「fitness」の検索結果

Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

日本語の概要は準備中です。原文の説明を表示しています。

Create personalized triathlon, marathon, and ultra-endurance training plans. Use when athletes ask for training plans, workout schedules, race preparation, or coaching advice. Can sync with Strava to analyze training history, or work from manually provided fitness data. Generates periodized plans with sport-specific workouts, zones, and race-day strategies.

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrating ecosystem self-evolution: lifecycle-phase detection, agent relevance, cross-agent knowledge synthesis, evolution proposals. Use when auditing skill-ecosystem health or fitness.

日本語の概要は準備中です。原文の説明を表示しています。

Query Strava fitness data including activities, athlete stats, segments, routes, clubs, and gear. Use when the user asks about cycling, running, swimming, workouts, training, or Strava data.

日本語の概要は準備中です。原文の説明を表示しています。

"Apply Complex Adaptive Systems theory to analyze phenomena exhibiting emergence, self-organization, co-evolution, and edge-of-chaos dynamics. Use this skill when the user needs to understand why a system behaves unpredictably despite known components, model agent-based interactions that produce emergent outcomes, analyze fitness landscapes, or when they ask 'why does this system behave in ways no one designed', 'how do local interactions create global patterns', or 'why do small changes sometimes cause massive system shifts'.".

日本語の概要は準備中です。原文の説明を表示しています。

Connect to Peloton to browse fitness classes, check schedules, and book workouts.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a task needs the judgment of an Adapted Physical Education Specialist — writing a legally-defensible PE present level and annual goal from motor/fitness assessment data, choosing the right test battery and alternate items for a student's mobility profile, recommending a placement step on the PE least-restrictive-environment continuum, or distinguishing a motor/balance deficit from a behavioral avoidance pattern.

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สร้าง workout program 4 สัปดาห์ + exercise library + progression + tracking sheet สำหรับ home/gym

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Use when assessing body fat percentage from skinfold measurements, calculating body density, or interpreting body composition results using Durnin-Womersley or Jackson-Pollock equations.

日本語の概要は準備中です。原文の説明を表示しています。

Use when estimating one-rep max (1RM), converting between weight and rep ranges, or calculating training loads from a validated percentage-of-max table.

日本語の概要は準備中です。原文の説明を表示しています。

Content-addressed baseline-archive epoch partitioning. Partition baseline_archive.jsonl + the self-improving hub's baseline serving by a HASH of the full baseline-production+measurement spec — when the spec (margin_rule, fitness/margin logic version, the 4 roles' model+source, rubric/dim-set, bench, seed-pool identity) changes, the hash changes → a new epoch series (like seed-gen gen-*). Triggered by "baseline epoch", "baseline 아카이빙", "epoch partition", "spec hash", "content-addressed", "margin_rule namespace", "production logic 구분", "baseline 하위 서빙" keywords.

日本語の概要は準備中です。原文の説明を表示しています。

Assigns pathogen lineages (SARS-CoV-2 Pangolin UShER mode; Nextclade clade + QC; pango-designation alias resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage-fitness modelling (multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data and Nextclade dataset version pinning (mandatory; lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme churn (V3/V4/V4.1/V5.3.2/Midnight) with dropout regions, and recombinant X-prefix designation lag. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater into lineage frequencies with Freyja, tracking lineage frequencies over time, handling ARTIC primer dropouts, or running surveillance for SARS-CoV-2/influenza/Mpox/RSV/H5N1/measles.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF calibration (BF >6 ≈ 90% posterior per Hart 2017; ~5% FDR by BAGEL convention). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

日本語の概要は準備中です。原文の説明を表示しています。

Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

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Heart rate variability biometrics and emotional awareness training. Expert in HRV analysis, interoception training, biofeedback, and emotional intelligence. Activate on 'HRV', 'heart rate variability', 'alexithymia', 'biofeedback', 'vagal tone', 'interoception', 'RMSSD', 'autonomic nervous system'. NOT for general fitness tracking without HRV focus, simple heart rate monitoring, or diagnosing medical conditions (only licensed professionals diagnose).

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This skill recommends that all patients with Cushing’s syndrome receive monitoring and adjunctive treatment for cortisol-dependent comorbidities including psychiatric disorders, diabetes, hypertension, hypokalemia, infections, dyslipidemia, osteoporosis, and poor physical fitness. Apply when managing any CS patient to address associated health issues; triggers include confirmed or suspected hypercortisolism, preoperative evaluation, postoperative follow‑up, or persistent hypercortisolism despite treatment.

日本語の概要は準備中です。原文の説明を表示しています。

Talk to your Apple Health data — ask questions about your workouts, heart rate, activity rings, and fitness trends.

日本語の概要は準備中です。原文の説明を表示しています。

Use when designing, evaluating, documenting, modernizing, reviewing, refactoring, or implementing software architecture and code-level structure, including requirements, context, architecture style selection, microservices patterns, WebAssembly/WASI/Component Model, UMA portable capabilities, runtime contracts, capability graphs, governed MCP/agent orchestration, clean code, code smells, Rust crate/library API architecture, Cargo feature/MSRV/SemVer policy, unsafe/FFI/no_std/library testing, modularity, views, NFR tactics, IAM/auth, security patterns, cost estimation, architecture-as-code fitness functions, ADR/RFC work, and engineering execution plans.

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Personal trainer operations: client check-ins, workout-program delivery, progress reminders, session reminders, lead follow-up, and workout tracking. Use when an owner is a coach/personal trainer or when managing fitness clients and training routines.

日本語の概要は準備中です。原文の説明を表示しています。

Gym workout planner and nutrition tracker. Search 690+ exercises by muscle, equipment, or category via wger. Look up macros and calories for 380,000+ foods via USDA FoodData Central. Compute BMI, TDEE, one-rep max, macro splits, and body fat — pure Python, no pip installs. Built for anyone chasing gains, cutting weight, or just trying to eat better.

日本語の概要は準備中です。原文の説明を表示しています。

Book reservations through Google Maps using browser automation. Searches for businesses, checks availability, and completes bookings via "Reserve with Google" or 3rd-party providers (OpenTable, Resy, Vagaro). Supports restaurants (primary), salons, fitness, healthcare. Use when user wants to book, reserve, or schedule at a business found on Google Maps.

日本語の概要は準備中です。原文の説明を表示しています。

Rank and prioritize neoantigen/epitope candidates by likely T-cell response using NeoFox feature annotation, PRIME2.0, BigMHC-IM, the Łuksza/Balachandran fitness model (agretopicity + foreignness), and pVACtools tiering. Encodes the field's hard truths that immunogenicity is the least-solved layer (dedicated scores ~AUROC 0.6-0.7, modest PPV), that scores are valid only for RANKING within one patient (never absolute go/no-go or cross-patient), that DAI has anchor-inflation and WT-denominator traps, and that stacking weak correlated scores into one number is a red flag. Use when ordering a candidate list for a vaccine. Binding lives in mhc-binding-prediction; calling in neoantigen-prediction.

日本語の概要は準備中です。原文の説明を表示しています。

Assigns pathogen lineages (SARS-CoV-2 Pangolin via UShER mode; Nextclade clade + QC; pango-designation alias_key.json resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage fitness modelling (Wenseleers / Bedford-Figgins multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data version pinning (mandatory for reproducibility), Nextclade dataset versioning (lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme version churn (V3 / V4 / V4.1 / V5.3.2 / Midnight 1200) with documented dropout regions, recombinant X-prefix Pango designation lag, GISAID vs INSDC dual-deposition tensions, and the Karthikeyan 2022 wastewater early-detection signal with explicit reproducibility caveats. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater pooled samples into lineage frequencies with Freyja, tracking lineage frequencies and growth advantages over time, pinning pangolin-data / Nextclade dataset versions for reproducibility, handling ARTIC primer dropouts (V4.1 amplicons 64 / 76 / 88-90), or running variant surveillance for SARS-CoV-2 / influenza / Mpox / RSV / H5N1 / measles.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

日本語の概要は準備中です。原文の説明を表示しています。