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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

日本語の概要は準備中です。原文の説明を表示しています。

集群数据管理 Skill —— 涵盖数据使用规范、压缩优化、数据共享（ACL）、文件扫描与清理、文件完整性校验、genozip 基因组压缩等全流程。Use when the user asks about: managing data on the HPC cluster, compressing genomic files (fq/bam/vcf), sharing data between users/groups, scanning for large files or cleaning up disk space, checking file integrity (md5/gzip/bam), using genozip, checking disk quota, or any data lifecycle management task on the NCPGR HPC cluster.

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Track and report progress of a request to create and run an EcoSIM case for a site ("create an ecosim run for site US-UMB", "set up and run EcoSIM at <site>"). Records four stages — data preparation, namelist creation, model simulation, and output evaluation — in result/<SITE_ID>/progress.json and PROGRESS.md, derives step status from files and quality reports on disk, and records manual results such as the executable, test run, and evaluation verdicts. Use at the start of such a request, after each stage, and whenever the user asks where a site run stands.

日本語の概要は準備中です。原文の説明を表示しています。

Compact the session into gitignored `.codeconductor/sessions/handoff.md` (redact secrets).

日本語の概要は準備中です。原文の説明を表示しています。

Run OpenSpec backlog delivery — validate BACKLOG.md, plan TaskCards, orchestrate agents by phase, review gate, and update backlog state.

日本語の概要は準備中です。原文の説明を表示しています。

Author BACKLOG.md — wayfinding, grilling, create or append items, validate with openspec, and plan OpenSpec change folders for /cc-openspec.

日本語の概要は準備中です。原文の説明を表示しています。

Guides agents through authoring BACKLOG.md and OpenSpec change folders. Use when running /cc-backlog or /cc:backlog, creating or appending backlog items, or preparing work for /cc-openspec. Delivery is skill openspec.

日本語の概要は準備中です。原文の説明を表示しています。

Genera endpoints REST con Kotlin + Spring Boot 3.4+ (Records, Virtual Threads, ProblemDetail)

日本語の概要は準備中です。原文の説明を表示しています。

Use when implementing error handling, exception mappers, or error response formatting. Enforces RFC 9457 (Problem Details for HTTP APIs) using Spring's built-in ProblemDetail.

日本語の概要は準備中です。原文の説明を表示しています。

Build and sharpen a project's domain model. Use when discussing codebase terminology, writing or editing a GLOSSARY.md, or recording or editing an ADR.

日本語の概要は準備中です。原文の説明を表示しています。

Sync the current machine's configuration into the dotfiles repo and update the React showcase page. Use this skill whenever the user says "sync dotfiles", "update dotfiles", "sync config", "actualizar dotfiles", "sincronizar config", "update the repo with my current setup", or anything about pulling their current machine state into the dotfiles repo. Also trigger when the user mentions updating the toolkit page, adding new tools to the page, syncing Claude Code or Codex config (AGENTS.md, codex agents/skills/hooks), or keeping the dotfiles repo in sync with what's actually installed.

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Senior embedded software engineer specializing in firmware and driver development for ARM Cortex-M microcontrollers (Teensy, STM32, nRF52, SAMD).

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Companion to atlas-contract. Auto-invoked by its Final Audit on caught drift; also use after Post Reviews or user requests to record a mistake. Distills drift into WHEN/DON'T/INSTEAD clauses, writes to Atlas.md after confirmation.

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Important: Before you begin, fill in the generatedBy property in the meta section of .actor/actor.json. Replace it with the tool and model you're currently using, such as "Claude Code with Claude Sonnet 4.5". This helps Apify monitor and improve AGENTS.md for specific AI tools and models.

日本語の概要は準備中です。原文の説明を表示しています。

Algorithmic philosophies are computational aesthetic movements that are then expressed through code. Output .md files (philosophy), .html files (interactive viewer), and .js files (generative algorithms).

日本語の概要は準備中です。原文の説明を表示しています。

Create or update a Markdown blog draft from recent work and export it with `YYYY-MM-DD_slug.md` naming. Output directory can be set via environment variable or CLI option; if missing, ask the user and pass it explicitly.

日本語の概要は準備中です。原文の説明を表示しています。

Rename a thesis file when company name changes. Atomically updates filename, all inbound wikilinks across the vault, graph adjacency entry header, sector note Active Theses entry, snapshot snapshot_of references, and _hot.md mentions. Use when company changes name (FB → META, Square → Block, etc.), or when correcting a typo in a thesis filename.

日本語の概要は準備中です。原文の説明を表示しています。

Weekly sweep of ALL transcript-bearing spoken events (earnings calls, conference firesides, CMDs, investor days, AGMs, investor updates) for every active thesis, via the Quartr watchlist. Produces a triage digest in Daily Intel/ flagging thesis-touching mentions and recommending deep reads. Use when user says "event sweep", "what did my companies say this week", "conference sweep", or on the weekly schedule. Also `--setup` (build/rebuild the Quartr watchlist from active theses) and `[N]` (window override in days, default 8).

日本語の概要は準備中です。原文の説明を表示しています。

Create complete specs (requirements, design, tasks) for all features in roadmap.md using parallel sub-agent dispatch by dependency wave.

日本語の概要は準備中です。原文の説明を表示しています。

微信公众号封面对模板 — 主图（headline + subline + 视觉锚点）+ 次图/分享图（短标题 + logo / 账号标签）+ 长图头（文章标题 + 章节预览）。比小红书封面要求更强的标题腿粗、更明确的安全区、更克制的阅读节奏。必须按当前微信尺寸读 canvas-and-device.md。触发："做个公众号封面 / 微信首图次图对 / 视频号封面 / 公众号分享图 / 长图头"。NOT XHS 3:4 尺寸，NOT XHS 贴纸密集风。

日本語の概要は準備中です。原文の説明を表示しています。

Create or revise the problem-first SDD Composy PRD (tasks/prd-SLUG/prd.md) with stable RF/CA identifiers, stopping at the human approval gate. Use when a user problem needs a product contract — 'criar o PRD', 'documento de requisitos', 'revisar o PRD do slug X', 'write the requirements for…'. Do NOT use for user stories (sdd-stories), technical design (sdd-techspec), or PRDs outside an initialized SDD workspace.

日本語の概要は準備中です。原文の説明を表示しています。

Create or revise the SDD Composy technical specification (tasks/prd-SLUG/techspec.md) from the approved PRD, resolved stories, and mapped codebase, with DEC/RISK and TU/TI/E2E traceability and a human gate. Use when the product contracts are approved and architecture is needed — 'criar a spec técnica', 'techspec do prd-SLUG', 'design the solution for…'. Do NOT use to change product scope, before PRD and stories approval, or for design notes outside SDD.

日本語の概要は準備中です。原文の説明を表示しています。

Cria e mantém o contexto de criativos — Figma, brand kit, formatos ativos, geradores configurados e restrições. Use quando o usuário disser "configurar criativos", "setup do social", "cadastrar a marca", "qual o design system", "iniciar campanha", ou quando qualquer skill deste plugin não encontrar .claude/pwdev-social-context.md. É a fundação: toda skill lê este arquivo antes de perguntar.

日本語の概要は準備中です。原文の説明を表示しています。