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Provides utilities for identifying drug-target interactions for sets of small molecule or gene/protein identifiers. The required drug-target interaction information is obained from a local SQLite instance of the ChEMBL database. ChEMBL has been chosen for this purpose, because it provides one of the most comprehensive and best annotatated knowledge resources for drug-target information available in the public domain.

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R generic interface to Hi-C contact matrices in `.(m)cool`, `.hic` or HiC-Pro derived formats, as well as other Hi-C processed file formats. Contact matrices can be partially parsed using a random access method, allowing a memory-efficient representation of Hi-C data in R. The `HiCExperiment` class stores the Hi-C contacts parsed from local contact matrix files. `HiCExperiment` instances can be further investigated in R using the `HiContacts` analysis package.

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Universal LaTeX document skill: create, compile, and convert any document to professional PDF with PNG previews. Supports resumes, reports, cover letters, invoices, academic papers, theses/dissertations, academic CVs, presentations (Beamer), scientific posters, formal letters, exams/quizzes, books, cheat sheets, reference cards, exam formula sheets, fillable PDF forms (hyperref form fields), conditional content (etoolbox toggles), mail merge from CSV/JSON (Jinja2 templates), version diffing (latexdiff), charts (pgfplots + matplotlib), tables (booktabs + CSV import), images (TikZ), Mermaid diagrams, AI-generated images, watermarks, landscape pages, bibliography/citations (BibTeX/biblatex), multi-language/CJK (auto XeLaTeX), algorithms/pseudocode, colored boxes (tcolorbox), SI units (siunitx), Pandoc format conversion (Markdown/DOCX/HTML ↔ LaTeX), and PDF-to-LaTeX conversion of handwritten or printed documents (math, business, legal, general). Compile script supports pdflatex, xelatex, lualatex with auto-detection, latexmk backend, texfot log filtering, PDF/A output, and verbosity control (--verbose/--quiet). Empirically optimized scaling: single agent 1-10 pages, split 11-20, batch-7 pipeline 21+. Use when user asks to: (1) create a resume/CV/cover letter, (2) write a LaTeX document, (3) create PDF with tables/charts/images, (4) compile a .tex file, (5) make a report/invoice/presentation, (6) anything involving LaTeX or pdflatex, (7) convert/OCR a PDF to LaTeX, (8) convert handwritten notes, (9) create charts/graphs/diagrams, (10) create slides, (11) write a thesis or dissertation, (12) create an academic CV, (13) create a poster, (14) create an exam/quiz, (15) create a book, (16) convert between document formats (Markdown, DOCX, HTML to/from LaTeX), (17) generate Mermaid diagrams for LaTeX, (18) create a formal business letter, (19) create a cheat sheet or reference card, (20) create an exam formula sheet or crib sheet, (21) condense lecture notes/PDFs into a cheat sheet, (22) create a fillable PDF form with text fields/checkboxes/dropdowns, (23) create a document with conditional content/toggles (show/hide sections), (24) generate batch/mail-merge documents from CSV/JSON data, (25) create a version diff PDF (latexdiff) highlighting changes between documents, (26) create a homework or assignment submission with problems and solutions, (27) create a lab report with data tables, graphs, and error analysis, (28) encrypt or password-protect a PDF, (29) merge multiple PDFs into one, (30) optimize/compress a PDF for web or email, (31) lint or check a LaTeX document for common issues, (32) count words in a LaTeX document, (33) analyze document statistics (figures, tables, citations), (34) fetch BibTeX from a DOI, (35) convert a Graphviz .dot file to PDF/PNG, (36) convert a PlantUML .puml file to PDF/PNG, (37) create a one-pager/fact sheet/executive summary, (38) create a datasheet or product specification sheet, (39) extract pages from a PDF (page ranges, odd/even), (40) check LaTeX package availability before compiling, (41) analyze citations and cross-reference with .bib files, (42) debug LaTeX compilation errors, (43) make a document accessible (PDF/A, tagged PDF), (44) create lecture notes or course handouts, (45) fill an existing PDF form (fillable fields or non-fillable with annotations), (46) extract text or tables from a PDF (pdfplumber, pypdf), (47) OCR a scanned PDF to text (pytesseract), (48) create a PDF programmatically with reportlab (Canvas, Platypus), (49) rotate or crop PDF pages (pypdf), (50) add a watermark to an existing PDF, (51) extract metadata from a PDF (title, author, subject).

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Expert knowledge for Azure Security development including best practices, decision making, security, configuration, integrations & coding patterns, and deployment. Use when configuring Azure antimalware, container SBOM/signing, CMK encryption, AKS/VM hardening, or Key Vault keys, and other Azure Security related development tasks. Not for Azure Defender For Cloud (use azure-defender-for-cloud), Azure Information Protection (use azure-information-protection), Azure DDoS Protection (use azure-ddos-protection), Azure Web Application Firewall (use azure-web-application-firewall).

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Expert knowledge for Azure Key Vault development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when managing secrets/keys, Managed HSM, Private Link, Entra ID auth, or key rotation/backup, and other Azure Key Vault related development tasks. Not for Azure Cloud Hsm (use azure-cloud-hsm), Azure Dedicated HSM (use azure-dedicated-hsm), Azure Payment Hsm (use azure-payment-hsm), Azure Information Protection (use azure-information-protection).

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Expert knowledge for Azure Active Directory B2C development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when building B2C user flows/custom policies, configuring IdPs/MFA, securing APIs, automating CI/CD, or monitoring with Sentinel, and other Azure Active Directory B2C related development tasks. Not for Azure Role-based access control (use azure-rbac), Azure Information Protection (use azure-information-protection), Azure Security (use azure-security), Azure Sentinel (use azure-sentinel).

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Plan and execute a brand transformation — from diagnosis to new brand definition to rollout. Use when the user says "rebrand", "rebranding", "brand refresh", "update the brand", "modernize the brand", "our brand is outdated", "we've outgrown our brand", "the brand needs to change", "brand transformation", "pivot the brand", "we're changing the brand", "the old brand doesn't fit anymore", or when a brand has evolved in direction, audience, or market position and needs its identity to catch up.

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Use when the user wants to apply a named Higgsfield motion preset, asks about VFX presets, transformation effects, elemental effects, or transition presets. Contains the full named preset library with descriptions and prompt usage.

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Repurpose and atomize content across platforms and formats. Use when the user says "repurpose this", "turn this into", "convert blog to", "make a thread from", "content atomization", "repurpose content", "turn this article into social posts", or asks about adapting content from one format to another.

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Repurpose one piece of affiliate content into multiple formats. Triggers on: "repurpose my content", "turn my blog into tweets", "cross-post this", "content recycling", "convert to newsletter", "make a tweet thread from this", "adapt for TikTok", "omnichannel content", "scale my content", "turn this into a LinkedIn post", "repurpose for email", "content multiplication".

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Download YouTube videos with customizable quality and format options. Use this skill when the user asks to download, save, or grab YouTube videos. Supports various quality settings (best, 1080p, 720p, 480p, 360p), multiple formats (mp4, webm, mkv), and audio-only downloads as MP3.

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Convert 'Applied intelligently' Cursor rules (.cursor/rules/*.mdc) and slash commands (.cursor/commands/*.md) to Agent Skills format (.cursor/skills/). Use when the user wants to migrate rules or commands to skills, convert .mdc rules to SKILL.md format, or consolidate commands into the skills directory.

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YAML output format and approval criteria for platform design reviews. Load when generating review feedback.

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Download YouTube videos with customizable quality and format options. Use this skill when the user asks to download, save, or grab YouTube videos. Supports various quality settings (best, 1080p, 720p, 480p, 360p), multiple formats (mp4, webm, mkv), and audio-only downloads as MP3.

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Use this skill any time a spreadsheet file is the primary input or output. This means any task where the user wants to: open, read, edit, or fix an existing .xlsx, .xlsm, .csv, or .tsv file (e.g., adding columns, computing formulas, formatting, charting, cleaning messy data); create a new spreadsheet from scratch or from other data sources; or convert between tabular file formats. Trigger especially when the user references a spreadsheet file by name or path — even casually (like "the xlsx in my downloads") — and wants something done to it or produced from it. Also trigger for cleaning or restructuring messy tabular data files (malformed rows, misplaced headers, junk data) into proper spreadsheets. The deliverable must be a spreadsheet file. Do NOT trigger when the primary deliverable is a Word document, HTML report, standalone Python script, database pipeline, or Google Sheets API integration, even if tabular data is involved.

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Creates a Check for Understanding (CFU) for a math topic or standard: 1–3 targeted formative items whose distractors come from documented student misconceptions, plus a teacher guide routing each likely response to a specific next instructional step. Load BEFORE asking any clarifying question about grade, standard, or topic. This skill is for math; for other subjects, help as you normally would and don't mention the skill to the user. Triggers on asks to create, write, generate, or design a check for understanding, formative check, quick check, or exit ticket for a math concept or standard, and on implicit signals like "I need to see who got it before I move on." Not a quiz, test, or practice set — a CFU is read for what it reveals, not scored, so a numbered quiz or a bare answer key is a different job. Does not create a lesson (k12-lesson-plan-creation, which brings its own exit ticket), tier one (k12-lesson-differentiation), or prepare a teacher to teach one (k12-lesson-prep).

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This skill should be used when generating spec artifacts (research.md, requirements.md, design.md, tasks.md), formatting agent output, structuring phase results, or when any Ralph agent needs guidance on concise, scannable output formatting. Applies to all Ralph spec phase agents.

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Lossless session context compression for token efficiency. Extracts entities, decisions, and state into compact format before context window fills. 10-30x reduction in context size while preserving all actionable information.

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Use this skill when visual quality and design identity matter for a PDF. CREATE (generate from scratch): "make a PDF", "generate a report", "write a proposal", "create a resume", "beautiful PDF", "professional document", "cover page", "polished PDF", "client-ready document". FILL (complete form fields): "fill in the form", "fill out this PDF", "complete the form fields", "write values into PDF", "what fields does this PDF have". REFORMAT (apply design to an existing doc): "reformat this document", "apply our style", "convert this Markdown/text to PDF", "make this doc look good", "re-style this PDF". This skill uses a token-based design system: color, typography, and spacing are derived from the document type and flow through every page. The output is print-ready. Prefer this skill when appearance matters, not just when any PDF output is needed.

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Data pipelines, feature stores, and embedding generation for AI/ML systems. Use when building RAG pipelines, ML feature serving, or data transformations. Covers feature stores (Feast, Tecton), embedding pipelines, chunking strategies, orchestration (Dagster, Prefect, Airflow), dbt transformations, data versioning (LakeFS), and experiment tracking (MLflow, W&B).

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Search the web with LLM-optimized results via the Tavily CLI. Use this skill when the user wants to search the web, find articles, look up information, get recent news, discover sources, or says "search for", "find me", "look up", "what's the latest on", "find articles about", or needs current information from the internet. Returns relevant results with content snippets, relevance scores, and metadata — optimized for LLM consumption. Supports domain filtering, time ranges, and multiple search depths.

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Set up or refine open-source .NET code-quality gates for CI: formatting, `.editorconfig`, SDK analyzers, third-party analyzers, coverage, mutation testing, architecture tests, and security scanning. USE FOR: .NET quality gates in CI; analyzer, coverage, mutation, and architecture-test choices; standardizing `.editorconfig`, `dotnet format`, and warning policy. DO NOT USE FOR: non-.NET repositories; generic CI/CD guidance with no .NET quality stack decisions. INVOKES: inspect the repository context, edit targeted files, and run relevant build, test, lint, or validation commands when changes are made.

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Guide for modernizing and migrating MSBuild project files to SDK-style format. USE FOR: converting legacy .csproj/.vbproj with verbose XML to SDK-style, migrating packages.config to PackageReference, removing Properties/AssemblyInfo.cs in favor of auto-generation, eliminating explicit Compile Include lists via implicit globbing, consolidating shared settings into Directory.Build.props. Indicators of legacy projects: ToolsVersion attribute, an Import of Microsoft.CSharp.targets via $(MSBuildToolsPath), .csproj files over 50 lines for simple projects. DO NOT USE FOR: projects already in SDK-style format, non-.NET build systems (npm, Maven, CMake), .NET Framework projects that cannot move to SDK-style.

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Use the free official JetBrains ReSharper Command Line Tools for .NET repositories. USE FOR: `jb inspectcode`; `jb cleanupcode`; stronger C# inspections, cleanup profiles, and CI-friendly JetBrains analysis. DO NOT USE FOR: replacing tests with inspection output; ad-hoc formatting-only work when the repo intentionally standardizes on another formatter. INVOKES: inspect the repository context, edit targeted files, and run relevant build, test, lint, or validation commands when changes are made.

日本語の概要は準備中です。原文の説明を表示しています。