「sam」の検索結果

Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

日本語の概要は準備中です。原文の説明を表示しています。

Estimate bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

日本語の概要は準備中です。原文の説明を表示しています。

Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

日本語の概要は準備中です。原文の説明を表示しています。

Sort alignment files by coordinate or read name using samtools and pysam. Use when preparing BAM files for indexing, variant calling, or paired-end analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Filter alignments by flags, mapping quality, and regions using samtools view and pysam. Use when extracting specific reads, removing low-quality alignments, or subsetting to target regions.

日本語の概要は準備中です。原文の説明を表示しています。

Create and use BAI/CSI indices for BAM/CRAM files using samtools and pysam. Use when enabling random access to alignment files or fetching specific genomic regions.

日本語の概要は準備中です。原文の説明を表示しています。

Analyze TF motif accessibility variability across samples or single cells using chromVAR. Use when identifying TF motifs whose accessibility correlates with conditions, computing per-sample motif z-scores after matched background correction, comparing to ArchR / Signac equivalents, or distinguishing motif-accessibility signal from per-site footprinting.

日本語の概要は準備中です。原文の説明を表示しています。

Generate pileup data for variant calling using samtools mpileup and pysam. Use when preparing data for variant calling, analyzing per-position read data, or calculating allele frequencies.

日本語の概要は準備中です。原文の説明を表示しています。

Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a carrier is evaluating ELD / telematics / dashcam platforms and needs an objective comparison of Samsara, Motive (formerly KeepTruckin), and Geotab. Covers ELD compliance, AI dashcams, driver scoring, integrations, pricing structure, and which fleet profile suits which platform.

日本語の概要は準備中です。原文の説明を表示しています。

This skill should be used when the user wants to "synthesize two competing solutions without averaging", "resolve a design/value disagreement by lifting to a higher frame", "止揚 / アウフヘーベン", "矛盾を止揚", "独立案を統合", "平均化せず統合", "contradiction lift", "sublate competing designs", or has two good-but-divergent answers to the same question and wants a higher-order resolution (a selection mechanism) or an honest aporia — not a compromise. NOTE: Use this when two independent solutions diverge and you want to PRESERVE both truth-moments while lifting to a higher frame. Use devils-advocate to stress-test ONE proposal with an assigned opponent, strong-inference to find an unknown cause, and dialectic-loop to validate a claim against a real corpus.

Detect OS credential dumping techniques targeting LSASS memory, SAM database, NTDS.dit, and cached credentials using EDR telemetry, Sysmon process access monitoring, and Windows security event correlation.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies and unpacks UPX-packed and other packed malware samples to expose the original executable code for static analysis. Covers both standard UPX unpacking and handling modified UPX headers that prevent automated decompression. Activates for requests involving malware unpacking, UPX decompression, packer removal, or preparing packed samples for analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Apply consistent photo adjustments across a set of images so they look like they were edited together. Use this skill whenever the user says "make my photos look cohesive", "give all these the same style", "apply a warm and golden feel to all of these", "make this cinematic", "match the look across my photos", "edit all my travel photos the same way", "batch edit these", "make these consistent", "fix my phone photos", or uploads a folder of photos and wants a unified, polished result. Also triggers for requests like "apply a preset to all of these", "make these look professional", or "they were shot in mixed lighting — can you fix them all". Outputs direct final image URLs plus an in-chat preview grid and optional Firefly Board link. Access: 🔐 Signed-In required | Gen AI: ❌

日本語の概要は準備中です。原文の説明を表示しています。

Hunting skill for csrf vulnerabilities. Built from 15 public bug bounty reports including modern variants — SameSite=Lax sibling-subdomain bypass (Argo CD CVE-2024-22424), GraphQL mutations-via-GET (GitLab $3,370), framework-wide CSRF middleware disabled (Stripe Dashboard $5,000), path-traversal CSRF-token bypass (GitHub Enterprise CVE-2022-23732 $10k), Origin-omission bypass (TikTok $2,500), OAuth-state null-byte (Streamlabs), WebSocket CSRF / CSWSH (Coda), default-SameSite email-change → ATO (YoYo Games $400), social-account-link CSRF (HackerOne), JSON-CSRF via text/plain on email-change (TikTok $500). Use when hunting modern CSRF — heavy emphasis on chain-to-ATO patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Triage ASM/recon output for ownership before testing — separate the target's real assets from namespace-collision noise. Automated recon keyword-matches on the brand name, so for any target whose name is a common/dictionary word, the output is dominated by assets belonging to UNRELATED same-named companies (repos, cloud buckets, mobile apps, breach corpora, typosquats). Built from an authorized engagement where an ASM report's 'Criticals' were overwhelmingly false positives and the combo/repos/mobile/bucket lists were polluted with unrelated same-named orgs. Use at the START of any engagement, immediately on receiving any ASM/recon/OSINT dataset, BEFORE testing anything.

日本語の概要は準備中です。原文の説明を表示しています。

Calculate TAM, SAM, and SOM for new market segments using top-down and bottom-up methods

日本語の概要は準備中です。原文の説明を表示しています。

Build low-fidelity wireframes, screen mockups, and user-flow diagrams in Frame0 (the hand-drawn Balsamiq-style wireframing tool) through its connected MCP server. Use when asked to wireframe a screen, sketch a UI, make a low-fi mockup, lay out an app's screens, or diagram a user flow with clickable links. Triggers: "wireframe", "frame0", "low-fi mockup", "sketch a screen", "user flow", "lo-fi", "rough out the UI". NOT for high-fidelity visual design, brand systems, or color/typography polish (use web-design-expert / Figma); NOT for production UI code (use frontend skills).

日本語の概要は準備中です。原文の説明を表示しています。

Implementing distributed tracing with W3C Trace Context — the byte-precise `traceparent` and `tracestate` header formats, OpenTelemetry's W3CTraceContextPropagator as the modern default (replacing X-B3-* and X-Datadog-*), head vs tail sampling, and HTTP→SQL trace propagation via sqlcommenter. Grounded in the W3C REC and OpenTelemetry specs. NOT for OTel metrics/logs pipelines, vendor backend setup (Datadog/Honeycomb/Jaeger/Tempo), or browser RUM tracing.

日本語の概要は準備中です。原文の説明を表示しています。

OpenClawのターミナル画面を固定のサンプルデータで試作し、実際の描画部品を使った2〜6案をtmuxで並べて操作・比較するスキル。

• 初期設定画面の案を比較したいとき
• チャットや選択画面の配置検討
• 既存画面と改善案を比べたいとき

OpenClawのテスト中に起きるメモリ増加や不足を調べます。測定結果やメモリ内の記録を比較し、実際の解放漏れとテスト実行側の保持を見分け、修正を検証します。

• Vitestのメモリ不足を調べたいとき
• 同一プロセスのメモリ記録を比較したいとき
• 解放漏れとモジュール保持を見分けたいとき

OpenClawのPRやIssueの重複を根拠付きで判断し、関連する作業をprtagsで一つのグループに整理して判断理由と確信度を記録するスキルです。

• PRが既存作業と重複するか調べたいとき
• 同じ問題を報告するIssueを探したいとき
• 関連作業を一つの重複グループに整理

指定した会話と期間で共有されたOpenClawの変更提案や課題を集め、GitHubで状態と根拠を確認し、影響度と対応準備に応じて優先順位を付けるスキル。

• 先週の会話で共有されたPRの整理
• 掲載済み提案の状態を再確認したいとき
• 同じ期間から未掲載の提案を探す

本格的な開発に進む前に小さな試作品を動かし、アイデアの実現性や方式の違いを検証して、実行結果を根拠に採用・調整・見送りの判断をまとめるスキル。

• アイデアの実現性を確かめたいとき
• 二つの方式を同じ条件で比較
• 本格開発前の例外条件の検証