「character」の検索結果

Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

日本語の概要は準備中です。原文の説明を表示しています。

Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

日本語の概要は準備中です。原文の説明を表示しています。

Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.

日本語の概要は準備中です。原文の説明を表示しています。

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。

Detect antimicrobial resistance genes using AMRFinderPlus, ResFinder, and CARD. Screen isolates and metagenomes for resistance determinants. Use when characterizing resistance profiles in clinical isolates, surveillance samples, or metagenomic data.

日本語の概要は準備中です。原文の説明を表示しています。

Reconstruct ancestral states at internal phylogenetic nodes for sequences (PAML codeml, IQ-TREE --ancestral, GRASP, FastML), discrete traits (corHMM hidden-rate Markov, ape::ace, phytools::make.simmap stochastic mapping, BayesTraits), and continuous traits (phytools::fastAnc, geiger Brownian/OU, RPANDA). Use when designing constructs for ancestral protein resurrection, tracing trait evolution along a tree, performing stochastic character mapping, testing models of trait evolution (BM vs OU vs EB), inferring ancestral genome content via Dollo or DTL reconciliation, or quantifying ancestral-state uncertainty for downstream comparative analyses.

日本語の概要は準備中です。原文の説明を表示しています。

Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

日本語の概要は準備中です。原文の説明を表示しています。

SPR and BLI assay planning, kinetic interpretation, and troubleshooting guidance. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

日本語の概要は準備中です。原文の説明を表示しています。

Restructure existing code safely without changing externally observable behavior. Composes context, design, architecture, code quality, and testing guardrails into a characterization-first refactoring workflow. Use when the user says 'refactor this', 'clean this up', 'untangle this module', 'move this to the right layer', 'simplify this code', or 'improve this structure'.

日本語の概要は準備中です。原文の説明を表示しています。

A vibrant claymation-meets-data interface for Clay.com (GTM data-orchestration platform). Anchors on white canvas with dark-navy primary CTAs, custom rounded display type, and saturated single-color feature cards — hot pink, deep teal, lavender, peach, ochre — that punctuate long-scroll explainer pages. Brand voltage comes from 3D-rendered claymation illustrations (mountains, characters, mascots) used as full-bleed hero artifacts and the bright multi-color card surfaces showing product UI fragments.

日本語の概要は準備中です。原文の説明を表示しています。

v2.4.0 · Dungeon Master assistant for running persistent D&D 5e campaigns. Handles campaign creation/loading, character management, combat tracking, NPC generation, dice rolling, and session state — all persisted across sessions. Invoke with /dm:dnd followed by a subcommand, or just speak naturally once a campaign is loaded.

日本語の概要は準備中です。原文の説明を表示しています。

Makes working code easier to read and change without altering what it does, and proves the behaviour stayed the same. Use when someone says "simplify this", "clean up this function", "this file is a mess", "reduce the complexity", "refactor for readability", "tidy my diff before the PR", or when a linter reports high cyclomatic complexity or deep nesting. Covers pinning current behaviour with characterization tests, measuring complexity, choosing a named refactoring, applying it in small verified steps, and reporting suspected bugs found on the way instead of fixing them silently.

日本語の概要は準備中です。原文の説明を表示しています。

Animates 3D objects and characters in Blender with Python (bpy): keyframes, armatures and IK rigs, shape keys, F-Curves, the NLA editor and drivers. Use when the user wants to keyframe properties, create armatures and rigs, set up IK/FK chains, animate shape keys for facial animation, edit F-Curves, blend actions with NLA strips, add drivers, or script any animation workflow in Blender from the terminal.

日本語の概要は準備中です。原文の説明を表示しています。

Make hand-painted watercolour-and-ink cartoon videos (MP4) with code — p5.js + p5.brush rendered frame by frame in headless Chrome, encoded with ffmpeg — starring Clawd or any character. Use when the user asks to make an animation, animated short, cartoon, music video, lyric video, animated GIF/loop or "a video of Clawd…", or mentions the PDoomVideo / ClaudeAnimationBase approach. Covers storyboarding, the engine API, the render-and-look review loop, music/lyric sync and splitting long videos across subagents.

日本語の概要は準備中です。原文の説明を表示しています。

Expert in entertainment industry concept art workflows, from initial ideation through final production-ready deliverables. Combines traditional art fundamentals with modern digital workflows used at AAA studios and film production houses. Draws from methodologies of industry masters: Feng Zhu's efficient design process, Scott Robertson's perspective and vehicle design systems, Sparth's graphic shape language, and Syd Mead's industrial design thinking. Use when "concept art, visual development, vis dev, keyframe, color script, production design, mood board, thumbnail sketch, environment concept, character concept, prop design, callout sheet, orthographic views, design exploration, photobash, speedpaint, concept-art, visual-development, game-art, film-art, pre-production, ideation, design" mentioned.

日本語の概要は準備中です。原文の説明を表示しています。

Expert in absurdist, unhinged, and deliberately weird brand voices that work. Covers the Duolingo owl energy, chaotic social media presence, and knowing exactly how far to push. Understands why weird works and when it catastrophically fails. Use when "absurdist, unhinged, duolingo, weird brand, chaotic energy, off the rails, brand character, " mentioned.

日本語の概要は準備中です。原文の説明を表示しています。

The specialized craft of writing copy that sells—headlines that stop thumbs, body copy that persuades, CTAs that convert. This is copywriting specifically tuned for advertising: paid media, performance marketing, direct response. Ad copy is different from content writing. Every word costs money (CPM/CPC). Every character competes for attention. There's no time for warm-up—you have one chance to hook, persuade, and convert. The best ad copy feels effortless but is engineered word by word. In the age of AI-generated creative at scale, ad copywriting becomes both more important (you need more variations) and more challenging (everyone has access to the same tools). The differentiation is in the strategy, the insight, and the craft that AI assists but doesn't replace. Use when "ad copy, headline, ad text, CTA, call to action, Facebook ad, Google ad, ad variations, direct response, performance copy, primary text, ad headline, ad-copy, headlines, direct-response, performance, conversion, cta, advertising" mentioned.

日本語の概要は準備中です。原文の説明を表示しています。

Mastery of the new frontier: AI-generated video that rivals—and reimagines—traditional production. This skill covers Veo3, Runway Gen-3, Sora, Kling, Pika, Luma Dream Machine, and the rapidly evolving landscape of neural video synthesis. We're not just using AI to replace traditional video—we're unlocking visuals that were previously impossible, unaffordable, or unimaginable. Flying through abstract data visualizations, impossible camera moves, photorealistic product renders from text, and consistent character performances without actors or sets. The practitioners of this skill understand that AI video is not about cost savings— it's about creative expansion. The ceiling has been removed. What would you create if production cost was zero and physics was optional? Use when "AI video, generate video, Veo3, Veo 3, Runway, Sora, Kling, Pika, Luma, text to video, image to video, video generation, AI footage, neural video, synthetic video, impossible shot, ai-video, veo3, runway, sora, kling, pika, generation, text-to-video, neural, synthesis" mentioned.

日本語の概要は準備中です。原文の説明を表示しています。

Master AI-powered game asset pipelines using ComfyUI, Stable Diffusion, FLUX, ControlNet, and IP-Adapter. Creates production-ready sprites, textures, UI, and environments with consistency, proper licensing, and game engine integration. Use when "AI game art, generate game assets, ComfyUI game, stable diffusion sprites, AI texture generation, character consistency AI, procedural art generation, SDXL game assets, FLUX textures, train LoRA game, AI tileable texture, spritesheet generation, " mentioned.

日本語の概要は準備中です。原文の説明を表示しています。

游戏设计 (Game Design) — 设计游戏的规则 / 系统 / 机制 / 体验 的从业者认知操作系统 (以电子游戏为主, 含桌游 / 卡牌 / 棋盘游戏): 决定「玩家做什么、为什么有意义、每一刻的体验如何」的学科 —— 区别于游戏程序 (引擎 / 代码)、游戏美术 (视觉 / 音频)、游戏制作 (排期 / 预算 / 团队)。覆盖 (a) 核心设计理论与框架 (MDA 机制-动态-美学 Hunicke/LeBlanc/Zubek + Schell 的「透镜」+ Koster「乐趣即学习」理论 + Sid Meier「一连串有趣的决策」+ Salen & Zimmerman「有意义的游玩」/「二阶设计」/「魔法圈」+ Costikyan 论不确定性 + Suits/Huizinga 游戏哲学), (b) 系统与机制设计 (核心循环 + 游戏经济 sink/source/产出-消耗 + 正负反馈环 + 资源与成长系统 + 涌现 vs 脚本 Will Wright「可能性空间」+ Machinations 经济建模 Dormans + 支配 / 退化策略 + 正交设计 Garfield), (c) 关卡与遭遇设计 (灰盒 blockout + 节奏与张力 + 预告 telegraphing + 主线 vs 探索 + 环境叙事 + 锁钥 gating + 难度曲线), (d) 游戏手感与「juice」(Steve Swink《Game Feel》+ 即时响应 + 屏震 / 反馈 / 打磨 + 输入与镜头 + 「手感」是设计出来的不是附带的), (e) 玩家心理与 UX (Celia Hodent《The Gamer's Brain》+ 心流通道 挑战 vs 技能 Csikszentmihalyi/陈星汉 Jenova Chen + Bartle 玩家类型 + 动机与奖励节奏 + 新手引导 FTUE / 教学化 + 认知负荷 + 无障碍), (f) 平衡与调优 (Ian Schreiber《Game Balance》+ 对称 / 非对称 + 动态难度 DDA + 传递 / 非传递平衡 + nerf/buff + 消除支配策略 + 测试驱动调优), (g) 叙事与任务设计 (ludonarrative 失调 / 和谐 + 环境与系统叙事 + 分支 vs 线性 + Amy Hennig 角色驱动 + 任务结构), (h) 以玩家为中心的迭代流程 (Tracy Fullerton《Game Design Workshop》playcentric + 纸面原型 + 垂直切片 + 测试协议「看而不说 / 你不是你的玩家」+ 快速迭代 + game jam), (i) 类型与形态工艺 (roguelike/roguelite 与程序生成 Derek Yu + 平台跳跃 + RPG 系统 + 策略 4X + 解谜设计 Jonathan Blow + 多人 / PvP 平衡 + 桌游 / 卡牌设计 Reiner Knizia/Richard Garfield/Brenda Romero), (j) F2P / 长线运营 / 商业化设计 (核心 / 元 / 经济循环 + 抽卡 gacha / 开箱 loot box / 战令 battle pass 机制 + 留存 D1/D7/D30 + 转化 + 鲸鱼 + live ops 内容节奏 —— 并诚实处理掠夺式暗黑模式 / 强迫循环 / 剥削式商业化的伦理), (k) 设计师角色与工艺职业 (系统 / 关卡 / 叙事 / UX 设计师之分 + 通才 vs 专才 + 独立作者 vs 3A 团队 + 设计文档 + 传达设计意图 + GDC 工艺社区)。跨 3A / 独立 / 手游 F2P / 桌游。不含 游戏程序 / 引擎 (Unity/Unreal 编码 / 图形 / 网络同步) / 游戏美术 / 动画 / 音频 / 游戏制作 / 项目管理 / 排期 / QA / 游戏作为生意 / 发行 / 市场 / 电竞运营为终点 / 泛泛「我想做游戏」的 game-dev 教程 —— 本 skill 是「设计」学科: 规则 / 系统 / 机制 / 体验。 (Game Design — the cognitive operating system of practitioners who design the rules, systems, mechanics, and experiences of games (video games primarily, plus tabletop/board/card games): the discipline of deciding WHAT the player does, WHY it is meaningful, and HOW the moment-to-moment experience feels — distinct from game programming (builds the engine/code), game art (visuals/audio), and game production (schedule/budget/team). Covers (a) core design theory & frameworks (MDA Mechanics-Dynamics-Aesthetics Hunicke/LeBlanc/Zubek, Schell's Lenses, Koster's theory of fun = learning, Sid Meier 'a series of interesting decisions', Salen & Zimmerman 'meaningful play'/'second-order design'/'magic circle', Costikyan on uncertainty, Suits/Huizinga play philosophy), (b) systems & mechanics design (core loops, game economy sink/source/faucet-drain, feedback loops positive/negative, resource & progression systems, emergence vs scripting Will Wright 'possibility space', Machinations economy modeling Dormans, dominant/degenerate strategy, orthogonal design Garfield), (c) level & encounter design (blockout/greybox, pacing & tension, telegraphing, critical path vs exploration, environmental storytelling, gating & lock-and-key, difficulty curve), (d) game feel & juice (Steve Swink 'Game Feel', moment-to-moment responsiveness, screenshake/feedback/polish, input & camera, the 'feel' is designed not incidental), (e) player psychology & UX (Celia Hodent 'The Gamer's Brain', flow channel challenge-vs-skill Csikszentmihalyi/Jenova Chen, Bartle player types, motivation & reward schedules, onboarding/FTUE/tutorialization, cognitive load, accessibility), (f) balancing & tuning (Ian Schreiber 'Game Balance', symmetry/asymmetry, dynamic difficulty adjustment DDA, transitive/intransitive balance, nerf/buff, dominant strategy elimination, playtesting-driven tuning), (g) narrative & quest design (ludonarrative dissonance/harmony, environmental & systemic storytelling, branching vs linear, Amy Hennig character-driven, quest structure), (h) player-centric iterative process (Tracy Fullerton 'Game Design Workshop' playcentric design, paper prototyping, vertical slice, playtesting protocol 'watch don't talk / you are not your play

日本語の概要は準備中です。原文の説明を表示しています。

Dùng khi cần prompt ảnh thiết kế nhân vật (3 góc toàn thân + cận mặt trong 1 ảnh) cho Midjourney/SD/Flux để giữ nhân vật nhất quán khi làm video AI. Bản Lite.

日本語の概要は準備中です。原文の説明を表示しています。

Create platform-specific social media posts for LinkedIn, Facebook, Instagram, and Reddit. Handles character limits, hashtag strategies, hook placement, and image specs per platform. Works from scratch, from existing content (blog, newsletter, announcement), or as a multi-platform campaign. Produces copy-paste-ready posts. Triggers: 'social media post', 'linkedin post', 'facebook post', 'instagram caption', 'reddit post', 'social posts', 'post to social', 'repurpose for social', 'social media campaign'.

日本語の概要は準備中です。原文の説明を表示しています。

Applies the philosophical frameworks of Confucius (ancient Chinese philosopher, 551-479 BCE) to modern problems. Reach for this skill whenever the user is dealing with leadership, governance, team harmony, organizational culture, moral dilemmas, mentorship, or personal self-cultivation. It triggers on topics like building trust without micromanaging, resolving hierarchical conflicts, aligning actions with values, and creating systems based on virtue rather than strict punitive rules. Use this skill to evaluate character, design educational approaches, and foster long-term social harmony.

日本語の概要は準備中です。原文の説明を表示しています。

Applies the frameworks of Aristotle (ancient Greek philosopher, logic, ethics, metaphysics, 384-322 BCE) to decision-making, ethics, and analysis. Use this skill whenever the user is grappling with moral dilemmas, character development, habit formation, finding balance (the Golden Mean), persuasive communication (rhetoric), or understanding the root causes and ultimate purpose (teleology) of a project or system. Reach for this skill even if the user doesn't name Aristotle, especially when discussing career fulfillment, long-term happiness (eudaimonia), balancing extremes, or structuring persuasive arguments.

日本語の概要は準備中です。原文の説明を表示しています。