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概要と使いどころ
Use when evaluating US stocks through Serenity / @aleabitoreddit's AI and semiconductor supply-chain lens: upstream chokepoints, photonics/CPO bottlenecks, hyperscaler capex, institutional rotation, dilution risk, and thesis validation.
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Use when evaluating Nicolas Darvas-style box breakouts, new-high momentum, volume confirmation, and mechanical stop placement for liquid growth stocks.
日本語の概要は準備中です。原文の説明を表示しています。
Extract a written voice profile from your own prior papers, then use it to keep new drafts sounding like you. Reads a corpus one document at a time via subagents, produces a reusable profile on disk (lexicon, sentence rhythm, how you open and close, hedging habits, deliberate quirks), and audits a draft against it. Use when the user says "make this sound like me", "match my voice", "profile my writing", "why does this draft not sound like my papers", or before drafting prose that will carry their name. The positive counterpart to /humanize, which only detects AI tells.
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Apply IRQL graph functions to KQL or IRQL query results for Kusto Explorer visualization. Generates Lift_To_Graph mappings and composes Graph_Render_View, Graph_Fold_By_Property, Extract_Node_*, Enrich_Node_*, and Enrich_Graph_* calls. Accepts a supplied query or limited basic natural-language source request; it is not a general natural-language-to-KQL/IRQL skill. WHEN: Lift_To_Graph, Graph_Render_View, Graph_Fold_By_Property, IRQL graph enrichment, graph mapping for existing query results, icon-decorated graph, fold graph nodes. Use azure-kusto-graph for native make-graph analysis, graph-match, shortest paths, components, or persistent graphs.
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Generate and render Mermaid diagrams for architecture docs, READMEs, PRs, terminals, chats, and CI as themed SVG, PNG, or ASCII/Unicode art. Use this skill whenever the user provides Mermaid code or .mmd files; asks for a flowchart, sequence/state/class diagram, ERD, XY chart, or architecture/workflow/data-model visualization; or wants to beautify, theme, batch-convert, or make a diagram terminal-friendly. Runs locally without a browser or DOM, with 15 built-in themes and custom colors.
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Plan, generate, source, normalize, and validate cohesive visual game assets. Use for art direction, style bibles, sprites, tilesets, backgrounds, UI art, icons, textures, concept art, or 3D asset briefs.
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Transcribes audio or video to speaker-labeled, timestamped text, locally with MLX on Apple Silicon or remotely. Use for 转录 / 录音转文字 / 说话人分离 / 字幕, and also for preparing audio for ASR without transcribing: 转格式, 降采样到 16kHz, merging recorder segments, or compressing and speeding up audio before 飞书妙记 — even when it looks like a one-line ffmpeg job.
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Google Maps scraper for lead generation. Turns a business type and a place into a clean CSV of local businesses by driving the gosom/google-maps-scraper engine, running locally in Docker as a REST API on localhost:8080. Returns 8 lead fields by default (name, phone, email, website, category, address, rating and review count), plus optional Instagram, Facebook and LinkedIn profiles or all ~34 raw fields. Use when the user wants a lead list, "a list of [businesses] in [place]", local business data, contact enrichment for places (emails, phones, socials), or a whole-city run past Google's ~120 results per search. Do not use for scraping Instagram, TikTok, YouTube, X or any other social media platform directly.
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Use AtomLane to compile and execute safe atomic parallel plans on macOS and native Windows Preview for worthwhile independent argv tasks, dependency DAGs, supported platform entrypoints, or Apple-silicon operators. Use at task start or an execution boundary when structured local work may contain two or more worthwhile units; skip plain answers, one quick command, and work whose effects cannot be safely bounded.
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AI image generation for SEO assets: OG/social preview images, blog hero images, schema images, product photography, infographics. Powered by Gemini via nanobanana-mcp. Requires banana extension installed. Use when user says "generate image", "OG image", "social preview", "hero image", "blog image", "product photo", "infographic", "seo image", "create visual", "image-gen", "favicon", "schema image", "pinterest pin", "generate visual", "banner", or "thumbnail".
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Use when targeting Environmental Health Perspectives or deciding whether an environmental-health manuscript fits this venue. Encodes the journal's fit, the public-health-relevance and methodological-rigor bar, epidemiological/toxicological expectations, house style, official-submission re-check, and desk-reject heuristics.
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Final QC gate for a rendered 9:16 video ad, run before it is published. One script checks what a machine can decide — exact 1080x1920 size, a hook that moves and speaks in the first second, no frozen stretches, no dead air, no black frames, the brand's real logo on the end card (never a favicon, never a redrawn or wrong logo), end-card colours near the brand palette — and builds one contact sheet (frames with the TikTok/Reels UI safe zones shaded, beside the logo, product images and a font specimen) for the checks that need eyes — font, product likeness, product consistency across scenes, safe zones. A declared silent-text profile covers silent, text-led formats such as kinetic text (no audio track needed, short blank beats between text beats allowed within fixed bounds). Exit 0 PASS / 2 FAIL / 3 ERROR. Use on every finished video master before pinning it.
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Assemble an iMessage notification-cascade video ad (≈14s, 9:16) from a plate of a phone lying face-up (setting chosen by the user) + 3–5 messages — authentic Apple Messages banners composited in PIL (SF Pro text, green Messages icon, warm translucent-greige fill, soft shadow) spring in one-by-one at the BOTTOM and push the stack UP, a right-aligned Show-less/X pill rides above, the X clears the stack, then a serif end card resolves. FREE assembly (PIL + ffmpeg); the recipe supplies the per-brand plate, notifications, and end-card config and gates the paid plate-clean/music calls to their own capabilities. Use for the imessage-notification-cascade format.
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Render a 'brand identity reveal' video from a config — a single poster frame in a real, softly-lit space (real wall, soft-focus plant in the corner, dappled leaf shadow, illuminated poster) whose artwork HARD-CUTS through ~10 on-brand poster mockups (hero product, IG post, hanging banners, sticker sheet, logo lockup, poster, two lifestyle stills, packaging, big icon) then holds on a brand end card. The environment plate is one create-image-fal generation; the mockups are real-DOM HTML frame-stepped via Playwright, perspective-composited into the detected frame quad with the plate's real leaf-shadow multiplied back onto each poster (reads as behind glass), sequenced by FFmpeg. Deterministic assembly, FREE (the plate comes from create-image-fal, the bed from create-music-elevenlabs), music bed only and approved brand copy only. Use for the brand-identity-reveal format.
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Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.
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Assigns isolate identity at the right resolution for the question -- ANI/Mash species triage, 7-locus MLST historical comparability, cgMLST/wgMLST outbreak resolution (chewBBACA, BIGSdb, Ridom SeqSphere, EnteroBase HierCC), in-silico serotyping (SISTR/SeqSero2 Salmonella, SerotypeFinder E. coli, Kaptive Klebsiella, SeroBA pneumococcus, spa+SCCmec S. aureus), and lineage callers (TB-Profiler/Mykrobe barcode for MTBC, Pangolin + Nextclade for SARS-CoV-2, PopPUNK GPSC for S. pneumoniae). Use when typing bacterial isolates for surveillance or outbreak investigation, choosing between cgMLST allele distance and core-SNP distance for cluster definition, harmonising calls across schemas/database versions, assigning MTBC lineage with the Napier 90-SNP barcode, calling Salmonella serovar via SISTR with monophasic Typhimurium awareness, running Pangolin UShER mode with pangolin-data version pinning, or selecting a typing resolution to match the surveillance question.
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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.
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Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.
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Processes eDNA metabarcoding from raw paired-end reads to species tables, navigating ASV (DADA2, UNOISE3) vs OTU (swarm v2) decision (Callahan 2017 vs Schloss multi-copy-16S critique), marker/primer choice (Leray COI, MiFish 12S, 515F/806R 16S, ITS2) with primer-specific bias, OBITools3 v3 command-name break (obi stats plural; .tar.gz taxonomy), tag-jumping with dual-indexing (Schnell 2015; NovaSeq 10x MiSeq), decontam as screening-not-classifier (Davis 2018), read-counts-not-abundance critique (Lamb 2019), site-occupancy modeling (Ficetola 2015), Naive-Bayes calibration limits (Bokulich 2018), and eDNA decay (Strickler 2015). Use when going from raw eDNA FASTQ to species tables, picking marker + denoising pipeline, deciding whether read counts represent abundance, applying occupancy modeling, configuring OBITools3 v3, or interpreting decontam output. Not for clinical 16S microbiome (see microbiome/amplicon-processing).
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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.
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Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.
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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.
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Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprint for a chemotype-aware task.
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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2024 bioRxiv; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.
日本語の概要は準備中です。原文の説明を表示しています。