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概要と使いどころ
Persistent memory systems for LLM conversations including short-term, long-term, and entity-based memory Use when: conversation memory, remember, memory persistence, long-term memory, chat history.
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Memory is the cornerstone of intelligent agents. Without it, every interaction starts from zero. This skill covers the architecture of agent memory: short-term (context window), long-term (vector stores), and the cognitive architectures that organize them. Key insight: Memory isn't just storage - it's retrieval. A million stored facts mean nothing if you can't find the right one. Chunking, embedding, and retrieval strategies determine whether your agent remembers or forgets. The field is fragm
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Provides AI and machine learning techniques for CTF challenges. Use when attacking ML models, crafting adversarial examples, performing model extraction, prompt injection, membership inference, training data poisoning, fine-tuning manipulation, neural network analysis, LoRA adapt
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Yuanbao (元宝) groups: @mention users, query info/members.
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Busabase-backed family-office App-in-Skill that consolidates multi-entity investment holdings into one read-only dashboard. Use when the user invokes $kelly-family-office or /kelly-family-office, wants a consolidated family office view, multi-entity aggregation across an individual, trust, company, fund, or foundation, total AUM in a base currency, asset allocation by asset class, by entity/member, or by custodian/institution, multi-currency FX consolidation, CSV import of holdings, unrealized P/L, or read-only portfolio monitoring. It reads Busabase only and NEVER moves money or trades.
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Fetch unread GitHub notifications for open PRs where review is requested from a specified team or opened by a team member. Use when asked to "find PRs I need to review", "show my review requests", "what needs my review", "fetch GitHub review requests", or "check team review queue".
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Plan a user interview topic in PostHog — pick who to target (cohort, emails, or PostHog distinct IDs), draft what to ask about, and prepare the voice-agent context plus a question list. Use when the user asks to "talk to users", "check how users feel about X", "interview some customers", "set up a user interview", "run a user-research call", "find users to ask about Y", or otherwise wants qualitative feedback through a conversation. Walks the user through targeting (cohorts-list, persons-list, or accepting emails / distinct IDs directly), captures the topic, and prompts for agent context and questions before calling user-interview-topics-create. Cohort targeting is resolved to explicit emails/distinct_ids at create time — topics snapshot their audience and do not re-evaluate cohort membership later. Do NOT trigger when the user is uploading a recorded interview audio file (that's the separate UserInterview/transcript flow) or only browsing existing topics with user-interview-topics-list.
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
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KEGG-based disease-drug-variant network research. Connects diseases to causal genes, drugs to molecular targets, and variants to pathways using KEGG's editorially curated databases (KEGG Disease, Drug, Network, Variant, Pathway). Use for drug repurposing via shared pathways, mechanistic disease-gene-drug networks, and pathway-based target discovery. Distinguishes direct (binding) vs indirect (pathway co-membership) drug-target relationships.
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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
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Molecular featurization for ML (100+ featurizers). ECFP, MACCS, descriptors, pretrained models (ChemBERTa), convert SMILES to features, for QSAR and molecular ML.
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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.
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Build UpSet plots to visualize set intersections beyond 4 sets (where Venn fails) using ComplexUpset (modern, ggplot2-grammar) or the unmaintained UpSetR, with explicit cardinality vs degree sorting, attribute panels, and query highlighting. Use when comparing overlap across many gene sets, peak sets, variant lists, or any set membership matrix where Venn diagrams become illegible.
日本語の概要は準備中です。原文の説明を表示しています。
Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.
日本語の概要は準備中です。原文の説明を表示しています。
Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
日本語の概要は準備中です。原文の説明を表示しています。
Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
日本語の概要は準備中です。原文の説明を表示しています。
Launch, inspect, and tear down autonomous phase fleets in isolated Git worktrees, on the Codex or the Claude runtime. Use when approved Flow phase slugs should run in parallel, when fleet status is requested, or when a fleet member must be stopped or explicitly merged.
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Use when approved phases should run in parallel — visually in a cmux panel or unattended — when fleet status is requested, or when a fleet member must be stopped or merged
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Roslyn-powered semantic query CLI for C# solutions. Use when you need to find references, callers, implementations, dependencies, members, or trace call chains in a C# codebase — replaces multi-round grep/read cycles with single precise queries.
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Orchestrate persistent agent memory across coding sessions, repos, and tools. Load when the user asks to remember, recall context, save project memory, create a handoff, manage global memory, update memory, compact memory, audit memory, forget memory, continue from prior sessions, or before commit/push/git operations that checkpoint project state.
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Delete, redact, or archive project and global memories when the user says forget this, delete memory, remove that preference, do not remember, redact sensitive information, or retire stale memory.
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Promote project-specific memories into strict, small global memory only when they are cross-project, stable, useful, safe, and worth the global context cost. Load when the user says make this global, remember across projects, save this globally, or promote this learning.
日本語の概要は準備中です。原文の説明を表示しています。
Capture durable project memory from work, debates, debugging discoveries, learned conventions, deferred options, and session outcomes. Load when the user says remember this, save this learning, record what happened, update project memory, or preserve context for future agents.
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Capture actionable learnings that emerge during conversation — when the agent or user discovers that a skill, a set of skills, or a process needs to be updated based on what's happening in the current chat. Sub-skill of the learn-from orchestrator. Load when the user says "we should update the skill for this", "this should be a skill rule", "add this as a gotcha", "the skill should know about this", "update the process for this", "remember this for next time", "this is important for the skill". Also triggers when the agent notices a skill's guidance was wrong or incomplete, a process step failed or was unnecessary, a new pattern emerged, a guardrail was missing, a workaround became a pattern, or a debugging session reveals a gap.
日本語の概要は準備中です。原文の説明を表示しています。