「bi」の検索結果

Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

日本語の概要は準備中です。原文の説明を表示しています。

Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.

日本語の概要は準備中です。原文の説明を表示しています。

Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

日本語の概要は準備中です。原文の説明を表示しています。

Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

日本語の概要は準備中です。原文の説明を表示しています。

Performs retrosynthetic planning using AiZynthFinder (template-based MCTS), maintained or version-pinned template-free models, ASKCOS, and emerging RetroSynFormer with explicit handling of route scoring, configurable MCTS rewards, building-block availability, and forward-prediction checks. Use when assessing synthetic feasibility of generated or selected molecules, planning multi-step syntheses, building synthesis-aware design pipelines, or screening libraries for retro-route feasibility.

日本語の概要は準備中です。原文の説明を表示しています。

Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2024 bioRxiv; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

日本語の概要は準備中です。原文の説明を表示しています。

Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

日本語の概要は準備中です。原文の説明を表示しています。

Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), mSINGS, and MANTIS for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.

日本語の概要は準備中です。原文の説明を表示しています。

Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, applies the Patel et al 2024 *Nat Biotechnol* failure-mode framework, and validates that normalization is applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

日本語の概要は準備中です。原文の説明を表示しています。

Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or Enformer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.

日本語の概要は準備中です。原文の説明を表示しています。

Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.

日本語の概要は準備中です。原文の説明を表示しています。

Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessibility between treatment groups, choosing between consensus-peak vs sliding-window approaches, picking the correct normalization (full library vs reads-in-peaks), correcting batch with SVA/RUVseq, or interpreting log2FC and FDR thresholds in a chromatin context.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3 (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.

日本語の概要は準備中です。原文の説明を表示しています。

Direct TMDL file authoring and BIM-to-TMDL conversion for semantic models in PBIP projects. Automatically invoke when the user asks to "edit TMDL", "add a measure in TMDL", "TMDL syntax", "fix formatString", "fix summarizeBy", "TMDL indentation", "convert BIM to TMDL", "add a column description", "create a calculated column in TMDL", or mentions .tmdl file editing or BIM-to-TMDL migration.

日本語の概要は準備中です。原文の説明を表示しています。

Author, validate, publish, and test Power BI paginated reports in the RDL format. Automatically invoke when the user mentions "paginated report", "RDL", ".rdl", "Report Builder", "Power BI Report Builder", "SSRS report", "PBIRS", "Power BI Report Server", or asks to "create a paginated report", "build an invoice/statement report", "make a print-perfect report", "connect a paginated report to a semantic model", "edit an RDL file", "publish an .rdl", or "render a paginated report to PDF/Excel".

日本語の概要は準備中です。原文の説明を表示しています。

Step-by-step workflow for creating complete Power BI reports from scratch using pbir CLI. Covers model discovery, report creation, page layout, theme setup, visual placement, field binding, filtering, formatting, validation, and publishing. Automatically invoke when the user asks to "create a new report", "build a report from scratch", "make a dashboard", "set up a report with KPIs", "create an executive dashboard", "add pages and visuals to a new report".

日本語の概要は準備中です。原文の説明を表示しています。

Assemble the final `.ppmplugin` binary bundle for a PAM native extension and verify its contents. First **reconciles** the manifest's declared `entrypoints` against the binaries actually staged — if the manifest declares a platform with no built binary it gates (build it / ship without it / stop) rather than shipping a broken bundle. Then re-runs the plugin's upload-compatibility checks on the reconciled manifest, zips the manifest plus whichever of `android/<PascalName>Plugin.dex` and `ios/<PascalName>Plugin.framework/` are present into `ppmplugin/<name>.ppmplugin`, and verifies the archive layout with `jar tf` (exactly the manifest + the shipped binaries — nothing missing, nothing extra). Output: a statically verified `.ppmplugin` file on disk. Prereqs: `jar` (JDK). Run after /generate-ppmplugin-manifest and the build skill(s).

日本語の概要は準備中です。原文の説明を表示しています。

Expert CSRD (Corporate Sustainability Reporting Directive, EU 2022/2464) compliance advisor. Use this skill whenever a user asks about CSRD, European Sustainability Reporting Standards (ESRS), double materiality assessment, sustainability reporting obligations, ESG disclosure, CSRD scope and thresholds, value chain reporting, XBRL digital tagging, third-party assurance, CSRD gap assessments, CSRD implementation timelines, ESRS E1–E5 environmental standards, ESRS S1–S4 social standards, ESRS G1 governance, the 2026 Omnibus scope change (Directive (EU) 2026/470, 1,000+ employees) and revised/simplified ESRS (July 2026), CSRD vs GRI/TCFD/SASB alignment, or any EU corporate sustainability reporting question. Trigger even if the user only mentions "ESG reporting Europe", "sustainability disclosure EU", or "non-financial reporting".

日本語の概要は準備中です。原文の説明を表示しています。

Calendar litigation and arbitration deadlines from a scheduling order. Parses a PDF scheduling order, identifies key dates, computes backward deadlines using the applicable rules (Colorado CRCP, Federal FRCP, or arbitration forum rules for AAA/JAMS), and generates an .ics calendar file for Outlook or Google Calendar import. Use this skill whenever the user mentions: litigation deadlines, scheduling order, case management order, deadline calendaring, discovery deadlines, trial preparation deadlines, arbitration scheduling, or anything related to computing or tracking court or arbitration deadlines. Also trigger when the user uploads a PDF that appears to be a court scheduling order or arbitration scheduling order.

日本語の概要は準備中です。原文の説明を表示しています。

Expert CSRD (Corporate Sustainability Reporting Directive, EU 2022/2464) compliance advisor. Use this skill whenever a user asks about CSRD, European Sustainability Reporting Standards (ESRS), double materiality assessment, sustainability reporting obligations, ESG disclosure, CSRD scope and thresholds, value chain reporting, XBRL digital tagging, third-party assurance, CSRD gap assessments, CSRD implementation timelines, ESRS E1–E5 environmental standards, ESRS S1–S4 social standards, ESRS G1 governance, CSRD vs GRI/TCFD/SASB alignment, or any EU corporate sustainability reporting question. Trigger even if the user only mentions "ESG reporting Europe", "sustainability disclosure EU", or "non-financial reporting".

日本語の概要は準備中です。原文の説明を表示しています。

Adversarially stress-tests a legal text — a contract, statute, regulation, or judicial opinion — for interpretive ambiguity: it finds the seams where the people governed by it will later disagree about what it means and turns each into a concrete dispute scenario with both sides' arguments, the likely outcome, and a fix. Use it whenever someone wants to pressure-test, red-team, audit, or find weak spots, loopholes, gaps, ambiguities, or drafting problems in a legal document; whenever a drafter wants to tighten a contract, statute, regulation, or opinion before it issues; whenever a litigator wants to mine an opinion or contract for arguments; or whenever someone hands over a legal text and asks where it will be fought over or for issue-spotting. Trigger it for contract review, statutory-ambiguity analysis, judicial-opinion scope analysis, and drafting QA — even if the user never says "stress-test" or "ambiguity."

日本語の概要は準備中です。原文の説明を表示しています。

When you want to brainstorm and check available .com domains for a new project — brand naming, aftermarket pricing (HugeDomains / Afternic / Sedo / Dan), USPTO trademark screening, and social handle availability. Built on Laura Roeder's "work backwards from availability" method. Combines Vercel CLI, whois, Domainr, Namecheap, and agent-browser, each for what it reliably does. Workflow: budget → brainstorm → availability check → whois cross-check → price → aftermarket sweep (plus liveness probe and drop-watch) → bucket → negotiate → trademark + socials → buy. Triggers on "/domain," "find a domain," "check domain availability," "brainstorm a domain," "what .com is available for X," "domain hunt," "name my project," "is X.com available," "aftermarket price on X.com," "trademark check for X."

日本語の概要は準備中です。原文の説明を表示しています。