「mbr」の検索結果

Memória é a base de agentes inteligentes. Sem ela, cada interação começa do zero. Esta skill cobre a arquitetura de memória de agentes: curto prazo (janela de contexto), longo prazo (vector stores), e as arquiteturas cognitivas que as organizam. Insight-chave: Memória não é apenas armazenamento - é recuperação. Um milhão de fatos armazenados não significam nada se você não conseguir encontrar o certo. Estratégias de chunking, embedding e recuperação determinam se seu agente se lembra ou esquece. O campo é fragm

日本語の概要は準備中です。原文の説明を表示しています。

Manages your own skill landscape: surveys and compares existing skills (Audit mode), researches the web for new skills/plugins (Explore mode), and is at the same time the installer that generates lean subskills (Skill-Finder, family umbrella, maintenance skills) instead of loading a monolith. Use this skill for "compare/audit skills", "which skills are duplicated", "form skill families", "clean up/consolidate skills", "maintain the skill register", "find skills/plugins for topic X", "install new skills", "browse the skill marketplace", or for `/skill-explorer`. Delivers a sub-report per family and a globally numbered decision list; installs/uninstalls only after a security check and explicit approval.

日本語の概要は準備中です。原文の説明を表示しています。

Builds one DRAFT message house for a product, service, programme or initiative from the source material the user provides: an umbrella statement, two to four pillars and graded proof points under each, with every proof point that lacks a source flagged, a claim sensitivity table, an audience coverage check and open questions. Use when the user asks to "build a message house", "write our messaging framework", "what are the key messages for this launch", "turn this research into messaging pillars" or "test our current messaging against the evidence". Do not use for a campaign one-pager, use campaign-brief-builder instead; to check whether a written document's claims are substantiated, use claims-evidence-map. Drafts for human review; never approves, authorises or signs off.

日本語の概要は準備中です。原文の説明を表示しています。

Run a broad SEO audit across technical SEO, on-page SEO, schema, sitemaps, content quality, AI search readiness, and GEO. Use as the umbrella skill when the user asks for a full SEO analysis or strategy.

日本語の概要は準備中です。原文の説明を表示しています。

Extract property ownership, legal descriptions, encumbrances, and recording details from property deeds and land registry documents.

日本語の概要は準備中です。原文の説明を表示しています。

Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Segment single cells from multiplexed IMC/MIBI tissue images using Mesmer/DeepCell, Cellpose, or ilastik+CellProfiler, covering whole-cell vs nuclear segmentation, the summed-membrane-channel decision, nuclear-expansion bias, lateral spillover, resolution-floor parameters, and downstream-proxy evaluation. Use when delineating cells after preprocessing, choosing a segmentation model, building a cell mask for quantification, diagnosing impossible double-positive populations, or troubleshooting over/under-segmentation.

日本語の概要は準備中です。原文の説明を表示しています。

Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

日本語の概要は準備中です。原文の説明を表示しています。

Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), MSIngs, MANTIS, MSIPanel, MSIDetect, and ngsMSI for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.

日本語の概要は準備中です。原文の説明を表示しています。

Construye o actualiza el corpus y el perfil técnico de un reviewer real a partir de sus comentarios en PRs de GitHub. Usar cuando se pida "crear el agente reviewer de X", "armar el perfil de X", "actualizar el corpus de X", "agregar el frontend al perfil de X", o "/generate-github-coder-profile <dir> <Nombre> <login>".

日本語の概要は準備中です。原文の説明を表示しています。

Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Segment single cells from multiplexed IMC/MIBI tissue images using Mesmer/DeepCell, Cellpose, or ilastik+CellProfiler, covering whole-cell vs nuclear segmentation, the summed-membrane-channel decision, nuclear-expansion bias, lateral spillover, resolution-floor parameters, and downstream-proxy evaluation. Use when delineating cells after preprocessing, choosing a segmentation model, building a cell mask for quantification, diagnosing impossible double-positive populations, or troubleshooting over/under-segmentation.

日本語の概要は準備中です。原文の説明を表示しています。

Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), MSIngs, MANTIS, MSIPanel, MSIDetect, and ngsMSI for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.

日本語の概要は準備中です。原文の説明を表示しています。

Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

日本語の概要は準備中です。原文の説明を表示しています。

license: Apache-2.0 NOT for unrelated tasks outside this domain.

日本語の概要は準備中です。原文の説明を表示しています。