「aria」の検索結果

Provider-independent FFmpeg finishing workflow for AI agents preparing generated or edited media deliverables. Use when finalizing images, image sequences, video, audio, captions, overlays, social/export variants, checksums, manifests, delivery specs, and QA with ffmpeg/ffprobe, including transcode versus stream-copy decisions, scaling, frame-rate handling, color metadata caution, loudness normalization, subtitle burn-in or sidecars, concat/trim, GIFs, batch variants, and reproducible command reporting.

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Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.

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End-to-end pooled and single-cell CRISPR screen analysis from FASTQ to hit genes. Orchestrates library design QC, guide counting, six-stage screen QC (plasmid Gini, replicate Pearson, CEGv2 PR-AUC, copy-number artifact), method-appropriate hit calling across MAGeCK RRA/MLE, BAGEL2, drugZ, JACKS, and Chronos, cancer-cell-line copy-number correction (CRISPRcleanR / Chronos), batch correction for multi-batch screens, and the specialized branches for combinatorial paralog screens, single-cell Perturb-seq, base-editor variant-function screens, prime-editor screens, and in vivo bottleneck-aware screens. Use when analyzing any pooled CRISPR screen end-to-end, choosing the correct hit-calling method by experimental design, integrating copy-number correction into the pipeline, or branching the workflow for single-cell, combinatorial, base-editor, prime-editor, or in vivo variants.

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Detects somatic mutations in circulating tumor DNA using variant callers optimized for low allele fractions with UMI-based error suppression. Reliably detects mutations at VAF above 0.5 percent using consensus-based approaches. Use when identifying tumor mutations from plasma DNA or tracking specific variants.

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Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.

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Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.

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Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or EnFormer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

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Query Ensembl for genomic data. Use when user asks about gene coordinates, genomic sequences, variants, gene structure, exons, transcripts, or species comparison. Triggers on "ensembl", "gene coordinates", "genomic location", "exon", "transcript", "variant location", "rsid", "rs number".

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Bulk-regenerate broken test selectors after a UI refactor or redesign. Detects drift between old and new DOM with an aria-snapshot diff, maps old locators to new equivalents using role-first + region scoping, validates against the new build, and produces a single PR with grouped per-file selector updates and per-change evidence. Assumes Playwright >= 1.50 (trace viewer DOM-snapshot panel, getByRole filtering, ariaSnapshot). Use when: "UI refactor broke tests," "redesign broke tests," "bulk update selectors," "regenerate selectors after refactor," "selector drift," "fix N broken tests after redesign." Not for: healing one flaky test at runtime — use test-reliability. Not for: writing a new test suite from scratch — use playwright-automation. Not for: re-recording tests after a framework switch (Selenium to Playwright) — use test-migration. Related: test-reliability, playwright-automation, test-migration, ci-cd-integration, visual-testing.

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Test for WCAG 2.2 AA compliance with axe-core + Playwright, keyboard navigation audits, screen reader testing, ARIA pattern validation, and legal compliance mapping (ADA, EAA, Section 508). Automated tools catch 30-40% of issues — this skill covers automated and manual testing together. Use when: "accessibility," "a11y," "WCAG," "screen reader," "axe," "keyboard navigation," "ARIA," "ADA compliance." Not for: cookie-consent/GDPR compliance — use compliance-testing; pixel-diff visual regression — use visual-testing. Related: playwright-automation, compliance-testing, visual-testing, ci-cd-integration.

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Manage secrets and environment variables using the Doppler CLI. Use when the user wants to set up Doppler, inject secrets into processes, manage projects and configs, upload or download secrets, create service tokens, use secret templates, or integrate Doppler with Docker, Kubernetes, or CI/CD pipelines. Trigger words: doppler, secrets manager, env vars, secret injection, doppler run, doppler setup, service token, secret rotation.

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World-class accessibility design expertise combining the inclusive design principles of Microsoft's Inclusive Design team, the technical rigor of the W3C WCAG working group, and the lived experience perspective of disability advocates. Accessibility is not a feature - it's a fundamental quality attribute that makes products usable by everyone. Great accessibility design is invisible to those who don't need it and essential to those who do. It benefits everyone: captions help in noisy environments, keyboard navigation helps power users, high contrast helps in bright sunlight. When you design for the extremes, you improve the experience for all. Accessibility is not a checklist - it's a mindset that asks "who are we excluding?" at every design decision. Use when "accessibility, a11y, wcag, screen reader, keyboard navigation, color contrast, alt text, aria, focus management, skip link, assistive technology, inclusive design, ada compliance, section 508, accessible, voiceover, nvda, jaws, tab order, focus trap, accessibility, a11y, wcag, inclusive-design, screen-reader, keyboard-navigation, color-contrast, aria, focus-management, assistive-technology" mentioned.

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The specialized craft of writing copy that sells—headlines that stop thumbs, body copy that persuades, CTAs that convert. This is copywriting specifically tuned for advertising: paid media, performance marketing, direct response. Ad copy is different from content writing. Every word costs money (CPM/CPC). Every character competes for attention. There's no time for warm-up—you have one chance to hook, persuade, and convert. The best ad copy feels effortless but is engineered word by word. In the age of AI-generated creative at scale, ad copywriting becomes both more important (you need more variations) and more challenging (everyone has access to the same tools). The differentiation is in the strategy, the insight, and the craft that AI assists but doesn't replace. Use when "ad copy, headline, ad text, CTA, call to action, Facebook ad, Google ad, ad variations, direct response, performance copy, primary text, ad headline, ad-copy, headlines, direct-response, performance, conversion, cta, advertising" mentioned.

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World-class expertise in measuring, attributing, and optimizing AI-generated content performance. Combining data science rigor with content strategy intelligence to answer the questions traditional content analytics can't: Is AI content performing? Which AI variations convert? What's the true ROI of AI vs traditional content creation? This isn't vanity metrics for robots. This is the discipline of proving AI content drives business outcomes - and using that data to make AI content systems better, faster, and more profitable. Built on the principles of companies like Jasper, Copy.ai, and Notion who've scaled AI content operations with measurement as the foundation. Use when "ai content performance, ai content analytics, measure ai content, ai content roi, ai vs human content, ai content attribution, ai content testing, ai variation testing, ai content dashboard, ai content metrics, prompt performance, ai content conversion, ai content quality score, content velocity, ai content efficiency, ai-content, analytics, measurement, attribution, roi, ab-testing, performance, optimization, data-driven, content-analytics" mentioned.

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Refuses "flaky" as a diagnosis. Turns an intermittent failure into a reproduction by isolating it from the environment, naming the variable that controls it, forcing that variable, and measuring before and after with enough runs to count. Separates real defects from environment contention with evidence, and never retries to green or widens a threshold. Use when a test, performance check, or deploy step fails intermittently or passes on rerun.

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Azure AI Anomaly Detector SDK for Java workflow skill. Use this skill when the user needs Build anomaly detection applications with Azure AI Anomaly Detector SDK for Java. Use when implementing univariate/multivariate anomaly detection, time-series analysis, or AI-powered monitoring and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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Azure AI Anomaly Detector SDK for Java workflow skill. Use this skill when the user needs Build anomaly detection applications with Azure AI Anomaly Detector SDK for Java. Use when implementing univariate/multivariate anomaly detection, time-series analysis, or AI-powered monitoring and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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ADVOGADO CRIMINALISTA SENIOR — ESPECIALISTA EM DIREITO PENAL E MARIA DA PENHA workflow skill. Use this skill when the user needs Advogado criminalista especializado em Maria da Penha, violencia domestica, feminicidio, direito penal brasileiro, medidas protetivas, inquerito policial e acao penal and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

日本語の概要は準備中です。原文の説明を表示しています。

ADVOGADO CRIMINALISTA SENIOR — ESPECIALISTA EM DIREITO PENAL E MARIA DA PENHA workflow skill. Use this skill when the user needs Advogado criminalista especializado em Maria da Penha, violencia domestica, feminicidio, direito penal brasileiro, medidas protetivas, inquerito policial e acao penal and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

日本語の概要は準備中です。原文の説明を表示しています。