7,150 件 ・ 関連度順
Convert raw Nanopore signal data (FAST5/POD5) to nucleotide sequences using Dorado basecaller. Covers model selection, GPU acceleration, modified base detection, and quality filtering. Use when processing raw Nanopore data before alignment. Note: Guppy is deprecated; use Dorado for all new analyses.
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
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Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.
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Bulk transcriptomics differential expression with count-aware modeling, design validation, contrast handling, thresholded exports, and publication-ready DE figures.
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Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.
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All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For backbone-only generation, use rfdiffusion. For sequence-only design, use proteinmpnn. For structure validation, use boltz.
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ESM2 protein language model for sequence scoring, embeddings, and plausibility checks. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai1-structure-prediction or boltz-structure-prediction. For QC thresholds, use protein-design-qc.
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Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch, (3) Scaffolding functional motifs into new proteins, (4) Specifying hotspot residues for interface design, (5) Creating symmetric oligomers. For sequence design after backbone generation, use proteinmpnn. For structure validation, use alphafold or chai. For QC thresholds, use protein-qc.
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ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc.
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Chai-1 structure prediction for protein complexes and design validation. Use this skill when: (1) Predicting protein-protein complex structures, (2) Validating designed binders, (3) Predicting protein-ligand complexes, (4) Using the Chai API for high-throughput prediction, (5) Need an alternative to AlphaFold2. For QC thresholds, use protein-design-qc. For AlphaFold2 prediction, use alphafold2-multimer. For ESM-based analysis, use esm2-sequence-scoring.
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Extract and analyze pricing information from competitor websites. Identifies pricing tiers, features per tier, billing models, and positioning relative to market alternatives. Ideal for competitive pricing strategy and market positioning research.
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Plan and produce short AI videos with SandBase image, video, music, and speech models. Use for commercials, social clips, explainers, short films, storyboards, or multi-shot video generation; use a simpler image or audio skill when no video deliverable is needed.
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Researches products across retailers and review sites with Firecrawl and recommends what to buy within the user's budget and preferences, with current prices and sources. Use when the user wants to compare products, find the best option or check reviews before buying, since prices and models change faster than training data. Adds to a cart only when asked and a signed-in browser profile exists.
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Test application security against OWASP Top 10 (2025) with automated CI tooling: OWASP ZAP (DAST), dependency/supply-chain scanning (OSV-Scanner, SBOM, provenance), Semgrep SAST, auth/session tests (JWT, OAuth, RBAC), and XSS/CSRF/SQLi/SSRF Playwright patterns. Use when: "security test," "OWASP," "vulnerability," "ZAP," "XSS," "SSRF," "dependency scan," "auth testing," "OWASP LLM Top 10." Scope is automated scanning + negative-path security tests in CI, not manual penetration testing. Not for: mapping security controls to regulations (SOC 2, HIPAA, PCI, GDPR) — use compliance-testing; pipeline stage wiring and deploy gating mechanics — use ci-cd-integration; purely functional API auth/input tests with no attacker model — see api-testing; testing your product's own LLM features or defending the agent itself (prompt-injection detector, indirect injection, jailbreak red-teaming) — use ai-system-testing. Related: ci-cd-integration, compliance-testing, api-testing, shift-left-testing, ai-system-testing.
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Move quality earlier in the development lifecycle. Covers dev/QA pairing patterns, Three Amigos sessions, TDD facilitation (Red-Green-Refactor), PR review checklists for testability, and Definition of Done with quality gates. Includes shift-left maturity model for team assessment. Use when: "shift left," "TDD," "dev-QA pairing," "definition of done," "testability," "quality culture," "QA in sprint planning." Not for: writing the unit tests themselves — use unit-testing; automated PR test-quality review at scale — use ai-qa-review; multi-quarter QA direction or roadmap — use test-strategy. Related: unit-testing, ai-qa-review, test-strategy.
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Write production-grade Playwright tests in TypeScript: Page Object Model, fixtures, auto-waiting, user-facing locators, parallel execution, CI integration, sharding, and installed-version checks. Includes an explicit "do not" list for AI agents. Use when: "Playwright," "write E2E test," "page object," "new Playwright suite," "Playwright config." Not for: fixing one flaky test at runtime — use test-reliability. Not for: bulk regenerating selectors after a UI refactor — use selector-drift-recovery. Not for: visual baseline creation/management — use visual-testing. Not for: deep WCAG/axe audits — use accessibility-testing. Related: visual-testing, ci-cd-integration, api-testing, test-reliability, selector-drift-recovery, accessibility-testing.
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Identify disruption opportunities and architect business model innovation. Use when the user says "lets create an innovation strategy" or "I want to find disruption opportunities"
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Disruptive innovation oracle for business model innovation and strategic disruption. Use when the user asks to talk to Victor or requests the Disruptive Innovation Oracle.
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Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).
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CesiumJS interaction and picking - ScreenSpaceEventHandler, multi-key KeyboardEventModifier input actions, Scene.pick, Scene.drillPick, Scene.pickPosition, Scene.snap edge snapping (1.144), mouse and touch events. Use when handling user clicks on the globe, selecting entities or 3D Tiles features, registering modifier-key shortcuts, implementing hover effects, snapping to model edges for measurement, or building drag-based interactions.
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CesiumJS entities and data sources - Entity, EntityCollection, DataSource, GeoJsonDataSource, KmlDataSource, CzmlDataSource, Graphics types, PathGraphics, PathMode, Visualizers. Use when adding points, labels, models, polygons, polylines, or time-segmented paths, loading GeoJSON/KML/CZML/GPX data, or working with the high-level Entity API.
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CustomShader authoring — vertexShaderText and fragmentShaderText against VertexInput, FragmentInput, FeatureIds, Metadata, czm_modelMaterial. Use when reading EXT_mesh_features or EXT_structural_metadata property textures/tables, vertex displacement, or shading VoxelPrimitive.
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CesiumJS spatial math - Cartesian3, Cartographic, Matrix4, Quaternion, Transforms, Ellipsoid, BoundingSphere, projections, coordinate conversions. Use when converting between coordinate systems, computing positions on the ellipsoid, performing spatial intersection tests, building model matrices, or working with geographic projections.
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Generate Simulink Test Sequence blocks and harnesses from EARS requirements. Use when asked to create a test case from a requirement, generate tests from a .slreqx file, or verify a Simulink model with requirement-based tests.
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