoff and organizer review. Use after solving a CTF challenge to document the solution steps, tools used, and lessons learned in a structured format.
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[omh] Turn repeated lessons into written rules: extract repeated principles from skills, prompts, traces, reviews, and failures into reviewed rule candidates without auto-mutating guidance. Use when the user says: rules-distill, rules distill, distill rules, rule distillation, principle distill, skill principles, extract agent rules, turn traces into rules.
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[omh] Missed route or run lessons to record: classify and review self-improvement store routes as an auxiliary review lane before durable writes, then record workflow attempts as metadata-only traces, evals, review queues, patch proposals, regression cases, audits, indexes, and exports. Use when the user says: workflow-learning, workflow learning, route-signal, self-improvement store routing, store route review, memory skill wiki routing, learning trace, learning audit.
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Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.
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Search PubMed for scientific literature, including published clinical trials. Fetch abstracts and full text. Link published research to biological databases (gene, protein, nucleotide, PubChem) to discover associations between papers and specific compounds or genes. Verify medical spelling, match raw citations, and cache result sets for bulk processing. Interfaces NCBI E-utilities and PMC BioC APIs.
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Query the QuickGO and Evidence & Conclusion Ontology (ECO) REST API. Use this when you need to map genes to biological processes, molecular functions, or cellular components, find genes associated with a specific pathway/GO term, or explore the Gene Ontology hierarchy. Do not use for querying drug targets (use OpenTargets) or mechanistic signaling pathway diagrams (use KEGG).
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Use when you want to look up, map, and search for short genetic variants (SNPs, indels) in NCBI's dbSNP database. Resolves between rsIDs, genomic coordinates in VCF format, and HGVS strings. For an rsID, returns variant type, gene associations, clinical significance, allele frequencies, and genomic coordinates (GRCh38).
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Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.
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Troubleshoot and resolve issues with Azure Messaging SDKs for Event Hubs and Service Bus. Covers connection failures, authentication errors, message processing issues, and SDK configuration problems. WHEN: event hub SDK error, service bus SDK issue, messaging connection failure, AMQP error, event processor host issue, message lock lost, message lock expired, lock renewal, lock renewal batch, send timeout, receiver disconnected, SDK troubleshooting, azure messaging SDK, event hub consumer, service bus queue issue, topic subscription error, enable logging event hub, service bus logging, eventhub python, servicebus java, eventhub javascript, servicebus dotnet, event hub checkpoint, event hub not receiving messages, service bus dead letter, batch processing lock, session lock expired, idle timeout, connection inactive, link detach, slow reconnect, session error, duplicate events, offset reset, receive batch.
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Azure Weights & Biases SDK for .NET. ML experiment tracking and model management via Azure Marketplace. Use for creating W&B instances, managing SSO, marketplace integration, and ML observability. Triggers: "Weights and Biases", "W&B", "WeightsAndBiases", "ML experiment tracking", "model registry", "experiment management", "wandb".
日本語の概要は準備中です。原文の説明を表示しています。
Azure Service Bus SDK for .NET. Enterprise messaging with queues, topics, subscriptions, and sessions. Use for reliable message delivery, pub/sub patterns, dead letter handling, and background processing. Triggers: "Service Bus", "ServiceBusClient", "ServiceBusSender", "ServiceBusReceiver", "ServiceBusProcessor", "message queue", "pub/sub .NET", "dead letter queue".
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Call topologically associating domains (TADs) from Hi-C data using insulation score, HiCExplorer, and other methods. Identify domain boundaries and hierarchical domain structure. Use when calling TADs from Hi-C insulation scores.
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Design homology-directed repair donor templates for CRISPR knock-ins using primer3-py. Create ssODN, dsDNA, or plasmid templates with optimized homology arms. Use when designing donor templates for precise insertions, tagging, or allele replacement.
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Identifies super-enhancers from H3K27ac ChIP-seq data using ROSE and related tools. Use when studying cell identity genes, cancer-associated regulatory elements, or master transcription factor binding regions that cluster into large enhancer domains.
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Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.
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Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instruments, or running sensitivity analyses for causal inference.
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Identify likely causal variants within GWAS loci using SuSiE for sum of single effects regression and FINEMAP for shotgun stochastic search. Computes posterior inclusion probabilities and credible sets to prioritize variants for functional follow-up. Use when narrowing GWAS association signals to candidate causal variants or building credible sets for functional validation.
日本語の概要は準備中です。原文の説明を表示しています。
Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.
日本語の概要は準備中です。原文の説明を表示しています。