「clo」の検索結果

Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.

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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.

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Run read-only SQL against BigQuery public datasets with local result capture, cost safeguards, and reproducibility outputs.

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Recommends use of hybrid closed-loop pump rather than insulin pump with CGM (without algorithm) or multiple daily injections with CGM for pregnant individuals with type 1 diabetes. Triggered when deciding on insulin delivery methods for pregnant patients with type 1 diabetes.

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Recommends withdrawing interfering medications and repeating aldosterone-to-renin ratio screening when initial screen is negative but clinical suspicion remains due to hypokalemia or medication interference. Trigger phrases include "initial screen negative", "hypokalemia", "resistant hypertension", and use of MRAs, ACE inhibitors, ARBs, beta-blockers, clonidine, or alpha-methyldopa.

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Read-only view of the execution roadmap. Lists every epic with its per-status tallies, nests the still-open rows beneath their epic, collapses wholly-finished epics into one rollup line, and closes by naming the next planned task in file order. Four verbs — `list` (the reader's view), `tasks` and `epics` (filterable row and epic queries), `next` (the first planned task). Invoke any time to see what is left to build. Not a workflow phase; never writes; never starts or commits work.

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Power batch-sprint helper — hosts the two behaviours that distinguish the `power` workflow track from spec-entry. (1) Per-ticket iteration: security runs once PER TICKET over workflow.json.tickets[] while the mechanical phases run once for the batch. (2) Commit split: at the commit phase, group the batch's working tree into ordered Conventional Commits via commit-split.mjs, closure last. Invoked within a `power`-track workflow; not a standalone feature. Opt-in via velocity.power_mode.enabled; requires git.

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Create new agent skills with proper structure, progressive disclosure, and bundled resources. Use when user wants to create, write, or build a new skill.

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Evaluate and install ecosystem tools (Hermes plugins, skills, integrations) — assess complexity vs. benefit before installation, show examples for visual tools, and avoid "cloned but not configured" states.

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Clone/create/fork repos; manage remotes, releases.

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Dark-themed SVG architecture/cloud/infra diagrams as HTML.

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Azure Event Grid SDK for Python. Use for publishing events, handling CloudEvents, and event-driven architectures.

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Azure Event Grid SDK for .NET. Client library for publishing and consuming events with Azure Event Grid. Use for event-driven architectures, pub/sub messaging, CloudEvents, and EventGridEvents.

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Design Azure architectures for startups and enterprises. Use when asked to design Azure infrastructure, create Bicep/ARM templates, optimize Azure costs, set up Azure DevOps pipelines, or migrate to Azure. Covers AKS, App Service, Azure Functions, Cosmos DB, and cost optimization.

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Provide comprehensive techniques for penetration testing AWS cloud environments. Covers IAM enumeration, privilege escalation, SSRF to metadata endpoint, S3 bucket exploitation, Lambda code extraction, and persistence techniques for red team operations.

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AWS development with infrastructure automation and cloud architecture patterns

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Design AWS architectures for startups using serverless patterns and IaC templates. Use when asked to design serverless architecture, create CloudFormation templates, optimize AWS costs, set up CI/CD pipelines, or migrate to AWS. Covers Lambda, API Gateway, DynamoDB, ECS, Aurora, and cost optimization.

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Enterprise-specific view across CopilotKit + AG-UI. "Enterprise" here = CopilotKit's COMMERCIAL surfaces (Premium / CopilotKit Enterprise / Intelligence Platform / paid tiers), NOT CopilotKit running inside a big company. Tracks the commercial product surfaces (from product-surface-scan — Enterprise Intelligence, Cloud, self-host license, threads/persistence tier, Inspector, premium UI/Angular SDK, analytics, security bundle, Slack/Teams), applies the free-vs-paid classifier to decide if an issue belongs here, surfaces cross-page product contradictions, and tracks enterprise questions/complaints, community-sourced prospects (with a sales owner), and enterprise reporters with prior-week trend. Elevated to the top of the weekly report. Runs standalone ("who's at enterprise this week") or invoked by weekly-report. Triggers on "enterprise report", "enterprise signals", "enterprise status", "who at enterprise this week".

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Subagent flow for deep-reading GitHub issues + their linked/closing PRs to the bottom. Captures CURRENT state, maintainer status updates, reporter repro, blocking reviewer concerns, hidden second bugs, cross-repo duplicates. Invoked by weekly-report orchestrator; runs as a general-purpose subagent so the orchestrator's context stays small.

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CLI for ElevenLabs AI audio platform - text-to-speech, speech-to-text, voice cloning.

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Expert-level environmental remediation covering site characterization, risk assessment, remediation technology selection, in-situ and ex-situ treatment, and regulatory closure.

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Expert-level topology knowledge. Use when working with topological spaces, continuity, compactness, connectedness, metric spaces, homeomorphisms, fundamental groups, homology, manifolds, or algebraic topology. Also use when the user mentions 'open set', 'closed set', 'compactness', 'connectedness', 'homeomorphism', 'homotopy', 'fundamental group', 'covering space', 'manifold', 'homology', 'Euler characteristic', or 'topological invariant'.

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Delete local branches that have been merged or whose PRs are closed/stale

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Codex workflow tips from Boris Cherny (creator of Codex) and the Codex team. Use when: setting up Codex, optimizing workflows, running parallel sessions, configuring AGENTS.md, using skills/commands, subagents, hooks, MCP integrations, or learning best practices. Covers: git worktrees, plan mode, verification, permissions, Slack MCP, BigQuery, prompting tips, plugins, custom agents, sandboxing, keybindings, status lines, output styles, customization, /simplify for code quality, /batch for parallel code migrations, /loop for scheduled tasks, code review agents, /btw for mid-task questions, /effort max reasoning, remote control sessions, voice mode, setup scripts, session naming, /color, PostCompact hook, auto mode, /schedule cloud jobs, iMessage plugin, auto-memory, and auto-dream, mobile app, session teleporting, Cowork Dispatch, Chrome extension, Desktop app, /branch forking, --bare SDK startup, --add-dir multi-repo, --agent custom agents, /voice input.

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