「anchore」の検索結果

Turn ONE topic into a finished Vox-style paper-collage explainer / ad video, end to end on the Atlas Cloud API + local ffmpeg — script, collage keyframes, motion, voice-over, music, captions, all automated. Use this whenever the user wants a "Vox style" video, a paper/torn-paper collage animation, a "motion collage", a narrated explainer or short ad built from AI-generated collage posters, a scrapbook-style tribute, or wants to turn a topic / product / person into a punchy narrated collage video — even if they don't say the word "Vox". Also use when reproducing Stav Zilber / rom1trs / Higgsfield-style collage ad workflows. Three input modalities: a topic (B-roll), a talking-head video (A-roll mode), or a single photo of a person/product anchored into the collage (C-roll mode). Triggers: "vox video", "collage video", "motion collage", "paper collage explainer", "make a collage ad", "turn this topic into a collage video", "turn my photo/this product shot into a collage video".

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Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.

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Converts an arxiv paper into a minimal, citation-anchored Python implementation. Trigger when user runs /paper2code with an arxiv URL or paper ID, says "implement this paper", or pastes an arxiv link asking for implementation. Flags all ambiguities honestly. Never invents implementation details not stated in the paper.

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Use when framing or sharpening a topic for 《会计研究》 (Accounting Research) — turning a generic "X affects Y" empirical idea into an accounting contribution anchored in China's institutional setting, accounting theory, and standard-setting / practice relevance. Use before literature review.

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Render a 'hand-swipe flavor listicle' video from a config — the brand's REAL product cutouts each float on a flat flavor-matched color field under a persistent title and slide RIGHT-TO-LEFT one to the next like a phone-feed scroll, while a green-screen hand clip (back of hand toward camera, index finger up) is trimmed to its clean finger-up window, looped once per flavor, keyed with a green-dominance alpha key, scaled down and anchored at the bottom, with an optional end card and an optional instrumental music bed — deterministic PIL plus FFmpeg assembly, FREE (the hand clip comes from create-video-fal and the bed from create-music-elevenlabs), so labels stay pixel-crisp. Use for the hand-swipe-flavor-listicle format.

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Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and coverage-biased, so generic Hi-C loop callers (cooltools dots, Juicer HiCCUPS) use the wrong null. Covers FitHiChIP (config-driven coverage+distance-decay spline regression, peak-to-peak vs peak-to-all foreground, loose vs stringent background, coverage vs ICE bias), MAPS (positive Poisson regression on bias factors for PLAC-seq/HiChIP), hichipper (restriction-site-distance bias model + library QC), CHiCAGO (Delaporte two-component Brownian+technical background for asymmetric bait x other-end Capture Hi-C), the with/without separate-ChIP anchor decision, and differential loops via diffloop. Use when calling loops from HiChIP/PLAC-seq/Capture Hi-C, choosing FitHiChIP/MAPS/CHiCAGO, picking peak-to-all vs peak-to-peak, setting the loop FDR, supplying ChIP peaks as anchors, QCing a HiChIP library, or comparing loops between conditions.

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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

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Handles batch effects in bulk RNA-seq via design-matrix inclusion (the correct path for DE), ComBat/ComBat-seq for visualization, SVA for unknown latent factors, RUVSeq for negative-control-gene-anchored unwanted variation, and limma::removeBatchEffect for plotting only. Encodes the Nygaard 2016 cardinal sin against testing on a batch-corrected matrix, the choice between SVA/RUVg/RUVs/RUVr, the confounding non-identifiability problem, the single-cell boundary (Harmony/MNN are NOT for bulk), and the Goh 2017 harmonization critique. Use when designing a DE analysis with batch structure, troubleshooting batch-dominated PCA, choosing ComBat vs ComBat-seq, handling unknown batch via SVA, integrating across studies, or deciding when (rarely) to subtract batch.

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Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.

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Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma, Schwede & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2021 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.

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Detect, date, and contextualize whole-genome duplication (WGD / paleopolyploidy) events using wgd v2 (Chen et al 2024), KsRates (Sensalari 2022 substitution-rate-corrected Ks dating), DupGen_finder (Qiao 2019), MAPS (Li 2018 phylogenomic), POInT (Conant 2008 ordered-block), SLEDGe (2024 ML-based), Whale.jl (Bayesian DL+WGD), and synteny-anchored paranome construction. Use when identifying ancient polyploidy from Ks distributions and synteny block analysis, positioning WGD events relative to speciation, distinguishing tandem from segmental from WGD duplications, dating the 2R/3R vertebrate / fish / salmonid WGDs, building paranome and Ks-age mixture models, applying KsRates substitution-rate correction across lineages, or testing alternative biased-fractionation / dosage-balance models post-WGD.

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Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.

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Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Colic et al. 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving greater sensitivity to small-effect hits than MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).

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Audits existing table permissions on a Power Pages site by analyzing them against site code and Dataverse metadata, then GRADES the configuration with deterministic 1–5 scores across 3 security/usability/correctness categories (9 dimensions). Detection is anchored by a recurring-issue catalog so findings and severities stay consistent run-to-run. Generates an HTML report with an at-a-glance verdict and per-category scores in the Overview plus a single list of **major/minor** issues (each major issue labelled permissions-only or upstream-caused with a short justification), and suggested fixes. Use when the user wants to review, verify, check, score, or grade table permissions for security issues.

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No Inference / Source-Locked Verification. Forces Claude to answer ONLY from user-provided materials and/or online sources actually accessed — no inference, no assumptions, no gap-filling. Every factual, legal, numerical, or procedural claim must be anchored to a cited source. Use whenever Claude reviews documents, summarises evidence, checks accuracy, drafts submissions, creates timelines, extracts facts, checks citations, analyses rules, prepares legal arguments, compares documents, verifies claims, produces chronologies, works from uploaded materials, performs legal research, checks case status, or does anything where evidential fidelity matters. Also trigger on: 'source-locked', 'no inference', 'only from the materials', 'don't assume', 'stick to the evidence', 'verify this', 'check this is right', 'work from the documents'. Overrides Claude's default tendency to fill gaps. If evidential accuracy matters, use this skill.

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A drafting-and-review copilot for a founders' / co-founders' agreement — the terms fixing equity, vesting, IP, roles, control, deadlock, and departure between cofounders. Jurisdiction-agnostic, anchored on the Delaware C-corp default. Two modes: DRAFT (intake → equity & vesting → clauses → blocker triage → pre-signature check) and REVIEW (audit an existing agreement against an 18-clause checklist and red-flag scan). It handles the highest-dispute terms first-class: the equity split as documented reasoning (not a fake calculator), reverse vesting and the 83(b) clock, present-tense IP assignment (the Stanford v. Roche trap), leaver buyback and dead equity, and the deadlock clause most tools omit. It drafts for the venture, never one founder against another. Not legal advice.

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Design an inquiry sequence anchored in a local ecosystem that embeds science or geography curriculum content. Use when teaching through local living systems like gardens, ponds, or hedgerows.

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Canonical AT completeness gate — research-anchored 7-category taxonomy (C1-C7) + 15-item mechanical checklist. Paradigm-neutral. Drives acceptance-designer reviewer verdict deterministically.

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Generate exactly one finished CRT retro computer-interface illustration from an uploaded portrait, group photo, creature, object, or described theme. Use when the user wants anchored subjects re-authored as an exaggerated circa-1980s bitmap editorial caricature beneath early Macintosh or Minitel-style windows, optionally invoking the exact Chinese presets 街头怪诞, 巨像符号, or 冷面几何. Before generation, collect a named or image-derived palette and aspect ratio through a strict two-stage intake unless supplied. Preserve each intended subject as a distinct identity, one shared pixel lattice, restricted non-skin checkerboard midtones, low-facet geometry, unequal extraction windows, mandatory barrel-curved CRT edges, and the immutable tait-crt-interface-skill title-bar signature. Never trace, auto-pixelate, imitate photographic detail, omit, merge, or duplicate subjects, retry, resize, expose prompts, or ask users to choose a style preset.

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Portfolio mapping and model coordination in OpenConstructionERP: the 3D geo hub (Cesium), the coordination hub with clash AI, and geo-anchored projects. Use for multi-project portfolio views and BIM clash workflows.

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Turn ONE topic, talking-head video, or photo into a finished Vox-style paper-collage explainer / ad video on the MuAPI platform (api.muapi.ai) + local ffmpeg — script, collage keyframes, motion, voice-over, music, captions, all automated. Three input modalities: a topic (B-roll), a talking-head video (A-roll mode), or a single photo of a person/product anchored into the collage (C-roll mode).

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Creative Designer skill. Takes a post concept, a client product photo, or a real lifestyle photo and produces on-brand social media visuals using the client's brand style guide. Four modes — Generate (AI image from concept), Composite (client product photo anchored in an AI-generated scene), Brand (apply text overlay treatment to a real client photo), Stop-Motion Reel (6-frame action sequence exported as MP4). Reads brand-style.md, builds prompts, generates/edits images via Nano Banana MCP, outputs images + prompt log + creative brief.

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Think and work like an expert Hematologist. Use when a task calls for Hematologist judgment. Reasons from hematopoietic hierarchy, clonal evolution, and hemostatic balance through peripheral smear review, reticulocyte production index, flow cytometry, mixing studies, and WHO/ICC-anchored NGS and cytogenetics, while treating pseudothrombocytopenia, preanalytic line-draw and EDTA artifacts, and missed consumptive emergencies like TTP and DIC as first-class failure modes.

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Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Li & Hart 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving 2-3x sensitivity over MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).

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