「specificity」の検索結果

Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

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Systematic copy editing through focused passes (the Seven Sweeps Framework) covering clarity, voice, proof, specificity, and friction removal. Use when editing marketing copy, reviewing drafts, polishing content, or proofreading.

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Systematic contract negotiation strategies for technology services agreements with German/EU law specificity. Provides three-position framework (provider-favorable, balanced, client-favorable), deal-size calibration (€100K to €10M+), five-tier objection handling with regulatory leverage (GDPR, DORA, NIS2, BGB), concession packaging, and position matrices for liability, IP, payment, SLA, data protection, and termination. Use when: (1) Developing negotiation strategies for SaaS, cloud, or managed services agreements, (2) Preparing position papers and fallback positions, (3) Responding to counterparty objections, (4) Structuring concession packages that protect core economics, (5) Calibrating tactics to deal size and leverage, or (6) Applying German contract law constraints (BGB §§ 305-310 AGB, § 309 Nr. 7 liability limits, § 288 statutory interest).

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Analyse existing written feedback for quality, specificity, actionability, and impact on student learning. Use when reviewing teacher or peer feedback to improve feedback practices.

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Design a sequence where students compare AI's handling of the same question across disciplines, developing a mental model of where AI is reliable vs. distorting based on knowledge type.

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mastR is an R package designed for automated screening of signatures of interest for specific research questions. The package is developed for generating refined lists of signature genes from multiple group comparisons based on the results from edgeR and limma differential expression (DE) analysis workflow. It also takes into account the background noise of tissue-specificity, which is often ignored by other marker generation tools. This package is particularly useful for the identification of g

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Provides R wrappers of several on-target and off-target scoring methods for CRISPR guide RNAs (gRNAs). The following nucleases are supported: SpCas9, AsCas12a, enAsCas12a, and RfxCas13d (CasRx). The available on-target cutting efficiency scoring methods are RuleSet1, Azimuth, DeepHF, DeepCpf1, enPAM+GB, and CRISPRscan. Both the CFD and MIT scoring methods are available for off-target specificity prediction. The package also provides a Lindel-derived score to predict the probability of a gRNA to

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Epialleles are specific DNA methylation patterns that are mitotically and/or meiotically inherited. This package calls and reports cytosine methylation as well as frequencies of hypermethylated epialleles at the level of genomic regions or individual cytosines in next-generation sequencing data using binary alignment map (BAM) files as an input. Among other things, this package can also extract and visualise methylation patterns and assess allele specificity of methylation.

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5 concrete real-life actions, leverage-scored against open loops with specificity and anti-fluff gates

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Standardizes the creation and evaluation of high-density Agent Skills (Claude, Cursor, Windsurf). Ensures skills achieve high Activation (specificity/completeness) and Implementation (conciseness/actionability) scores. Use when: writing or auditing SKILL.md, improving trigger accuracy, or refactoring skills to reduce redundancy and maximize token ROI.

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Delight pass — adds one or two memorable micro-interactions (copy specificity, hover choreography, state transitions, one signature detail) without decoration or confetti. Use when the UI works but feels generic, or when the user says "make it feel special" / "add some personality". Invoke when the user asks for delight on their UI, or mentions 'delight' alongside design / UI / frontend work.

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BRENDA Enzyme DB SOAP/REST queries: kinetic parameters (Km, Vmax, kcat, Ki), EC classes, substrate specificity, inhibitors, cofactors, organism data. 80K+ enzymes, 7M+ values. Free academic registration. For metabolic modeling use cobrapy-metabolic-modeling; metabolites use hmdb-database.

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Review IEEE conference, journal, Transactions, Letters, or magazine manuscripts from a technical reviewer perspective using routed IEEE review gates. Use when evaluating scope fit, novelty, validity, data, clarity, compliance, advancement, engineering significance, method soundness, experiment sufficiency, baseline fairness, figure/table quality, formatting risks, rejection risk, major revision strategy, pre-submission readiness, or the quality and specificity of reviewer comments that may be generic, careless, contradictory, or possibly AI-generated.

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Think and work like an expert Epigeneticist. Use when a task calls for Epigeneticist judgment. Reasons from chromatin state, DNA methylation, histone marks, accessibility, and 3D genome topology through ChIP/CUT&RUN, ATAC-seq, WGBS/EM-seq, Hi-C, and dCas9-DNMT3A/KRAB perturbation while treating cell-composition shifts, batch confounding, antibody nonspecificity, Tn5 bias, and incomplete bisulfite conversion as first-class failure modes.

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Assesses ChIP-seq quality across antibody specificity, fragmentation, enrichment, replicate concordance, and library complexity. Computes FRiP, NSC/RSC (phantompeakqualtools), library complexity (NRF/PBC1/PBC2), deepTools plotFingerprint (JS distance, AUC, synthetic JS), ChIPQC, IDR with ENCODE Nself/Nt rules, and detects hyper-ChIPable artifacts. Use when validating an antibody, diagnosing failed peak calls, deciding whether to proceed with downstream analysis, grading against ENCODE thresholds, or auditing replicate concordance.

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Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.

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Edit English prose for clarity, specificity, natural flow, and fit to the requested voice. Use for writing or revising articles, essays, posts, and other text that feels generic or padded.

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MANUAL TRIGGER ONLY: invoke only when user types /office-hours. YC Office Hours — two modes. Startup mode: six forcing questions that expose demand reality, status quo, desperate specificity, narrowest wedge, observation, and future-fit. Builder mode: design thinking brainstorming for side projects, hackathons, learning, and open source. Saves a design doc. Use when asked to "brainstorm this", "I have an idea", "help me think through this", "office hours", or "is this worth building". Proactively suggest when the user describes a new product idea or is exploring whether something is worth building — before any code is written.

日本語の概要は準備中です。原文の説明を表示しています。

Analyse existing written feedback for quality, specificity, actionability, and impact on student learning. Use when reviewing teacher or peer feedback to improve feedback practices.

日本語の概要は準備中です。原文の説明を表示しています。

Design a sequence where students compare AI's handling of the same question across disciplines, developing a mental model of where AI is reliable vs. distorting based on knowledge type.

日本語の概要は準備中です。原文の説明を表示しています。

Prioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with integrated DepMap CRISPR essentiality + gnomAD constraint), PubMed, the Human Protein Atlas (HPA), and ChEMBL tool compounds, then re-ranking by a composite score combining protein localization, druggability, disease genetics, tissue specificity (safety), focus-cell-type expression, CRISPR essentiality, LoF safety constraint, and research maturity. Use whenever the user wants to filter, triage, prioritize, or "do due diligence" on a list of candidate genes for drug discovery, especially after a DE / DEG analysis when they say things like "which of these should I follow up on", "filter for druggable targets", "make a target dossier", "rank these for tractability", "annotate these genes for druggability", or "build a target report". Trigger even when the user says just "filter these candidate genes" or hands over a CSV from a DE pipeline.

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Generate, rank, and gate a reusable hook bank — sourced pains × named hook formula families, scored on clarity/specificity/curiosity/proof-backing, gated at the 10/16 ad threshold, delivered in 3 lengths with per-hook provenance and downstream routing. Use when "hook bank", "generate hooks", "hook generator", "write hooks for", "ad hooks", "scroll stoppers", "opening lines", "hook ideas", "first 3 seconds", "hook matrix", "I need 50 hooks", or any request to batch-produce attention-openers for ads, social, or video.

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Evaluates and scores Claude prompts and system prompts using a six-dimension Scorecard with anchored 1-5 rubrics. Trigger on: "review my prompt," "score this prompt," "rate my prompt," "evaluate this prompt," "improve my prompt," "what's wrong with my prompt." Also trigger on: "why isn't my prompt working," "my prompt produces bad output," "help me fix this prompt," "is this prompt any good." Scorecard covers Objective Clarity, Context Specificity, Reasoning Fit, Output Precision, Behavioral Calibration, and Architectural Efficiency, plus a five-question Output Evaluation Rubric for assessing actual output. Also use when the user pastes a system prompt and asks for feedback. Activate whenever structured quality assessment of a single prompt is the primary need. Do NOT use for project-level audits involving Custom Instructions architecture, knowledge file organization, or multi-file Project structure (use rootnode-project-audit if available).

日本語の概要は準備中です。原文の説明を表示しています。

YC Office Hours — two modes. Startup mode: six forcing questions that expose demand reality, status quo, desperate specificity, narrowest wedge, observation, and future-fit. Builder mode: design thinking brainstorming for side projects, hackathons, learning, and open source. Saves a design doc. Use before /plan-ceo-review or /plan-eng-review.

日本語の概要は準備中です。原文の説明を表示しています。