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概要と使いどころ
Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
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Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.
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De novo motif discovery and known motif enrichment analysis using HOMER and MEME-ChIP. Identify transcription factor binding motifs in ChIP-seq, ATAC-seq, or other genomic peak data. Use when finding enriched DNA motifs in peak sequences.
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Use when the user asks to "find trending topics", "what trends should my brand jump on", or "time a campaign around a cultural moment"; produces a ranked trend report with brand-fit scores, format calls (rising/peak/declining), a cultural calendar, and go/skip recommendations. Not for finding the creators to run those trends — use influencer-discovery; not for building the brand posting calendar from a go verdict — use social-calendar-builder. 热点趋势洞察/借势营销
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Use when the user asks to "analyze the SERP" or "SERP分析"; maps SERP features, layout, ranking factors, search intent, AI Overviews, and snippet opportunities for a query. Not for keyword demand discovery — use keyword-research. SERP分析/搜索结果
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Use when the user asks to "find influencers", "build an influencer list", or "discover creators in [niche]"; produces a multi-platform candidate pool, per-influencer evidence profiles, authenticity red-flag screening, and a Fit-readiness queue without action ranking. Not for STAR scoring or ranking a known shortlist — use fit-scorer. 达人挖掘/找达人/创作者名单
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Use when the user asks to "track competitor influencer marketing", "see who my rivals partner with", or "benchmark my influencer program"; produces a competitor partnership roster, campaign and content-strategy breakdown, performance estimates, and a gap/opportunity list. Not for finding your own new creators — use influencer-discovery. 竞品达人合作追踪/竞品营销分析
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Use when the user asks to "find content gaps", "竞品写了什么", or "还应该写什么"; builds a competitor-relative coverage map of missing topics, keyword gaps, and editorial-calendar opportunities. Not for raw keyword demand discovery — use keyword-research. 内容缺口/选题规划
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Use when the user asks to "score this influencer", "rank these creators for our campaign", or "tell me which influencer is the best fit"; produces the typed STAR Suitability (S) read plus a separately labeled campaign-fit ranking without mixing campaign-specific commercial fit into the Suitability read. Not for finding new influencers — use influencer-discovery; not for sending outreach — use outreach-manager. 达人适配度评分/创作者筛选排名
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Use when the user asks to "analyze my target audience", "build an audience profile for influencer targeting", "research a niche community", or "deep-dive a subculture before partnering with creators"; in audience mode produces demographic/psychographic profiles, a platform-priority matrix, named personas, and an influencer-selection criteria set, and in niche mode produces a community map, culture decode (language/norms/taboos), key-voice tiers, a Brand Fit Score, and a phased entry strategy. Not for finding specific creators to contract — use influencer-discovery; not for scoring a shortlist on Suitability — use fit-scorer. 目标受众画像/人群分析 · 细分社群/亚文化调研
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Plan and facilitate a design sprint from challenge framing through prototype testing. Use when compressing discovery into days. For ongoing team cadence, use `team-workflow`.
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Have a fast, conversational analysis with the AWS DevOps Agent. Use for cost optimization, architecture review, topology mapping, knowledge / runbook discovery, security audits, dependency questions, and quick diagnostics — anything that needs a 5-30 second answer rather than a 5-8 minute deep investigation. Trigger words include cost, optimize, review, architecture, topology, what runbooks, show me, compare, audit, what if.
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Startup-tailored AWS architecture advice for non-agent workloads, adjusted to the company's stage (pre-revenue through Series B+), team size, runway, and credits. Not for AI agents: deploying an AI agent on AWS, picking its runtime, or any agentic architecture is agent-advisor. Use when a founder wants guidance or a recommendation rather than code changes: which services to choose, how to plan or review an architecture, how to stretch credits and control cost, or how to prepare architecture for a fundraise or technical diligence. For an interactive discovery flow that scaffolds and writes the architecture into the codebase, use start-building-for-startups. Do not use for: writing or scaffolding code, factual AWS Activate / programs / credits lookups (see knowledge-base-for-startups), a single copy-paste prompt (see prompt-library-for-startups), or migration intent such as GCP-to-AWS, Azure-to-AWS, or Heroku-to-AWS (see the migration skills: `gcp-to-aws`, `azure-to-aws`, `heroku-to-aws`, `llm-to-bedrock`).
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Migrate workloads from Microsoft Azure to AWS. Triggers on: migrate from Azure, Azure to AWS, move off Azure, migrate AKS to EKS, migrate App Service or Azure VMs to AWS compute, migrate Azure SQL or Azure Database to RDS, migrate Cosmos DB to DynamoDB, migrate Azure OpenAI to Bedrock, move Azure AI or agentic workloads to AWS, estimate AWS costs for my Azure infrastructure, what-if workshop. Runs a 6-phase process: discover Azure resources from Terraform, the live `az` CLI, app code, and billing exports, then clarify, design, estimate costs, optionally reprice scenarios, generate artifacts, and collect feedback. Clarify gates Design, Estimate, and Generate; Generate is opt-in at the post-Estimate decision gate. Bicep/ARM discovery is not yet implemented; a Bicep/ARM-only workspace halts. Do not use for: GCP migrations (see gcp-to-aws), Heroku migrations (see heroku-to-aws), general AWS architecture advice (see architect-for-startups), AWS-to-Azure reverse migration, or Azure-to-Azure refactoring.
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Guides an end-to-end data-warehouse migration to Amazon Redshift — discovery, schema/SQL/stored-procedure/macro/script conversion, data migration, validation, performance comparison, and reporting. Source-routed via `references/<source>/`; Teradata (Vantage) is the supported source; additional sources are added as their own `references/<source>/` sets. Text-only knowledge (no executable code) — the AI generates all execution at runtime. Applies when a user wants to migrate Teradata to Amazon Redshift, convert Teradata DDL/SQL/stored procedures/macros/BTEQ to Redshift/RSQL, or assess Teradata-to-Redshift migration complexity. Applies only to migrations targeting Amazon Redshift; migrations to other platforms (Snowflake, BigQuery, Databricks, etc.) are out of scope regardless of source. Does not cover general Redshift administration, performance tuning, or troubleshooting of existing Redshift clusters (no migration involved), or sources not listed under references/.
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Implement a safe Attio record lifecycle for standard or custom objects, including schema discovery, query, create or assert, update, and delete controls. Use when building record synchronization or CRM write paths. Trigger with "Attio records", "Attio CRUD", or "sync Attio objects".
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Design a production Attio integration architecture with tenant-bound credentials, schema discovery, queued writes, verified webhooks, idempotency, reconciliation, and rollback ownership. Use when planning or reviewing a multi-workspace Attio service. Trigger with "Attio architecture", "design Attio integration", or "Attio system design".
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Build an NFT discovery workflow with Alchemy NFT API v3 and isolate typed on-chain reads through viem. Use when creating collection explorers or ownership checks. Trigger with "Alchemy NFT API", "NFT collection explorer", or "read an NFT contract".
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Deploy and orchestrate Vertex AI ADK agents using A2A protocol. Manages AgentCard discovery, task submission, Code Execution Sandbox, and Memory Bank. Use when asked to "deploy ADK agent" or "orchestrate agents". Trigger with phrases like 'deploy', 'infrastructure', or 'CI/CD'.
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Org-grade attack-surface mapping: given a company's legal identity, discover its ENTIRE owned internet footprint — corporate family -> owned domains -> owned netblocks/ASN -> live assets — with attribution discipline, not just DNS breadth. The org-first attribution pyramid (legal entity -> LEI/registration -> corporate family -> owned domains -> owned netblocks/ASN -> live assets). Corporate-identity resolution via the GLEIF LEI API (legal name -> LEI, exact-LEI direct-children expansion, downward-only depth-capped BFS, NEVER a name re-resolution), SEC-EDGAR full-text search + Exhibit-21 subsidiary entity names, OpenCorporates entity corroboration, Wikidata SPARQL corporate graph (P856/P355/P749/P1830). Domain attribution via reverse-WHOIS (WhoisXML preview-then-purchase quota guard, SecurityTrails associated-domains — both paid), crt.sh O= certificate-transparency organization pivot (keyless), infrastructure correlation (shared NS/MX/SaaS-TXT, netblock membership, reverse-DNS PTR), and the independent-evidence combiner (1-prod(1-w_i), rule of three, OwnerTier NONE/WEAK/MODERATE/STRONG/CONFIRMED) — discover-only `related:` candidates are NEVER auto-scanned. Netblock/ASN attribution via org-first RIR queries (ARIN Whois-RWS org-handle search, RIPE DB organisation + inverse-org search) that recover 'dark netblocks' with no DNS link to the seed, ASN discovery (RIPEstat + BGPView union), the HYPERSCALER-SCOPE GUARD (never attribute a whole AWS/GCP/Azure/Cloudflare announced range to a tenant — keep only the seed-containing block, tag shared_hosting_cdn), and org-identity-seeded internet-scan-index queries (Shodan/Censys/ZoomEye/FOFA/BinaryEdge org: filters + an always-on keyless crt.sh fallback). Promote-to-scan triage ranks forgotten discover-only netblocks by remote-access exposure (gateway-vendor/KEV/control-plane/datastore port scoring) into an operator queue. Attribution confidence rubric + anti-patterns (namesake grafting via GLEIF name re-resolution, single-signal ownership, hyperscaler over-attribution, privacy-WHOIS pivot poisoning, RIR org-name collisions). Passive/keyless-first OSINT only — every paid-key dependency is enrichment on top of a keyless core, never a hard requirement. Use when mapping an organization's full corporate-family internet footprint, resolving a legal entity to its LEI/subsidiaries, discovering domains/netblocks/ASNs an org owns beyond its one seed domain, auditing M&A/shadow-IT sprawl, or scoping an engagement that starts from a company NAME rather than a domain.
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Inflate skill discovery through repeated activation keywords
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Universal AI-powered web scraper for any platform. Scrape data from Instagram, Facebook, TikTok, YouTube, LinkedIn, X/Twitter, Google Maps, Google Search, Google Trends, Reddit, Airbnb, Yelp, and 15+ more platforms. Use for lead generation, brand monitoring, competitor analysis, influencer discovery, trend research, content analytics, audience analysis, review analysis, SEO intelligence, recruitment, or any data extraction task.
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Guided journey from an app people sign up for and then quietly abandon to a sealed retention engine with a habit loop, an activated first run, and one metric the whole team trusts. Orchestrates eight skills phase by phase - hooked-ux, improve-retention, continuous-discovery, lean-ux, inspired-product, lean-analytics, microinteractions, drive-motivation - asking the user questions at every decision point and recording results in the project docs/ folder (PRODUCT.md, METRICS.md, GROW-APP-PLAN.md) so the journey resumes across sessions. Use when the user wants to lift activation and retention, design a habit loop, fix a leaky onboarding funnel, or says 'users sign up then disappear'. Do not use to fix broken UX or performance that no engagement mechanic can paper over - run improve-app first; if there is no app yet, use create-app. For one framework in isolation, invoke that skill directly.
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Talk to customers without leading them using Mom Test rules: discuss their life not your idea, ask about specifics in the past, and talk less. Use when the user mentions "customer interviews", "validate my idea", "users say they want it but dont buy", "leading questions", "The Mom Test", "customer feedback bias", or "interview script". Also trigger when preparing user-research questions, interpreting ambiguous feedback, or designing customer-discovery that avoids false positives. Covers commitment and advancement, avoiding compliments, and extracting signal from noise. For product-market fit, see jobs-to-be-done. For rapid prototype testing, see design-sprint.
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