「spa」の検索結果

Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.

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Audit required bioinformatics command-line tools against Lmod or Environment Modules on Linux HPC clusters, resolve executable and version requirements, and reproducibly deploy missing software through a site-approved EasyBuild, Spack, Bioconda/micromamba, Apptainer, binary, or source-build workflow. Use when Codex must inspect module availability, diagnose a missing or wrong-version bioinformatics tool, install scientific software on Slurm/PBS clusters, publish or validate modulefiles, or produce an auditable and rollback-ready cluster software deployment.

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集群数据管理 Skill —— 涵盖数据使用规范、压缩优化、数据共享（ACL）、文件扫描与清理、文件完整性校验、genozip 基因组压缩等全流程。Use when the user asks about: managing data on the HPC cluster, compressing genomic files (fq/bam/vcf), sharing data between users/groups, scanning for large files or cleaning up disk space, checking file integrity (md5/gzip/bam), using genozip, checking disk quota, or any data lifecycle management task on the NCPGR HPC cluster.

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The GitHub Actions cost rules ($100/week cap). Use when editing .github/workflows, adding a schedule or cron, dispatching a workflow, publishing a package version, hitting a billing block, or seeing a CI SPEND OFF TRACK line, ci-breaker issue or spend alert.

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Audits and realigns UI to match design system standards, spacing, tokens, and patterns. Use when the user mentions consistency, design drift, mismatched styles, tokens, or wants to bring a feature back in line with the system.

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Performs a final quality pass fixing alignment, spacing, consistency, and micro-detail issues before shipping. Use when the user mentions polish, finishing touches, pre-launch review, something looks off, or wants to go from good to great.

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Project workflow for PRDs, task tracking, changelog sync, and documentation updates. Use for any non-trivial task that spans multiple steps, touches several files, changes architecture, or needs project tracking updates. Also activates with @update to sync task.md, changelog.md, and files.md after completing work.

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Read this before the first Google Drive, Docs, Sheets or Slides connector call whenever the task creates or changes a Google file. Use this skill whenever the user wants to create or change a Google Doc, Sheet or Slides file in their Google Drive. Triggers include: a request that names Google Docs, Sheets, Slides or Drive and asks to make, edit, format, copy or rename a file; a docs.google.com link with a request to change that file, even a one-line fix or suggested edits; and any follow-up change to a Google file from earlier in the chat, even "change it" or "add a tab". Includes helper scripts for document positions, cell ranges and slide layout. However, if the user asks for a doc, deck or spreadsheet without naming Google, or gives a Google file only as source material for something new, use Claude's own output type instead. Do NOT use for read-only questions about a Google file, or for Word, Excel, PowerPoint or PDF files.

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Use this skill when the user's prompt requires (1) researching a topic across multiple sources, comparing options or alternatives, analyzing trends or history, understanding markets or industries, or reviewing literature or studies and (2) synthesizing that research into a comprehensive, narrative report. If you're planning to search the web or internal knowledge bases, consider using this skill. This skill coordinates research subagents, so use it only when you have a tool for spawning subagents (the Agent or Task tool); otherwise, research the question directly.

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Automate Bitbucket repositories, pull requests, branches, issues, and workspace management via Rube MCP (Composio). Always search tools first for current schemas.

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Azure Monitor Ingestion SDK for Python. Use for sending custom logs to Log Analytics workspace via Logs Ingestion API.

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Azure Monitor Query SDK for Python. Use for querying Log Analytics workspaces and Azure Monitor metrics.

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Azure Monitor Query SDK for Java. Execute Kusto queries against Log Analytics workspaces and query metrics from Azure resources.

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Azure Machine Learning SDK v2 for Python. Use for ML workspaces, jobs, models, datasets, compute, and pipelines.

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Automate Asana tasks via Rube MCP (Composio): tasks, projects, sections, teams, workspaces. Always search tools first for current schemas.

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Generate hand-drawn 16:9 article illustrations with the Grav character IP, sparse annotations, and absurd but clear visual metaphors.

日本語の概要は準備中です。原文の説明を表示しています。

Core UI/UX engineering skill for building highly interactive, spatial, weightless, and glassmorphism-based web interfaces using GSAP and 3D CSS.

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrate autonomous AI development pipelines through your Kanban board (Asana, GitHub Projects, Linear). Manages multi-worker Claude Code dispatch, deterministic quality gates, adversarial review, per-task cost tracking, and crash-proof pipeline execution.

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Arquitecto de Soluciones Principal y Consultor Tecnológico de Andru.ia. Diagnostica y traza la hoja de ruta óptima para proyectos de IA en español.

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Extract and analyze Figma designs to create structured design specifications. Use this skill when you need to analyze Figma nodes, extract design properties (layout, spacing, typography), classify components using Atomic Design principles, and generate design specification documents that can be used for implementation.

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Build EcoSIM atmospheric greenhouse-gas forcing files by combining a historical monthly atmgas NetCDF with RCMIP/CMIP6 SSP concentration pathways. Use when Codex needs SSP245/SSP585 or other SSP atmospheric CO2, CH4, and N2O concentrations, key-year tables, or scenario NetCDF files spanning historical years through 2100 for EcoSIM or related biogeochemical forcing workflows.

日本語の概要は準備中です。原文の説明を表示しています。

Create complete specs (requirements, design, tasks) for all features in roadmap.md using parallel sub-agent dispatch by dependency wave.

日本語の概要は準備中です。原文の説明を表示しています。

Implement approved tasks using TDD with subagent dispatch. Runs all pending tasks autonomously or selected tasks manually.

日本語の概要は準備中です。原文の説明を表示しています。