「rop」の検索結果

Number antibody variable domains, annotate CDRs, and assess developability from sequence. Use this skill to apply IMGT, Kabat, Chothia, Martin, or AHo numbering with ANARCI, delimit CDRs and framework regions, scan for chemical liabilities (N-glycosylation sequons, deamidation NG, isomerisation DG, oxidation, unpaired cysteine, fragmentation), compute pI, net charge, extinction coefficient and hydrophobicity, and plan humanisation by CDR grafting. Also trigger on antibody, nanobody, VHH, scFv, Fab, CDR, framework, ANARCI, abnumber, IgBLAST, OAS, SAbDab, humanization, Vernier residues, or developability.

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Use when a local coding agent (Codex, Claude Code, Cursor, or similar) needs to operate Multica through the authenticated `multica` CLI: reading or updating issues, comments, metadata, labels, custom properties, subscribers, projects, agents, squads, runtimes, repos, skills, autopilots, attachments, or workspace state; searching issues; inspecting or cancelling agent runs; replying to a Multica issue from an external agent; creating or triaging issues; checking linked pull requests; or safely handling Multica mention/status side effects without relying on the Multica hosted agent runtime.

日本語の概要は準備中です。原文の説明を表示しています。

The TaskBarHero game updated (new version) and the tbh-meter reader needs re-calibration — symptoms are gold showing 0, stage mode "?", or the live party/XP/stats dropping out (party empty / no live levels / runs degraded) after a patch, or you're prepping a meter release for a new game build. Runs the diagnose→dump→diff→reseed→bump→verify playbook (the fix is usually a reseed, but a build can also change an Obscured encoding with zero offset movement — caught only by the live gate, fixed by a read-strategy change). Use when the game version changed, after a TBH patch, when a player reports gold/stage/party/XP broken following an update, or when asked to re-seed / re-calibrate the reader for a new build.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user needs to write, rewrite, review, or critique commercial copy meant to drive a reader toward action — landing pages, hero sections, headlines, email (cold outreach, nurture, promo, launch), CTAs, microcopy, product descriptions, value propositions, ads, or taglines. Also for copy audits, clarity checks, conversion reviews, or choosing a framework (AIDA, PAS, BAB, FAB, 4U's). Applies even when the user just says "write me an email" or "review this page." Not for channel/budget strategy (use channel-expert) or pricing structure (use pricing).

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Use when the user needs to design, run, or audit product or GTM analytics — metric hierarchies and north stars, funnels, cohort retention, churn, pipeline velocity, forecasting, lead scoring, NRR, A/B tests, or analytical SQL — or uploads a dataset to analyze. Triggers on questions like "why did activation drop", "is this metric meaningful", "review my dashboard", or "what should I measure". For writing the spec that defines a feature's success metrics, use product-spec.

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Use when a B2B SaaS product needs upstream positioning or messaging clarity — defining who it's for, the category, competitive alternatives, differentiation, value props, strategic narrative, or a messaging hierarchy. Triggers include "my messaging isn't working," "we sound like everyone else," repositioning, or auditing an existing positioning doc. Use before homepage, deck, or sales-narrative work. Not for writing the final copy (use copywriter-skill) or running the sales process (use sales-skill).

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Review software architecture for coupling, cohesion, SOLID principles, API design, scalability, and technical debt. Covers system-level evaluation, architecture decision record review, and improvement recommendations. Use when evaluating a proposed architecture before implementation, assessing an existing system for scalability or security, reviewing ADRs, performing a technical debt assessment, or evaluating readiness for significant scale-up.

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Redact reverse-engineering findings for public disclosure while preserving methodology, generalizable patterns, and teaching value. Covers the private-vs-public repo split, deny-list pattern maintenance, orphan-commit publish pattern that prevents `git log` leaks, category-based redaction calibration (methodology/pattern/version-finding/internal), and the `check-redaction.sh`-style CI gate that blocks merges when a deny-listed pattern appears. Use when publishing findings about a CLI harness you don't own, when preparing upstream proposals to an unrelated project, or when archiving a private research repo for public reference.

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Close out a finished memex milestone slice by writing the handoff trail: update `docs/CONTINUE_HERE.md` §1 current-state and §3 next-slice, tick the `docs/ROADMAP.md` scoreboard (milestone header ✅ + version, `- [x]` items), confirm any new observation is logged (deferring to memex-observe), and propose the git tag plus a `MN Slice X:` commit subject. Use after you finish a milestone slice in the memex repo and before you commit/tag it, when handing the next slice to a fresh session, or whenever CONTINUE_HERE and ROADMAP have drifted behind what actually shipped.

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Plan a comprehensive spectroscopic analysis campaign by defining the analytical question, assessing sample characteristics, selecting appropriate techniques using a decision matrix, planning sample preparation for each technique, sequencing analyses from non-destructive to destructive, and defining success criteria with a cross-validation strategy.

日本語の概要は準備中です。原文の説明を表示しています。

Plan a hiking tour with trail selection by difficulty (SAC/UIAA), time estimation using Munter's formula, elevation analysis, and safety assessment. Covers multi-day hut-to-hut tours, day hikes, and alpine routes with terrain classification and group fitness considerations. Use when planning a day hike or multi-day trekking tour, selecting trails appropriate for a group's fitness and experience, estimating realistic hiking times, or planning hut-to-hut tours with overnight logistics.

日本語の概要は準備中です。原文の説明を表示しています。

Implement cloud cost optimization strategies for Kubernetes workloads using tools like Kubecost for visibility, right-sizing recommendations, horizontal and vertical pod autoscaling, spot/preemptible instances, and resource quotas. Covers cost allocation, showback reporting, and continuous optimization practices. Use when cloud costs are growing without proportional business value, when resource requests are misaligned with actual usage, when manual scaling leads to over-provisioning, or when implementing showback and chargeback for internal cost accountability.

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Field identification of fungi using morphological features, spore prints, habitat analysis, and seasonal context with a safety-first approach. Covers cap, gill, stem, and spore characteristics, look-alike differentiation, toxicity risk assessment, and the critical rule of absolute certainty before consumption. Use when encountering an unknown fungus, foraging for edible mushrooms and needing to confirm species before consumption, assessing whether fungi in a garden or property are harmful, or differentiating an edible species from a dangerous look-alike.

日本語の概要は準備中です。原文の説明を表示しています。

Extract data from web pages using the scrapling Python library — select the appropriate fetcher tier (HTTP, stealth Chromium, or full browser automation) based on target site defenses, configure headless browsing, and extract structured data with CSS selectors. Use when WebFetch is insufficient for JS-rendered pages, anti-bot-protected sites, or structured multi-element extraction requiring DOM traversal.

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Systematically interpret nuclear magnetic resonance spectra (1H, 13C, DEPT, and 2D experiments) to elucidate molecular structure. Covers chemical shift assignment, coupling pattern analysis, integration, and correlation of multi-dimensional data into coherent structural proposals.

日本語の概要は準備中です。原文の説明を表示しています。

Implement a JSON-RPC 2.0 A2A server with full task lifecycle management (submitted/working/completed/failed/canceled/input-required), SSE streaming, and push notifications. Use when implementing an agent that participates in multi-agent A2A workflows, building a backend for an Agent Card, adding A2A protocol support to an existing agent or service, or deploying an agent that must interoperate with other A2A-compliant agents.

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Formulate a quantum mechanics or quantum chemistry problem with proper mathematical framework including Hilbert space, operators, boundary conditions, and approximation method selection. Use when setting up a quantum mechanics problem for analytic or numerical solution, formulating a quantum chemistry calculation, translating a physical scenario into the Schrodinger or Dirac formalism, or choosing between perturbation theory, variational methods, DFT, and exact diagonalization.

日本語の概要は準備中です。原文の説明を表示しています。

Instrument applications with OpenTelemetry for distributed tracing, including auto and manual instrumentation, context propagation, sampling strategies, and integration with Jaeger or Tempo. Use when debugging latency issues in distributed systems, understanding request flow across microservices, correlating traces with logs and metrics for root cause analysis, measuring end-to-end latency, or migrating from legacy tracing systems to OpenTelemetry.

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Systematically interpret mass spectra to determine molecular formula, identify fragmentation pathways, and propose molecular structures. Covers ionization method assessment, molecular ion identification, isotope pattern analysis, common fragmentation losses, and purity evaluation.

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Identify gemstones using optical properties, physical tests, and inclusion analysis. Covers refractive index, specific gravity, pleochroism, spectroscopy indicators, and common simulant detection. Use when identifying an unknown gemstone, verifying a seller's claim about species identity, distinguishing natural stones from simulants or synthetics, building gemological literacy through structured observation, or identifying rough material before cutting to ensure safe handling.

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Epistemic transparency — acknowledging uncertainty, flagging limitations, avoiding overconfidence, and communicating what is known, unknown, and uncertain with proportional confidence. Maps the HEXACO personality dimension to AI reasoning: truthful calibration of confidence, proactive disclosure of gaps, and resistance to the temptation to appear more certain than warranted. Use before presenting a conclusion, when answering questions where knowledge is partial or inferred, after noticing a temptation to state uncertain information as certain, or when a user is making decisions based on provided information.

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Generate a Quarto-based tour report with embedded maps, daily itineraries, logistics tables, and accommodation/transport details. Produces a self-contained HTML or PDF document suitable for offline use during travel. Use when compiling a planned tour into a shareable document, creating an offline-accessible travel guide, documenting a completed trip with photos and statistics, or producing a professional tour proposal for a group or client.

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Evaluate and compare levitation mechanisms for a given application through a structured trade study. Covers magnetic (passive diamagnetic, active feedback, superconducting), acoustic (standing wave, phased array), aerodynamic (hovercraft, air bearings, Coanda effect), and electrostatic (Coulomb suspension, ion traps) mechanisms. Use when selecting the most appropriate levitation approach for transport, sample handling, display, bearings, or precision measurement applications.

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Cut gemstones using cabochon and faceting techniques. Covers rough assessment, orientation for optimal color and yield, dopping, cutting angles, and crown/pavilion geometry for standard brilliant cuts. Use when you have rough gemstone material to cut into a cabochon or faceted stone, planning cutting orientation for optimal colour or optical phenomena, setting up a cabbing or faceting machine, or selecting the appropriate cutting approach for a given material.

日本語の概要は準備中です。原文の説明を表示しています。