「what」の検索結果

Review code changes for correctness, completeness, bugs, edge cases, and quality. Load when the user explicitly asks to review code, check a PR, review a diff, audit recent changes, or verify an implementation matches requirements. Also triggers on "review this code", "check this PR", "review my changes", "code review", "did this implement correctly", "audit this diff", or any explicit request for a formal code review. Do NOT load for "review changes for context" or "review what happened" — those are requests to read code, not to perform a formal review.

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Orchestrate one or more thinking frameworks to work through any problem, decision, document, or idea rigorously. Diagnoses which frameworks fit — inversion, pre-mortem, assumption-mapping, socratic, adversarial-hat — then guides the user through them in the right sequence. Load when the user asks for deep thinking, says "help me think through this properly", "apply your best thinking frameworks", "I need to think carefully before deciding", or "what thinking tools should I use here". Also the entry point for any complex problem where the right framework is unclear. Covers product decisions, engineering tradeoffs, personal decisions, strategy, creative challenges — any domain.

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Design structured evaluation rubrics for scoring LLM and agent outputs — defining quality dimensions, scoring scales, hard gates, score descriptions, and edge cases. Load when the user asks to create an eval rubric, define evaluation criteria, design scoring dimensions, write an eval spec, or says "what should I evaluate", "design a rubric", "create eval criteria", "define quality dimensions", "evaluation rubric for", "how do I measure quality of". Sub-skill of eval-output orchestrator.

日本語の概要は準備中です。原文の説明を表示しています。

Generate user-facing or internal release notes and changelogs. Load when the user prepares a release, tags a version, or wants to summarize recent progress. Also triggers on "write a changelog", "prepare release notes", "what's new in this version", "summarize my commits", or "create a release summary". Auto-triggered by library-skill after major repo changes (new skills added, skills renamed, structure changes). Applicable to any project, including this skill library itself.

日本語の概要は準備中です。原文の説明を表示しています。

Build the smallest, highest-signal context package for an AI coding task — goal, constraints, repo facts, boundaries, and a verification plan. Load when prompts are underspecified, the agent is missing key files or decisions, the user says "use the right context", "here's the repo", or when work is drifting due to missing constraints. Also triggers on "context engineering", "gather context", "what do you need from me", "before you start". Not for cross-session continuity (use memory-startup/memory-recall).

日本語の概要は準備中です。原文の説明を表示しています。

Pick the right business-model canvas (Lean Canvas, Business Model Canvas, or Value Proposition Canvas) for the stage and fill it with specifics — one segment, one primary canvas, top-3 assumptions, no fluff in the moat or channel boxes. Load when the user asks to fill a business model canvas, lean canvas, value proposition canvas, model this business, map the business model, says "fill the BMC", "make a Lean Canvas", "Value Proposition Canvas for this", "model this idea", "what's the business model", "design the business model". Sub-skill of `venture-exploration`. Hard-bans "everyone" segments, generic channels ("SEO/social/content/ads"), and "unfair advantage = AI/data/network effects" with no concrete asset. Does NOT score viability — for that use `idea-evaluation`.

日本語の概要は準備中です。原文の説明を表示しています。

Select alternative execution paths when a plan step fails — branch on outcomes instead of blind retry. Load when a structured plan step fails, an unexpected observation arrives, or the user asks what to try next after an error. Also triggers on "try another approach", "route around this failure", "replan on failure", "if X fails try Y", or outcome-based branching during multi-step work. Pairs with structured-planning and debug-and-fix. Does not replace root-cause debugging — adds plan-level path selection.

日本語の概要は準備中です。原文の説明を表示しています。

Fix broken or failing functionality through structured reproduction, root-cause analysis, minimal fix, and verification. Load when the user asks to fix a bug, debug an error, resolve an issue, or work on a Linear ticket. Also triggers on "this is broken", "fix this bug", "why is this failing", "debug this", "resolve this error", "what went wrong", or any request to diagnose and fix a problem.

日本語の概要は準備中です。原文の説明を表示しています。

Quickly understand an unfamiliar codebase or project by mapping its architecture, identifying key components and data flows, and surfacing complexity hotspots. Load when the user asks to understand a repo, explain how something works, map the architecture, onboard to a codebase, or explore how components connect. Also triggers on "walk me through this codebase", "how does this project work", "explain the architecture", "what does this repo do", "show me the structure", "onboard me", or any request to build a mental model of a codebase before making changes.

日本語の概要は準備中です。原文の説明を表示しています。

Propose a new change with all artifacts generated in one step. Use when the user wants to quickly describe what they want to build and get a complete proposal with design, specs, and tasks ready for implementation.

日本語の概要は準備中です。原文の説明を表示しています。

Verify a code change end-to-end in the current worktree: identify what changed, run the relevant tests, get the app running, drive a browser over the affected areas, and report a verdict with screenshots. Generic across project types (Laravel/Herd, Node/bun, frontend, CLI, library). Use when the user wants to verify/QA/smoke-test a change, check that a PR or branch works, validate uncommitted work, or says "/flow", "verify this change", "does this PR work", "test and click through this". Optional target: PR number/URL, branch/ref, or worktree path; default is the current working changes.

日本語の概要は準備中です。原文の説明を表示しています。

Create branch, atomic commits, push, and open a pull request with terse, exact messages. Conventional branch + commit format. PR title ≤70 chars, body says "why", not "what". Use when the user says "create pr", "create pullrequest", "create pull request", "make pr", "open pr", "open pullrequest", "open pull request", "submit pr", "raise pr", "/create-pr", or asks to ship/send changes as a pull request (PR/pullrequest/pull-request, any spelling).

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Extracts and analyzes competitors' ads from ad libraries (Facebook, LinkedIn, etc.) to understand what messaging, problems, and creative approaches are working. Helps inspire and improve your own ad campaigns.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill instead of WebSearch for ANY question requiring web research. Trigger on queries like "what is X", "explain X", "compare X and Y", "research X", or before content generation tasks. Provides systematic multi-angle research methodology instead of single superficial searches. Use this proactively when the user's question needs online information.

日本語の概要は準備中です。原文の説明を表示しています。

Loads, converts, and manipulates Hi-C contact matrices in cooler format (.cool/.mcool/.scool) and Juicer .hic, using cooler (Python + CLI), hic2cool, and hictk. Covers the single-resolution mcool URI (file.mcool::/resolutions/<bp>), the load-bearing divisive-vs-multiplicative weight-naming rule (KR/VC/VC_SQRT auto-divisive vs cooler's multiplicative weight), what survives .hic<->.cool conversion (FRAG matrices and norm vectors do not), raw-vs-balanced coarsening, the .pairs upper-triangle/chromsize-order contract, and chrom-naming/bin-table provenance. Use when loading a cooler, converting .hic to .mcool, selecting a resolution, building a cooler from pairs or a matrix, coarsening/zoomifying, importing Juicer norm vectors, or debugging all-NaN balanced matrices and chr1-vs-1 empty fetches.

日本語の概要は準備中です。原文の説明を表示しています。

Computes and interprets sequencing read depth and coverage over a genome, windows, or target regions with mosdepth (windowed depth, cumulative distribution, --quantize callable BEDs), bedtools genomecov/coverage (bedGraph tracks, per-target stats), samtools depth/coverage (per-base depth, per-contig depth+breadth). Covers the breadth-vs-mean distinction, the cumulative-coverage curve, evenness (CV/Fano/fold-80/Gini), what each tool silently counts (duplicates, secondary/supplementary, MAPQ, read span vs fragment, mate-overlap), the samtools-depth 8000-cap version trap, and the bedtools coverage -a/-b orientation flip. Use when assessing sequencing adequacy, building coverage tracks, computing breadth at a depth threshold, defining callable regions, or QCing target-capture uniformity.

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Assesses the quality and completeness of a genome annotation with BUSCO (conserved single-copy ortholog recovery), OMArk (proteome completeness, consistency, and contamination), CheckM2 (prokaryotic completeness/contamination), and a gene-set sanity panel (gene count, mono-exonic fraction, protein-length distribution, mRNA:gene ratio, coding density). Covers the assembly-BUSCO-vs-proteome-BUSCO diagnostic, what BUSCO-Duplicated really means, why gene count is a vanity metric, and the QC of transferred annotations. Use when judging whether an annotation is good enough to publish or submit, diagnosing a suspect annotation, or comparing annotation completeness across pipelines.

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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

日本語の概要は準備中です。原文の説明を表示しています。

Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.

日本語の概要は準備中です。原文の説明を表示しています。

Pull pre-computed ortholog calls from public databases (OrthoDB, Ensembl Compara, OMA browser, eggNOG, PANTHER, KEGG Orthology, HomoloGene) via their REST APIs. Use when orthologs are already curated upstream, when the question is "what is the X ortholog of Y" rather than "how to infer orthology de novo", when batch-mapping gene IDs across species, or when comparing the resources for consensus calls. Encodes confidence-level semantics, 1:1 vs 1:many vs many:many, HomoloGene deprecation, and when to defect to de novo computation.

日本語の概要は準備中です。原文の説明を表示しています。

Produce and interpret PCA, t-SNE, UMAP, and PHATE plots for high-dimensional omics data with rigor about which method preserves what (variance, local structure, manifold, transitions), hyperparameter sensitivity, and the well-documented limits of 2D embeddings. Covers PCA biplot/scree/loadings, t-SNE PCA initialization (Kobak-Berens 2019), UMAP n_neighbors/min_dist trade-offs, and the Chari-Pachter 2023 critique. Use when visualizing high-dimensional data — bulk PCA, single-cell embeddings, multi-omics integration projections.

日本語の概要は準備中です。原文の説明を表示しています。

Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.

日本語の概要は準備中です。原文の説明を表示しています。

Add MAUI DevFlow to a .NET MAUI project with agent package references, MauiProgram.cs registration, Blazor WebView support, GTK variants, Central Package Management guidance, and verification commands. USE FOR: first-time DevFlow setup, reviewing what files to edit, choosing DevFlow packages, or continuing after `maui devflow init` installs skills. DO NOT USE FOR: troubleshooting an already-integrated app that cannot connect, iterative app debugging, UI inspection, or generic MAUI build failures (use maui-devflow-debug). INVOKES: maui devflow CLI and dotnet CLI.

日本語の概要は準備中です。原文の説明を表示しています。