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Detect antimicrobial resistance genes using AMRFinderPlus, ResFinder, and CARD. Screen isolates and metagenomes for resistance determinants. Use when characterizing resistance profiles in clinical isolates, surveillance samples, or metagenomic data.
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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.
日本語の概要は準備中です。原文の説明を表示しています。
Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.
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Pull pre-computed ortholog calls from public databases (OrthoDB, Ensembl Compara, OMA browser, eggNOG, PANTHER, KEGG Orthology, HomoloGene) via their REST APIs. Use when orthologs are already curated upstream, when the question is "what is the X ortholog of Y" rather than "how to infer orthology de novo", when batch-mapping gene IDs across species, or when comparing the resources for consensus calls. Encodes confidence-level semantics, 1:1 vs 1:many vs many:many, HomoloGene deprecation, and when to defect to de novo computation.
日本語の概要は準備中です。原文の説明を表示しています。
Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for outbreak-style pathogen genomics, surveillance, lineage assignment, and transmission-oriented comparative analysis.
日本語の概要は準備中です。原文の説明を表示しています。
SPR and BLI assay planning, kinetic interpretation, and troubleshooting guidance. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.
日本語の概要は準備中です。原文の説明を表示しています。
Mass spectrometry proteomics QC, quantification, comparative analysis, and export for DDA, DIA, and protein-level result tables.
日本語の概要は準備中です。原文の説明を表示しています。
Goal-oriented binder design campaign planning and health assessment. Use this skill when: (1) Planning a complete binder design campaign, (2) Converting high-level goals into runnable pipelines, (3) Assessing campaign health and pass rates, (4) Diagnosing why designs are failing QC, (5) Estimating time, cost, and expected yields, (6) Selecting between design tools for a specific target. This skill orchestrates the other protein design tools. For individual tool parameters, use the specific tool skills.
日本語の概要は準備中です。原文の説明を表示しています。
Binder design tool selection and workflow routing guidance. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end protein design pipeline guide across preparation, generation, validation, and filtering. Use this skill when: (1) Starting a new protein design project, (2) Need step-by-step workflow guidance, (3) Understanding the full design pipeline, (4) Planning compute resources and timelines, (5) Integrating multiple design tools. For tool selection, use binder-design-tool-selection. For QC thresholds, use protein-design-qc.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for orthology, synteny, ancestral reconstruction, and evolutionary comparison across genomes.
日本語の概要は準備中です。原文の説明を表示しています。
Binder design campaign planning, monitoring, and troubleshooting. Use this skill when: (1) Planning a complete binder design campaign, (2) Converting high-level goals into runnable pipelines, (3) Assessing campaign health and pass rates, (4) Diagnosing why designs are failing QC, (5) Estimating time, cost, and expected yields, (6) Selecting between design tools for a specific target. This skill orchestrates the other protein design tools. For individual tool parameters, use the specific tool skills.
日本語の概要は準備中です。原文の説明を表示しています。
Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
日本語の概要は準備中です。原文の説明を表示しています。
Research podcasts, episodes, and audio content by searching YouTube (where most podcasts crosspost), web sources, and transcript databases. Discover relevant shows, track guest appearances, and analyze topic coverage in the podcast ecosystem.
日本語の概要は準備中です。原文の説明を表示しています。
Validate email addresses for deliverability, check reputation scores, verify MX records, and assess email-sending safety. Covers deliverability checks, reputation scoring, bounce risk assessment, and bulk validation for outreach campaign preparation.
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Prepare personalized email outreach by researching prospects, verifying email addresses, building company context, and generating relevant talking points. End-to-end outreach preparation from prospect identification to send-ready intelligence.
日本語の概要は準備中です。原文の説明を表示しています。
Produce pre-meeting lead intelligence briefs with Firecrawl. Use when the user needs company research, person research, recent news, talking points, pain points, or outreach preparation before a sales call, partnership meeting, investor conversation, or customer interview.
日本語の概要は準備中です。原文の説明を表示しています。
Visual communication and presentation expert for slide decks, pitch decks, and visual storytelling. Use when the user asks to talk to Caravaggio or requests the Presentation Expert.
日本語の概要は準備中です。原文の説明を表示しています。
Use when implementing or extending /config (storage, prompt injection, request params, UI-only toggles) with tests and strict UI parity.
日本語の概要は準備中です。原文の説明を表示しています。
Set up or resume THIS session's retalk user — from your existing users (global ~/.agent-talk or project-local ./.agent-talk) or a new one. Use for first-time setup, to pick which identity this session acts as, or when a command fails with "no identity". agent-talk has no default user; pick one with AskUserQuestion (distinct per parallel session). All human input (relay, passphrase, peers, receive source, delivery mode — auto-receive recommended) is gathered here so send/receive run autonomously afterward.
日本語の概要は準備中です。原文の説明を表示しています。
Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, or applications. Generates creative, polished code that avoids generic AI aesthetics.
日本語の概要は準備中です。原文の説明を表示しています。
Performs comprehensive, multi-layered research on any topic with structured analysis and synthesis of information from multiple sources. Use when the user needs thorough investigation, market research, technical deep-dives, due diligence, or comprehensive analysis on any subject.
日本語の概要は準備中です。原文の説明を表示しています。