1.7万 件 ・ 関連度順
概要と使いどころ
Primary retained Python toolkit for molecular biology sequence work. Preferred for sequence manipulation, FASTA/FASTQ/GenBank parsing, Bio.Entrez, BLAST workflows, alignments, structures, and phylogenetics. For biological database evidence lookup, use bio-database-evidence. For single-cell workflows use scanpy. For direct literature REST API, use pubmed-database.
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B站视频投稿：把视频投稿到哔哩哔哩，支持标题/简介/分区/标签/封面/转载声明/定时发布。 当用户说"投稿B站""发B站""上传到哔哩哔哩""B站视频发布""投个稿""发到bilibili"时使用。 包装成熟的 biliup CLI，扫码登录 + cookie 复用。
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Use this skill when the user wants to invoke the read-only doca_caps CLI to ask what DOCA sees on this host — listing DOCA devices and PCIe addresses, listing representor devices, asking which DOCA libraries are available on the current OS, checking per-device per-library capabilities, scoping output to a specific PCIe address, or capturing a side-effect-free capability snapshot for debug or install smoke-test. Trigger even when the user does not explicitly mention "doca_caps" or "capabilities print tool" — typical implicit phrasings include "what does DOCA actually see on this box", "is my BlueField PF visible to DOCA", "is Flow available on my RHEL host", "enumerate VF representors for pf0", "doca_caps: command not found", or "empty output for RDMA, is the tool broken". Refuse and route elsewhere for DOCA installation (doca-setup owns it; never walk the steps), library-internal capability matrices (Flow pipe creation, RDMA verbs features), streaming telemetry / DTS, or modifying the shipped binary.
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NOTE: molecule and target inputs and your NGC_API_KEY are transmitted to external NVIDIA-hosted API endpoints on every call. Use local NIM containers for confidential or proprietary data. Run a complete computational drug discovery pipeline using NVIDIA BioNeMo NIMs: generate drug-like molecules with GenMol, dock them to a protein target with DiffDock, then predict binding affinity with Boltz2. Use this skill whenever the user wants to generate and screen small molecule drug candidates, perform hit discovery, optimize leads against a protein target, or do virtual screening combining molecule generation, docking, and affinity prediction. Triggers on: drug discovery pipeline, hit discovery, lead optimization, virtual screening, molecule generation, molecular docking, binding affinity, GenMol, DiffDock, Boltz2, SMILES, SAFE notation, NIM microservice. This is a multi-step pipeline composing three BioNeMo NIMs.
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Calculate an ETF's premium or discount to NAV from Yahoo Finance data (yfinance), compare or screen ETFs by premium, explain why a gap exists, and decompose a sudden ETF move into NAV-driven vs structural components (dealer gamma exposure, blocked AP arbitrage, sentiment). Use this skill whenever the user asks whether an ETF trades above or below NAV, compares ETF premiums or discounts, screens for the biggest ones, asks about ETF arbitrage or premium convergence, or wants to know why an ETF jumped or diverged from its holdings — including gamma squeezes, dealer gamma exposure (GEX), and blocked creation/redemption. Especially relevant for leveraged, inverse, international, bond, commodity, and crypto ETFs (IBIT, BITO, HYG, KWEB).
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[omh] Screen-reader or keyboard accessibility gaps: prepare WCAG, keyboard, focus, screen-reader, target-size, and reflow evidence gates for UI surfaces. Use when the user says: accessibility-audit, accessibility audit, a11y audit, a11y architect, wcag audit, wcag 2.2, wcag 2.2 aa, accessibility pass.
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Azure Weights & Biases SDK for .NET. ML experiment tracking and model management via Azure Marketplace. Use for creating W&B instances, managing SSO, marketplace integration, and ML observability. Triggers: "Weights and Biases", "W&B", "WeightsAndBiases", "ML experiment tracking", "model registry", "experiment management", "wandb".
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Azure Resource Manager SDK for Arize AI Observability and Evaluation (.NET). Use when managing Arize AI organizations on Azure via Azure Marketplace, creating/updating/deleting Arize resources, or integrating Arize ML observability into .NET applications. Triggers: "Arize AI", "ML observability", "ArizeAIObservabilityEval", "Arize organization".
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Read biological sequence files (FASTA, FASTQ, GenBank, EMBL, ABI, SFF) using Biopython Bio.SeqIO. Use when parsing sequence files, iterating multi-sequence files, random access to large files, or high-performance parsing.
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Bisulfite sequencing read alignment using Bismark with bowtie2/hisat2. Handles genome preparation and produces BAM files with methylation information. Use when aligning WGBS, RRBS, or other bisulfite-converted sequencing reads to a reference genome.
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Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.
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Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted safety.
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Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires replicate samples. Outputs differentially bound regions with fold changes and p-values. Use when comparing ChIP-seq binding between conditions.
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Sets up CloudWatch observability for the first time - Omni (CloudWatch Application Observability) and classic CloudWatch. Omni: creating a Space or Domain; access grants (who has access, at what level) and access profiles bounding async alerts, integrations, or agents; instrumenting an app or AI agent with the plain ADOT SDK so traces reach Omni (Python/Node/Java/.NET on EC2/ECS/EKS/Lambda), incl. no-image-rebuild and .NET CoreCLR vars; ingesting Azure telemetry via the CloudWatch agent on an Azure VM or AKS; connecting Slack to a Space; whether GitHub or a custom MCP tool server (HTTP/stdio; API key, bearer, OAuth2) can be connected. CloudWatch: onboarding a service to Application Signals - ADOT auto-instrumentation, the amazon-cloudwatch-observability add-on, monitored service, reporting telemetry, ServiceEvents, CI/CD git/deployment metadata, Terraform/manifest edits. For using what is set up - queries, dashboards, alarms, Omni alerts, X-Ray, synthetics, Dynamic Instrumentation - use aws-observability.
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Analyze AWS costs, find savings, manage budgets, evaluate Savings Plans and Reserved Instances, right-size EC2/Lambda/RDS/EBS with Compute Optimizer, look up service pricing, query CUR with Athena, detect cost anomalies, scope costs to billing views, and monitor Free Tier usage. Triggers on: AWS bill, cost analysis, reduce spend, savings plan, reserved instance, right-size, budget alert, cost optimization, pricing, free tier, cost anomaly, CUR, cost audit, billing view, billing view ARN.
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Notaire IA pour le droit immobilier, les successions, les donations, le droit de la famille et le droit des sociétés en France. Copilote juridique pour la préparation d'actes, le conseil patrimonial, les calculs de frais et la vérification de conformité. Couvre le calcul des frais de notaire (DMTO, émoluments, débours, CSI), la plus-value immobilière, les droits de succession et donation, le démembrement, les contrats de mariage, les PACS, les SCI, et la rédaction de projets d'actes (compromis, statuts, testaments). Triggers: notaire, frais de notaire, acte de vente, compromis, succession, donation, héritage, testament, PACS, contrat de mariage, SCI, plus-value immobilière, droits de mutation, DMTO, usufruit, nue-propriété, partage successoral, réserve héréditaire, viager, donation-partage, diagnostics immobilier, droit de préemption, acte notarié, droit immobilier
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Evaluate and improve interface usability using heuristic analysis. Use when the user mentions "usability audit", "users are confused", "form usability", "navigation problems", "Nielsen heuristics", "cognitive walkthrough", or "is this easy to use". Also trigger when reviewing a design for usability issues, improving form-completion rates, or evaluating information architecture and navigation. Covers Krug's laws, Nielsen's 10 heuristics, severity ratings, dark-pattern recognition, and accessibility. For visual design fixes, see refactoring-ui. For conversion-focused audits, see cro-methodology.
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This skill is applicable when using LaminDB. LaminDB is an open-source data framework for biology that makes data queryable, traceable, reproducible, and FAIR-compliant. It is suitable for managing biological datasets (scRNA-seq, spatial transcriptomics, flow cytometry, etc.), tracking computational workflows, curating and validating data with biological ontologies, building data lakes, or ensuring data lineage and reproducibility in biological research. It covers data management, annotation, ontologies (genes, cell types, diseases, tissues), schema validation, integration with workflow managers (Nextflow, Snakemake) and MLOps platforms (W&B, MLflow), and deployment strategies.
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Plans confounder control, variable adjustment logic, and bias mitigation strategies at the protocol stage for clinical, epidemiologic, translational, observational, and biomarker studies. Always use this skill when a user needs to identify major confounders, decide which variables should or should not be adjusted for, compare matching/stratification/weighting approaches, anticipate selection or measurement bias, or pressure-test a study design before execution. Focus on bias sensing, causal structure awareness, variable-role classification, and critical design review rather than generic statistical advice.
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Designs primary, secondary, and exploratory endpoints for biomedical and clinical research protocols. Always use this skill when a user needs to translate study aims into operational endpoint definitions with event rules, assessment timing, composite logic, interpretability, and protocol-stage auditability. Focus on endpoint precision, feasibility, clinical meaning, ambiguity reduction, and implementation readiness rather than generic study design advice.
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Designs a realistic, execution-aware biomedical study version under explicit constraints of samples, time, budget, data access, lab capacity, team skill, and validation resources. Always use this skill when the user has a real study idea, a candidate route, or a partially framed project but cannot assume ideal conditions. If critical feasibility inputs are missing, first clarify what resources are currently available, what resources may be obtainable, and what resources are realistically unavailable. Do not invent access, capabilities, collaborations, or validation resources. Focus first on feasibility-constrained study framing, route narrowing, dependency control, and minimum viable study design.
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Designs discovery, modeling, and validation workflows for prognostic biomarkers in biomedical and clinical research. Always use this skill when the user needs a prognostic biomarker study blueprint rather than a diagnostic test protocol, predictive biomarker design, treatment recommendation, or a completed manuscript. Focus on endpoint family, follow-up horizon, time scale, candidate marker strategy, model-building logic, risk stratification framework, and internal/external validation requirements. Do not invent cohort size, event rate, assay readiness, literature support, or validation access.
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Identifies translationally meaningful paths for bioinformatics findings by mapping omics or computational discoveries to diagnosis, stratification, prognosis, treatment-response, monitoring, or target-nomination use cases, while auditing bridge evidence, assayability, and validation burden. Use this skill when a user wants to know whether a bioinformatics finding can be framed as a stronger translational topic without overclaiming clinical relevance. Always separate statistical signal from translational value, and never imply clinical utility, targetability, or validation depth without explicit evidence support.
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Generates complete bidirectional multi-phenotype Mendelian randomization research designs from a user-provided exposure family and outcome family. Always use this skill whenever a user wants to design, plan, or build a genome-wide causal-inference study based on publicly available GWAS summary statistics, especially when the article logic includes multiple exposures, multiple outcomes or subtypes, bidirectional MR, IV filtering, IVW as the main estimator, weighted median / MR-Egger / MR-PRESSO sensitivity analyses, leave-one-out testing, heterogeneity / pleiotropy checks, and multiple-testing control with FDR. Covers five study patterns (single-family bidirectional MR, multi-phenotype screening MR, subtype-resolved MR, phenome-style bidirectional causal map, mechanism-prioritized MR follow-up) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version...
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