677 件 ・ 関連度順
概要と使いどころ
Use when writing, reviewing, or refactoring Vue 3 code — components, composables, reactivity, Pinia state, Pinia Colada data-fetching, file-based routing, and forms. Targets Composition API + <script setup> + TypeScript. Auto-activates on .vue files. For deep best-practices review/recommendations or the full ordered workflow (built-in components, animations, performance pass), use mk:vue-best-practices.
日本語の概要は準備中です。原文の説明を表示しています。
Load relevant memories at session start for context continuity. IMPORTANT: Use this AUTOMATICALLY at the START of every session. Search for memories related to: - Current working directory/project - Recent activity (last 7 days) - Topics the user mentions in their first message Execute silently - do not announce what you're loading.
日本語の概要は準備中です。原文の説明を表示しています。
Use when building content-heavy sites with Astro, deciding between SSG/SSR/hybrid, choosing client directives (idle/visible/load/media), structuring content collections with type-safe schemas, integrating React/Vue/Solid/Svelte components in the same project, or migrating from Next.js for marketing/docs. Triggers: client:idle vs client:load tradeoffs, content collections schema with zod, image optimization via @astrojs/image, view transitions, server islands, MDX layouts. NOT for SPA-style apps that need full interactivity (use Next/Remix), Astro internals/plugin authoring, or non-content sites where islands provide no benefit.
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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.
日本語の概要は準備中です。原文の説明を表示しています。
Queries PharmGKB / CPIC / DPWG for drug-gene interactions; calls CYP2D6/CYP2C9/CYP2C19/DPYD/TPMT/NUDT15/UGT1A1/SLCO1B1 star alleles and phenotype with PharmCAT, Cyrius (CYP2D6 structural variants), Aldy, Stargazer; applies Caudle 2020 activity-score translation. Use when implementing pharmacogenomic-guided prescribing, applying CPIC vs DPWG guidance, screening HLA risk alleles for ICI / antiepileptics / abacavir, or interpreting compound TPMT+NUDT15 thiopurine risk.
日本語の概要は準備中です。原文の説明を表示しています。
Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
日本語の概要は準備中です。原文の説明を表示しています。
Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.
日本語の概要は準備中です。原文の説明を表示しています。
Determines if primary aldosteronism is confirmed based on upright plasma aldosterone ≤6 ng/dL (170 nmol/L) on day 4 at 10 AM of fludrocortisone suppression test, provided plasma renin activity ≥1 ng/mL/h and plasma cortisol concentration lower than the 7 AM value to exclude ACTH confounding. Use when reviewing FST results to diagnose PA; triggers include "FST", "upright aldosterone ≤6 ng/dL", "PRA ≥1 ng/mL/h", and "cortisol drop".
日本語の概要は準備中です。原文の説明を表示しています。
Evaluates likelihood of primary aldosteronism by measuring plasma aldosterone suppression after oral captopril; normal suppression ≥30% makes PA unlikely, while lack of suppression with persistently suppressed plasma renin activity suggests PA. Use when assessing captopril challenge test (CCT) results for PA diagnosis in patients with positive aldosterone-to-renin ratio.
日本語の概要は準備中です。原文の説明を表示しています。
Calculates the lowest effective glucocorticoid dose (dexamethasone or prednisone) to normalize blood pressure and serum potassium in glucocorticoid-remediable aldosteronism (GRA/FH-I) by titrating to biochemical and clinical targets. Indicated when initiating medical treatment for confirmed GRA, triggered by findings such as early-onset hypertension, family history of stroke before age 40, spontaneous hypokalemia, or suppressed plasma renin activity with elevated aldosterone.
日本語の概要は準備中です。原文の説明を表示しています。
In patients with primary aldosteronism receiving mineralocorticoid receptor antagonist therapy, the guideline recommends titrating the MRA dose upward to raise renin when blood pressure remains uncontrolled and renin is suppressed. Consider this step when hypertension is not at goal despite MRA therapy and plasma renin activity (or direct renin concentration) is low.
日本語の概要は準備中です。原文の説明を表示しています。
Automate Amplitude tasks via Rube MCP (Composio): events, user activity, cohorts, user identification. Always search tools first for current schemas.
日本語の概要は準備中です。原文の説明を表示しています。
Monitor DX clusters for rare station spots, track active DX expeditions, and get daily band activity digests.
日本語の概要は準備中です。原文の説明を表示しています。
Talk to your Apple Health data — ask questions about your workouts, heart rate, activity rings, and fitness trends.
日本語の概要は準備中です。原文の説明を表示しています。
Expert-level medicinal chemistry knowledge. Use when working with drug design, structure-activity relationships, ADMET properties, pharmacophores, lead optimization, target identification, drug metabolism, or pharmaceutical development. Also use when the user mentions 'SAR', 'drug design', 'pharmacophore', 'ADMET', 'lead compound', 'hit to lead', 'drug metabolism', 'bioavailability', 'selectivity', 'binding affinity', 'scaffold hopping', or 'bioisostere'.
日本語の概要は準備中です。原文の説明を表示しています。
Track a Linear ticket or GitHub PR in today's daily note with fields and timestamped activity. Use when invoked as `$work-track-item` or when the user asks to track a work item.
日本語の概要は準備中です。原文の説明を表示しています。
Generates Angular code and provides architectural guidance. Trigger when creating projects, components, or services, or for best practices on reactivity (signals, linkedSignal, resource), forms, dependency injection, routing, SSR, accessibility (ARIA), animations, styling (component styles, Tailwind CSS), testing, or CLI tooling.
日本語の概要は準備中です。原文の説明を表示しています。
Generates Angular code and provides architectural guidance. Trigger when creating projects, components, services, or HTTP communication, or for best practices on reactivity (signals, linkedSignal, resource, httpResource), forms, dependency injection, routing, SSR, accessibility (ARIA), animations, styling (component styles, Tailwind CSS), testing, naming conventions, or CLI tooling.
日本語の概要は準備中です。原文の説明を表示しています。
Use when designing or implementing feedback, status, progress, alerts, errors, success states, and live activity indicators in Apple-platform apps — inline status, banners, alerts, notifications, and loading states.
日本語の概要は準備中です。原文の説明を表示しています。
Appwrite Kotlin SDK skill. Use when building native Android apps or server-side Kotlin/JVM backends with Appwrite. Covers client-side auth (email, OAuth with Activity integration), database queries, file uploads, real-time subscriptions with coroutine support, and server-side admin via API keys for user management, database administration, storage, and functions.
日本語の概要は準備中です。原文の説明を表示しています。
Generate a daily "where are we?" digest from this repo's GitHub epics — a render-only HTML + plain-text email summarising the last 24h of activity plus a progress snapshot of every open epic. Use when asked for a "daily digest", "epic report", "status rapport", "what moved this week", or "where are we on the epics".
日本語の概要は準備中です。原文の説明を表示しています。
Azure AI VoiceLive SDK for Java. Real-time bidirectional voice conversations with AI assistants using WebSocket. Triggers: "VoiceLiveClient java", "voice assistant java", "real-time voice java", "audio streaming java", "voice activity detection java".
日本語の概要は準備中です。原文の説明を表示しています。
Automate Amplitude tasks via Rube MCP (Composio): events, user activity, cohorts, user identification. Always search tools first for current schemas.
日本語の概要は準備中です。原文の説明を表示しています。
Detect network reconnaissance and port scanning using Suricata and Snort IDS signatures, threshold-based detection rules, and traffic anomaly analysis to identify Nmap, Masscan, and custom scanning activity.
日本語の概要は準備中です。原文の説明を表示しています。