「output filtering」の検索結果

Generates complete bidirectional multi-phenotype Mendelian randomization research designs from a user-provided exposure family and outcome family. Always use this skill whenever a user wants to design, plan, or build a genome-wide causal-inference study based on publicly available GWAS summary statistics, especially when the article logic includes multiple exposures, multiple outcomes or subtypes, bidirectional MR, IV filtering, IVW as the main estimator, weighted median / MR-Egger / MR-PRESSO sensitivity analyses, leave-one-out testing, heterogeneity / pleiotropy checks, and multiple-testing control with FDR. Covers five study patterns (single-family bidirectional MR, multi-phenotype screening MR, subtype-resolved MR, phenome-style bidirectional causal map, mechanism-prioritized MR follow-up) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version...

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Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

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Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.

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Harden AI/LLM deployments against prompt injection, data exfiltration, model theft, and supply chain attacks. Covers input validation, output filtering, access control, model API security, and compliance controls for production AI systems.

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CloudBase declarative deployment from a cloudbaserc config (声明式部署, 配置式部署, cloudbaserc 部署) through the deployBuild / deployPlan / deployApply MCP tools. Use when deploying database, functions, app, hosting, or gateway resources described in cloudbaserc.json/yaml as a single desired-state config, when a user wants to build static hosting artifacts locally first (deployBuild), or wants a dry-run plan before applying (deployPlan), or when handling multi-environment deploys via mode / envOverrides. Covers build-plan-apply flow (deployBuild local build → deployPlan dry-run → deployApply confirm=true), hosting build-output neutralization, envId resolution priority, only/skip filtering, concurrency, and continueOnError. Prefer deployBuild (when hosting declares a buildCommand) and deployPlan before deployApply; do not confuse with per-resource tcb CLI deploy or single-function deploy.

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Use when the user has finished building a mobile app, started Metro with `npm run dev`, and wants the running app monitored for runtime errors AND silent failures (empty lists, blank screens, swallowed network errors) and fixed autonomously. Accepts a free-text symptom (e.g., `/debug-app "todos not appearing on home screen"`) to drive persisted-log diagnostics — injects temporary console.log statements at data-path boundaries, reads the sanitized `.powernative/metro-logs/` log, and cleans up logs after the root cause is fixed. Supports port/platform filtering, configurable clean-cycle and timeout limits, and watch-only `--no-fix` mode. Otherwise polls with a durable byte cursor, fixes inline or routes appropriately, verifies each fix from new output, and exits after the configured clean checks (default 3). Foreground loop — blocks the conversation while running. Run only after the app is loaded.

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The filtering uses intelligent methods to generate output 10X matrices as would be otherwise generated by CellRanger. The ranking option serves to illustrate the number of detected barcodes in the sample.

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Universal LaTeX document skill: create, compile, and convert any document to professional PDF with PNG previews. Supports resumes, reports, cover letters, invoices, academic papers, theses/dissertations, academic CVs, presentations (Beamer), scientific posters, formal letters, exams/quizzes, books, cheat sheets, reference cards, exam formula sheets, fillable PDF forms (hyperref form fields), conditional content (etoolbox toggles), mail merge from CSV/JSON (Jinja2 templates), version diffing (latexdiff), charts (pgfplots + matplotlib), tables (booktabs + CSV import), images (TikZ), Mermaid diagrams, AI-generated images, watermarks, landscape pages, bibliography/citations (BibTeX/biblatex), multi-language/CJK (auto XeLaTeX), algorithms/pseudocode, colored boxes (tcolorbox), SI units (siunitx), Pandoc format conversion (Markdown/DOCX/HTML ↔ LaTeX), and PDF-to-LaTeX conversion of handwritten or printed documents (math, business, legal, general). Compile script supports pdflatex, xelatex, lualatex with auto-detection, latexmk backend, texfot log filtering, PDF/A output, and verbosity control (--verbose/--quiet). Empirically optimized scaling: single agent 1-10 pages, split 11-20, batch-7 pipeline 21+. Use when user asks to: (1) create a resume/CV/cover letter, (2) write a LaTeX document, (3) create PDF with tables/charts/images, (4) compile a .tex file, (5) make a report/invoice/presentation, (6) anything involving LaTeX or pdflatex, (7) convert/OCR a PDF to LaTeX, (8) convert handwritten notes, (9) create charts/graphs/diagrams, (10) create slides, (11) write a thesis or dissertation, (12) create an academic CV, (13) create a poster, (14) create an exam/quiz, (15) create a book, (16) convert between document formats (Markdown, DOCX, HTML to/from LaTeX), (17) generate Mermaid diagrams for LaTeX, (18) create a formal business letter, (19) create a cheat sheet or reference card, (20) create an exam formula sheet or crib sheet, (21) condense lecture notes/PDFs into a cheat sheet, (22) create a fillable PDF form with text fields/checkboxes/dropdowns, (23) create a document with conditional content/toggles (show/hide sections), (24) generate batch/mail-merge documents from CSV/JSON data, (25) create a version diff PDF (latexdiff) highlighting changes between documents, (26) create a homework or assignment submission with problems and solutions, (27) create a lab report with data tables, graphs, and error analysis, (28) encrypt or password-protect a PDF, (29) merge multiple PDFs into one, (30) optimize/compress a PDF for web or email, (31) lint or check a LaTeX document for common issues, (32) count words in a LaTeX document, (33) analyze document statistics (figures, tables, citations), (34) fetch BibTeX from a DOI, (35) convert a Graphviz .dot file to PDF/PNG, (36) convert a PlantUML .puml file to PDF/PNG, (37) create a one-pager/fact sheet/executive summary, (38) create a datasheet or product specification sheet, (39) extract pages from a PDF (page ranges, odd/even), (40) check LaTeX package availability before compiling, (41) analyze citations and cross-reference with .bib files, (42) debug LaTeX compilation errors, (43) make a document accessible (PDF/A, tagged PDF), (44) create lecture notes or course handouts, (45) fill an existing PDF form (fillable fields or non-fillable with annotations), (46) extract text or tables from a PDF (pdfplumber, pypdf), (47) OCR a scanned PDF to text (pytesseract), (48) create a PDF programmatically with reportlab (Canvas, Platypus), (49) rotate or crop PDF pages (pypdf), (50) add a watermark to an existing PDF, (51) extract metadata from a PDF (title, author, subject).

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Find lookalike companies via DiscoLike's 65M+ business domain database. Search by seed domains ("find companies like clay.com and apollo.io") or natural-language ICP text ("B2B cold email outreach"). Supports negation domains (exclude competitors/existing customers) and country filtering. Use when you already know 3-10 reference companies and want hundreds more that look like them. Outputs CSV ready for /blitz-list-builder or the email waterfall.

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Agent safety boundaries - input validation, output filtering, scope constraints, and document creation policy

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Parses and processes SARIF files from static analysis tools like CodeQL, Semgrep, or other scanners. Triggers on "parse sarif", "read scan results", "aggregate findings", "deduplicate alerts", or "process sarif output". Handles filtering, deduplication, format conversion, and CI/CD integration of SARIF data. Does NOT run scans — use the Semgrep or CodeQL skills for that.

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Own concrete MSBuild ItemGroup and item-expression questions. USE FOR: Include, Remove, Update, item identity and metadata, transforms, filtering, batching, duplicate or overlapping items, and reviews that verify whether those operations are correct. Generated items stay in scope when the central defect is item identity, metadata, batching, duplicate declarations, or glob/Remove/Update semantics. For a generated artifact missing from compilation or output, wrong target timing/path, or FileWrites clean tracking without a broader item-semantics defect, use including-generated-files. The item operation may be broken, suspected, or already correct. Exclude property-only issues, general incrementality with no item question, broad reviews with no concrete item concern, and non-MSBuild systems.

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Guide CUDA-enabled BindCraft protein-binder design from target PDB preparation through AF2/MPNN/PyRosetta execution, filtering, output analysis, and conservative troubleshooting.

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Collect, normalize, and structure execution traces from instrumented programs (strace, ltrace) into JSON format for downstream analysis. Use when working with system call traces, library call traces, or execution logs that need to be analyzed for debugging, test case reproduction, or verification. Supports parsing strace/ltrace output, filtering noise, extracting debug information, and preparing traces for bug analysis or reproduction workflows.

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Load and parse mass spectrometry data formats including mzML, mzXML, and quantification tool outputs like MaxQuant proteinGroups.txt. Use when starting a proteomics analysis with raw or processed MS data. Handles contaminant filtering and missing value assessment.

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Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Binder design ranking using ipSAE (interprotein Score from Aligned Errors). Use this skill when: (1) Ranking binder designs for experimental testing, (2) Filtering BindCraft or RFdiffusion outputs, (3) Comparing AF2/AF3/Boltz predictions, (4) Predicting binding success rates, (5) Need better ranking than ipTM or iPAE. For structure prediction, use chai or alphafold. For QC thresholds, use protein-qc.

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Build content filtering for AI outputs. TRIGGERS - Use when user needs help with ai-content-filter related tasks.

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Use the hyalo CLI instead of read/edit/grep/write when working with markdown (.md) files that have YAML frontmatter. This skill MUST be consulted whenever pi is working with markdown documentation directories, knowledgebases, wikis, notes, Obsidian-compatible collections, Zettelkasten systems, iteration plans, or any collection of .md files with frontmatter. Trigger this skill when: searching or filtering markdown files by content, tags, or properties; reading or modifying YAML frontmatter; managing tags or metadata across documents; toggling task checkboxes in markdown; getting an overview of a documentation directory; querying document properties or status fields; bulk-updating metadata across many markdown files; or when you find yourself repeatedly using read/edit/grep/write on .md files. Even if the user does not mention "hyalo" by name, use this skill whenever the task involves structured markdown documents with frontmatter. For pi sessions, ALWAYS use `--format text` for compact, LLM-friendly output.

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Apply these opinionated testing conventions whenever writing, reviewing, or planning tests: what earns a test and what is coverage theatre, asserting outputs rather than mock calls, the three modes (functional, performance, security), naming and isolation rules, where to mock, and reporting findings for coverage rather than self-filtering. Includes house Jest standards for NestJS unit and contract tests, TDD discipline, and test-report structure.

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Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

日本語の概要は準備中です。原文の説明を表示しています。

Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

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Use when running verbose CLI commands — wraps them with rtk (Rust Token Killer, third-party Apache-2.0; upstream reports 60-90% token savings). Covers installation, configuration, and usage patterns.

日本語の概要は準備中です。原文の説明を表示しています。