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概要と使いどころ
Metabolomics research — metabolite identification, study analysis, and database searches across HMDB, MetaboLights, Metabolomics Workbench, KEGG. Use for annotating mass-spec features to known metabolites, finding metabolomics studies of a disease, and structured metabolomics research reports with metabolite-pathway mapping.
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Metabolomics pathway analysis — metabolite identification (HMDB, KEGG, ChEBI), pathway mapping (Reactome, KEGG, MetaCyc), disease associations, enzyme/gene linkage. Use for metabolite-to-pathway-to-disease connections, BridgeDb-based ID conversion, and integrating metabolomics with gene-level pathway analyses.
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Lipid analysis and lipid-disease associations using LIPID MAPS classification, HMDB metabolite data, KEGG/Reactome lipid pathways (sphingolipid, eicosanoid, steroid, fatty acid), and PubChem chemical info. Use for lipid identification, lipid metabolism pathway mapping, and lipid-associated disease analysis (cardiovascular, diabetes, NAFLD).
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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.
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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
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Rewrite a rough request into a sharp, structured prompt before acting on it. Use when the user says "reprompt this", "reprompt", "improve this prompt", "make this prompt better", "structure this request", or hands you a vague/underspecified ask you should sharpen first. Complements the automatic per-turn sharpener (the UserPromptSubmit hook) for explicit, heavier rewrites. Personalizes from ~/.stellar-build/profile.md when present.
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Design workflow — create design systems, DESIGN.md, and design tokens with anti-pattern enforcement and accessibility checks
日本語の概要は準備中です。原文の説明を表示しています。
When the user wants to create or update their product marketing context document. Also use when the user mentions 'product context,' 'marketing context,' 'set up context,' 'positioning,' or wants to avoid repeating foundational information across marketing tasks. Creates `.claude/product-marketing-context.md` that other marketing skills reference.
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Define or review a visual system, DESIGN.md, or redesign direction. Use for typography, layout, color, motion, and interaction design decisions.
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Convert the canonical markdown+JSON deliverable of any SfSkills runtime agent into Excel, PDF, CSV, Notion card, ServiceNow ticket, or similar downstream format WITHOUT polluting the consumer's project with new dependencies or regenerating from the agent's source logic. NOT for authoring new agent output formats (use DELIVERABLE_CONTRACT.md). NOT for data-export SOQL (use bulk-api-2-patterns).
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Central authority for Claude Agent SDK (TypeScript and Python SDKs). Covers SDK installation, authentication (Anthropic key, Bedrock, Vertex), sessions and resumption, forking sessions, streaming vs single mode, custom tools, permissions (allowedTools, disallowedTools, permissionMode), MCP integration, system prompts (CLAUDE.md, appendSystemPrompt, outputStyle), cost tracking, todo tracking, structured outputs, hosting patterns, plugins, and SDK branding guidelines. Assists with building custom agents, configuring SDK options, and troubleshooting SDK issues. Delegates 100% to docs-management skill for official documentation.
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Adverse event monitoring and reporting skill for MDR/MEDWATCH compliance
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Detect project tech stack and configure Claude Code hooks for mechanical enforcement of linting and security rules. Use this skill when a user wants to set up hooks, configure auto-linting, add security guards, or move from advisory CLAUDE.md rules to mechanical enforcement.
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Audit agent configuration files for security vulnerabilities and misconfigurations. Covers settings.json, .mcp.json, .codex/config.toml, AGENTS.md, hooks, plugin manifests, and relay config. Classify findings as P0 or P1.
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Manage Linux systems covering systemd services, process management, filesystems, networking, performance tuning, and troubleshooting. Use when deploying applications, optimizing server performance, diagnosing production issues, or managing users and security on Linux servers.
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Use when you need to add or configure Maven plugins in your pom.xml — including quality tools (enforcer, surefire, failsafe, jacoco, pitest, spotbugs, pmd), security scanning (OWASP), code formatting (Spotless), version management, container image build (Jib), build information tracking, and benchmarking (JMH) — through a consultative, modular step-by-step approach that only adds what you actually need. This should trigger for requests such as Add Maven plugins in pom.xml; Improve Maven plugins in pom.xml. Part of cursor-rules-java project
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Incremental re-specialization — re-scans the project and updates only auto-generated zones in CLAUDE.md and agents
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Enriches CLAUDE.md by exploring the project and specializes agents to the real stack
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Builds an interactive HTML dashboard visualizing the Agent Skills ecosystem by fetching live data from github.com/agentskills/agentskills. Use this skill whenever the user wants to explore, research, or visualize Skills architecture, the SKILL.md spec, ecosystem adoption, repo stats, or any Skills intelligence dashboard. Trigger when the user mentions "skills dashboard", "skills ecosystem", "skills architecture overview", "agentskills repo", or wants to analyze how different tools implement Agent Skills. Optimized for Perplexity Computer — Computer fetches all data live, no static files required.
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Assembles microbial-community sequencing into metagenome-assembled genomes (MAGs) with metaFlye (ONT), metaSPAdes/MEGAHIT (Illumina), and hifiasm-meta/metaMDBG (PacBio HiFi), then recovers genomes via multi-binner consolidation (MetaBAT2, MaxBin2, CONCOCT, SemiBin2, VAMB -> DAS_Tool) and QCs them against MIMAG with CheckM2, GUNC, and GTDB-Tk. Covers why a metagenome is not a genome (uneven coverage, micro-diversity, strain collapse to consensus), differential-coverage binning, co-assembly vs per-sample, the rRNA-operon collapse that fails short-read MAGs, and strain resolution with inStrain. Use when reconstructing genomes from a microbiome, soil, ocean, or gut community, recovering MAGs, or resolving strain-level variation.
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Download raw sequencing reads from NCBI SRA using sra-tools (prefetch, fasterq-dump, vdb-validate) or the ENA mirror. Use when pulling FASTQ for SRR/ERR/DRR accessions, deciding between SRA-direct, ENA mirror, or AWS/GCP cloud mirror (STRIDES), handling --include-technical for 10x and other single-cell records, validating with MD5/vdb-validate, navigating SRR/SRX/SRS/SRP/PRJNA hierarchy, or finding accessions via pysradb. Encodes SRA cloud-egress economics, the fasterq-dump uncompressed-scratch trap, and the --max-size default that silently truncates large prefetches.
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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.
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Build local BLAST databases and run searches using NCBI BLAST+ command-line tools. Use when running >50 queries, building custom databases with -parse_seqids and -taxid, downloading prebuilt NCBI databases via update_blastdb.pl, choosing -task variants (megablast/dc-megablast/blastn/blastn-short), tuning soft/hard masking, scaling threads, or extracting hits with blastdbcmd. Encodes BLAST v5 vs v4 database format, taxonomy filtering, makeblastdb pitfalls.
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Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO, BioProject to SRA runs, or discovering all link relationships for a record. Covers linkname semantics, cmd= variants, asymmetric link warnings, neighbor_history for >200 input IDs, and per-database link tables.
日本語の概要は準備中です。原文の説明を表示しています。