6,348 件 ・ 関連度順
概要と使いどころ
Build comprehensive chromatin contact maps by aggregating Hi-C loop calls (BEDPE) across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "what regions are in 3D contact in my tissue?" by creating a union catalog of chromatin loops. Handles resolution-aware anchor matching, cross-lab variation, and Hi-C-specific quality metrics.
日本語の概要は準備中です。原文の説明を表示しています。
Conduct rigorous cross-study meta-analysis of scRNA-seq data from ENCODE, integrating multiple single-cell transcriptomic datasets for a tissue/cell type. Use when the user wants to answer "what cell types exist in my tissue and what genes define them?" by combining scRNA-seq data across donors, labs, and platforms. Follows the Mawla et al. 2019 framework for assessing cross-study reproducibility, TIN-based quality filtering, and detection-limit-aware interpretation. Handles batch correction (Harmony/Seurat), dropout awareness, cross-contamination artifacts, and platform-specific biases. Use this skill for ANY scRNA-seq integration task, cross-dataset comparison, cell atlas construction, or reproducibility assessment involving ENCODE single-cell data.
日本語の概要は準備中です。原文の説明を表示しています。
Annotate genetic variants (GWAS hits, eQTLs, rare variants) with ENCODE functional data to interpret non-coding variation. Use when the user has variants of interest and wants to understand their regulatory context, identify causal variants from GWAS loci, assess variant impact on regulatory elements, perform enrichment testing of variant sets in tissue-specific annotations, or link variants to target genes through enhancer-gene maps. Handles the full post-GWAS workflow from variant set → tissue mapping → functional annotation → fine-mapping awareness → enrichment → variant-to-gene → prioritization. Use this skill for ANY variant interpretation task involving ENCODE chromatin, accessibility, TF binding, or 3D genome data.
日本語の概要は準備中です。原文の説明を表示しています。
Search, query, and cross-reference NCBI GEO (Gene Expression Omnibus) datasets with ENCODE experiments. Use when the user wants to find GEO accessions for ENCODE experiments, search GEO for complementary datasets, download GEO metadata or series matrices, cross-reference ENCODE and GEO data, find supplementary files from GEO, or link GEO series to ENCODE experiments for provenance tracking. Also use when the user mentions GEO, GSE, GSM, GPL, GDS, series matrix, SOFT format, or needs to find expression data in GEO that complements their ENCODE analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Query the UCSC Genome Browser REST API to retrieve regulatory tracks, DNA sequences, cCRE annotations, TF binding clusters, and track schemas for any genomic region. Use when the user wants to look up what regulatory elements exist at a genomic locus, retrieve DNA sequence under peaks, query ENCODE cCREs or TF rPeak clusters from UCSC, check what tracks are available for a genome assembly, get chromatin accessibility across cell types, or cross-reference ENCODE data with UCSC-hosted annotations. Also use when the user mentions UCSC, genome browser, cCRE lookup, SCREEN, TF binding clusters, DNA sequence retrieval, or track data extraction.
日本語の概要は準備中です。原文の説明を表示しています。
Build comprehensive epigenomic profiles for tissues or cell types using ENCODE data. Use when the user wants to characterize chromatin states, assemble histone modification panels, create epigenomic landscapes, run ChromHMM segmentation, identify super-enhancers or bivalent domains, profile regulatory elements across a biosample, or understand epigenetic regulation in a specific biological context. Covers histone marks, chromatin accessibility, TF binding, transcription, DNA methylation, and 3D genome structure.
日本語の概要は準備中です。原文の説明を表示しています。
Track ENCODE experiments locally with publications, citations, and provenance. Use when the user wants to build a collection of experiments, manage citations, compare experiments, or track data provenance.
日本語の概要は準備中です。原文の説明を表示しています。
Download ENCODE genomics files (BED, FASTQ, BAM, bigWig, etc.) to the user's machine. Use when the user wants to download data files from ENCODE experiments.
日本語の概要は準備中です。原文の説明を表示しています。
Use ENCODE functional genomics data for disease mechanism research. Use when the user wants to connect GWAS variants to regulatory elements, annotate disease-associated loci with functional data, identify therapeutic targets from epigenomic data, build disease regulatory models, cross-reference with clinical trials and drug databases, or conduct any disease-focused, pathology-driven, or clinical variant interpretation workflow. Covers the full pipeline from disease-tissue mapping through GWAS variant annotation, heritability enrichment, cancer epigenomics, drug target identification, and clinical trial cross-referencing. Integrates ENCODE with Open Targets, PubMed, ClinicalTrials.gov, and bioRxiv.
日本語の概要は準備中です。原文の説明を表示しています。
Plan and execute integrative analysis combining multiple ENCODE experiments for cross-dataset or multi-omic workflows. Use when the user wants to combine experiments, perform cross-dataset comparison, multi-omic integration, peak overlap analysis, differential binding, signal correlation, chromatin state segmentation, enhancer-gene linkage, or any analysis that requires merging or comparing data from two or more ENCODE experiments. Covers same-assay cross-sample, multi-omic same-sample, cross-organism, and perturbation integration designs. Guides compatibility checks, batch effect detection, normalization, integration strategy selection, and provenance documentation.
日本語の概要は準備中です。原文の説明を表示しています。
Build comprehensive DNA methylation maps by aggregating WGBS (Whole Genome Bisulfite Sequencing) data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is DNA methylated/unmethylated in my tissue?" by combining per-CpG methylation data into tissue-level methylation profiles. Handles coverage filtering, identifies hypomethylated regions (HMRs) and partially methylated domains (PMDs), and manages cross-lab variation.
日本語の概要は準備中です。原文の説明を表示しています。
Build comprehensive chromatin accessibility maps by aggregating ATAC-seq and DNase-seq narrowPeak data across multiple ENCODE experiments, donors, and labs. Use when the user wants to answer "where is chromatin accessible in my tissue?" by combining peak calls into a union peak set. Handles cross-lab variation, ATAC vs DNase platform differences, and ENCODE blocklist filtering.
日本語の概要は準備中です。原文の説明を表示しています。
Search and explore ENCODE Project genomics data. Use when the user wants to find experiments, files, or explore what data is available for specific assays, organs, cell lines, or targets.
日本語の概要は準備中です。原文の説明を表示しています。
Guide users through structured collaborative documentation creation. Use when user wants to write documentation, update README, create architecture docs, draft proposals, technical specs, decision docs, refactor documentation, create API docs, or document code.
日本語の概要は準備中です。原文の説明を表示しています。
Execute an autonomous development loop that picks one task per iteration, implements it, verifies it, and commits the result — each iteration in a fresh context window. Use when user runs /ralph, mentions "ralph loop", "autonomous loop", "builder verifier", "run tasks automatically", "iterate on tasks", "develop autonomously", or wants an automated build-verify-commit cycle with task tracking.
日本語の概要は準備中です。原文の説明を表示しています。
Manage architecture RFCs: create, review, list, update, and transition status. Use when user mentions "RFC", "technical proposal", "architecture proposal", or wants to draft, review, list, update, or change status of RFCs.
日本語の概要は準備中です。原文の説明を表示しています。
Audit, classify, validate, and scaffold documentation using the Diataxis framework (Tutorials, How-to guides, Reference, Explanation). Use when user mentions "diataxis", "documentation framework", "quadrant", "doc audit", "doc coverage", "collapsed document", "tutorial vs how-to", "quadrant purity", "documentation types", or wants to classify docs by type.
日本語の概要は準備中です。原文の説明を表示しています。
Zero-dependency live-preview server providing an agent↔browser bidirectional companion. Watches a content directory, wraps HTML fragments in a frame template, broadcasts live-reload over WebSocket, and captures browser-side click events to a JSONL file. Use when an agent needs to show HTML to the user in a browser and react to clicks — mockups, design exploration, gallery browsing, multi-select choices, prototype iteration. Triggered by "live preview", "browser companion", "preview server", "browser mockup", "show in browser", "arkhe-preview", or any skill that wants to write HTML fragments and have the user see them reload in real time.
日本語の概要は準備中です。原文の説明を表示しています。
Orchestrates 6-phase SDLC pipeline (discovery, requirements, architecture, workstreams, implementation, summary) for guided feature development. Use when user runs /core:develop command, requests spec-driven development, wants to create implementation plans with architecture decisions, or mentions "SDLC", "spec-driven", "plan feature", "development pipeline". Supports plan persistence, wave-based resume, autonomous mode, and architecture/implementation verification.
日本語の概要は準備中です。原文の説明を表示しています。
Create Product Requirements Document (PRD) and setup for Ralph autonomous loop. Use when user runs /create-prd command, wants to set up a project for Ralph, mentions "ralph setup", "create prd", "product requirements", or needs to generate tasks for autonomous development.
日本語の概要は準備中です。原文の説明を表示しています。
Explains complex code through clear narratives, visual diagrams, and step-by-step breakdowns. Use when user asks to explain code, understand algorithms, analyze design patterns, wants code walkthroughs, or mentions "explain this code", "how does this work", "code breakdown", or "understand this function".
日本語の概要は準備中です。原文の説明を表示しています。
Use this when the user wants to generate, normalize, verify, deduplicate, or export training datasets for Codex, Antigravity, or Claude Code from topics, URLs, reference material, web research, or existing JSONL/CSV files. Supports SFT and DPO workflows, custom export schemas, and deterministic local pipeline scripts.
日本語の概要は準備中です。原文の説明を表示しています。
List, select, and install Volcengine skills from the volcengine-skills marketplace. Use when a user asks which Volcengine skill or plugin handles a task, wants to browse every available skill, needs an optional skill that is not currently installed, or asks to install or check the installation status of a Volcengine skill. Also use to discover any core skill, including this finder. Use as a fallback during a Volcengine operation when the currently loaded or installed skills cannot cover the required product, tool, or workflow; inspect the full catalog, select the missing capability, and install it.
日本語の概要は準備中です。原文の説明を表示しています。
Deploy a local project directory or Git repository to Volcengine as a running, reachable cloud service. USE WHEN: deploy to Volcengine, deploy to 火山引擎/火山, deploy this repo/project, publish current code, launch the app, run it in the cloud, expose it as a service, deploy to ECS/VKE/veFaaS, run on ECS, push to VKE, deploy as serverless/FaaS, or the user wants the agent to choose a Volcengine hosting target. If the user only asks which Volcengine deployment target to choose, use `volcengine-prepare` skill first. Not for creating a single standalone resource — use `volcengine-cli` skill for that.
日本語の概要は準備中です。原文の説明を表示しています。