「bolt」の検索結果

Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.

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Browse, inspect, and pick reusable CAD parts with the Bits & Bolts plugin.

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Route Boltz package tasks for biomolecular structure and affinity prediction, data preparation, training, and evaluation workflows.

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Binder design tool selection and workflow routing guidance. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).

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Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).

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Expert guide for chatbot and messaging platform integration (WhatsApp Business, Telegram Bot, Discord.js, Slack Bolt) and conversational AI / Panduan ahli integrasi chatbot dan platform messaging (WhatsApp Business, Telegram Bot, Discord.js, Slack Bolt) dan AI percakapan.

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Access a collection of open-source molecular design and structural biology tools on the Tamarind Bio platform, via its REST API or MCP server — no local GPUs required. Tamarind bundles popular open-source models for structure prediction (AlphaFold, Boltz, Chai, ESMFold), protein, binder, and de novo design (RFdiffusion, ProteinMPNN, BoltzGen), antibody and nanobody design and developability, protein-ligand docking (DiffDock, Autodock Vina), binding-affinity prediction, MSA generation, and molecular dynamics. Use when the user mentions Tamarind or tamarind.bio, wants to run any of these open-source tools in the cloud, references app.tamarind.bio/api or the x-api-key header, or needs to submit batches of sequences for structural or biophysical characterization.

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End-to-end AI website generation pipeline. Claude Opus 4.8 emits Bolt-style <boltArtifact> envelopes (multi-file, plan-first) that customize Vite+React+Tailwind templates from pre-researched business data. Pre-research via APIs, media acquisition, brand extraction, visual inspection via GPT Image 2 vision, R2 upload (per-file content-type by extension), D1 status updates. Supports all business types: SaaS, portfolio, non-profit, restaurant, salon, medical, legal, retail, tech.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a task needs the judgment of an Engine and Other Machine Assembler — following the specified multi-stage torque sequence for a multi-bolt joint rather than tightening bolts to final value in convenient order, measuring bearing clearance directly rather than confirming free rotation by hand, verifying critical clearances on the actual assembled stack-up rather than trusting individually-in-tolerance components, or testing sub-assemblies before final integration rather than only at final test.

日本語の概要は準備中です。原文の説明を表示しています。

Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).

日本語の概要は準備中です。原文の説明を表示しています。

Build Slack apps using the Bolt framework across Python, JavaScript, and Java. Covers Block Kit for rich UIs, interactive components, slash commands, event handling, OAuth installation flows, and Workflow Builder integration. Focus on best practices for production-ready Slack apps. Use when: slack bot, slack app, bolt framework, block kit, slash command.

日本語の概要は準備中です。原文の説明を表示しています。

Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.

日本語の概要は準備中です。原文の説明を表示しています。

Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.

日本語の概要は準備中です。原文の説明を表示しています。

Automate Bolt Iot tasks via Rube MCP (Composio). Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Performs ML-based protein-ligand pose prediction and scoring using DiffDock-L (diffusion-based), Boltz-1 / Boltz-2 (foundation model with affinity), Chai-1, AlphaFold3 ligand, EquiBind, TANKBind, NeuralPLexer, and hybrid workflows (DiffDock pose + GNINA rescore + PoseBusters QC). Explicit handling of when ML beats classical docking, when classical beats ML, the PB-invalid pose problem, and rescoring as the standard production hybrid. Use when modern docking is needed: foundation-model ligand-pose prediction, AI rescoring of classical poses, or scaffold-hopping in cross-docking scenarios.

日本語の概要は準備中です。原文の説明を表示しています。

Add a macOS menu bar status indicator for NanoClaw. Shows a bolt icon with a green/red dot indicating whether NanoClaw is running, with Start, Stop, and Restart controls. macOS only.

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Find, evaluate, and download common purchasable CAD parts from step.parts, including named off-the-shelf actuators, servos, motors, electronics boards, connectors, screws, bolts, nuts, washers, bearings, standoffs, and other catalog components. Use when Codex needs to search the hosted step.parts catalog before creating simplified placeholder geometry, resolve fuzzy part names, standards, aliases, or dimensions, choose a matching part, fetch a canonical .step file, verify checksums, or use the step.parts API/OpenAPI/catalog endpoints for standard part discovery.

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Draws hand-authored SVG spot illustrations in a bold pop-geometric style for design and coding scenes. Identifying traits: a thick navy outline on every shape, solid navy extrusions that always step down-right, saturated flat fills (hot pink, lemon, aqua, violet, mint, lime) textured with navy hatching and dots, and a dense overlapping cluster of chunky props (browser windows, pinwheel tiles, iso cubes, lightning bolts) around one slim cartoon character. Covers palette, line weights, extrusion and union-outline techniques, a JS helper for the repeated marks, characters and hands, composition and a render-and-critique loop. Use when someone asks for bold pop, pop geometric, retro pop, memphis-style, navy-outline, chunky outlined or loud colourful illustrations, or for empty states, onboarding, 404 or error pages, blog headers, feature spots and marketing cards in that look.

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Cloud-based quantum chemistry platform with Python API. Preferred for computational chemistry workflows including pKa prediction, geometry optimization, conformer searching, molecular property calculations, protein-ligand docking (AutoDock Vina), and AI protein cofolding (Chai-1, Boltz-1/2). Use when tasks involve quantum chemistry calculations, molecular property prediction, DFT or semiempirical methods, neural network potentials (AIMNet2), protein-ligand binding predictions, or automated computational chemistry pipelines. Provides cloud compute resources with no local setup required.

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Migrates vibe-coded web applications to AWS. Handles the full workflow from analysis through migration to deployment, producing deployable AWS Blocks infrastructure code. Supports full-stack apps built with vibe-coding platforms (Lovable, Bolt.new, Replit) and frontend web applications and websites: React, Vue, Angular, Next.js, Nuxt, Astro, SvelteKit, Gatsby, Vite, Svelte, Solid, Docusaurus, and others (static sites, SPAs, and SSR frameworks with static export). Triggers on: launch with AWS, launch on AWS, deploy to AWS, migrate to AWS, host my app on AWS, move my app to AWS, transfer my app to AWS. Activates when the user wants to migrate a vibe-coded app or frontend web app to AWS, even if they don't say 'migrate' explicitly.

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Break large features into independently verifiable, human-reviewable slices under a feature directory in specs/. Use for risky or multi-step feature work that needs upfront questioning, API seams, browser-playable checkpoints, HTML visualizations, screenshot gates, staged implementation plans, recursive fog-of-war reslicing, or proactive research into reference implementations/best practices before slicing. Pairs with your project's verification harness and screenshot gates (the browser checkpoints), [refactor-clean](../refactor-clean/SKILL.md) (review the materialized spec so the plan describes one-owner architecture, not the feature bolted on), [screenshot-critique](../../visual/screenshot-critique/SKILL.md) and [compare-screenshots](../../visual/compare-screenshots/SKILL.md) (the visual gates), and a code-review pass (audit each slice before it lands).

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Puts a built website live on a free HTTPS link, or your own .com with no DNS. Use when the user says "put it online", "go live", "make it live", "put this live", "publish my site", "share it with friends", "send my friends a link", "get a link", "make it public", "it only works on localhost" or "get a .com", or asks to deploy or host a site built with an AI tool (Claude Code, Cursor, Codex, Windsurf, Lovable, Bolt, v0, ChatGPT), or mentions DropTheHassle, and has not picked another host. Covers building first, CLI or MCP setup, deploying, the claim link, the live check, linking a server part the user hosts on AWS, Google Cloud, DigitalOcean or their own server with set_backend, and domain search. The agent never spends money. The human pays.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Estimates SNP heritability and partitions it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

日本語の概要は準備中です。原文の説明を表示しています。