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Query UniProt's REST API (post-2022 endpoint at rest.uniprot.org) for protein sequences, annotations, GO terms, cross-references, ID mappings, and proteomes. Use when fetching UniProtKB entries, navigating the JSON schema, choosing between UniProtKB/UniRef/UniParc/Proteomes resources, deciding stream vs search endpoint for batch retrieval, running ID-mapping jobs with the async pattern, handling isoform suffixes, or filtering reviewed Swiss-Prot vs auto-annotated TrEMBL. Encodes the legacy URL migration (2022), the new JSON schema layout, and bulk-pull patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.

日本語の概要は準備中です。原文の説明を表示しています。

Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioisosteric replacements, prospective scaffold hopping, or expanding hit series beyond 2D similarity.

日本語の概要は準備中です。原文の説明を表示しています。

Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.

日本語の概要は準備中です。原文の説明を表示しています。

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。

Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.

日本語の概要は準備中です。原文の説明を表示しています。

Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

日本語の概要は準備中です。原文の説明を表示しています。

Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Builds multiplayer spatial board games using TabletopKit on visionOS. Use when creating tabletop game experiences with boards, pieces, cards, or dice; managing seats, turns, equipment state, TabletopAction flows, or TabletopInteraction delegates; synchronizing gameplay through FaceTime Group Activities; rendering with RealityKit; or implementing snapping, tosses, and physics on a virtual table surface.

日本語の概要は準備中です。原文の説明を表示しています。

Runs LiveKit agent simulations and acts on the results. Use when the user says "run my simulations", "regression test my agent before deploying", "run the scenarios", "use lk agent simulate", "did my agent pass", "why did this scenario fail", "run simulations in CI", "test the audio pipeline", "check turn-taking and interruptions", or wants to check whole-conversation behavior before shipping. Covers text and audio mode and what each catches, running against a local or deployed agent, degraded-audio flags, automating a pre-release run, and triaging failures with list, view and export. For writing the scenarios use writing-livekit-scenarios. Not the default for a bare "test my agent", which goes to debugging-livekit-agents. Use this skill when the user names simulations, scenarios, a run, CI, or shipping.

日本語の概要は準備中です。原文の説明を表示しています。

Builds voice and chat AI agents with LiveKit Agents on LiveKit Cloud or a self-hosted server. Use when the user asks to "build a voice agent", "create a LiveKit agent", "add voice AI to my app", "implement handoffs", "structure an agent workflow", "my agent is slow / too chatty", "it says it booked but nothing was saved", "make it confirm before committing", "it keeps re-asking things the caller already said", or is writing code against the LiveKit Agents SDK. Covers architecture: designing for latency, keeping context small, splitting a monolithic agent into handoffs and tasks, and designing for voice. Also covers keeping the model in charge of meaning while code owns state, approvals, and effects. For API specifics use reading-livekit-docs. To check behavior use debugging-livekit-agents and testing-livekit-agents.

日本語の概要は準備中です。原文の説明を表示しています。

Deploys and operates a LiveKit agent in production: shipping a version to LiveKit Cloud and rolling it back, secrets and configuration, the worker process model and prewarming, safe async inside worker processes, provider timeouts and degradation, graceful shutdown, SDK upgrades, and observability. Use when the user says "deploy my agent", "roll back the deployment", "tail the agent logs", "the first call after a restart is slow", "attached to a different loop / event loop is closed", "prewarm the VAD", "shut down without dropping calls", "upgrade livekit-agents safely", "correlate logs by session", or is changing an agent codebase that is already live. Not for designing the agent (building-livekit-agents) or reproducing one bad conversation locally (debugging-livekit-agents).

日本語の概要は準備中です。原文の説明を表示しています。

Bandpass, lowpass, bandstop filter design — hairpin, coupled-line, combline, stub, SIW for frequency selection and harmonic rejection. TRIGGER: user asks to design, create, or analyze any RF filter (bandpass, lowpass, highpass, bandstop, hairpin, coupled-line, combline, stub, SIW). Invoke BEFORE writing code — filter class names differ from what you would guess. SKIP: EM simulation/S-parameter extraction of an existing filter (use matlab-analyze-em), general PCB layout assembly (use matlab-assemble-pcb-layout), material/stackup setup only (use matlab-manage-pcb-material), optimization sweeps (use matlab-optimize-pcb-design).

日本語の概要は準備中です。原文の説明を表示しています。

Import recorded driving sensor data (GPS, camera, lidar, actor tracks, lanes) into scenariobuilder.* objects (GPSData, CameraData, LidarData, ActorTrackData, Trajectory, laneData) and run preprocessing — synchronize, offset correction, crop, normalizeTimestamps, convertTimestamps. Also: compute actor tracks from lidar when no annotations exist, attach camera/lidar mounting + intrinsics, export to MAT/workspace/timetable/script. Use for raw driving dataset files (KITTI, nuScenes, Waymo, Pandaset, ROS/ROS2 bags, .mat, .csv, .mp4) or driving/vehicle/sensor logs that need wrapping. drivingLogAnalyzer (DLA) is OPT-IN ONLY — invoke only on explicit user request ('DLA', 'open in DLA', 'inspect/explore/analyze the recording') or reported sensor problem (sync drift, timestamp mismatch, overlay misalignment). NEVER auto-launch DLA after wrapping (Rule 0). For 'build scenario / export to RoadRunner / drivingScenario / OpenSCENARIO / Unreal / simulate', hand off to matlab-use-scenario-builder.

日本語の概要は準備中です。原文の説明を表示しています。

Dropshipping setup and scaling — supplier integration, automation, pricing strategy, customer experience

日本語の概要は準備中です。原文の説明を表示しています。

Optimize Google Shopping campaigns and product feeds for maximum visibility and ROAS. Feed optimization, bidding strategy, campaign structure, and Performance Max integration.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants indie hacker or bootstrapping founder strategy—growth, channels, Build in Public, or solo founder tactics. Also use when the user mentions "indie hacker," "indie developer," "bootstrapping," "bootstrapped founder," "solo founder," "Build in Public," "scratch your own itch," "Micro-SaaS," "first 100 users," or "solo company." For cold start, use cold-start-strategy.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to plan, create, or repurpose visual content (images, infographics, social post images) across channels. Also use when the user mentions "content images," "social media images," "infographic," "visual content," "post image," "image specs," "visual repurposing," "content visuals," or "image for social post." For Pinterest, use pinterest-posts.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a Unity 6.3 URP task involves shaders: hand-written HLSL, Shader Graph water, toon, dissolve or outline, Custom Function nodes, a renderer feature or full-screen effect on Render Graph, compute shaders, shader variants, keywords, stripping, Shader Build Settings, PSO warm-up, or shader cost; or when a material turns pink or invisible, casts no shadow, ignores extra lights under Forward+, an effect 'does nothing', the game stutters the first time something appears, or builds bloat with variants.

日本語の概要は準備中です。原文の説明を表示しています。

Use when texturing, shading or look-developing in Blender: building a PBR material from a texture set, displacement, procedural materials, edge wear, dirt, grime, color variation, decals, box or triplanar mapping on meshes without UVs, stylized character skin (subsurface, pores), eyes and cornea, hand-painted stylized textures, texture painting or painting masks headless. Also when a material looks plastic, CG, waxy or blown out, color spaces are wrong, or EEVEE and Cycles disagree.

日本語の概要は準備中です。原文の説明を表示しています。

Use when turning a dense sculpt, scan, ZBrush export or AI-generated mesh into animation-ready or game-ready topology in Maya without a mouse ("clean up this AI mesh", "retopo this character", Quad Draw, Retopologize), testing it deforms before rigging (bad elbow or wrist bend, lids popping through the eyes), or unwrapping UVs, cutting seams, setting texel density, mip-safe padding, UDIMs, lightmap UVs, stacking mirrored shells, or preparing a low poly and cage for baking. Keywords: edge flow, eye and mouth loops, Unfold3D, bake prep.

日本語の概要は準備中です。原文の説明を表示しています。

Use when skinning a character in Maya ("bind skin", "fix the weights", weight painting, Skin Tools or ngSkinTools layers), when deformation looks wrong (pinching, candy-wrapper wrist, collapsing elbow or shoulder, volume loss, clothes poking through), when mirroring, copying or capping skin weights for Unreal or Unity, building blend shapes, corrective shapes or pose space deformation (Pose Editor on IK-driven joints), a face rig with shapes or joints, multiple skinClusters, Delta Mush or the ML Deformer, or running a range-of-motion deformation test.

日本語の概要は準備中です。原文の説明を表示しています。

Generate e-commerce product advertisement video prompts for Seedance 2.0 on Higgsfield. Use whenever the user wants product ads, e-commerce videos, product showcases, unboxing, product demos, shopping ads, fashion ads, beauty ads, food ads, or any commercial product video for online selling. Triggers on: product ad, e-commerce, product showcase, Amazon video, Shopify ad, Instagram shop, TikTok shop, product commercial, fashion video, beauty ad, food ad, product demo, dropshipping video, or any product promotional video request. Use even for "make a video for my product" or "product promo.

日本語の概要は準備中です。原文の説明を表示しています。

Expert CIS Controls v8 (CIS Top 18) advisor — implementation group scoping (IG1/IG2/IG3), control gap assessments, safeguard-level guidance, asset inventory, software inventory, data protection, secure configuration, account management, access control, continuous vulnerability management, audit log management, email and web browser protections, malware defenses, network infrastructure management, network monitoring and defense, application software security, incident response, penetration testing, and CIS Controls mapping to NIST CSF, ISO 27001, SOC 2, and CMMC. Use for any question about CIS Controls, CIS Benchmarks, Implementation Groups, or prioritized cyber hygiene for any organization size.

日本語の概要は準備中です。原文の説明を表示しています。