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概要と使いどころ
Build a five-level rubric with coherent logic for a learning target within a developmental band. Use for Manning methodology programmes where Competent = success. For general curriculum rubrics, use criterion-referenced-rubric-generator instead.
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Evaluate a teacher-drafted central historical question for its capacity to drive genuine historical inquiry. Use when assessing whether a question will generate real evidence-weighing or produce shallow responses.
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Design formative assessments that make students' historical thinking visible — revealing whether they source, close-read, contextualise, and corroborate. Use when assessing historical thinking skills or planning a diagnostic.
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Design a Concrete-Pictorial-Abstract learning sequence for a mathematical concept using manipulatives. Use when teaching maths through Singapore method or when students struggle with abstraction.
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Classify curriculum content into Know, Understand, and Do categories to align teaching and assessment approaches. Use when planning units, writing objectives, or selecting assessment methods.
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Method for scalable identification of spatially variable genes (SVGs) in spatially-resolved transcriptomics data. The method is based on nearest-neighbor Gaussian processes and uses the BRISC algorithm for model fitting and parameter estimation. Allows identification and ranking of SVGs with flexible length scales across a tissue slide or within spatial domains defined by covariates. Scales linearly with the number of spatial locations and can be applied to datasets containing thousands or more
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The package implements a method for normalising microarray intensities from single- and multiple-color arrays. It can also be used for data from other technologies, as long as they have similar format. The method uses a robust variant of th
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Variance-stabilizing transformations help with the analysis of heteroskedastic data (i.e., data where the variance is not constant, like count data). This package provide two types of variance stabilizing transformations: (1) methods based on the delta method (e.g., 'acosh', 'log(x+1)'), (2) model residual based (Pearson and randomized quantile residuals).
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The scDblFinder package gathers various methods for the detection and handling of doublets/multiplets in single-cell sequencing data (i.e. multiple cells captured within the same droplet or reaction volume). It includes methods formerly fou
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The epistack package main objective is the visualizations of stacks of genomic tracks (such as, but not restricted to, ChIP-seq, ATAC-seq, DNA methyation or genomic conservation data) centered at genomic regions of interest. epistack needs three different inputs: 1) a genomic score objects, such as ChIP-seq coverage or DNA methylation values, provided as a `GRanges` (easily obtained from `bigwig` or `bam` files). 2) a list of feature of interest, such as peaks or transcription start sites, provi
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Implements a variety of methods for batch correction of single-cell (RNA sequencing) data. This includes methods based on detecting mutually nearest neighbors, as well as several efficient variants of linear regression of the log-expression
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A package for demultiplexing single-cell sequencing experiments of pooled cells labeled with barcode oligonucleotides. The package implements methods to fit regression mixture models for a probabilistic classification of cells, including multiplet detection. Demultiplexing error rates can be estimated, and methods for quality control are provided.
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Provides methods to convert between Python AnnData objects and SingleCellExperiment objects. These are primarily intended for use by downstream Bioconductor packages that wrap Python methods for single-cell data analysis. It also includes f
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Provides Bayesian PCA, Probabilistic PCA, Nipals PCA, Inverse Non-Linear PCA and the conventional SVD PCA. A cluster based method for missing value estimation is included for comparison. BPCA, PPCA and NipalsPCA may be used to perform PCA o
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Decode any Base transaction into a plain-English story - method, token movements, swaps/approvals, counterparties, and suspicious-approval flags. Keyless via Base RPC + Etherscan v2.
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Applies the Bullseye Framework from Traction by Gabriel Weinberg and Justin Mares. Use when choosing growth channels, testing customer acquisition strategies, or deciding where to spend marketing effort. Covers all 19 traction channels with selection methodology, testing protocol, and phase-matched channel advice. Triggers include 'how do we get customers', 'which marketing channel should we use', 'we have a product but no users', 'our growth has stalled', 'should we do content marketing or paid ads', 'how do we test traction channels', 'what channels work at our stage'. NOT for product development (use Lean Startup), not for positioning/messaging (use Obviously Awesome), not for pricing (use Monetizing Innovation), not for enterprise sales methodology (use SPIN Selling).
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Applies Steve Blank's Customer Development methodology from The Four Steps to the Epiphany. Use when a startup is searching for customers and a business model before scaling. Covers Customer Discovery, Customer Validation, Customer Creation, and Company Building. Triggers include 'we built it but no one's buying', 'should we hire salespeople yet', 'how do we find our first customers', 'we're burning cash and sales aren't scaling', 'are we in a new or existing market', 'when do we scale'. NOT for companies that have already crossed the chasm into mainstream (use Crossing the Chasm instead), not for optimizing an existing sales funnel, not for product development methodology (this is its companion, not replacement).
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嵌入式网络调试工具，用于发现接口、抓包、分析 pcap/pcapng、做连通性测试、端口扫描和流量统计。 当用户提到 Wireshark、tshark、Npcap、抓包、网络联调、端口扫描、连通性排查、pcap 分析、 网络接口、ping 测试、traceroute、流量统计、Modbus TCP、EtherNet/IP 等网络协议调试时自动触发， 也兼容 /net 显式调用。即使用户只是说"抓个包看看"、"扫一下端口"、"网络通不通"或"分析一下这个 pcap"， 只要上下文中出现具体工具名（tshark、Wireshark、Npcap）、协议名（Modbus TCP、EtherNet/IP、ICMP 等）、 调试动作（抓包、端口扫描、连通性测试、ping、traceroute、流量统计、pcap 分析）或网络接口操作，就应触发此 skill。
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Point at something on the human's macOS screen with a big arrow and a sign ("Franz, click HERE") using the bigarrow CLI. Use whenever the human has to look at, click, type into or choose a specific spot, button, field, window, tab or menu: show me where, point to it, which button, where do I click, zeig mir wo, guide me through this UI, the human must approve or sign something, or you need the human's hand and they may not be looking at the terminal. Mandatory when it is time-critical: a code that expires, a login or payment page that times out, a build waiting on the human.
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雪峰式AI-Native产品开发方法论。适用于：(1) 用户行为开放、不可穷举的AI-native产品（AI日历、AI助手、AI推荐、对话式产品等），(2) 强模型依赖型场景，AI驱动核心决策而非仅辅助，(3) 多专精Agent架构设计与分工，(4) 上线后快速校准、行为审计与漂移检测，(5) 模型选择和智能路由策略，(6) 概率性输出的质量评估。触发场景包括"AI-native产品怎么做"、"用户行为不可预测怎么办"、"多agent怎么分工"、"模型漂移怎么处理"、"校准到95%太难了"、"唯快不破"、"怎么选模型"、"agent并行分工"、"AI产品上线后怎么迭代"。注意：如果产品是场景明确、边界可定义的+AI类型，请改用 keqian-method skill。即使用户没有明确说"AI-native"，但在讨论AI驱动决策、用户行为不可预测、概率性输出等话题时也应触发。
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胥克谦式AI-Native产品开发方法论。适用于：(1) 使用AI Agent（Claude Code、Codex、Cursor等）进行产品级软件开发，(2) 设计和优化Harness/Skill体系，(3) 文档驱动开发(SDD)流程，(4) 构建自动化质量门禁和eval机制，(5) Token成本优化与缓存策略，(6) 产品人转型开发者的AI编程实践。触发场景包括"帮我设计开发流程"、"怎么降低token成本"、"怎么提高AI编码质量"、"文档驱动"、"质量门禁"、"harness设计"、"单agent vs multi-agent"、"自动化迭代"、"AI产品开发"、"SDD"、"eval机制"等。即使用户只是说"帮我用AI写代码"或"怎么让agent干活更靠谱"也应触发。注意：如果产品是行为开放、用户输入不可穷举的AI-native类型，请改用 xuefeng-method skill。不用于：单个bug修复或小改动（无需方法论）、PRD需求文档写作（用product-manager）。
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Step 4 of the PaperOrchestra pipeline (arXiv:2604.05018). ONE single multimodal LLM call that drafts the remaining paper sections (Abstract, Methodology, Experiments, Conclusion), extracts numeric values from experimental_log.md into LaTeX booktabs tables, splices the generated figures from Step 2, and merges everything into the template that already contains Intro + Related Work from Step 3. TRIGGER when the orchestrator delegates Step 4 or when the user asks to "write the methodology and experiments sections" or "fill in the rest of the paper".
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Toyota 5 Whys methodology with multi-causal branching, evidence requirements, and validation techniques
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Enhanced Mikado Method for complex architectural refactoring - systematic dependency discovery, tree-based planning, and bottom-up execution
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