520 件 ・ 関連度順
概要と使いどころ
Diagnose Sentry issues without copy-pasting stack traces. Uses the Composio CLI to pull issue details, events, breadcrumbs, and suspect commits, then maps the frames to local source so the agent can propose a fix directly.
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Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers. Covers MA plot (with the shrunken-LFC compression effect), volcano (with the apeglm caveat that p-values are unchanged), PCA on VST/rlog (never raw counts), sample distance heatmaps, top-DE-gene heatmaps with the row-scaling trap, dispersion / BCV plot interpretation, p-value histogram diagnostics, plotCounts for individual genes, blind=TRUE vs FALSE rationale, and the n=3 visualization stake. Use when generating DE diagnostic plots, choosing VST vs rlog for visualization, troubleshooting suspicious plot patterns (shifted MA cloud, batch-dominated PCA, anti-conservative p-value histogram), or building a standard QC figure panel.
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Assigns pathogen lineages (SARS-CoV-2 Pangolin via UShER mode; Nextclade clade + QC; pango-designation alias_key.json resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage fitness modelling (Wenseleers / Bedford-Figgins multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data version pinning (mandatory for reproducibility), Nextclade dataset versioning (lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme version churn (V3 / V4 / V4.1 / V5.3.2 / Midnight 1200) with documented dropout regions, recombinant X-prefix Pango designation lag, GISAID vs INSDC dual-deposition tensions, and the Karthikeyan 2022 wastewater early-detection signal with explicit reproducibility caveats. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater pooled samples into lineage frequencies with Freyja, tracking lineage frequencies and growth advantages over time, pinning pangolin-data / Nextclade dataset versions for reproducibility, handling ARTIC primer dropouts (V4.1 amplicons 64 / 76 / 88-90), or running variant surveillance for SARS-CoV-2 / influenza / Mpox / RSV / H5N1 / measles.
日本語の概要は準備中です。原文の説明を表示しています。
Assesses the quality and completeness of a genome annotation with BUSCO (conserved single-copy ortholog recovery), OMArk (proteome completeness, consistency, and contamination), CheckM2 (prokaryotic completeness/contamination), and a gene-set sanity panel (gene count, mono-exonic fraction, protein-length distribution, mRNA:gene ratio, coding density). Covers the assembly-BUSCO-vs-proteome-BUSCO diagnostic, what BUSCO-Duplicated really means, why gene count is a vanity metric, and the QC of transferred annotations. Use when judging whether an annotation is good enough to publish or submit, diagnosing a suspect annotation, or comparing annotation completeness across pipelines.
日本語の概要は準備中です。原文の説明を表示しています。
Detects and removes doublets/aggregates from flow, spectral, and mass cytometry before clustering or quantification. Covers FSC-A vs FSC-H singlet discrimination (the Area-Height non-proportionality, not a 1D area gate), FSC-W/SSC width gating, CyTOF Gaussian discrimination parameters (Center/Offset/Width/Residual/Event_length) and DNA intercalator gating, and the residual heterotypic conjugates that survive scatter gating and masquerade as double-positive populations. Use when filtering aggregates before phenotyping, choosing a doublet method for flow vs CyTOF, or diagnosing a suspicious double-positive cluster.
日本語の概要は準備中です。原文の説明を表示しています。
Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.
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Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use when building PPI networks, choosing between physical vs functional vs genetic interactions, signed/directed vs undirected, high-throughput vs curated, picking confidence thresholds, aggregating across resources, or navigating license constraints. Encodes the database decision matrix, STRING v12 channel semantics, OmniPath as meta-database, SIGNOR for signed signaling, and per-resource rate limits.
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Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.
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Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates across robust methods.
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Use this skill when the user asks about commercial driver drug & alcohol testing under 49 CFR 382 + 40 — the six testing reasons (pre-employment, random, post-accident, reasonable suspicion, return-to-duty, follow-up), MRO process, SAP/return-to-duty process, post-accident triggers, random selection rates, what panels are tested, refusal definitions, or testing programs and consortiums. Cite specific 49 CFR 382 or 40 subsection.
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Use this skill when the user asks about driver discipline — when to coach vs warn vs suspend vs terminate, progressive discipline frameworks, at-will employment in trucking, documenting violations, separating "willful violation" from "human error," and how to handle a driver who refuses corrective action. Reference state employment law + ATA SMP.
日本語の概要は準備中です。原文の説明を表示しています。
SSR-first Next.js App Router doctrine with zero layout shift. Use when creating a page or data-fetching UI, fixing CLS, layout shift, or hydration mismatches, placing 'use client', Suspense, or skeleton boundaries, awaiting params/searchParams/cookies, adding server-only guards or cache() dedup, or choosing Route Handlers vs Server Actions.
日本語の概要は準備中です。原文の説明を表示しています。
Generic loading UI repair for Pattern Patrol P8. Use when you find 'Loading...' text, unlabeled spinners, meaningless pulses, Suspense fallbacks, or loading placeholders, or when running a P8 patrol.
日本語の概要は準備中です。原文の説明を表示しています。
Detects typosquatting attacks in npm and PyPI package registries by analyzing package name similarity using Levenshtein distance and other string metrics, examining publish date heuristics to identify recently created packages mimicking established ones, and flagging download count anomalies where suspicious packages have disproportionately low usage compared to their legitimate targets. The analyst queries the PyPI JSON API and npm registry API to gather package metadata for automated comparison. Activates for requests involving package typosquatting detection, dependency confusion analysis, malicious package identification, or software supply chain threat hunting in package registries.
日本語の概要は準備中です。原文の説明を表示しています。
Detect risky OAuth application consent grants in Azure AD / Microsoft Entra ID using Microsoft Graph API, audit logs, and permission analysis to identify illicit consent grant attacks.
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Detects ransomware encryption activity in real time using entropy analysis, file system I/O monitoring, and behavioral heuristics. Identifies mass file modification patterns, abnormal entropy spikes in written data, and suspicious process behavior characteristic of ransomware encryption routines. Activates for requests involving ransomware behavioral detection, entropy-based file monitoring, I/O anomaly detection, or real-time encryption activity alerting.
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Configures Fail2ban with custom filters and actions to detect port scanning activity, SSH brute force attempts, and network reconnaissance, automatically banning offending IP addresses and alerting security teams to suspicious network probing.
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Detect abuse of legitimate Windows binaries (LOLBins) used for living off the land attacks. Monitors process creation, command-line arguments, and parent-child relationships to identify suspicious LOLBin execution patterns.
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Detect malicious scheduled task creation and modification using Sysmon Event IDs 1 (Process Create for schtasks.exe), 11 (File Create for task XML), and Windows Security Event 4698/4702. The analyst correlates task creation with suspicious parent processes, public directory paths, and encoded command arguments to identify persistence and lateral movement via scheduled tasks. Activates for requests involving scheduled task detection, Sysmon persistence hunting, or T1053.005 Scheduled Task/Job analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Detects defense evasion techniques used by adversaries in endpoint logs including log tampering, timestomping, process injection, and security tool disabling. Use when investigating suspicious endpoint behavior, building detection rules for evasion tactics, or conducting threat hunting for stealthy adversary activity. Activates for requests involving evasion detection, defense evasion analysis, log tampering detection, or MITRE ATT&CK TA0005.
日本語の概要は準備中です。原文の説明を表示しています。
Detect compromised O365 and Google Workspace email accounts by analyzing inbox rule creation, suspicious sign-in locations, mail forwarding rules, and unusual API access patterns via Microsoft Graph and audit logs.
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Detects anomalous authentication patterns using UEBA analytics, statistical baselines, and machine learning models to identify impossible travel, credential stuffing, brute force, password spraying, and compromised account behaviors across authentication logs. Activates for requests involving authentication anomaly detection, login behavior analysis, UEBA implementation, or suspicious sign-in investigation.
日本語の概要は準備中です。原文の説明を表示しています。
Detects command-and-control (C2) communications tunneled through DNS protocol including DNS tunneling tools (Iodine, dnscat2, dns2tcp, Cobalt Strike DNS beacon), domain generation algorithms (DGA), encoded payload delivery via TXT/CNAME records, and DNS beaconing patterns. Covers Shannon entropy analysis of query subdomains, statistical anomaly detection, ML-based DGA classification, passive DNS correlation, and Zeek/Suricata signature development. Activates for requests involving DNS-based C2 detection, DNS tunnel identification, suspicious DNS traffic investigation, or DGA domain classification.
日本語の概要は準備中です。原文の説明を表示しています。
Implement a phishing report button in email clients with automated triage workflow that analyzes user-reported suspicious emails and provides feedback to reporters.
日本語の概要は準備中です。原文の説明を表示しています。