「scaffold」の検索結果

Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2/PE3/PE3b/PEmax variants, MOSAIC in situ saturation mutagenesis, the PRIME pooled-screen methodology (Ren 2023; ~3,699 ClinVar variant screens), chromatin context as a major locus-level determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

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Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioisosteric replacements, prospective scaffold hopping, or expanding hit series beyond 2D similarity.

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Track performance across sessions and reduce scaffolding as competence grows. Makes fading visible — the learner knows when scaffolds are removed and why. Use for sustained learning engagement where independence is the goal.

日本語の概要は準備中です。原文の説明を表示しています。

Generate scaffolds supporting student self-regulation across planning, monitoring, and evaluation phases. Use when students struggle to manage their own learning during extended or independent tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Create a writing scaffold teaching the genre conventions specific to an academic discipline. Use when students write lab reports, historical essays, or other discipline-specific text types.

日本語の概要は準備中です。原文の説明を表示しています。

Generate argument structure scaffolds using Toulmin, PEEL, or CER frameworks for a specific claim or question. Use when teaching argumentative or analytical writing across any subject.

日本語の概要は準備中です。原文の説明を表示しています。

Modify a classroom task with language scaffolds that preserve cognitive demand for EAL learners. Use when adapting existing tasks for students at different English proficiency levels.

日本語の概要は準備中です。原文の説明を表示しています。

Scaffold end-to-end testing infrastructure. Use when the user says "e2e scaffold" or "set up e2e testing"

日本語の概要は準備中です。原文の説明を表示しています。

Seed a fresh (greenfield) repository with the PRD-Driven Context Engineering scaffold — PRD.md, SoT/ knowledge files, EPIC templates, domain-profile config, and agent MEMORY starters. Invoked as /prd-ce:init when the plugin is installed. The framework itself (skills, agents, hooks, scripts) ships LIVE in the plugin; this skill only plants the consumer-owned files the plugin cannot carry as behavior. Triggers on "/prd-ce:init", "set up PRD lifecycle here", "scaffold a new PRD-CE project", "initialize the methodology". Outputs a seeded scaffold + a verification report.

日本語の概要は準備中です。原文の説明を表示しています。

Scaffold-time observability so a shipped product is not blind in prod from day one — error capture (Sentry), request-id structured logging, and /healthz + /readyz endpoints. stack-baseline pins Sentry but nothing wires it; this is the wiring. Loaded by app-scaffolder (bake into the scaffold), infra-provisioner (prod env + probes), and consumed by l3-support (traces) and devops (deploy gate).

日本語の概要は準備中です。原文の説明を表示しています。

Modify a classroom task with language scaffolds that preserve cognitive demand for EAL learners. Use when adapting existing tasks for students at different English proficiency levels.

日本語の概要は準備中です。原文の説明を表示しています。

Generate scaffolds supporting student self-regulation across planning, monitoring, and evaluation phases. Use when students struggle to manage their own learning during extended or independent tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Track performance across sessions and reduce scaffolding as competence grows. Makes fading visible — the learner knows when scaffolds are removed and why. Use for sustained learning engagement where independence is the goal.

日本語の概要は準備中です。原文の説明を表示しています。

Create a writing scaffold teaching the genre conventions specific to an academic discipline. Use when students write lab reports, historical essays, or other discipline-specific text types.

日本語の概要は準備中です。原文の説明を表示しています。

Generate argument structure scaffolds using Toulmin, PEEL, or CER frameworks for a specific claim or question. Use when teaching argumentative or analytical writing across any subject.

日本語の概要は準備中です。原文の説明を表示しています。

Run a Meta-Harness-style optimization loop NATIVELY — automatically search over the scaffolding around a FIXED base model (memory, retrieval, context construction, prompt templates, summarization, tool-selection logic) by proposing candidate variants, scoring each on a cheap deterministic eval, and keeping a Pareto frontier of quality vs cost — using native Agent / Workflow / loop tools instead of a standalone Python harness. Use this whenever the user wants to optimize, evolve, tune, distill, or search over a harness, scaffold, prompt system, memory or retrieval policy, context-assembly code, or summarizer while keeping the model fixed; whenever they mention Meta-Harness, harness optimization, scaffold evolution, automatic prompt/memory optimization, an evolutionary or Pareto search over candidate implementations, or "make the harness/agent better without retraining"; and whenever the gain must come from the code AROUND the model rather than the model weights. Reproduces the Meta-Harness paper's method natively, with no claude_wrapper.py and no metered solver API.

日本語の概要は準備中です。原文の説明を表示しています。

Vygotsky's Zone of Proximal Development and scaffolding as a working framework for learning support. Covers the ZPD definition, the distinction between independent and assisted performance, the six scaffolding functions (recruitment, reduction in degrees of freedom, direction maintenance, marking critical features, frustration control, demonstration), fading, sociocultural mediation, and the relationship between ZPD and deliberate practice. Use when deciding how much help to give, designing collaborative learning, or assessing a learner's ceiling rather than just their current floor.

日本語の概要は準備中です。原文の説明を表示しています。

Scaffolds Remotion project folder structure, base configuration files, and file organization. Focuses ONLY on directory creation, empty file templates, and Remotion configuration. Use when starting a new video project or when asked to "scaffold Remotion project", "create project structure", "setup Remotion folders".

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrates component scaffolding by delegating to component-specific scaffolding skills.

日本語の概要は準備中です。原文の説明を表示しています。

Scaffold Quarkus + LangChain4j projects end-to-end and add agentic components to existing ones — AI services, tools, agents and multi-agent workflows, RAG pipelines, MCP clients and servers (Model Context Protocol), guardrails, and embedding store setups. Use this whenever the user wants a new Quarkus + LangChain4j project or module created, or an agentic component added to an existing project in this stack, including a baseline pom.xml, application.properties, project layout, or starter classes.

日本語の概要は準備中です。原文の説明を表示しています。

"Apply constructivist learning theory to design instruction based on active knowledge construction, scaffolding, and the zone of proximal development. Use this skill when the user needs to design learner-centered instruction, apply Vygotsky's ZPD or scaffolding principles, or evaluate learning environments for constructivist alignment — even if they say 'how do people really learn', 'student-centered design', or 'scaffolding for learners'.".

日本語の概要は準備中です。原文の説明を表示しています。

Inspect or exercise the paused gaia curate orchestration scaffold for one source URL. The command currently persists an INITIALIZED run ledger and reports status; its 25 named workflow states and transition methods are a design skeleton, not an implemented automated curation or merge pipeline. Use only for scaffold development, status inspection, or dry-run contract work. For live curation, use gaia-full-pipeline or gaia-consult. Trigger phrases: "/gaia-quick-curate", "inspect gaia curate", "curate scaffold", "quick curate status". For batch/multi-page runs use gaia-curate-dynamic; for crawler branches use gaia-bot-curate; for pending intake proposals use gaia-draft-curate.

日本語の概要は準備中です。原文の説明を表示しています。

Install Tilt and scaffold or audit Tiltfile + tilt/ configurations with ecosystem-aware templates. Auto-detects Java/Gradle (Spring Boot), Next.js, Python/uv, and external infrastructure; recommends single-file or modular tilt/*.star + service-config.yaml + environments.yaml patterns based on project complexity. Bakes in production-context safety guards, PVC persistence toggles, JDWP debug ports, and optional Prometheus/Grafana/Traefik scaffolds. Use when user runs /devtools:tilt-setup, mentions "tilt setup", "setup tilt", "scaffold tiltfile", "audit tiltfile", "tilt configure", "tilt project setup", "Tiltfile", "local kubernetes dev", or "kubernetes development environment".

日本語の概要は準備中です。原文の説明を表示しています。

Run a Meta-Harness-style optimization loop NATIVELY — automatically search over the scaffolding around a FIXED base model (memory, retrieval, context construction, prompt templates, summarization, tool-selection logic) by proposing candidate variants, scoring each on a cheap deterministic eval, and keeping a Pareto frontier of quality vs cost — using native Agent / Workflow / loop tools instead of a standalone Python harness. Use this whenever the user wants to optimize, evolve, tune, distill, or search over a harness, scaffold, prompt system, memory or retrieval policy, context-assembly code, or summarizer while keeping the model fixed; whenever they mention Meta-Harness, harness optimization, scaffold evolution, automatic prompt/memory optimization, an evolutionary or Pareto search over candidate implementations, or "make the harness/agent better without retraining"; and whenever the gain must come from the code AROUND the model rather than the model weights. Reproduces the Meta-Harness paper's method natively, with no claude_wrapper.py and no metered solver API.

日本語の概要は準備中です。原文の説明を表示しています。