「express」の検索結果

Interactive scientific and statistical data visualization library for Python. Use when creating charts, plots, or visualizations including scatter plots, line charts, bar charts, heatmaps, 3D plots, geographic maps, statistical distributions, financial charts, and dashboards. Supports both quick visualizations (Plotly Express) and fine-grained customization (graph objects). Outputs interactive HTML or static images (PNG, PDF, SVG).

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Build production-ready Node.js backend services with Express/Fastify, implementing middleware patterns, error handling, authentication, database integration, and API design best practices. Use when creating Node.js servers, REST APIs, GraphQL backends, or microservices architectures.

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Use this skill when stuck in circular debugging, when solutions aren't working despite multiple attempts, or when the user expresses frustration with lack of progress. Bring in GPT-5 as a third-party consultant to provide fresh perspective on complex technical problems, architectural decisions, or multi-system debugging issues. Ideal when you've tried multiple approaches without success, when the problem involves obscure edge cases or novel challenges, or when a second expert opinion would help break through an impasse. Gather all context from the conversation so far and present it comprehensively to GPT-5.

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Query CZ CELLxGENE Census (61M+ cells). Filter by cell type/tissue/disease, retrieve expression data, integrate with scanpy/PyTorch, for population-scale single-cell analysis.

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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

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Comprehensive backend development guide for Langfuse's Next.js 14/tRPC/Express/TypeScript monorepo. Use when creating tRPC routers, public API endpoints, BullMQ queue processors, services, or working with tRPC procedures, Next.js API routes, Prisma database access, ClickHouse analytics queries, Redis queues, OpenTelemetry instrumentation, Zod v4 validation, env.mjs configuration, tenant isolation patterns, or async patterns. Covers layered architecture (tRPC procedures → services, queue processors → services), dual database system (PostgreSQL + ClickHouse), projectId filtering for multi-tenant isolation, traceException error handling, observability patterns, and testing strategies (Jest for web, vitest for worker).

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Helps users discover and install agent skills when they ask questions like "how do I do X", "find a skill for X", "is there a skill that can...", or express interest in extending capabilities. This skill should be used when the user is looking for functionality that might exist as an installable skill.

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Diagrams and checkable docs from a codebase. Draws ERDs, C4 context/container/component views, API endpoint catalogues, lifecycle/state machines, and service-to-service call maps as a validated JSON spec plus a standalone HTML viewer, with Mermaid export. Imports OpenAPI, GraphQL SDL and Prisma; otherwise reads the code (NestJS, TypeORM, Express) and writes the spec. Use for: database diagram, ERD, data model, table relationships, C4 or architecture diagram, system context, API map, endpoint list, "show me the endpoints", status flow, state machine, allowed transitions, "what happens after X is approved", how services call each other, microservice map, Mermaid diagram. Also writes documentation as a fact graph: each statement carries its source and a computed confidence, and a drift check fails CI when the code moves. Use to document a system, write architecture or onboarding docs, or explain how a system works.

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Analyzes conversation transcripts to extract user corrections, patterns, and preferences, then proposes skill improvements. Use this skill when users provide corrections, express preferences about code style, or when patterns emerge from successful approaches. Can be triggered manually with /reflect or automatically at session end when enabled.

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Build production-ready Node.js backend services with Express/Fastify, implementing middleware patterns, error handling, authentication, database integration, and API design best practices. Use when creating Node.js servers, REST APIs, GraphQL backends, or microservices architectures.

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Helps users discover and install agent skills when they ask questions like "how do I do X", "find a skill for X", "is there a skill that can...", or express interest in extending capabilities. This skill should be used when the user is looking for functionality that might exist as an installable skill.

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Use when adding durable execution to a TypeScript project — building retry-safe webhook handlers, background jobs that survive crashes, scheduled tasks, or long-running workflows that outlive a single request. Covers Inngest SDK installation, client config, environment variables, serve endpoints (Next.js, Express, Hono, Fastify), connect-as-worker mode, and the local dev server.

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Interactive visualization with Plotly. 40+ chart types (scatter, line, heatmap, 3D, geographic) with hover, zoom, pan. Two APIs: Plotly Express (DataFrame) and Graph Objects (fine control). For static publication figures use matplotlib; for statistical grammar use seaborn.

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NCBI GEO access via GEOparse and E-utilities. Search by keyword/organism/platform, download GSE series matrices, parse GPL annotations, extract GSM metadata, load expression matrices into pandas. For single-cell use cellxgene-census; for multi-DB access use gget-genomic-databases.

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Bulk RNA-seq DE with PyDESeq2: load counts, normalize, fit negative binomial models, Wald test (BH-FDR), LFC shrinkage, volcano/MA plots. Use for two-group comparisons, multi-factor designs with batch correction, multiple contrasts.

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Unified CLI/Python interface to 20+ genomic databases. Gene lookups (Ensembl search/info/seq), BLAST/BLAT, AlphaFold, Enrichr enrichment, OpenTargets disease/drug, CELLxGENE single-cell, cBioPortal/COSMIC cancer, ARCHS4 expression. Spans genomics, proteomics, disease. For batch/advanced BLAST use biopython; for multi-DB Python SDK use bioservices.

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NCBI Gene via E-utilities: curated records across 1M+ taxa. Official symbols, aliases, RefSeq IDs, summaries, coordinates, GO, interactions. Use for gene ID resolution and cross-species function queries. For sequences use Ensembl; for expression use geo-database.

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Cancer genomics (TCGA et al.) via cBioPortal REST API. Retrieve somatic mutations, CNAs, expression, clinical data (survival/stage/treatment) across thousands of studies. Use for TMB, oncoprints, survival analysis. For population frequencies use gnomad-database; for drug-gene interactions use opentargets-database.

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Infer and visualize intercellular communication from scRNA-seq with CellChat (R). Build CellChat from Seurat/counts → subset CellChatDB ligand-receptor pairs → over-expressed genes per group → communication probabilities → pathway signaling → network centrality (senders/receivers/influencers) → chord/heatmap/bubble plots → cross-condition compare. Human, mouse. Use liana for pure-Python.

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Fast in-memory DataFrame with lazy evaluation, parallel execution, Arrow backend. Use for tabular data in RAM (1–100 GB) when pandas is too slow. Expression API: select, filter, group_by, joins, pivots, window. Lazy mode enables predicate/projection pushdown. Reads CSV, Parquet, JSON, Excel, DBs, cloud. Larger-than-RAM: Dask; GPU: cuDF.

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GRN inference from expression via GRNBoost2 (gradient boosting) or GENIE3 (Random Forest). Load matrix, filter by TFs, infer TF-target-importance links, save network. Dask-parallelized to single-cell scale. Core SCENIC component.

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omics-plotting: publication-style figure authoring for omics / bioinformatics results with matplotlib / seaborn. Read this before writing any plotting or figure code in any omics analysis — RNA-seq, proteomics, single-cell, variant, or database results — not only when a plot is explicitly requested: whenever an analysis will produce a figure, load this first and follow its recipes. Covers volcano, MA, expression / correlation heatmap, GSEA bar / dot plot, box / violin / bar / ridgeline, PCA / UMAP / t-SNE scatter, Kaplan–Meier, Manhattan / QQ / forest. Supplies a shared journal-ready style and copy-paste recipes so every figure looks like one consistent system. To combine several plots into ONE multi-panel composite figure, use the sibling `multipanel` skill.

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Provides security review capability for TypeScript/Node.js applications, validates code against XSS, injection, CSRF, JWT/OAuth2 flaws, dependency CVEs, and secrets exposure. Use when performing security audits, before deployment, reviewing authentication/authorization implementations, or ensuring OWASP compliance for Express, NestJS, and Next.js. Triggers on "security review", "check for security issues", "TypeScript security audit".

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Generates comprehensive TypeScript documentation using JSDoc, TypeDoc, and multi-layered documentation patterns for different audiences. Use when creating API documentation, architectural decision records (ADRs), code examples, and framework-specific patterns for NestJS, Express, React, Angular, and Vue.

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