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概要と使いどころ
Quantitative agent evaluation using 4-metric framework (correctness/step_ratio/tool_call_ratio/latency_ratio) with ideal trajectory annotation and capability-categorical taxonomy. Use when measuring agent efficiency, comparing agent variants, or gating new agents through correctness→efficiency phases. Complements harness-eval (SE benchmarks) and evaluator-optimizer (qualitative rubric).
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Modern Java 25 LTS patterns from Virtual Threads, Pattern Matching, Records, and Sealed Classes
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Monitor reviewed Grafana telemetry and freshness evidence for IoT devices and edge fleets. Use for smart devices, home automation sensors, remote equipment, wind turbines, space hardware, device-fleet freshness, missing telemetry, and bounded edge-health comparisons.
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Investigate reviewed Grafana APM evidence for request rate, error rate, and operational latency. Use when an application is slow, erroring, dropping traffic, regressing against a baseline, or needs a bounded request-rate, error, and p95 latency health assessment.
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Inspect an explicit Fusion design, parameters, geometry, references, configuration and health without editing it. Use for model understanding or engineering audits.
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Use this skill for ANY of the following — do not skip it even if the query seems simple: strategic decisions, business analysis, thesis building, complex problem solving, geopolitical analysis (non-market), philosophical reasoning, academic research, system design, decision under uncertainty, long-form thinking, or any question that benefits from First Principle deconstruction and multi-agent reasoning. ALWAYS use this skill when the user asks about: why something works the way it does, whether a decision is correct, how to think about a complex problem, what could go wrong, analyzing a situation from multiple angles, or any "should I..." question involving real-world trade-offs. This is NOT a market/trading skill — for financial markets, BTC, gold, stocks, forex, macro economics, use money-atlas-intelligence-os instead.
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Turn a reference image or mockup into a working local frontend that matches it closely. Inspects the image, extracts the design system (layout, type, spacing, color, components), implements it, then screenshot-compares and iterates to close the gap. Use when the user says "image to code", "build this mockup", "code this screenshot", "make this design real", or provides a UI image to implement. Part of the Product Design set. Uses a browser tool for screenshot verification.
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Build visuals that sell a specific offer and value proposition. Translates an offer (price, bundle, guarantee, bonus, deadline) into hero visuals that make the value legible at a glance. Use when the user says "visualize the offer", "promo creative", "make the deal look good", "value prop hero", or has a concrete offer to merchandise. Part of the Creative Production set.
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Stop AI agents from secretly bypassing your rules. Mechanical enforcement with git hooks, secret detection, deployment verification, and import registries. Born from real production incidents: server crashes, token leaks, code rewrites. Works with Claude Code, Clawdbot, Cursor. Install once, enforce forever.
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Openapi utility services - real-time currency exchange rates, HTML-to-PDF conversion (renders JavaScript), .it domain registration/management, and managed RAG (retrieval-augmented generation over your documents). Use for these one-off utility tasks.
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Digital signatures and time stamps through Openapi - eIDAS-compliant electronic signatures (SES with OTP, qualified QES, e-seals, massive automatic signing) and qualified time stamping of documents. Use when the user needs a document signed electronically or time-stamped with legal validity.
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Italian geographic and property data through Openapi - geocoding/reverse geocoding, zip codes (CAP), municipalities/provinces/regions with ISTAT codes, Italian cadastre (catasto) property and owner lookups, visure catastali/ipotecarie, real estate valuations.
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Save important context to persistent memory for future sessions. PROACTIVELY USE THIS when you detect: - Decisions: "let's go with", "decided to", "chose", "went with" - Learnings: "I learned", "turns out", "TIL", "realized", "discovered" - Errors resolved: "fixed", "the problem was", "solution was" - Client info: names, emails, phone numbers, addresses, invoice amounts - Preferences: "I prefer", "I like", "don't like", "always use" - References: API keys locations, file paths, URLs, credentials - Patterns: "pattern", "convention", "always do", "standard approach" - Important commands run worth remembering Do NOT ask permission - just capture silently when these patterns appear.
日本語の概要は準備中です。原文の説明を表示しています。
Hand over a spec and walk away — plans, builds, tests and audits on its own, stopping only at a real blocker.
日本語の概要は準備中です。原文の説明を表示しています。
Runnable end-to-end validation playbook for the Rembric TUI installer — catch breakage before merging/deploying, AND a sandboxed manual walkthrough to evaluate/iterate its UI/UX without polluting your real env. Apply before shipping any change touching `apps/plugin/install.sh`, the repo-root `install.sh` shim, any per-client `install.sh`/`uninstall.sh`, or distribution docs, or when you want to preview/try/demo the installer and polish how it looks and feels. Layered: CI-safe headless (vitest + `sh -n`), local install round-trips, operator interactive pty smoke, an optional full Docker `up` smoke, plus a sandboxed manual UX walkthrough. For the installer contract/what-not-to-break, see `rembric-tui-installer`.
日本語の概要は準備中です。原文の説明を表示しています。
Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.
日本語の概要は準備中です。原文の説明を表示しています。
Assesses the quality and completeness of a genome annotation with BUSCO (conserved single-copy ortholog recovery), OMArk (proteome completeness, consistency, and contamination), CheckM2 (prokaryotic completeness/contamination), and a gene-set sanity panel (gene count, mono-exonic fraction, protein-length distribution, mRNA:gene ratio, coding density). Covers the assembly-BUSCO-vs-proteome-BUSCO diagnostic, what BUSCO-Duplicated really means, why gene count is a vanity metric, and the QC of transferred annotations. Use when judging whether an annotation is good enough to publish or submit, diagnosing a suspect annotation, or comparing annotation completeness across pipelines.
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Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 (GC-bias-aware differential via its bam_ip/bam_input control + bam_treated_ip/bam_treated_input treatment arms), QNB beta-binomial, MeTDiff HMM, and RADAR, plus the paired-symmetric edgeR/DESeq2-on-peak-counts route when batch/lot covariates need fixed-effect handling that exomePeak2's API does not accept. Covers paired vs unpaired vs interaction designs, batch confounding and per-lot meta-analysis, the stoichiometry-vs-expression-vs-IP-efficiency confound, and effect-size filtering against under-powered N=2 designs. Use when comparing m6A across two or more conditions, choosing between exomePeak2/QNB/RADAR/MeTDiff for a design, handling batch confounding when exomePeak2's API is too rigid, distinguishing real hyper/hypo-methylation from expression shifts, applying effect-size thresholds, or planning orthogonal stoichiometry validation (GLORI/SAC-seq/m6Anet mod_ratio).
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Extracts, filters, annotates, and exports differential expression results from DESeq2 or edgeR with proper handling of padj=NA (independent filtering, Cook's outliers, all-zero), multiple-testing correction choice (BH vs Storey q-value vs IHW vs lfsr), TREAT vs post-hoc fold-change filtering, p-value histogram diagnostics, gene annotation via org.db/biomaRt/mygene, GSEA preranked input, ORA background construction, replication reality (Schurch 2016 small-n result), and SABV/sex-stratified reporting. Use when extracting and interpreting DE results, troubleshooting padj=NA, choosing FDR method, preparing ranked lists for pathway analysis, annotating gene IDs, or comparing DESeq2 vs edgeR outputs.
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Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.
日本語の概要は準備中です。原文の説明を表示しています。
Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.
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Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sliding-window DESeq2), Flipper (Skipper-downstream), ASpeak, edgeR, or limma-voom. Use when computing condition-level changes in RBP binding intensity, choosing peak-level vs window-level vs crosslink-level testing, designing replicate experiments, or distinguishing biological binding shifts from technical confounders.
日本語の概要は準備中です。原文の説明を表示しています。
Perform pairwise sequence alignment using Biopython Bio.Align.PairwiseAligner. Use when comparing two sequences, finding optimal alignments, scoring similarity, and identifying local or global matches between DNA, RNA, or protein sequences.
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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.
日本語の概要は準備中です。原文の説明を表示しています。