「cfd」の検索結果

Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.

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Expert CSRD (Corporate Sustainability Reporting Directive, EU 2022/2464) compliance advisor. Use this skill whenever a user asks about CSRD, European Sustainability Reporting Standards (ESRS), double materiality assessment, sustainability reporting obligations, ESG disclosure, CSRD scope and thresholds, value chain reporting, XBRL digital tagging, third-party assurance, CSRD gap assessments, CSRD implementation timelines, ESRS E1–E5 environmental standards, ESRS S1–S4 social standards, ESRS G1 governance, the 2026 Omnibus scope change (Directive (EU) 2026/470, 1,000+ employees) and revised/simplified ESRS (July 2026), CSRD vs GRI/TCFD/SASB alignment, or any EU corporate sustainability reporting question. Trigger even if the user only mentions "ESG reporting Europe", "sustainability disclosure EU", or "non-financial reporting".

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Expert CSRD (Corporate Sustainability Reporting Directive, EU 2022/2464) compliance advisor. Use this skill whenever a user asks about CSRD, European Sustainability Reporting Standards (ESRS), double materiality assessment, sustainability reporting obligations, ESG disclosure, CSRD scope and thresholds, value chain reporting, XBRL digital tagging, third-party assurance, CSRD gap assessments, CSRD implementation timelines, ESRS E1–E5 environmental standards, ESRS S1–S4 social standards, ESRS G1 governance, CSRD vs GRI/TCFD/SASB alignment, or any EU corporate sustainability reporting question. Trigger even if the user only mentions "ESG reporting Europe", "sustainability disclosure EU", or "non-financial reporting".

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Provides R wrappers of several on-target and off-target scoring methods for CRISPR guide RNAs (gRNAs). The following nucleases are supported: SpCas9, AsCas12a, enAsCas12a, and RfxCas13d (CasRx). The available on-target cutting efficiency scoring methods are RuleSet1, Azimuth, DeepHF, DeepCpf1, enPAM+GB, and CRISPRscan. Both the CFD and MIT scoring methods are available for off-target specificity prediction. The package also provides a Lindel-derived score to predict the probability of a gRNA to

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Think and work like an expert Heat Transfer Engineer. Use when a task calls for Heat Transfer Engineer judgment. Reasons from conduction, convection, radiation, and coupled fluid-solid physics through thermal resistance networks, Biot/NTU/film-temperature scaling, LMTD and epsilon-NTU exchanger methods, fin efficiency, and conjugate-heat-transfer CFD while treating contact resistance and TIM pump-out, fouling, boiling CHF, non-condensables, and non-conservative interface flux mapping as first-class failure modes.

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Think and work like an expert Fluid Mechanics Engineer. Use when a task calls for Fluid Mechanics Engineer judgment. Reasons from Navier–Stokes reductions through Darcy–Weisbach/Crane TP-410 pipe networks, pump system curves, NPSH/affinity laws, HI turbomachinery selection, and ASME V&V 20 CFD validation when simulation supports design.

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Think and work like an expert Climate Risk Analyst. Use when a task calls for Climate Risk Analyst judgment. Reasons from TCFD/IFRS S2 four-pillar disclosure, NGFS Phase V orderly/disorderly/hot-house scenarios, hazard–exposure–vulnerability and RMS/AIR/CLIMADA cat economics, transition carbon-price and stranded-asset pathways, and PCAF financed emissions while treating exposure geocoding quality, Kotz damage-function retraction, and scenario-not-forecast misuse as first-class failure modes.

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Think and work like an expert Combustion Engineer. Use when a task calls for Combustion Engineer judgment. Reasons from stoichiometry, flame stability, emissions, and CFD-reacted flows while treating blow-off, flashback, and soot formation as first-class failure modes.

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Think and work like an expert Aeronautical Engineer. Use when a task calls for Aeronautical Engineer judgment. Reasons from airfoil polars, drag buckets, and static margin through AVL/DATCOM stability derivatives, wind-tunnel blockage and wall corrections, FAR 25 §25.101–25.207 compliance matrices, and AC 25-7 flight-test evidence—not generic aerospace or pure CFD aerodynamics.

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Think and work like an expert Aerodynamicist. Use when a task calls for Aerodynamicist judgment. Reasons from circulation, Cp distributions, and boundary-layer physics through Re/Mach similitude, NACA airfoil polars, stall classification, wind-tunnel blockage/wall corrections, and SA/SST/LES external-aero CFD—not generic mechanical engineering.

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Think and work like an expert Aerospace Engineer. Use when a task calls for Aerospace Engineer judgment. Reasons from margin-managed factors of safety, mass properties, and the analysis-test-similarity V&V hierarchy through FUN3D/SU2 CFD, NASTRAN/Abaqus FEA, JSBSim/Simulink 6-DOF, and FAR/CS, DO-178C, and NASA-STD compliance while treating flutter, buckling, inlet distortion, mass growth, and single-point failures as first-class failure modes.

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Analyzes cfDNA fragment size distributions and fragmentomics features using FinaleToolkit or Griffin. Extracts nucleosome positioning patterns, fragment ratios, and DELFI-style fragmentation profiles for cancer detection. Use when leveraging fragment patterns for tumor detection or tissue-of-origin analysis.

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Synthesize behavioral personas from prior stage evidence for journey mapping and marketing during PRD v0.4 User Journeys. Triggers on requests to define personas, create user profiles, identify target users, or when user asks "who are our users?", "define personas", "user profiles", "target users", "persona creation", "who uses this product?". Consumes CFD- (v0.1-v0.3), BR- (targeting from v0.3 Moat), FEA- (v0.3 Feature Value Planning). Outputs PER- entries with behavioral profiles and feature relationships. Feeds v0.4 User Journey Mapping.

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Build customer case studies as marketing and chasm-crossing reference assets during PRD v1.0 Market Adoption. Triggers on requests to build case studies, produce customer stories, create reference content, or when user asks "build a case study", "customer story", "reference account", "case study interview", "before/after story", "social proof page", "logo wall". Outputs CFD-CASE-* evidence entries, GTM-CASE-* marketing assets, and updates ADO-REF-* with story status.

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Map the competitive landscape before positioning your product for PRD v0.2 Market Definition. Triggers on completing v0.1 Spark, analyzing competitors, researching market, or requests like "competitive analysis", "who else solves this", "market landscape", "what alternatives exist", "competitor research", "feature comparison". Outputs CFD- entries for competitive intelligence and BR- entries for positioning rules.

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Transform vague product ideas into evidence-anchored problem statements for PRD v0.1 Spark. Triggers on starting new products/features, validating market opportunities, drafting PRD Why sections, or requests like "frame the problem", "define pain points", "write problem statement", "start v0.1", "what problem are we solving". Outputs structured problem tables with CFD evidence IDs.

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Systematically harvest short testimonials from customers via NPS, milestones, post-purchase, and email during PRD v1.0 Market Adoption. Triggers on requests to collect testimonials, set up social proof harvest, gather customer quotes, or when user asks "how do we get testimonials?", "social proof harvest", "NPS responses", "testimonial wall", "customer quotes", "post-purchase survey", "milestone follow-up". Outputs CFD-TST-* testimonial entries and GTM-TST-* placement assets.

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Apply Rob Fitzpatrick's Mom Test discipline to customer interviews during PRD v1.0 Market Adoption. Triggers on requests to interview customers, run discovery calls, validate ideas with users, or when user asks "how do I interview customers?", "Mom Test", "Rob Fitzpatrick", "customer interview", "user research without lies", "talking to humans", "discovery conversation". Outputs CFD-* discovery entries with Mom Test-calibrated confidence.

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Establish weekly customer-discovery cadence and Opportunity Solution Tree practice using Teresa Torres's Continuous Discovery Habits framework during PRD v1.0 Market Adoption. Triggers on requests to set up discovery cadence, build opportunity solution tree, run weekly customer interviews, or when user asks "Torres", "continuous discovery", "opportunity solution tree", "outcomes vs outputs", "weekly interviews", "assumption mapping". Outputs CFD-* discovery entries and updates to ADO-STAGE-* and PER-* with new evidence.

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Establish channels and processes for capturing and processing post-launch feedback during PRD v0.9 Go-to-Market. Triggers on requests to set up feedback systems, capture user input, or when user asks "how do we collect feedback?", "feedback loop", "user research", "post-launch feedback", "customer feedback", "NPS", "voice of customer". Outputs CFD- entries specialized for post-launch feedback capture.

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Surface risks through guided questioning, helping users consider pivots, constraints, and prioritization during PRD v0.5 Red Team Review. Triggers on requests to identify risks, stress-test the idea, perform red team review, or when user asks "what could go wrong?", "identify risks", "red team", "risk assessment", "challenge assumptions", "stress test the idea". Consumes all prior IDs (CFD-, BR-, FEA-, PER-, UJ-, SCR-) as interview context. Outputs RISK- entries with owner decisions and mitigations. Feeds v0.5 Technical Stack Selection.

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Select and validate pricing model for PRD v0.3 Commercial Model. Triggers on requests to set pricing, choose monetization model, design pricing tiers, validate willingness to pay, or when user asks "how much should we charge?", "what pricing model?", "freemium vs paid?", "how to structure tiers?", "price point?". Consumes Competitive Landscape (CFD-) and Product Type (BR-) from v0.2. Outputs BR- entries for pricing rules, tier boundaries, and competitive positioning.

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Define and prioritize features with strategic traceability during PRD v0.3 Commercial Model. Triggers on requests to define features, prioritize capabilities, scope MVP, map features to pricing tiers, identify parity vs. delta features, or when user asks "what features do we build?", "what's in MVP?", "which features matter?", "feature priority", "parity features", "what's our delta?". Consumes KPI- (Outcome Definition), BR- (Pricing Model, Moat), and CFD- (Market Moat Analysis) from v0.3. Outputs FEA- entries with strategic traceability and BR-FEA- governance rules. Feeds v0.4 User Journeys.

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Transform validated pain points into articulated user value statements for PRD v0.1 Spark. Triggers on completing problem framing, defining user outcomes, articulating value propositions, or requests like "what value do users get", "define outcomes", "articulate the benefit", "finish v0.1", "pain to value", "what do they gain". Outputs CFD- entries tagged as value hypotheses with evidence tiers. Follows Problem Framing skill in workflow.

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